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Protein

Cysteinyl leukotriene receptor 2

Gene

CYSLTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

GO - Molecular functioni

  • galanin receptor activity Source: GO_Central
  • G protein-coupled peptide receptor activity Source: GO_Central
  • leukotriene receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Chemistry databases

SwissLipidsiSLP:000001584

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
G-protein coupled receptor GPCR21
Short name:
hGPCR21
G-protein coupled receptor HG57
HPN321
Gene namesi
Name:CYSLTR2
Synonyms:CYSLT2, CYSLT2R
ORF Names:PSEC0146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000152207.7
HGNCiHGNC:18274 CYSLTR2
MIMi605666 gene
neXtProtiNX_Q9NS75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 123ExtracellularSequence analysisAdd BLAST30
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 153CytoplasmicSequence analysis9
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 204ExtracellularSequence analysisAdd BLAST30
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 245CytoplasmicSequence analysisAdd BLAST20
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 346CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57105
MalaCardsiCYSLTR2
OpenTargetsiENSG00000152207
Orphaneti39044 Uveal melanoma
PharmGKBiPA38518

Chemistry databases

ChEMBLiCHEMBL4330
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi270

Polymorphism and mutation databases

BioMutaiCYSLTR2
DMDMi20138034

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693031 – 346Cysteinyl leukotriene receptor 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 187PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS75
PeptideAtlasiQ9NS75
PRIDEiQ9NS75
ProteomicsDBi82506

PTM databases

iPTMnetiQ9NS75
PhosphoSitePlusiQ9NS75

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Gene expression databases

BgeeiENSG00000152207 Expressed in 108 organ(s), highest expression level in left adrenal gland cortex
CleanExiHS_CYSLTR2
ExpressionAtlasiQ9NS75 baseline and differential
GenevisibleiQ9NS75 HS

Organism-specific databases

HPAiHPA046528

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121371, 1 interactor
IntActiQ9NS75, 5 interactors
MINTiQ9NS75
STRINGi9606.ENSP00000282018

Chemistry databases

BindingDBiQ9NS75

Structurei

3D structure databases

ProteinModelPortaliQ9NS75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGJM Eukaryota
ENOG410YDV0 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG099611
InParanoidiQ9NS75
KOiK04323
OMAiAANSCFN
OrthoDBiEOG091G0EA7
PhylomeDBiQ9NS75
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR013311 CLT2_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01903 CYSLT2RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NS75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF
60 70 80 90 100
WGVLGNGLSI YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR
110 120 130 140 150
GSNWIFGDLA CRIMSYSLYV NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT
160 170 180 190 200
SIRSAWILCG IIWILIMASS IMLLDSGSEQ NGSVTSCLEL NLYKIAKLQT
210 220 230 240 250
MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV SHRKALTTII
260 270 280 290 300
ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF
310 320 330 340
NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV
Length:346
Mass (Da):39,635
Last modified:October 1, 2000 - v1
Checksum:iEB54A4A2DDCE5EE4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GXM0A0A1B0GXM0_HUMAN
Cysteinyl leukotriene receptor 2
CYSLTR2
14Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038269 mRNA Translation: BAB03601.1
AF254664 Genomic DNA Translation: AAG17281.1
AF279611 Genomic DNA Translation: AAK69485.1
AB083603 Genomic DNA Translation: BAB89316.1
AY389504 Genomic DNA Translation: AAQ91330.1
AL137118 Genomic DNA No translation available.
BC069160 mRNA Translation: AAH69160.1
AB041644 Genomic DNA Translation: BAB16379.1
CCDSiCCDS9412.1
RefSeqiNP_001295394.1, NM_001308465.2
NP_001295396.1, NM_001308467.2
NP_001295397.1, NM_001308468.2
NP_001295398.1, NM_001308469.2
NP_001295399.1, NM_001308470.2
NP_001295400.1, NM_001308471.2
NP_001295405.1, NM_001308476.2
NP_065110.1, NM_020377.4
UniGeneiHs.253706
Hs.614318

Genome annotation databases

EnsembliENST00000282018; ENSP00000282018; ENSG00000152207
ENST00000614739; ENSP00000477930; ENSG00000152207
GeneIDi57105
KEGGihsa:57105
UCSCiuc010ada.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038269 mRNA Translation: BAB03601.1
AF254664 Genomic DNA Translation: AAG17281.1
AF279611 Genomic DNA Translation: AAK69485.1
AB083603 Genomic DNA Translation: BAB89316.1
AY389504 Genomic DNA Translation: AAQ91330.1
AL137118 Genomic DNA No translation available.
BC069160 mRNA Translation: AAH69160.1
AB041644 Genomic DNA Translation: BAB16379.1
CCDSiCCDS9412.1
RefSeqiNP_001295394.1, NM_001308465.2
NP_001295396.1, NM_001308467.2
NP_001295397.1, NM_001308468.2
NP_001295398.1, NM_001308469.2
NP_001295399.1, NM_001308470.2
NP_001295400.1, NM_001308471.2
NP_001295405.1, NM_001308476.2
NP_065110.1, NM_020377.4
UniGeneiHs.253706
Hs.614318

3D structure databases

ProteinModelPortaliQ9NS75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121371, 1 interactor
IntActiQ9NS75, 5 interactors
MINTiQ9NS75
STRINGi9606.ENSP00000282018

Chemistry databases

BindingDBiQ9NS75
ChEMBLiCHEMBL4330
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi270
SwissLipidsiSLP:000001584

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NS75
PhosphoSitePlusiQ9NS75

Polymorphism and mutation databases

BioMutaiCYSLTR2
DMDMi20138034

Proteomic databases

PaxDbiQ9NS75
PeptideAtlasiQ9NS75
PRIDEiQ9NS75
ProteomicsDBi82506

Protocols and materials databases

DNASUi57105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282018; ENSP00000282018; ENSG00000152207
ENST00000614739; ENSP00000477930; ENSG00000152207
GeneIDi57105
KEGGihsa:57105
UCSCiuc010ada.2 human

Organism-specific databases

CTDi57105
DisGeNETi57105
EuPathDBiHostDB:ENSG00000152207.7
GeneCardsiCYSLTR2
HGNCiHGNC:18274 CYSLTR2
HPAiHPA046528
MalaCardsiCYSLTR2
MIMi605666 gene
neXtProtiNX_Q9NS75
OpenTargetsiENSG00000152207
Orphaneti39044 Uveal melanoma
PharmGKBiPA38518
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJM Eukaryota
ENOG410YDV0 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG099611
InParanoidiQ9NS75
KOiK04323
OMAiAANSCFN
OrthoDBiEOG091G0EA7
PhylomeDBiQ9NS75
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiiCysteinyl_leukotriene_receptor_2
GenomeRNAii57105
PROiPR:Q9NS75
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152207 Expressed in 108 organ(s), highest expression level in left adrenal gland cortex
CleanExiHS_CYSLTR2
ExpressionAtlasiQ9NS75 baseline and differential
GenevisibleiQ9NS75 HS

Family and domain databases

InterProiView protein in InterPro
IPR013311 CLT2_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01903 CYSLT2RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLTR2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS75
Secondary accession number(s): Q9HCQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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