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UniProtKB - Q9NS91 (RAD18_HUMAN)

Entry version 188 (25 May 2022)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase RAD18

Gene

RAD18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi204ZincPROSITE-ProRule annotation1
Metal bindingi207ZincPROSITE-ProRule annotation1
Metal bindingi219ZincPROSITE-ProRule annotation1
Metal bindingi223ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri25 – 64RING-typePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri201 – 228UBZ4-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Transferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NS91

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NS91

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NS91

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RAD18 (EC:2.3.2.27)
Alternative name(s):
Postreplication repair protein RAD18
Short name:
hHR18
Short name:
hRAD18
RING finger protein 73
RING-type E3 ubiquitin transferase RAD18Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD18
Synonyms:RNF73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18278, RAD18

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605256, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NS91

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000070950

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27I → A: Lower activity toward PCNA monoubiquitination. 1 Publication1
Mutagenesisi442S → A: Does not interact with SLF1 and is defective in restoring cell survival after DNA damage; when associated with A-444. 2 Publications1
Mutagenesisi444S → A: Does not interact with SLF1 and is defective in restoring cell survival after DNA damage; when associated with A-442. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		56852

Open Targets

More...OpenTargetsi		ENSG00000070950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134912253

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NS91, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAD18

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104165

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561491 – 495E3 ubiquitin-protein ligase RAD18Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei471PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-3246
CPTAC-3247
CPTAC-3285
CPTAC-939
CPTAC-940

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NS91

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NS91

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NS91

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NS91

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NS91

PeptideAtlas

More...PeptideAtlasi		Q9NS91

PRoteomics IDEntifications database

More...PRIDEi		Q9NS91

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82515

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NS91, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NS91

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NS91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NS91

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NS91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000070950, Expressed in lung and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NS91, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NS91, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000070950, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:21549715).

Interacts with UBE2A and UBE2B, one homodimer binding one molecule of UBE2B.

Interacts with SHPRH (PubMed:17130289, PubMed:17108083).

Interacts with HLTF (PubMed:18316726, PubMed:18719106).

Interacts with SPRTN; leading to enhance chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (PubMed:22681887).

Interacts (via C-terminus and phosphorylated form) with SLF1 (via BRCT domains); this interaction is required for efficient repair of UV-induced DNA damage (PubMed:15632077, PubMed:22036607, PubMed:25931565).

Interacts with SLF2 (PubMed:25931565).

Interacts with SMC5; this interaction is increased in a SLF1 or SLF2-dependent manner (PubMed:25931565).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121212, 452 interactors

Database of interacting proteins

More...DIPi		DIP-29831N

Protein interaction database and analysis system

More...IntActi		Q9NS91, 74 interactors

Molecular INTeraction database

More...MINTi		Q9NS91

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NS91, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NS91

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NS91

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini248 – 282SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 197DisorderedSequence analysisAdd BLAST46
Regioni400 – 423DisorderedSequence analysisAdd BLAST24
Regioni456 – 495DisorderedSequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi232 – 240LR motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi166 – 184Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RAD18 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 64RING-typePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri201 – 228UBZ4-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0287, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011230

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NS91

Identification of Orthologs from Complete Genome Data

More...OMAi		ERTQGGH

Database of Orthologous Groups

More...OrthoDBi		1013108at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NS91

TreeFam database of animal gene trees

More...TreeFami		TF101214

Family and domain databases

Database of protein disorder

More...DisProti		DP01796

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.30, 1 hit
3.30.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00588

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039577, Rad18
IPR006642, Rad18_UBZ4
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...PANTHERi		PTHR14134, PTHR14134, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02037, SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184, RING, 1 hit
SM00513, SAP, 1 hit
SM00734, ZnF_Rad18, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50800, SAP, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit
PS51908, ZF_UBZ4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9NS91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSLAESRWP PGLAVMKTID DLLRCGICFE YFNIAMIIPQ CSHNYCSLCI 
        60         70         80         90        100
RKFLSYKTQC PTCCVTVTEP DLKNNRILDE LVKSLNFARN HLLQFALESP 
       110        120        130        140        150
AKSPASSSSK NLAVKVYTPV ASRQSLKQGS RLMDNFLIRE MSGSTSELLI 
       160        170        180        190        200
KENKSKFSPQ KEASPAAKTK ETRSVEEIAP DPSEAKRPEP PSTSTLKQVT 
       210        220        230        240        250
KVDCPVCGVN IPESHINKHL DSCLSREEKK ESLRSSVHKR KPLPKTVYNL 
       260        270        280        290        300
LSDRDLKKKL KEHGLSIQGN KQQLIKRHQE FVHMYNAQCD ALHPKSAAEI 
       310        320        330        340        350
VREIENIEKT RMRLEASKLN ESVMVFTKDQ TEKEIDEIHS KYRKKHKSEF 
       360        370        380        390        400
QLLVDQARKG YKKIAGMSQK TVTITKEDES TEKLSSVCMG QEDNMTSVTN 
       410        420        430        440        450
HFSQSKLDSP EELEPDREED SSSCIDIQEV LSSSESDSCN SSSSDIIRDL 
       460        470        480        490 
LEEEEAWEAS HKNDLQDTEI SPRQNRRTRA AESAEIEPRN KRNRN
Length:495
Mass (Da):56,223
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i744A053A50C65DD7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WE49F8WE49_HUMAN
RING-type E3 ubiquitin transferase
RAD18
310Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Q4C9J0Q4_HUMAN
E3 ubiquitin-protein ligase RAD18
RAD18
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFA6F8WFA6_HUMAN
E3 ubiquitin-protein ligase RAD18
RAD18
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAZ7F8WAZ7_HUMAN
E3 ubiquitin-protein ligase RAD18
RAD18
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0A5H7C0A5_HUMAN
E3 ubiquitin-protein ligase RAD18
RAD18
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3I2H7C3I2_HUMAN
E3 ubiquitin-protein ligase RAD18
RAD18
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191P → L in AAF80856 (PubMed:10908344).Curated1
Sequence conflicti482 – 484ESA → GKC in AAF80856 (PubMed:10908344).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0234236E → A1 PublicationCorresponds to variant dbSNP:rs45520133Ensembl.1
Natural variantiVAR_023424302R → Q6 PublicationsCorresponds to variant dbSNP:rs373572Ensembl.1
Natural variantiVAR_023425307I → V1 PublicationCorresponds to variant dbSNP:rs45569933Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB035274 mRNA Translation: BAA99284.1
AF169796 mRNA Translation: AAF80856.1
AY004333 mRNA Translation: AAF86618.1
AK023075 mRNA Translation: BAB14392.1
AY961989 Genomic DNA Translation: AAX44049.1
AC008151 Genomic DNA No translation available.
AC034186 Genomic DNA No translation available.
BC001302 mRNA Translation: AAH01302.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2571.1

NCBI Reference Sequences

More...RefSeqi		NP_064550.3, NM_020165.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264926.7; ENSP00000264926.2; ENSG00000070950.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56852

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56852

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000264926.7; ENSP00000264926.2; NM_020165.4; NP_064550.3

UCSC genome browser

More...UCSCi		uc003brd.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035274 mRNA Translation: BAA99284.1
AF169796 mRNA Translation: AAF80856.1
AY004333 mRNA Translation: AAF86618.1
AK023075 mRNA Translation: BAB14392.1
AY961989 Genomic DNA Translation: AAX44049.1
AC008151 Genomic DNA No translation available.
AC034186 Genomic DNA No translation available.
BC001302 mRNA Translation: AAH01302.1
CCDSiCCDS2571.1
RefSeqiNP_064550.3, NM_020165.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MRENMR-B198-227[»]
2MRFNMR-A198-227[»]
2Y43X-ray1.80A/B1-99[»]
2YBFX-ray2.00B340-366[»]
5VF0NMR-B198-240[»]
AlphaFoldDBiQ9NS91
SMRiQ9NS91
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121212, 452 interactors
DIPiDIP-29831N
IntActiQ9NS91, 74 interactors
MINTiQ9NS91
STRINGi9606.ENSP00000264926

PTM databases

GlyGeniQ9NS91, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9NS91
MetOSiteiQ9NS91
PhosphoSitePlusiQ9NS91
SwissPalmiQ9NS91

Genetic variation databases

BioMutaiRAD18
DMDMi313104165

Proteomic databases

CPTACiCPTAC-3246
CPTAC-3247
CPTAC-3285
CPTAC-939
CPTAC-940
EPDiQ9NS91
jPOSTiQ9NS91
MassIVEiQ9NS91
MaxQBiQ9NS91
PaxDbiQ9NS91
PeptideAtlasiQ9NS91
PRIDEiQ9NS91
ProteomicsDBi82515

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10148, 417 antibodies from 40 providers

The CPTC Antibody Portal

More...CPTCi		Q9NS91, 5 antibodies

The DNASU plasmid repository

More...DNASUi		56852

Genome annotation databases

EnsembliENST00000264926.7; ENSP00000264926.2; ENSG00000070950.10
GeneIDi56852
KEGGihsa:56852
MANE-SelectiENST00000264926.7; ENSP00000264926.2; NM_020165.4; NP_064550.3
UCSCiuc003brd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56852
DisGeNETi56852

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAD18
HGNCiHGNC:18278, RAD18
HPAiENSG00000070950, Low tissue specificity
MIMi605256, gene
neXtProtiNX_Q9NS91
OpenTargetsiENSG00000070950
PharmGKBiPA134912253
VEuPathDBiHostDB:ENSG00000070950

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0287, Eukaryota
GeneTreeiENSGT00390000011230
InParanoidiQ9NS91
OMAiERTQGGH
OrthoDBi1013108at2759
PhylomeDBiQ9NS91
TreeFamiTF101214

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9NS91
ReactomeiR-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins
SignaLinkiQ9NS91
SIGNORiQ9NS91

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56852, 52 hits in 1121 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAD18, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAD18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56852
PharosiQ9NS91, Tbio

Protein Ontology

More...PROi		PR:Q9NS91
RNActiQ9NS91, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000070950, Expressed in lung and 179 other tissues
ExpressionAtlasiQ9NS91, baseline and differential
GenevisibleiQ9NS91, HS

Family and domain databases

DisProtiDP01796
Gene3Di1.10.720.30, 1 hit
3.30.40.10, 1 hit
IDEALiIID00588
InterProiView protein in InterPro
IPR039577, Rad18
IPR006642, Rad18_UBZ4
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR14134, PTHR14134, 1 hit
PfamiView protein in Pfam
PF02037, SAP, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00513, SAP, 1 hit
SM00734, ZnF_Rad18, 1 hit
PROSITEiView protein in PROSITE
PS50800, SAP, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit
PS51908, ZF_UBZ4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS91
Secondary accession number(s): Q58F55, Q9NRT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 30, 2010
Last modified: May 25, 2022
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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