UniProtKB - Q9NS85 (CAH10_HUMAN)

BLAST

>sp|Q9NS85|CAH10_HUMAN Carbonic anhydrase-related protein 10 OS=Homo sapiens OX=9606 GN=CA10 PE=2 SV=1
MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC
SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG
PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV
VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT
IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN
INFSLQGKDCPNNRAQKLQYRVNEWLLK

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History
Entry version 136 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Carbonic anhydrase-related protein 10

Gene

CA10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Does not have a catalytic activity.

GO - Molecular functionⁱ

carbonate dehydratase activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: UniProtKB
Non-traceable author statementⁱ
- 11311946

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Carbonic anhydrase-related protein 10 Alternative name(s): Carbonic anhydrase-related protein X Short name: CA-RP X Short name: CARP X Cerebral protein 15
Gene namesⁱ	Name:CA10 ORF Names:hucep-15, UNQ533/PRO1076
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154975.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1369 CA10
MIMⁱ	604642 gene
neXtProtⁱ	NX_Q9NS85

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56934
Open Targets More...OpenTargetsⁱ	ENSG00000154975
PharmGKBⁱ	PA25985

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00909 Zonisamide

DrugBankⁱ

DB00909 Zonisamide

Polymorphism and mutation databases

BioMutaⁱ	CA10
DMDMⁱ	18203320

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000077436	1 – 328	Carbonic anhydrase-related protein 10Add BLAST		328

Proteomic databases

PaxDbⁱ	Q9NS85
PeptideAtlas More...PeptideAtlasⁱ	Q9NS85
PRIDEⁱ	Q9NS85
ProteomicsDBⁱ	82509

PTM databases

iPTMnetⁱ	Q9NS85
PhosphoSitePlusⁱ	Q9NS85

Expressionⁱ

Tissue specificityⁱ

Strong expression in brain and central nervous system.1 Publication

Developmental stageⁱ

Not expressed in fetal brain.

Gene expression databases

Bgeeⁱ	ENSG00000154975 Expressed in 111 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_CA10
ExpressionAtlasⁱ	Q9NS85 baseline and differential
Genevisibleⁱ	Q9NS85 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054825 HPA057837

HPAⁱ

HPA054825
HPA057837

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	121259, 26 interactors
STRINGⁱ	9606.ENSP00000285273

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NS85
SMRⁱ	Q9NS85
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 301	Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST		271

Sequence similaritiesⁱ

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0382 Eukaryota COG3338 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149072
HOGENOMⁱ	HOG000019899
HOVERGENⁱ	HBG097666
InParanoidⁱ	Q9NS85
OMAⁱ	VQNLHHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T4J
PhylomeDBⁱ	Q9NS85
TreeFamⁱ	TF352926

Family and domain databases

Gene3Dⁱ	3.10.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR018423 CA10 IPR001148 CA_dom IPR036398 CA_dom_sf IPR023561 Carbonic_anhydrase_a-class
PANTHERⁱ	PTHR18952 PTHR18952, 1 hit PTHR18952:SF91 PTHR18952:SF91, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00194 Carb_anhydrase, 1 hit
SMARTⁱ	View protein in SMART SM01057 Carb_anhydrase, 1 hit
SUPFAMⁱ	SSF51069 SSF51069, 1 hit
PROSITEⁱ	View protein in PROSITE PS51144 ALPHA_CA_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NS85-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW 
        60         70         80         90        100
GLVNSAWNLC SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN 
       110        120        130        140        150
TGRHVSLRLD KEHLVNISGG PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ 
       160        170        180        190        200
AFSGEVQLIH YNHELYTNVT EAAKSPNGLV VVSIFIKVSD SSNPFLNRML 
       210        220        230        240        250
NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT IPPCYETASW 
       260        270        280        290        300
IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN 
       310        320 
INFSLQGKDC PNNRAQKLQY RVNEWLLK

Length:328

Mass (Da):37,563

Last modified:October 1, 2000 - v1

Checksum:ⁱB20BFEC1800422B4

Isoform 2 (identifier: Q9NS85-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-75: Missing.

« Hide

        10         20         30         40         50
MIFDPFLTPL RINTGGRKVS GTMYNTGRHV SLRLDKEHLV NISGGPMTYS 
        60         70         80         90        100
HRLEEIRLHF GSEDSQGSEH LLNGQAFSGE VQLIHYNHEL YTNVTEAAKS 
       110        120        130        140        150
PNGLVVVSIF IKVSDSSNPF LNRMLNRDTI TRITYKNDAY LLQGLNIEEL 
       160        170        180        190        200
YPETSSFITY DGSMTIPPCY ETASWIIMNK PVYITRMQMH SLRLLSQNQP 
       210        220        230        240        250
SQIFLSMSDN FRPVQPLNNR CIRTNINFSL QGKDCPNNRA QKLQYRVNEW 

LLK

Note: No experimental confirmation available.

Show »

Length:253

Mass (Da):29,049

Checksum:ⁱ14D1A23D092D3178

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L375	I3L375_HUMAN	Carbonic anhydrase-related protein ... Carbonic anhydrase-related protein 10	CA10	276	Annotation score:
I3L0J7	I3L0J7_HUMAN	Carbonic anhydrase-related protein ... Carbonic anhydrase-related protein 10	CA10	56	Annotation score:
I3NI54	I3NI54_HUMAN	Carbonic anhydrase-related protein ... Carbonic anhydrase-related protein 10	CA10	42	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056940	1 – 75	Missing in isoform 2. 1 PublicationAdd BLAST		75

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB036836 mRNA Translation: BAB00615.1 AF288385 mRNA Translation: AAK11974.1 AB001597 mRNA Translation: BAB46928.1 AF064854 mRNA No translation available. AL161812 mRNA Translation: CAB82105.1 AY358509 mRNA Translation: AAQ88873.1 AK294652 mRNA Translation: BAG57827.1 AK313001 mRNA Translation: BAG35837.1 AC002090 Genomic DNA No translation available. AC004108 Genomic DNA No translation available. AC005883 Genomic DNA No translation available. AC006083 Genomic DNA No translation available. AC016473 Genomic DNA No translation available. AC092713 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94558.1 BC020577 mRNA Translation: AAH20577.1 BC047456 mRNA Translation: AAH47456.1 BC068462 mRNA Translation: AAH68462.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32684.1 [Q9NS85-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001076002.1, NM_001082533.1 [Q9NS85-1] NP_001076003.1, NM_001082534.1 [Q9NS85-1] NP_064563.1, NM_020178.4 [Q9NS85-1]
UniGeneⁱ	Hs.463466

Genome annotation databases

Ensemblⁱ	ENST00000285273; ENSP00000285273; ENSG00000154975 [Q9NS85-1] ENST00000442502; ENSP00000390666; ENSG00000154975 [Q9NS85-1] ENST00000451037; ENSP00000405388; ENSG00000154975 [Q9NS85-1] ENST00000570565; ENSP00000459619; ENSG00000154975 [Q9NS85-2]
GeneIDⁱ	56934
KEGGⁱ	hsa:56934
UCSC genome browser More...UCSCⁱ	uc002itw.5 human [Q9NS85-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9NS85	Carbonic anhydrase-related protein 10		MACFA		328	UniRef100_Q9NS85
Carbonic anhydrase-related protein 10		MOUSE		328
Carbonic anhydrase-related protein 10		PONAB		328
CA10 isoform 1		PANTR		328
Carbonic anhydrase 10		CALJA		328
+24
Q9NS85-2	CA10 isoform 2		PONAB		253	UniRef100_Q5REN8
Uncharacterized protein		PIG		231
Uncharacterized protein		MACNE		307
Carbonic anhydrase-related protein 10 (Fragment)		HETGA		283
Uncharacterized protein		MACMU		253
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9NS85	Carbonic anhydrase-related protein 10		MACFA		328	UniRef90_Q9NS85
Carbonic anhydrase-related protein 10		MOUSE		328
Carbonic anhydrase-related protein 10		PONAB		328
Carbonic anhydrase-related protein 10		BOVIN		328
CA10 isoform 1		PANTR		328
+90
Q9NS85-2	Carbonic anhydrase 10		OTOGA		333	UniRef90_H0WR30
carbonic anhydrase-related protein 10 isoform X1		TURTR		334
Uncharacterized protein		MACMU		334
Uncharacterized protein		MACFA		334
Uncharacterized protein DKFZp686I20267		HUMAN		334
+32

Protein	Similar proteins		Species	Score	Length	Source
Q9NS85	Carbonic anhydrase-related protein 10		MACFA		328	UniRef50_Q9NS85
Carbonic anhydrase-related protein 10		MOUSE		328
Carbonic anhydrase-related protein 10		PONAB		328
Carbonic anhydrase-related protein 10		BOVIN		328
CA10 isoform 1		PANTR		328
+217
Q9NS85-2	Carbonic anhydrase Xb		DANRE		326	UniRef50_E7EYF2
Carbonic anhydrase 11		HORSE		278
Uncharacterized protein		XENLA		329
Carbonic anhydrase-related protein 11		CRIGR		315
Uncharacterized protein		LATCH		328
+169

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB036836 mRNA Translation: BAB00615.1 AF288385 mRNA Translation: AAK11974.1 AB001597 mRNA Translation: BAB46928.1 AF064854 mRNA No translation available. AL161812 mRNA Translation: CAB82105.1 AY358509 mRNA Translation: AAQ88873.1 AK294652 mRNA Translation: BAG57827.1 AK313001 mRNA Translation: BAG35837.1 AC002090 Genomic DNA No translation available. AC004108 Genomic DNA No translation available. AC005883 Genomic DNA No translation available. AC006083 Genomic DNA No translation available. AC016473 Genomic DNA No translation available. AC092713 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94558.1 BC020577 mRNA Translation: AAH20577.1 BC047456 mRNA Translation: AAH47456.1 BC068462 mRNA Translation: AAH68462.1
CCDSⁱ	CCDS32684.1 [Q9NS85-1]
RefSeqⁱ	NP_001076002.1, NM_001082533.1 [Q9NS85-1] NP_001076003.1, NM_001082534.1 [Q9NS85-1] NP_064563.1, NM_020178.4 [Q9NS85-1]
UniGeneⁱ	Hs.463466

3D structure databases

ProteinModelPortalⁱ	Q9NS85
SMRⁱ	Q9NS85
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121259, 26 interactors
STRINGⁱ	9606.ENSP00000285273

Chemistry databases

DrugBankⁱ	DB00909 Zonisamide

DrugBankⁱ

DB00909 Zonisamide

PTM databases

iPTMnetⁱ	Q9NS85
PhosphoSitePlusⁱ	Q9NS85

Polymorphism and mutation databases

BioMutaⁱ	CA10
DMDMⁱ	18203320

Proteomic databases

PaxDbⁱ	Q9NS85
PeptideAtlasⁱ	Q9NS85
PRIDEⁱ	Q9NS85
ProteomicsDBⁱ	82509

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56934
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000285273; ENSP00000285273; ENSG00000154975 [Q9NS85-1] ENST00000442502; ENSP00000390666; ENSG00000154975 [Q9NS85-1] ENST00000451037; ENSP00000405388; ENSG00000154975 [Q9NS85-1] ENST00000570565; ENSP00000459619; ENSG00000154975 [Q9NS85-2]
GeneIDⁱ	56934
KEGGⁱ	hsa:56934
UCSCⁱ	uc002itw.5 human [Q9NS85-1]

Organism-specific databases

CTDⁱ	56934
DisGeNETⁱ	56934
EuPathDBⁱ	HostDB:ENSG00000154975.13
GeneCardsⁱ	CA10
HGNCⁱ	HGNC:1369 CA10
HPAⁱ	HPA054825 HPA057837
MIMⁱ	604642 gene
neXtProtⁱ	NX_Q9NS85
OpenTargetsⁱ	ENSG00000154975
PharmGKBⁱ	PA25985
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0382 Eukaryota COG3338 LUCA
GeneTreeⁱ	ENSGT00920000149072
HOGENOMⁱ	HOG000019899
HOVERGENⁱ	HBG097666
InParanoidⁱ	Q9NS85
OMAⁱ	VQNLHHR
OrthoDBⁱ	EOG091G0T4J
PhylomeDBⁱ	Q9NS85
TreeFamⁱ	TF352926

Miscellaneous databases

ChiTaRSⁱ	CA10 human
GeneWikiⁱ	CA10
GenomeRNAiⁱ	56934
Protein Ontology More...PROⁱ	PR:Q9NS85
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154975 Expressed in 111 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_CA10
ExpressionAtlasⁱ	Q9NS85 baseline and differential
Genevisibleⁱ	Q9NS85 HS

Family and domain databases

Gene3Dⁱ	3.10.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR018423 CA10 IPR001148 CA_dom IPR036398 CA_dom_sf IPR023561 Carbonic_anhydrase_a-class
PANTHERⁱ	PTHR18952 PTHR18952, 1 hit PTHR18952:SF91 PTHR18952:SF91, 1 hit
Pfamⁱ	View protein in Pfam PF00194 Carb_anhydrase, 1 hit
SMARTⁱ	View protein in SMART SM01057 Carb_anhydrase, 1 hit
SUPFAMⁱ	SSF51069 SSF51069, 1 hit
PROSITEⁱ	View protein in PROSITE PS51144 ALPHA_CA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAH10_HUMAN
Accessionⁱ	Q9NS85Primary (citable) accession number: Q9NS85 Secondary accession number(s): B2R7J0, B4DGL6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9NS85 (CAH10_HUMAN)

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Carbonic anhydrase-related protein 10

CA10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ