UniProtKB - Q9NS82 (AAA1_HUMAN)

BLAST

>sp|Q9NS82|AAA1_HUMAN Asc-type amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC7A10 PE=2 SV=1
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFI
SPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGF
LLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSV
RWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQ
GSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSN
AVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR
HCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPI
KVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLT
ESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ

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History
Entry version 136 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Asc-type amino acid transporter 1

Gene

SLC7A10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication

GO - Molecular functionⁱ

antiporter activity Source: GO_Central
L-serine transmembrane transporter activity
Source: ProtInc
Traceable author statementⁱ
- 10863037
neutral amino acid transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10863037

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amino acid transport
Source: ProtInc
Traceable author statementⁱ
- 10734121
D-alanine transport Source: GO_Central
D-serine transport Source: GO_Central
leukocyte migration Source: Reactome
neutral amino acid transport
Source: UniProtKB
Inferred from direct assayⁱ
- 10863037

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Transport

Biological process

Amino-acid transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210991 Basigin interactions R-HSA-352230 Amino acid transport across the plasma membrane

Reactomeⁱ

R-HSA-210991 Basigin interactions
R-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBⁱ	2.A.3.8.21 the amino acid-polyamine-organocation (apc) family

TCDBⁱ

2.A.3.8.21 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Asc-type amino acid transporter 1 Short name: Asc-1 Alternative name(s): Solute carrier family 7 member 10
Gene namesⁱ	Name:SLC7A10 Synonyms:ASC1
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130876.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11058 SLC7A10
MIMⁱ	607959 gene
neXtProtⁱ	NX_Q9NS82

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	40 – 60	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	72 – 92	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	113 – 133	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	268 – 288	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	310 – 330	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	362 – 382	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	388 – 408	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	424 – 444	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	448 – 468	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56301
Open Targets More...OpenTargetsⁱ	ENSG00000130876
PharmGKBⁱ	PA35918

Polymorphism and mutation databases

BioMutaⁱ	SLC7A10
DMDMⁱ	25089504

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000054276	1 – 523	Asc-type amino acid transporter 1Add BLAST		523

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	Q9NS82
PaxDbⁱ	Q9NS82
PeptideAtlas More...PeptideAtlasⁱ	Q9NS82
PRIDEⁱ	Q9NS82
ProteomicsDBⁱ	82507

PTM databases

iPTMnetⁱ	Q9NS82
PhosphoSitePlusⁱ	Q9NS82

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000130876 Expressed in 89 organ(s), highest expression level in omental fat pad
CleanExⁱ	HS_SLC7A10
ExpressionAtlasⁱ	Q9NS82 baseline and differential
Genevisibleⁱ	Q9NS82 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041884 HPA057036

HPAⁱ

HPA041884
HPA057036

Interactionⁱ

Subunit structureⁱ

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Protein-protein interaction databases

IntActⁱ	Q9NS82, 1 interactor
STRINGⁱ	9606.ENSP00000253188

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NS82
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the amino acid-polyamine-organocation (APC) superfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1287 Eukaryota COG0531 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119037
HOGENOMⁱ	HOG000098892
HOVERGENⁱ	HBG000476
InParanoidⁱ	Q9NS82
KEGG Orthology (KO) More...KOⁱ	K13782
OMAⁱ	EENGPCQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07EM
PhylomeDBⁱ	Q9NS82
TreeFamⁱ	TF313355

Family and domain databases

InterProⁱ	View protein in InterPro IPR002293 AA/rel_permease1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13520 AA_permease_2, 1 hit
PIRSFⁱ	PIRSF006060 AA_transporter, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9NS82-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII 
        60         70         80         90        100
GNIIGSGIFI SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI 
       110        120        130        140        150
PKSGGDYAYV TEIFGGLAGF LLLWSAVLIM YPTSLAVISM TFSNYVLQPV 
       160        170        180        190        200
FPNCIPPTTA SRVLSMACLM LLTWVNSSSV RWATRIQDMF TGGKLLALSL 
       210        220        230        240        250
IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ GSFAFSGWNF 
       260        270        280        290        300
LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN 
       310        320        330        340        350
AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL 
       360        370        380        390        400
PSLLAMIHVR HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG 
       410        420        430        440        450
VTILGLLLLR WRRPALHRPI KVNLLIPVAY LVFWAFLLVF SFISEPMVCG 
       460        470        480        490        500
VGVIIILTGV PIFFLGVFWR SKPKCVHRLT ESMTHWGQEL CFVVYPQDAP 
       510        520 
EEEENGPCPP SLLPATDKPS KPQ

Length:523

Mass (Da):56,798

Last modified:October 1, 2000 - v1

Checksum:ⁱ24BA0B36521AC2D4

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EK24	K7EK24_HUMAN	Asc-type amino acid transporter 1 Asc-type amino acid transporter 1	SLC7A10	389	Annotation score:
K7ENB6	K7ENB6_HUMAN	Asc-type amino acid transporter 1 Asc-type amino acid transporter 1	SLC7A10	71	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014282	112	E → D in a family with cystinuria. 1 PublicationCorresponds to variant dbSNP:rs79717007Ensembl.		1
Natural variantⁱVAR_048158	413	R → Q. Corresponds to variant dbSNP:rs34663170Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB037670 mRNA Translation: BAB03213.1 AF340165 AF340164 Genomic DNA Translation: AAK93960.1 AJ277731 mRNA Translation: CAC81900.1 AK316594 mRNA Translation: BAG38181.1 BC035627 mRNA Translation: AAH35627.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12431.1
NCBI Reference Sequences More...RefSeqⁱ	NP_062823.1, NM_019849.2
UniGeneⁱ	Hs.58679

Genome annotation databases

Ensemblⁱ	ENST00000253188; ENSP00000253188; ENSG00000130876
GeneIDⁱ	56301
KEGGⁱ	hsa:56301
UCSC genome browser More...UCSCⁱ	uc002num.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NS82	Asc-type amino acid transporter 1		HETGA		538	UniRef90_Q9NS82
asc-type amino acid transporter 1		LIPVE		526
Solute carrier family 7 member 10		CANLF		525
asc-type amino acid transporter 1		DELLE		524
asc-type amino acid transporter 1		PHYCD		524
+67

Protein	Similar proteins		Species	Score	Length	Source
Q9NS82	Large neutral amino acids transporter small subunit 2		HUMAN		535	UniRef50_Q9UHI5
Large neutral amino acids transporter small subunit 2		RABIT		535
Large neutral amino acids transporter small subunit 2		PONAB		535
Large neutral amino acids transporter small subunit 2		RAT		533
Large neutral amino acids transporter small subunit 2		MOUSE		531
+488

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB037670 mRNA Translation: BAB03213.1 AF340165 AF340164 Genomic DNA Translation: AAK93960.1 AJ277731 mRNA Translation: CAC81900.1 AK316594 mRNA Translation: BAG38181.1 BC035627 mRNA Translation: AAH35627.1
CCDSⁱ	CCDS12431.1
RefSeqⁱ	NP_062823.1, NM_019849.2
UniGeneⁱ	Hs.58679

3D structure databases

ProteinModelPortalⁱ	Q9NS82
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9NS82, 1 interactor
STRINGⁱ	9606.ENSP00000253188

Protein family/group databases

TCDBⁱ	2.A.3.8.21 the amino acid-polyamine-organocation (apc) family

TCDBⁱ

2.A.3.8.21 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetⁱ	Q9NS82
PhosphoSitePlusⁱ	Q9NS82

Polymorphism and mutation databases

BioMutaⁱ	SLC7A10
DMDMⁱ	25089504

Proteomic databases

EPDⁱ	Q9NS82
PaxDbⁱ	Q9NS82
PeptideAtlasⁱ	Q9NS82
PRIDEⁱ	Q9NS82
ProteomicsDBⁱ	82507

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56301
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000253188; ENSP00000253188; ENSG00000130876
GeneIDⁱ	56301
KEGGⁱ	hsa:56301
UCSCⁱ	uc002num.2 human

Organism-specific databases

CTDⁱ	56301
DisGeNETⁱ	56301
EuPathDBⁱ	HostDB:ENSG00000130876.11
GeneCardsⁱ	SLC7A10
HGNCⁱ	HGNC:11058 SLC7A10
HPAⁱ	HPA041884 HPA057036
MIMⁱ	607959 gene
neXtProtⁱ	NX_Q9NS82
OpenTargetsⁱ	ENSG00000130876
PharmGKBⁱ	PA35918
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1287 Eukaryota COG0531 LUCA
GeneTreeⁱ	ENSGT00760000119037
HOGENOMⁱ	HOG000098892
HOVERGENⁱ	HBG000476
InParanoidⁱ	Q9NS82
KOⁱ	K13782
OMAⁱ	EENGPCQ
OrthoDBⁱ	EOG091G07EM
PhylomeDBⁱ	Q9NS82
TreeFamⁱ	TF313355

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210991 Basigin interactions R-HSA-352230 Amino acid transport across the plasma membrane

Reactomeⁱ

R-HSA-210991 Basigin interactions
R-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

GeneWikiⁱ	SLC7A10
GenomeRNAiⁱ	56301
Protein Ontology More...PROⁱ	PR:Q9NS82
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130876 Expressed in 89 organ(s), highest expression level in omental fat pad
CleanExⁱ	HS_SLC7A10
ExpressionAtlasⁱ	Q9NS82 baseline and differential
Genevisibleⁱ	Q9NS82 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002293 AA/rel_permease1
Pfamⁱ	View protein in Pfam PF13520 AA_permease_2, 1 hit
PIRSFⁱ	PIRSF006060 AA_transporter, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AAA1_HUMAN
Accessionⁱ	Q9NS82Primary (citable) accession number: Q9NS82 Secondary accession number(s): B2RE84
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9NS82 (AAA1_HUMAN)

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Asc-type amino acid transporter 1

SLC7A10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ