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Protein

Asc-type amino acid transporter 1

Gene

SLC7A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-serine transmembrane transporter activity Source: ProtInc
  • neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-210991 Basigin interactions
R-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.3.8.21 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Asc-type amino acid transporter 1
Short name:
Asc-1
Alternative name(s):
Solute carrier family 7 member 10
Gene namesi
Name:SLC7A10
Synonyms:ASC1
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130876.11
HGNCiHGNC:11058 SLC7A10
MIMi607959 gene
neXtProtiNX_Q9NS82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56301
OpenTargetsiENSG00000130876
PharmGKBiPA35918

Polymorphism and mutation databases

BioMutaiSLC7A10
DMDMi25089504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542761 – 523Asc-type amino acid transporter 1Add BLAST523

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9NS82
PaxDbiQ9NS82
PeptideAtlasiQ9NS82
PRIDEiQ9NS82
ProteomicsDBi82507

PTM databases

iPTMnetiQ9NS82
PhosphoSitePlusiQ9NS82

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000130876 Expressed in 89 organ(s), highest expression level in omental fat pad
CleanExiHS_SLC7A10
ExpressionAtlasiQ9NS82 baseline and differential
GenevisibleiQ9NS82 HS

Organism-specific databases

HPAiHPA041884
HPA057036

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Protein-protein interaction databases

IntActiQ9NS82, 1 interactor
STRINGi9606.ENSP00000253188

Structurei

3D structure databases

ProteinModelPortaliQ9NS82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119037
HOGENOMiHOG000098892
HOVERGENiHBG000476
InParanoidiQ9NS82
KOiK13782
OMAiEENGPCQ
OrthoDBiEOG091G07EM
PhylomeDBiQ9NS82
TreeFamiTF313355

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9NS82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII
60 70 80 90 100
GNIIGSGIFI SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI
110 120 130 140 150
PKSGGDYAYV TEIFGGLAGF LLLWSAVLIM YPTSLAVISM TFSNYVLQPV
160 170 180 190 200
FPNCIPPTTA SRVLSMACLM LLTWVNSSSV RWATRIQDMF TGGKLLALSL
210 220 230 240 250
IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ GSFAFSGWNF
260 270 280 290 300
LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN
310 320 330 340 350
AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL
360 370 380 390 400
PSLLAMIHVR HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG
410 420 430 440 450
VTILGLLLLR WRRPALHRPI KVNLLIPVAY LVFWAFLLVF SFISEPMVCG
460 470 480 490 500
VGVIIILTGV PIFFLGVFWR SKPKCVHRLT ESMTHWGQEL CFVVYPQDAP
510 520
EEEENGPCPP SLLPATDKPS KPQ
Length:523
Mass (Da):56,798
Last modified:October 1, 2000 - v1
Checksum:i24BA0B36521AC2D4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EK24K7EK24_HUMAN
Asc-type amino acid transporter 1
SLC7A10
389Annotation score:
K7ENB6K7ENB6_HUMAN
Asc-type amino acid transporter 1
SLC7A10
71Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014282112E → D in a family with cystinuria. 1 PublicationCorresponds to variant dbSNP:rs79717007Ensembl.1
Natural variantiVAR_048158413R → Q. Corresponds to variant dbSNP:rs34663170Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037670 mRNA Translation: BAB03213.1
AF340165
, AF340155, AF340156, AF340157, AF340158, AF340159, AF340160, AF340161, AF340162, AF340163, AF340164 Genomic DNA Translation: AAK93960.1
AJ277731 mRNA Translation: CAC81900.1
AK316594 mRNA Translation: BAG38181.1
BC035627 mRNA Translation: AAH35627.1
CCDSiCCDS12431.1
RefSeqiNP_062823.1, NM_019849.2
UniGeneiHs.58679

Genome annotation databases

EnsembliENST00000253188; ENSP00000253188; ENSG00000130876
GeneIDi56301
KEGGihsa:56301
UCSCiuc002num.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAAA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NS82
Secondary accession number(s): B2RE84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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