UniProtKB - Q9NS82 (AAA1_HUMAN)
Protein
Asc-type amino acid transporter 1
Gene
SLC7A10
Organism
Homo sapiens (Human)
Status
Functioni
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication
GO - Molecular functioni
- L-amino acid transmembrane transporter activity Source: GO_Central
- L-serine transmembrane transporter activity Source: ProtInc
- neutral amino acid transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- amino acid transport Source: Reactome
- D-alanine transport Source: GO_Central
- D-serine transport Source: GO_Central
- leukocyte migration Source: Reactome
- neutral amino acid transport Source: UniProtKB
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NS82 |
Reactomei | R-HSA-210991, Basigin interactions R-HSA-352230, Amino acid transport across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.3.8.21, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Asc-type amino acid transporter 1Short name: Asc-1 Alternative name(s): Solute carrier family 7 member 10 |
Gene namesi | Name:SLC7A10 Synonyms:ASC1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11058, SLC7A10 |
MIMi | 607959, gene |
neXtProti | NX_Q9NS82 |
VEuPathDBi | HostDB:ENSG00000130876.11 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 40 – 60 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 113 – 133 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 310 – 330 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 362 – 382 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 388 – 408 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 424 – 444 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 448 – 468 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56301 |
OpenTargetsi | ENSG00000130876 |
PharmGKBi | PA35918 |
Miscellaneous databases
Pharosi | Q9NS82, Tbio |
Genetic variation databases
BioMutai | SLC7A10 |
DMDMi | 25089504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054276 | 1 – 523 | Asc-type amino acid transporter 1Add BLAST | 523 |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | Q9NS82 |
MassIVEi | Q9NS82 |
PaxDbi | Q9NS82 |
PeptideAtlasi | Q9NS82 |
PRIDEi | Q9NS82 |
ProteomicsDBi | 82507 |
PTM databases
iPTMneti | Q9NS82 |
PhosphoSitePlusi | Q9NS82 |
Expressioni
Tissue specificityi
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000130876, Expressed in adipose tissue and 108 other tissues |
ExpressionAtlasi | Q9NS82, baseline and differential |
Genevisiblei | Q9NS82, HS |
Organism-specific databases
HPAi | ENSG00000130876, Tissue enhanced (adipose tissue, brain, breast) |
Interactioni
Subunit structurei
Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
By similarityBinary interactionsi
Q9NS82
With | #Exp. | IntAct |
---|---|---|
APPBP2 [Q92624] | 3 | EBI-12068238,EBI-743771 |
Protein-protein interaction databases
BioGRIDi | 121136, 1 interactor |
IntActi | Q9NS82, 2 interactors |
STRINGi | 9606.ENSP00000253188 |
Miscellaneous databases
RNActi | Q9NS82, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1287, Eukaryota |
GeneTreei | ENSGT00940000156469 |
HOGENOMi | CLU_007946_3_0_1 |
InParanoidi | Q9NS82 |
OMAi | WILIANL |
OrthoDBi | 867824at2759 |
PhylomeDBi | Q9NS82 |
TreeFami | TF313355 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NS82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII
60 70 80 90 100
GNIIGSGIFI SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI
110 120 130 140 150
PKSGGDYAYV TEIFGGLAGF LLLWSAVLIM YPTSLAVISM TFSNYVLQPV
160 170 180 190 200
FPNCIPPTTA SRVLSMACLM LLTWVNSSSV RWATRIQDMF TGGKLLALSL
210 220 230 240 250
IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ GSFAFSGWNF
260 270 280 290 300
LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN
310 320 330 340 350
AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL
360 370 380 390 400
PSLLAMIHVR HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG
410 420 430 440 450
VTILGLLLLR WRRPALHRPI KVNLLIPVAY LVFWAFLLVF SFISEPMVCG
460 470 480 490 500
VGVIIILTGV PIFFLGVFWR SKPKCVHRLT ESMTHWGQEL CFVVYPQDAP
510 520
EEEENGPCPP SLLPATDKPS KPQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EK24 | K7EK24_HUMAN | Asc-type amino acid transporter 1 | SLC7A10 | 389 | Annotation score: | ||
K7ENB6 | K7ENB6_HUMAN | Asc-type amino acid transporter 1 | SLC7A10 | 71 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014282 | 112 | E → D in a family with cystinuria. 1 PublicationCorresponds to variant dbSNP:rs79717007Ensembl. | 1 | |
Natural variantiVAR_048158 | 413 | R → Q. Corresponds to variant dbSNP:rs34663170Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037670 mRNA Translation: BAB03213.1 AF340165 , AF340155, AF340156, AF340157, AF340158, AF340159, AF340160, AF340161, AF340162, AF340163, AF340164 Genomic DNA Translation: AAK93960.1 AJ277731 mRNA Translation: CAC81900.1 AK316594 mRNA Translation: BAG38181.1 BC035627 mRNA Translation: AAH35627.1 |
CCDSi | CCDS12431.1 |
RefSeqi | NP_062823.1, NM_019849.2 |
Genome annotation databases
Ensembli | ENST00000253188; ENSP00000253188; ENSG00000130876 |
GeneIDi | 56301 |
KEGGi | hsa:56301 |
UCSCi | uc002num.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037670 mRNA Translation: BAB03213.1 AF340165 , AF340155, AF340156, AF340157, AF340158, AF340159, AF340160, AF340161, AF340162, AF340163, AF340164 Genomic DNA Translation: AAK93960.1 AJ277731 mRNA Translation: CAC81900.1 AK316594 mRNA Translation: BAG38181.1 BC035627 mRNA Translation: AAH35627.1 |
CCDSi | CCDS12431.1 |
RefSeqi | NP_062823.1, NM_019849.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121136, 1 interactor |
IntActi | Q9NS82, 2 interactors |
STRINGi | 9606.ENSP00000253188 |
Protein family/group databases
TCDBi | 2.A.3.8.21, the amino acid-polyamine-organocation (apc) family |
PTM databases
iPTMneti | Q9NS82 |
PhosphoSitePlusi | Q9NS82 |
Genetic variation databases
BioMutai | SLC7A10 |
DMDMi | 25089504 |
Proteomic databases
jPOSTi | Q9NS82 |
MassIVEi | Q9NS82 |
PaxDbi | Q9NS82 |
PeptideAtlasi | Q9NS82 |
PRIDEi | Q9NS82 |
ProteomicsDBi | 82507 |
Protocols and materials databases
Antibodypediai | 47948, 92 antibodies |
DNASUi | 56301 |
Genome annotation databases
Ensembli | ENST00000253188; ENSP00000253188; ENSG00000130876 |
GeneIDi | 56301 |
KEGGi | hsa:56301 |
UCSCi | uc002num.2, human |
Organism-specific databases
CTDi | 56301 |
DisGeNETi | 56301 |
GeneCardsi | SLC7A10 |
HGNCi | HGNC:11058, SLC7A10 |
HPAi | ENSG00000130876, Tissue enhanced (adipose tissue, brain, breast) |
MIMi | 607959, gene |
neXtProti | NX_Q9NS82 |
OpenTargetsi | ENSG00000130876 |
PharmGKBi | PA35918 |
VEuPathDBi | HostDB:ENSG00000130876.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1287, Eukaryota |
GeneTreei | ENSGT00940000156469 |
HOGENOMi | CLU_007946_3_0_1 |
InParanoidi | Q9NS82 |
OMAi | WILIANL |
OrthoDBi | 867824at2759 |
PhylomeDBi | Q9NS82 |
TreeFami | TF313355 |
Enzyme and pathway databases
PathwayCommonsi | Q9NS82 |
Reactomei | R-HSA-210991, Basigin interactions R-HSA-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 56301, 7 hits in 984 CRISPR screens |
GeneWikii | SLC7A10 |
GenomeRNAii | 56301 |
Pharosi | Q9NS82, Tbio |
PROi | PR:Q9NS82 |
RNActi | Q9NS82, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130876, Expressed in adipose tissue and 108 other tissues |
ExpressionAtlasi | Q9NS82, baseline and differential |
Genevisiblei | Q9NS82, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AAA1_HUMAN | |
Accessioni | Q9NS82Primary (citable) accession number: Q9NS82 Secondary accession number(s): B2RE84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families