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Protein

Semaphorin-3G

Gene

SEMA3G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3G
Alternative name(s):
Semaphorin sem2
Gene namesi
Name:SEMA3G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000010319.6
HGNCiHGNC:30400 SEMA3G
neXtProtiNX_Q9NS98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56920
OpenTargetsiENSG00000010319
PharmGKBiPA142670937

Polymorphism and mutation databases

BioMutaiSEMA3G
DMDMi74761676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025779123 – 782Semaphorin-3GAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 116By similarity
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 143By similarity
Disulfide bondi270 ↔ 382By similarity
Disulfide bondi294 ↔ 342By similarity
Disulfide bondi522 ↔ 540By similarity
Disulfide bondi603 ↔ 655By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS98
PeptideAtlasiQ9NS98
PRIDEiQ9NS98
ProteomicsDBi82517

PTM databases

iPTMnetiQ9NS98
PhosphoSitePlusiQ9NS98

Expressioni

Gene expression databases

BgeeiENSG00000010319
CleanExiHS_SEMA3G
ExpressionAtlasiQ9NS98 baseline and differential
GenevisibleiQ9NS98 HS

Organism-specific databases

HPAiHPA001761

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121248, 1 interactor
IntActiQ9NS98, 1 interactor
STRINGi9606.ENSP00000231721

Structurei

3D structure databases

ProteinModelPortaliQ9NS98
SMRiQ9NS98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 519SemaPROSITE-ProRule annotationAdd BLAST488
Domaini569 – 671Ig-like C2-typeAdd BLAST103

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ9NS98
KOiK06840
OMAiEAMIFRS
OrthoDBiEOG091G01WA
PhylomeDBiQ9NS98
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013151 Immunoglobulin
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSAWAICW LLGGLLLHGG SSGPSPGPSV PRLRLSYRDL LSANRSAIFL
60 70 80 90 100
GPQGSLNLQA MYLDEYRDRL FLGGLDALYS LRLDQAWPDP REVLWPPQPG
110 120 130 140 150
QREECVRKGR DPLTECANFV RVLQPHNRTH LLACGTGAFQ PTCALITVGH
160 170 180 190 200
RGEHVLHLEP GSVESGRGRC PHEPSRPFAS TFIDGELYTG LTADFLGREA
210 220 230 240 250
MIFRSGGPRP ALRSDSDQSL LHDPRFVMAA RIPENSDQDN DKVYFFFSET
260 270 280 290 300
VPSPDGGSNH VTVSRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG
310 320 330 340 350
GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMADIW
360 370 380 390 400
EVFNGPFAHR DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY
410 420 430 440 450
PDEVLQFARA HPLMFWPVRP RHGRPVLVKT HLAQQLHQIV VDRVEAEDGT
460 470 480 490 500
YDVIFLGTDS GSVLKVIALQ AGGSAEPEEV VLEELQVFKV PTPITEMEIS
510 520 530 540 550
VKRQMLYVGS RLGVAQLRLH QCETYGTACA ECCLARDPYC AWDGASCTHY
560 570 580 590 600
RPSLGKRRFR RQDIRHGNPA LQCLGQSQEE EAVGLVAATM VYGTEHNSTF
610 620 630 640 650
LECLPKSPQA AVRWLLQRPG DEGPDQVKTD ERVLHTERGL LFRRLSRFDA
660 670 680 690 700
GTYTCTTLEH GFSQTVVRLA LVVIVASQLD NLFPPEPKPE EPPARGGLAS
710 720 730 740 750
TPPKAWYKDI LQLIGFANLP RVDEYCERVW CRGTTECSGC FRSRSRGKQA
760 770 780
RGKSWAGLEL GKKMKSRVHA EHNRTPREVE AT
Length:782
Mass (Da):86,701
Last modified:October 1, 2000 - v1
Checksum:i85CB424874DF6663
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051929180S → N. Corresponds to variant dbSNP:rs35811072Ensembl.1
Natural variantiVAR_030292232I → T. Corresponds to variant dbSNP:rs2276833Ensembl.1
Natural variantiVAR_051930332V → I. Corresponds to variant dbSNP:rs34540591Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029496 mRNA Translation: BAA98132.1
AK024425 mRNA Translation: BAB15715.1
BC098104 mRNA Translation: AAH98104.1
BC098137 mRNA Translation: AAH98137.1
BC099724 mRNA Translation: AAH99724.1
CCDSiCCDS2856.1
RefSeqiNP_064548.1, NM_020163.2
UniGeneiHs.59729

Genome annotation databases

EnsembliENST00000231721; ENSP00000231721; ENSG00000010319
GeneIDi56920
KEGGihsa:56920
UCSCiuc003dea.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEM3G_HUMAN
AccessioniPrimary (citable) accession number: Q9NS98
Secondary accession number(s): Q7L9D9, Q9H7Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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