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Protein

Kinesin-like protein KIF15

Gene

KIF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 116ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: ProtInc
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central
  • motor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF15
Alternative name(s):
Kinesin-like protein 2
Short name:
hKLP2
Kinesin-like protein 7
Serologically defined breast cancer antigen NY-BR-62
Gene namesi
Name:KIF15
Synonyms:KLP2, KNSL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163808.16
HGNCiHGNC:17273 KIF15
MIMi617569 gene
neXtProtiNX_Q9NS87

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi56992
MalaCardsiKIF15
OpenTargetsiENSG00000163808
Orphaneti3323 Thrombocytopenia-Robin sequence syndrome
PharmGKBiPA30183

Chemistry databases

ChEMBLiCHEMBL3632454

Polymorphism and mutation databases

BioMutaiKIF15
DMDMi74752937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286841 – 1388Kinesin-like protein KIF15Add BLAST1388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei399PhosphothreonineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei1009N6-acetyllysineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1169PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NS87
MaxQBiQ9NS87
PaxDbiQ9NS87
PeptideAtlasiQ9NS87
PRIDEiQ9NS87
ProteomicsDBi82511
82512 [Q9NS87-2]
82513 [Q9NS87-3]
82514 [Q9NS87-4]

PTM databases

CarbonylDBiQ9NS87
iPTMnetiQ9NS87
PhosphoSitePlusiQ9NS87

Expressioni

Tissue specificityi

Expressed in testis, colon, thymus and in breast cancer.1 Publication

Gene expression databases

BgeeiENSG00000163808 Expressed in 125 organ(s), highest expression level in secondary oocyte
CleanExiHS_KIF15
ExpressionAtlasiQ9NS87 baseline and differential
GenevisibleiQ9NS87 HS

Organism-specific databases

HPAiHPA035516
HPA035517

Interactioni

Subunit structurei

Interacts with MKI67 and TPX2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MKI67P460133EBI-712159,EBI-876367

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121307, 28 interactors
DIPiDIP-28133N
IntActiQ9NS87, 18 interactors
MINTiQ9NS87
STRINGi9606.ENSP00000324020

Structurei

Secondary structure

11388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NS87
SMRiQ9NS87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 363Kinesin motorPROSITE-ProRule annotationAdd BLAST338

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili368 – 1388Sequence analysisAdd BLAST1021

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150825
HOGENOMiHOG000113225
HOVERGENiHBG062662
InParanoidiQ9NS87
KOiK10400
OMAiNCKKENE
OrthoDBiEOG091G00LM
PhylomeDBiQ9NS87
TreeFamiTF320478

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR031794 HMMR_C
IPR027640 Kinesin-like_fam
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NS87-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGCKTELR SVTNGQSNQP SNEGDAIKVF VRIRPPAERS GSADGEQNLC
60 70 80 90 100
LSVLSSTSLR LHSNPEPKTF TFDHVADVDT TQESVFATVA KSIVESCMSG
110 120 130 140 150
YNGTIFAYGQ TGSGKTFTMM GPSESDNFSH NLRGVIPRSF EYLFSLIDRE
160 170 180 190 200
KEKAGAGKSF LCKCSFIEIY NEQIYDLLDS ASAGLYLREH IKKGVFVVGA
210 220 230 240 250
VEQVVTSAAE AYQVLSGGWR NRRVASTSMN RESSRSHAVF TITIESMEKS
260 270 280 290 300
NEIVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT
310 320 330 340 350
ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET
360 370 380 390 400
LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LAELASGQTP
410 420 430 440 450
PESFLTRDKK KTNYMEYFQE AMLFFKKSEQ EKKSLIEKVT QLEDLTLKKE
460 470 480 490 500
KFIQSNKMIV KFREDQIIRL EKLHKESRGG FLPEEQDRLL SELRNEIQTL
510 520 530 540 550
REQIEHHPRV AKYAMENHSL REENRRLRLL EPVKRAQEMD AQTIAKLEKA
560 570 580 590 600
FSEISGMEKS DKNQQGFSPK AQKEPCLFAN TEKLKAQLLQ IQTELNNSKQ
610 620 630 640 650
EYEEFKELTR KRQLELESEL QSLQKANLNL ENLLEATKAC KRQEVSQLNK
660 670 680 690 700
IHAETLKIIT TPTKAYQLHS RPVPKLSPEM GSFGSLYTQN SSILDNDILN
710 720 730 740 750
EPVPPEMNEQ AFEAISEELR TVQEQMSALQ AKLDEEEHKN LKLQQHVDKL
760 770 780 790 800
EHHSTQMQEL FSSERIDWTK QQEELLSQLN VLEKQLQETQ TKNDFLKSEV
810 820 830 840 850
HDLRVVLHSA DKELSSVKLE YSSFKTNQEK EFNKLSERHM HVQLQLDNLR
860 870 880 890 900
LENEKLLESK ACLQDSYDNL QEIMKFEIDQ LSRNLQNFKK ENETLKSDLN
910 920 930 940 950
NLMELLEAEK ERNNKLSLQF EEDKENSSKE ILKVLEAVRQ EKQKETAKCE
960 970 980 990 1000
QQMAKVQKLE ESLLATEKVI SSLEKSRDSD KKVVADLMNQ IQELRTSVCE
1010 1020 1030 1040 1050
KTETIDTLKQ ELKDINCKYN SALVDREESR VLIKKQEVDI LDLKETLRLR
1060 1070 1080 1090 1100
ILSEDIERDM LCEDLAHATE QLNMLTEASK KHSGLLQSAQ EELTKKEALI
1110 1120 1130 1140 1150
QELQHKLNQK KEEVEQKKNE YNFKMRQLEH VMDSAAEDPQ SPKTPPHFQT
1160 1170 1180 1190 1200
HLAKLLETQE QEIEDGRASK TSLEHLVTKL NEDREVKNAE ILRMKEQLRE
1210 1220 1230 1240 1250
MENLRLESQQ LIEKNWLLQG QLDDIKRQKE NSDQNHPDNQ QLKNEQEESI
1260 1270 1280 1290 1300
KERLAKSKIV EEMLKMKADL EEVQSALYNK EMECLRMTDE VERTQTLESK
1310 1320 1330 1340 1350
AFQEKEQLRS KLEEMYEERE RTSQEMEMLR KQVECLAEEN GKLVGHQNLH
1360 1370 1380
QKIQYVVRLK KENVRLAEET EKLRAENVFL KEKKRSES
Length:1,388
Mass (Da):160,160
Last modified:October 1, 2000 - v1
Checksum:iE127EB4B991CA83A
GO
Isoform 2 (identifier: Q9NS87-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:1,291
Mass (Da):149,784
Checksum:i86EABBD49A76151B
GO
Isoform 3 (identifier: Q9NS87-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-952: Missing.

Show »
Length:436
Mass (Da):51,433
Checksum:i3BE3ABBDB7A7821D
GO
Isoform 4 (identifier: Q9NS87-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1092-1119: ELTKKEALIQELQHKLNQKKEEVEQKKN → RTDQERSPDSGTSAQAKPKERGSRTEEE
     1200-1388: Missing.

Show »
Length:1,199
Mass (Da):137,169
Checksum:i18176A5A924EFB95
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCT7D6RCT7_HUMAN
Kinesin-like protein KIF15
KIF15
711Annotation score:
C9JKA9C9JKA9_HUMAN
Kinesin-like protein KIF15
KIF15
1,023Annotation score:
H7BZT2H7BZT2_HUMAN
Kinesin-like protein KIF15
KIF15
194Annotation score:
H7C1K7H7C1K7_HUMAN
Kinesin-like protein KIF15
KIF15
128Annotation score:
F8WC33F8WC33_HUMAN
Kinesin-like protein KIF15
KIF15
83Annotation score:

Sequence cautioni

The sequence AAG48261 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1057E → K in AAG48261 (PubMed:12747765).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042464211A → V. Corresponds to variant dbSNP:rs34862960Ensembl.1
Natural variantiVAR_042465996T → S2 PublicationsCorresponds to variant dbSNP:rs11710339Ensembl.1
Natural variantiVAR_0424661206L → M. Corresponds to variant dbSNP:rs3804583Ensembl.1
Natural variantiVAR_0424671272E → D. Corresponds to variant dbSNP:rs17076986Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0327521 – 952Missing in isoform 3. 1 PublicationAdd BLAST952
Alternative sequenceiVSP_0327531 – 97Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_0327541092 – 1119ELTKK…EQKKN → RTDQERSPDSGTSAQAKPKE RGSRTEEE in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0327551200 – 1388Missing in isoform 4. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035898 mRNA Translation: BAB03309.1
AK027816 mRNA Translation: BAB55389.1
BC117174 mRNA Translation: AAI17175.1
AL832908 mRNA Translation: CAH10635.1
AF308294 mRNA Translation: AAG48261.1 Frameshift.
CCDSiCCDS33744.1 [Q9NS87-1]
RefSeqiNP_064627.1, NM_020242.2 [Q9NS87-1]
UniGeneiHs.658939

Genome annotation databases

EnsembliENST00000326047; ENSP00000324020; ENSG00000163808 [Q9NS87-1]
ENST00000627272; ENSP00000486004; ENSG00000280610 [Q9NS87-1]
GeneIDi56992
KEGGihsa:56992
UCSCiuc003cnx.5 human [Q9NS87-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035898 mRNA Translation: BAB03309.1
AK027816 mRNA Translation: BAB55389.1
BC117174 mRNA Translation: AAI17175.1
AL832908 mRNA Translation: CAH10635.1
AF308294 mRNA Translation: AAG48261.1 Frameshift.
CCDSiCCDS33744.1 [Q9NS87-1]
RefSeqiNP_064627.1, NM_020242.2 [Q9NS87-1]
UniGeneiHs.658939

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BN2X-ray2.70A/B/C19-375[»]
ProteinModelPortaliQ9NS87
SMRiQ9NS87
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121307, 28 interactors
DIPiDIP-28133N
IntActiQ9NS87, 18 interactors
MINTiQ9NS87
STRINGi9606.ENSP00000324020

Chemistry databases

ChEMBLiCHEMBL3632454

PTM databases

CarbonylDBiQ9NS87
iPTMnetiQ9NS87
PhosphoSitePlusiQ9NS87

Polymorphism and mutation databases

BioMutaiKIF15
DMDMi74752937

Proteomic databases

EPDiQ9NS87
MaxQBiQ9NS87
PaxDbiQ9NS87
PeptideAtlasiQ9NS87
PRIDEiQ9NS87
ProteomicsDBi82511
82512 [Q9NS87-2]
82513 [Q9NS87-3]
82514 [Q9NS87-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326047; ENSP00000324020; ENSG00000163808 [Q9NS87-1]
ENST00000627272; ENSP00000486004; ENSG00000280610 [Q9NS87-1]
GeneIDi56992
KEGGihsa:56992
UCSCiuc003cnx.5 human [Q9NS87-1]

Organism-specific databases

CTDi56992
DisGeNETi56992
EuPathDBiHostDB:ENSG00000163808.16
GeneCardsiKIF15
HGNCiHGNC:17273 KIF15
HPAiHPA035516
HPA035517
MalaCardsiKIF15
MIMi617569 gene
neXtProtiNX_Q9NS87
OpenTargetsiENSG00000163808
Orphaneti3323 Thrombocytopenia-Robin sequence syndrome
PharmGKBiPA30183
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150825
HOGENOMiHOG000113225
HOVERGENiHBG062662
InParanoidiQ9NS87
KOiK10400
OMAiNCKKENE
OrthoDBiEOG091G00LM
PhylomeDBiQ9NS87
TreeFamiTF320478

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

GeneWikiiKIF15
GenomeRNAii56992
PROiPR:Q9NS87
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163808 Expressed in 125 organ(s), highest expression level in secondary oocyte
CleanExiHS_KIF15
ExpressionAtlasiQ9NS87 baseline and differential
GenevisibleiQ9NS87 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR031794 HMMR_C
IPR027640 Kinesin-like_fam
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF15_HUMAN
AccessioniPrimary (citable) accession number: Q9NS87
Secondary accession number(s): Q17RV9
, Q69YL6, Q96JX7, Q9H280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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