UniProtKB - Q9NS85 (CAH10_HUMAN)
Protein
Carbonic anhydrase-related protein 10
Gene
CA10
Organism
Homo sapiens (Human)
Status
Functioni
Does not have a catalytic activity.
GO - Molecular functioni
- carbonate dehydratase activity Source: InterPro
- hydro-lyase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- brain development Source: UniProtKB
- one-carbon metabolic process Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9NS85 |
Names & Taxonomyi
Protein namesi | Recommended name: Carbonic anhydrase-related protein 10Alternative name(s): Carbonic anhydrase-related protein X Short name: CA-RP X Short name: CARP X Cerebral protein 15 |
Gene namesi | Name:CA10 ORF Names:hucep-15, UNQ533/PRO1076 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1369, CA10 |
MIMi | 604642, gene |
neXtProti | NX_Q9NS85 |
VEuPathDBi | HostDB:ENSG00000154975.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56934 |
OpenTargetsi | ENSG00000154975 |
PharmGKBi | PA25985 |
Miscellaneous databases
Pharosi | Q9NS85, Tbio |
Chemistry databases
DrugBanki | DB00909, Zonisamide |
Genetic variation databases
BioMutai | CA10 |
DMDMi | 18203320 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077436 | 1 – 328 | Carbonic anhydrase-related protein 10Add BLAST | 328 |
Proteomic databases
MassIVEi | Q9NS85 |
PaxDbi | Q9NS85 |
PeptideAtlasi | Q9NS85 |
PRIDEi | Q9NS85 |
ProteomicsDBi | 4142 82509 [Q9NS85-1] |
PTM databases
iPTMneti | Q9NS85 |
PhosphoSitePlusi | Q9NS85 |
Expressioni
Tissue specificityi
Strong expression in brain and central nervous system.1 Publication
Developmental stagei
Not expressed in fetal brain.
Gene expression databases
Bgeei | ENSG00000154975, Expressed in cerebellar hemisphere and 129 other tissues |
ExpressionAtlasi | Q9NS85, baseline and differential |
Genevisiblei | Q9NS85, HS |
Organism-specific databases
HPAi | ENSG00000154975, Tissue enhanced (brain, cervix, uterine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121259, 26 interactors |
IntActi | Q9NS85, 24 interactors |
STRINGi | 9606.ENSP00000405388 |
Miscellaneous databases
RNActi | Q9NS85, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 301 | Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST | 271 |
Sequence similaritiesi
Belongs to the alpha-carbonic anhydrase family.Curated
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000155223 |
HOGENOMi | CLU_039326_7_1_1 |
InParanoidi | Q9NS85 |
OMAi | NLHHRTV |
OrthoDBi | 1377476at2759 |
PhylomeDBi | Q9NS85 |
TreeFami | TF352926 |
Family and domain databases
CDDi | cd03121, alpha_CARP_X_XI_like, 1 hit |
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR041878, Alpha_CARP_X/XI IPR018423, CA10 IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class |
PANTHERi | PTHR18952, PTHR18952, 1 hit PTHR18952:SF91, PTHR18952:SF91, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS51144, ALPHA_CA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NS85-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW
60 70 80 90 100
GLVNSAWNLC SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN
110 120 130 140 150
TGRHVSLRLD KEHLVNISGG PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ
160 170 180 190 200
AFSGEVQLIH YNHELYTNVT EAAKSPNGLV VVSIFIKVSD SSNPFLNRML
210 220 230 240 250
NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT IPPCYETASW
260 270 280 290 300
IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN
310 320
INFSLQGKDC PNNRAQKLQY RVNEWLLK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L375 | I3L375_HUMAN | Carbonic anhydrase-related protein ... | CA10 | 276 | Annotation score: | ||
I3L0J7 | I3L0J7_HUMAN | Carbonic anhydrase-related protein ... | CA10 | 56 | Annotation score: | ||
I3NI54 | I3NI54_HUMAN | Carbonic anhydrase-related protein ... | CA10 | 42 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056940 | 1 – 75 | Missing in isoform 2. 1 PublicationAdd BLAST | 75 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036836 mRNA Translation: BAB00615.1 AF288385 mRNA Translation: AAK11974.1 AB001597 mRNA Translation: BAB46928.1 AF064854 mRNA No translation available. AL161812 mRNA Translation: CAB82105.1 AY358509 mRNA Translation: AAQ88873.1 AK294652 mRNA Translation: BAG57827.1 AK313001 mRNA Translation: BAG35837.1 AC002090 Genomic DNA No translation available. AC004108 Genomic DNA No translation available. AC005883 Genomic DNA No translation available. AC006083 Genomic DNA No translation available. AC016473 Genomic DNA No translation available. AC092713 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94558.1 BC020577 mRNA Translation: AAH20577.1 BC047456 mRNA Translation: AAH47456.1 BC068462 mRNA Translation: AAH68462.1 |
CCDSi | CCDS32684.1 [Q9NS85-1] |
RefSeqi | NP_001076002.1, NM_001082533.1 [Q9NS85-1] NP_001076003.1, NM_001082534.1 [Q9NS85-1] NP_064563.1, NM_020178.4 [Q9NS85-1] |
Genome annotation databases
Ensembli | ENST00000285273; ENSP00000285273; ENSG00000154975 [Q9NS85-1] ENST00000442502; ENSP00000390666; ENSG00000154975 [Q9NS85-1] ENST00000451037; ENSP00000405388; ENSG00000154975 [Q9NS85-1] ENST00000570565; ENSP00000459619; ENSG00000154975 [Q9NS85-2] |
GeneIDi | 56934 |
KEGGi | hsa:56934 |
UCSCi | uc002itw.5, human [Q9NS85-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036836 mRNA Translation: BAB00615.1 AF288385 mRNA Translation: AAK11974.1 AB001597 mRNA Translation: BAB46928.1 AF064854 mRNA No translation available. AL161812 mRNA Translation: CAB82105.1 AY358509 mRNA Translation: AAQ88873.1 AK294652 mRNA Translation: BAG57827.1 AK313001 mRNA Translation: BAG35837.1 AC002090 Genomic DNA No translation available. AC004108 Genomic DNA No translation available. AC005883 Genomic DNA No translation available. AC006083 Genomic DNA No translation available. AC016473 Genomic DNA No translation available. AC092713 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94558.1 BC020577 mRNA Translation: AAH20577.1 BC047456 mRNA Translation: AAH47456.1 BC068462 mRNA Translation: AAH68462.1 |
CCDSi | CCDS32684.1 [Q9NS85-1] |
RefSeqi | NP_001076002.1, NM_001082533.1 [Q9NS85-1] NP_001076003.1, NM_001082534.1 [Q9NS85-1] NP_064563.1, NM_020178.4 [Q9NS85-1] |
3D structure databases
SMRi | Q9NS85 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121259, 26 interactors |
IntActi | Q9NS85, 24 interactors |
STRINGi | 9606.ENSP00000405388 |
Chemistry databases
DrugBanki | DB00909, Zonisamide |
PTM databases
iPTMneti | Q9NS85 |
PhosphoSitePlusi | Q9NS85 |
Genetic variation databases
BioMutai | CA10 |
DMDMi | 18203320 |
Proteomic databases
MassIVEi | Q9NS85 |
PaxDbi | Q9NS85 |
PeptideAtlasi | Q9NS85 |
PRIDEi | Q9NS85 |
ProteomicsDBi | 4142 82509 [Q9NS85-1] |
Protocols and materials databases
Antibodypediai | 30804, 182 antibodies |
DNASUi | 56934 |
Genome annotation databases
Ensembli | ENST00000285273; ENSP00000285273; ENSG00000154975 [Q9NS85-1] ENST00000442502; ENSP00000390666; ENSG00000154975 [Q9NS85-1] ENST00000451037; ENSP00000405388; ENSG00000154975 [Q9NS85-1] ENST00000570565; ENSP00000459619; ENSG00000154975 [Q9NS85-2] |
GeneIDi | 56934 |
KEGGi | hsa:56934 |
UCSCi | uc002itw.5, human [Q9NS85-1] |
Organism-specific databases
CTDi | 56934 |
DisGeNETi | 56934 |
GeneCardsi | CA10 |
HGNCi | HGNC:1369, CA10 |
HPAi | ENSG00000154975, Tissue enhanced (brain, cervix, uterine) |
MIMi | 604642, gene |
neXtProti | NX_Q9NS85 |
OpenTargetsi | ENSG00000154975 |
PharmGKBi | PA25985 |
VEuPathDBi | HostDB:ENSG00000154975.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000155223 |
HOGENOMi | CLU_039326_7_1_1 |
InParanoidi | Q9NS85 |
OMAi | NLHHRTV |
OrthoDBi | 1377476at2759 |
PhylomeDBi | Q9NS85 |
TreeFami | TF352926 |
Enzyme and pathway databases
PathwayCommonsi | Q9NS85 |
Miscellaneous databases
BioGRID-ORCSi | 56934, 5 hits in 871 CRISPR screens |
ChiTaRSi | CA10, human |
GeneWikii | CA10 |
GenomeRNAii | 56934 |
Pharosi | Q9NS85, Tbio |
PROi | PR:Q9NS85 |
RNActi | Q9NS85, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154975, Expressed in cerebellar hemisphere and 129 other tissues |
ExpressionAtlasi | Q9NS85, baseline and differential |
Genevisiblei | Q9NS85, HS |
Family and domain databases
CDDi | cd03121, alpha_CARP_X_XI_like, 1 hit |
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR041878, Alpha_CARP_X/XI IPR018423, CA10 IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class |
PANTHERi | PTHR18952, PTHR18952, 1 hit PTHR18952:SF91, PTHR18952:SF91, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS51144, ALPHA_CA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAH10_HUMAN | |
Accessioni | Q9NS85Primary (citable) accession number: Q9NS85 Secondary accession number(s): B2R7J0, B4DGL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families