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Entry version 156 (10 Apr 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Cysteinyl leukotriene receptor 2

Gene

CYSLTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001584

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
G-protein coupled receptor GPCR21
Short name:
hGPCR21
G-protein coupled receptor HG57
HPN321
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYSLTR2
Synonyms:CYSLT2, CYSLT2R
ORF Names:PSEC0146
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152207.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18274 CYSLTR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605666 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NS75

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 123ExtracellularSequence analysisAdd BLAST30
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 153CytoplasmicSequence analysis9
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 204ExtracellularSequence analysisAdd BLAST30
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 245CytoplasmicSequence analysisAdd BLAST20
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 346CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57105

MalaCards human disease database

More...
MalaCardsi
CYSLTR2

Open Targets

More...
OpenTargetsi
ENSG00000152207

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
39044 Uveal melanoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38518

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4330

Drug and drug target database

More...
DrugBanki
DB00716 Nedocromil

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
270

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYSLTR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138034

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693031 – 346Cysteinyl leukotriene receptor 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi111 ↔ 187PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NS75

PeptideAtlas

More...
PeptideAtlasi
Q9NS75

PRoteomics IDEntifications database

More...
PRIDEi
Q9NS75

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82506

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NS75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NS75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152207 Expressed in 108 organ(s), highest expression level in left adrenal gland cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NS75 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NS75 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046528

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121371, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9NS75, 30 interactors

Molecular INTeraction database

More...
MINTi
Q9NS75

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282018

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NS75

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NS75

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJM Eukaryota
ENOG410YDV0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182689

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236328

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG099611

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NS75

KEGG Orthology (KO)

More...
KOi
K04323

Identification of Orthologs from Complete Genome Data

More...
OMAi
AANSCFN

Database of Orthologous Groups

More...
OrthoDBi
49756at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NS75

TreeFam database of animal gene trees

More...
TreeFami
TF350009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013311 CLT2_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01903 CYSLT2RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NS75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF
60 70 80 90 100
WGVLGNGLSI YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR
110 120 130 140 150
GSNWIFGDLA CRIMSYSLYV NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT
160 170 180 190 200
SIRSAWILCG IIWILIMASS IMLLDSGSEQ NGSVTSCLEL NLYKIAKLQT
210 220 230 240 250
MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV SHRKALTTII
260 270 280 290 300
ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF
310 320 330 340
NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV
Length:346
Mass (Da):39,635
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB54A4A2DDCE5EE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GXM0A0A1B0GXM0_HUMAN
Cysteinyl leukotriene receptor 2
CYSLTR2
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB038269 mRNA Translation: BAB03601.1
AF254664 Genomic DNA Translation: AAG17281.1
AF279611 Genomic DNA Translation: AAK69485.1
AB083603 Genomic DNA Translation: BAB89316.1
AY389504 Genomic DNA Translation: AAQ91330.1
AL137118 Genomic DNA No translation available.
BC069160 mRNA Translation: AAH69160.1
AB041644 Genomic DNA Translation: BAB16379.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9412.1

NCBI Reference Sequences

More...
RefSeqi
NP_001295394.1, NM_001308465.2
NP_001295396.1, NM_001308467.2
NP_001295397.1, NM_001308468.2
NP_001295398.1, NM_001308469.2
NP_001295399.1, NM_001308470.2
NP_001295400.1, NM_001308471.2
NP_001295405.1, NM_001308476.2
NP_065110.1, NM_020377.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.253706
Hs.614318

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282018; ENSP00000282018; ENSG00000152207
ENST00000614739; ENSP00000477930; ENSG00000152207

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57105

UCSC genome browser

More...
UCSCi
uc010ada.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038269 mRNA Translation: BAB03601.1
AF254664 Genomic DNA Translation: AAG17281.1
AF279611 Genomic DNA Translation: AAK69485.1
AB083603 Genomic DNA Translation: BAB89316.1
AY389504 Genomic DNA Translation: AAQ91330.1
AL137118 Genomic DNA No translation available.
BC069160 mRNA Translation: AAH69160.1
AB041644 Genomic DNA Translation: BAB16379.1
CCDSiCCDS9412.1
RefSeqiNP_001295394.1, NM_001308465.2
NP_001295396.1, NM_001308467.2
NP_001295397.1, NM_001308468.2
NP_001295398.1, NM_001308469.2
NP_001295399.1, NM_001308470.2
NP_001295400.1, NM_001308471.2
NP_001295405.1, NM_001308476.2
NP_065110.1, NM_020377.4
UniGeneiHs.253706
Hs.614318

3D structure databases

ProteinModelPortaliQ9NS75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121371, 1 interactor
IntActiQ9NS75, 30 interactors
MINTiQ9NS75
STRINGi9606.ENSP00000282018

Chemistry databases

BindingDBiQ9NS75
ChEMBLiCHEMBL4330
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi270
SwissLipidsiSLP:000001584

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ9NS75
PhosphoSitePlusiQ9NS75

Polymorphism and mutation databases

BioMutaiCYSLTR2
DMDMi20138034

Proteomic databases

PaxDbiQ9NS75
PeptideAtlasiQ9NS75
PRIDEiQ9NS75
ProteomicsDBi82506

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282018; ENSP00000282018; ENSG00000152207
ENST00000614739; ENSP00000477930; ENSG00000152207
GeneIDi57105
KEGGihsa:57105
UCSCiuc010ada.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57105
DisGeNETi57105
EuPathDBiHostDB:ENSG00000152207.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYSLTR2
HGNCiHGNC:18274 CYSLTR2
HPAiHPA046528
MalaCardsiCYSLTR2
MIMi605666 gene
neXtProtiNX_Q9NS75
OpenTargetsiENSG00000152207
Orphaneti39044 Uveal melanoma
PharmGKBiPA38518

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGJM Eukaryota
ENOG410YDV0 LUCA
GeneTreeiENSGT00950000182689
HOGENOMiHOG000236328
HOVERGENiHBG099611
InParanoidiQ9NS75
KOiK04323
OMAiAANSCFN
OrthoDBi49756at2759
PhylomeDBiQ9NS75
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cysteinyl_leukotriene_receptor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57105

Protein Ontology

More...
PROi
PR:Q9NS75

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152207 Expressed in 108 organ(s), highest expression level in left adrenal gland cortex
ExpressionAtlasiQ9NS75 baseline and differential
GenevisibleiQ9NS75 HS

Family and domain databases

InterProiView protein in InterPro
IPR013311 CLT2_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01903 CYSLT2RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLTR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS75
Secondary accession number(s): Q9HCQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: April 10, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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