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Protein

Carbonic anhydrase-related protein 10

Gene

CA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not have a catalytic activity.

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase-related protein 10
Alternative name(s):
Carbonic anhydrase-related protein X
Short name:
CA-RP X
Short name:
CARP X
Cerebral protein 15
Gene namesi
Name:CA10
ORF Names:hucep-15, UNQ533/PRO1076
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000154975.13
HGNCiHGNC:1369 CA10
MIMi604642 gene
neXtProtiNX_Q9NS85

Pathology & Biotechi

Organism-specific databases

DisGeNETi56934
OpenTargetsiENSG00000154975
PharmGKBiPA25985

Chemistry databases

DrugBankiDB00909 Zonisamide

Polymorphism and mutation databases

BioMutaiCA10
DMDMi18203320

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774361 – 328Carbonic anhydrase-related protein 10Add BLAST328

Proteomic databases

PaxDbiQ9NS85
PeptideAtlasiQ9NS85
PRIDEiQ9NS85
ProteomicsDBi82509

PTM databases

iPTMnetiQ9NS85
PhosphoSitePlusiQ9NS85

Expressioni

Tissue specificityi

Strong expression in brain and central nervous system.1 Publication

Developmental stagei

Not expressed in fetal brain.

Gene expression databases

BgeeiENSG00000154975
CleanExiHS_CA10
ExpressionAtlasiQ9NS85 baseline and differential
GenevisibleiQ9NS85 HS

Organism-specific databases

HPAiHPA054825
HPA057837

Interactioni

Protein-protein interaction databases

BioGridi121259, 26 interactors
STRINGi9606.ENSP00000285273

Structurei

3D structure databases

ProteinModelPortaliQ9NS85
SMRiQ9NS85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 301Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00920000149072
HOGENOMiHOG000019899
HOVERGENiHBG097666
InParanoidiQ9NS85
OMAiVQNLHHR
OrthoDBiEOG091G0T4J
PhylomeDBiQ9NS85
TreeFamiTF352926

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR018423 CA10
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF91 PTHR18952:SF91, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS85-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW
60 70 80 90 100
GLVNSAWNLC SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN
110 120 130 140 150
TGRHVSLRLD KEHLVNISGG PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ
160 170 180 190 200
AFSGEVQLIH YNHELYTNVT EAAKSPNGLV VVSIFIKVSD SSNPFLNRML
210 220 230 240 250
NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT IPPCYETASW
260 270 280 290 300
IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN
310 320
INFSLQGKDC PNNRAQKLQY RVNEWLLK
Length:328
Mass (Da):37,563
Last modified:October 1, 2000 - v1
Checksum:iB20BFEC1800422B4
GO
Isoform 2 (identifier: Q9NS85-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):29,049
Checksum:i14D1A23D092D3178
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569401 – 75Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036836 mRNA Translation: BAB00615.1
AF288385 mRNA Translation: AAK11974.1
AB001597 mRNA Translation: BAB46928.1
AF064854 mRNA No translation available.
AL161812 mRNA Translation: CAB82105.1
AY358509 mRNA Translation: AAQ88873.1
AK294652 mRNA Translation: BAG57827.1
AK313001 mRNA Translation: BAG35837.1
AC002090 Genomic DNA No translation available.
AC004108 Genomic DNA No translation available.
AC005883 Genomic DNA No translation available.
AC006083 Genomic DNA No translation available.
AC016473 Genomic DNA No translation available.
AC092713 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94558.1
BC020577 mRNA Translation: AAH20577.1
BC047456 mRNA Translation: AAH47456.1
BC068462 mRNA Translation: AAH68462.1
CCDSiCCDS32684.1 [Q9NS85-1]
RefSeqiNP_001076002.1, NM_001082533.1 [Q9NS85-1]
NP_001076003.1, NM_001082534.1 [Q9NS85-1]
NP_064563.1, NM_020178.4 [Q9NS85-1]
UniGeneiHs.463466

Genome annotation databases

EnsembliENST00000285273; ENSP00000285273; ENSG00000154975 [Q9NS85-1]
ENST00000442502; ENSP00000390666; ENSG00000154975 [Q9NS85-1]
ENST00000451037; ENSP00000405388; ENSG00000154975 [Q9NS85-1]
ENST00000570565; ENSP00000459619; ENSG00000154975 [Q9NS85-2]
GeneIDi56934
KEGGihsa:56934
UCSCiuc002itw.5 human [Q9NS85-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCAH10_HUMAN
AccessioniPrimary (citable) accession number: Q9NS85
Secondary accession number(s): B2R7J0, B4DGL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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