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Protein

LanC-like protein 2

Gene

LANCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.1 Publication

Miscellaneous

Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin).

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • catalytic activity Source: InterPro
  • GTP binding Source: UniProtKB
  • phosphatidylinositol-3-phosphate binding Source: UniProtKB
  • phosphatidylinositol-4-phosphate binding Source: UniProtKB
  • phosphatidylinositol-5-phosphate binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 2
Alternative name(s):
Testis-specific adriamycin sensitivity protein
Gene namesi
Name:LANCL2
Synonyms:GPR69B, TASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000132434.9
HGNCiHGNC:6509 LANCL2
MIMi612919 gene
neXtProtiNX_Q9NS86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Loss of membrane localization and results in localization to the nucleus, particularly to the nucleoli. 1 Publication1

Organism-specific databases

DisGeNETi55915
OpenTargetsiENSG00000132434
PharmGKBiPA30294

Chemistry databases

ChEMBLiCHEMBL3351212

Polymorphism and mutation databases

BioMutaiLANCL2
DMDMi47116933

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001912722 – 450LanC-like protein 2Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei198PhosphotyrosineBy similarity1

Post-translational modificationi

Myristoylated. Essential for membrane association.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9NS86
MaxQBiQ9NS86
PaxDbiQ9NS86
PeptideAtlasiQ9NS86
PRIDEiQ9NS86
ProteomicsDBi82510

PTM databases

iPTMnetiQ9NS86
PhosphoSitePlusiQ9NS86

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000132434 Expressed in 206 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_LANCL2
ExpressionAtlasiQ9NS86 baseline and differential
GenevisibleiQ9NS86 HS

Organism-specific databases

HPAiHPA019711
HPA029535

Interactioni

Subunit structurei

Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi120998, 30 interactors
IntActiQ9NS86, 7 interactors
MINTiQ9NS86
STRINGi9606.ENSP00000254770

Chemistry databases

BindingDBiQ9NS86

Structurei

3D structure databases

ProteinModelPortaliQ9NS86
SMRiQ9NS86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 15Interaction with inositol phospholipidsAdd BLAST14

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiQ9NS86
OMAiMEERAFA
OrthoDBiEOG091G02TS
PhylomeDBiQ9NS86
TreeFamiTF300068

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NS86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGETMSKRLK LHLGGEAEME ERAFVNPFPD YEAAAGALLA SGAAEETGCV
60 70 80 90 100
RPPATTDEPG LPFHQDGKII HNFIRRIQTK IKDLLQQMEE GLKTADPHDC
110 120 130 140 150
SAYTGWTGIA LLYLQLYRVT CDQTYLLRSL DYVKRTLRNL NGRRVTFLCG
160 170 180 190 200
DAGPLAVGAV IYHKLRSDCE SQECVTKLLQ LQRSVVCQES DLPDELLYGR
210 220 230 240 250
AGYLYALLYL NTEIGPGTVC ESAIKEVVNA IIESGKTLSR EERKTERCPL
260 270 280 290 300
LYQWHRKQYV GAAHGMAGIY YMLMQPAAKV DQETLTEMVK PSIDYVRHKK
310 320 330 340 350
FRSGNYPSSL SNETDRLVHW CHGAPGVIHM LMQAYKVFKE EKYLKEAMEC
360 370 380 390 400
SDVIWQRGLL RKGYGICHGT AGNGYSFLSL YRLTQDKKYL YRACKFAEWC
410 420 430 440 450
LDYGAHGCRI PDRPYSLFEG MAGAIHFLSD VLGPETSRFP AFELDSSKRD
Length:450
Mass (Da):50,854
Last modified:October 1, 2000 - v1
Checksum:i8FD27E11BB91C05D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ40H7BZ40_HUMAN
LanC-like protein 2
LANCL2
40Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06006456T → P3 PublicationsCorresponds to variant dbSNP:rs2272263Ensembl.1
Natural variantiVAR_05348074I → V. Corresponds to variant dbSNP:rs6961412Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278245 mRNA Translation: CAC21715.1
AB035966 mRNA Translation: BAA96800.1
AF353942 mRNA Translation: AAK83286.1
AK313326 mRNA Translation: BAG36131.1
AC073347 Genomic DNA Translation: AAQ93360.1
CH236957 Genomic DNA Translation: EAL23810.1
CH471201 Genomic DNA Translation: EAW50968.1
BC004887 mRNA Translation: AAH04887.2
BC070049 mRNA Translation: AAH70049.1
AL713665 mRNA Translation: CAD28471.1
CCDSiCCDS5517.1
RefSeqiNP_061167.1, NM_018697.3
UniGeneiHs.595384
Hs.706612

Genome annotation databases

EnsembliENST00000254770; ENSP00000254770; ENSG00000132434
GeneIDi55915
KEGGihsa:55915
UCSCiuc003tqp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278245 mRNA Translation: CAC21715.1
AB035966 mRNA Translation: BAA96800.1
AF353942 mRNA Translation: AAK83286.1
AK313326 mRNA Translation: BAG36131.1
AC073347 Genomic DNA Translation: AAQ93360.1
CH236957 Genomic DNA Translation: EAL23810.1
CH471201 Genomic DNA Translation: EAW50968.1
BC004887 mRNA Translation: AAH04887.2
BC070049 mRNA Translation: AAH70049.1
AL713665 mRNA Translation: CAD28471.1
CCDSiCCDS5517.1
RefSeqiNP_061167.1, NM_018697.3
UniGeneiHs.595384
Hs.706612

3D structure databases

ProteinModelPortaliQ9NS86
SMRiQ9NS86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120998, 30 interactors
IntActiQ9NS86, 7 interactors
MINTiQ9NS86
STRINGi9606.ENSP00000254770

Chemistry databases

BindingDBiQ9NS86
ChEMBLiCHEMBL3351212

PTM databases

iPTMnetiQ9NS86
PhosphoSitePlusiQ9NS86

Polymorphism and mutation databases

BioMutaiLANCL2
DMDMi47116933

Proteomic databases

EPDiQ9NS86
MaxQBiQ9NS86
PaxDbiQ9NS86
PeptideAtlasiQ9NS86
PRIDEiQ9NS86
ProteomicsDBi82510

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254770; ENSP00000254770; ENSG00000132434
GeneIDi55915
KEGGihsa:55915
UCSCiuc003tqp.3 human

Organism-specific databases

CTDi55915
DisGeNETi55915
EuPathDBiHostDB:ENSG00000132434.9
GeneCardsiLANCL2
HGNCiHGNC:6509 LANCL2
HPAiHPA019711
HPA029535
MIMi612919 gene
neXtProtiNX_Q9NS86
OpenTargetsiENSG00000132434
PharmGKBiPA30294
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiQ9NS86
OMAiMEERAFA
OrthoDBiEOG091G02TS
PhylomeDBiQ9NS86
TreeFamiTF300068

Miscellaneous databases

ChiTaRSiLANCL2 human
GeneWikiiLANCL2
GenomeRNAii55915
PROiPR:Q9NS86
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132434 Expressed in 206 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_LANCL2
ExpressionAtlasiQ9NS86 baseline and differential
GenevisibleiQ9NS86 HS

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLANC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS86
Secondary accession number(s): B2R8D4
, Q6NSL4, Q8TCQ3, Q9BSR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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