MBIP

Functionⁱ

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 19060904
molybdopterin synthase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 10801814

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H3 acetylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18838386
inactivation of MAPK activity involved in osmosensory signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10801814
molybdopterin cofactor biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones
SignaLinkⁱ	Q9NS73

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAP3K12-binding inhibitory protein 1 Alternative name(s): MAPK upstream kinase-binding inhibitory protein Short name: MUK-binding inhibitory protein
Gene namesⁱ	Name:MBIP ORF Names:BM-015
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151332.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20427 MBIP
MIMⁱ	609431 gene
neXtProtⁱ	NX_Q9NS73

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000151332
PharmGKBⁱ	PA134929415

Polymorphism and mutation databases

BioMutaⁱ	MBIP
DMDMⁱ	160112798

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096269	1 – 344	MAP3K12-binding inhibitory protein 1Add BLAST		344

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	91	PhosphoserineCombined sources	1
Cross-linkⁱ	94	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	118	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	129	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	139	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	153	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	235	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	301	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	301	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	304	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	325	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NS73
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NS73
PaxDbⁱ	Q9NS73
PeptideAtlas More...PeptideAtlasⁱ	Q9NS73
PRIDEⁱ	Q9NS73
ProteomicsDBⁱ	82502 82503 [Q9NS73-2] 82504 [Q9NS73-3] 82505 [Q9NS73-5]

PTM databases

iPTMnetⁱ	Q9NS73
PhosphoSitePlusⁱ	Q9NS73

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. High expression seen in the heart and lung.

Gene expression databases

Bgeeⁱ	ENSG00000151332 Expressed in 216 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_MBIP
ExpressionAtlasⁱ	Q9NS73 baseline and differential
Genevisibleⁱ	Q9NS73 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003388

HPAⁱ

HPA003388

Interactionⁱ

Subunit structureⁱ

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-741953,EBI-741953
BFSP2	Q13515	6	EBI-10182361,EBI-10229433
CCNC	P24863	3	EBI-10182361,EBI-395261
DIP2A	Q14689-6	3	EBI-10182361,EBI-10233719
DRC7	Q8IY82	3	EBI-10182361,EBI-10262896
EPB41L3	Q96HL7	3	EBI-741953,EBI-749393
EXOC8	Q8IYI6	3	EBI-10182361,EBI-742102
FXR2	P51116	3	EBI-741953,EBI-740459
ING5	Q8WYH8	3	EBI-10182361,EBI-488533
KAT14	Q9H8E8	5	EBI-741953,EBI-750907
KLC3	Q6P597	3	EBI-10182361,EBI-1643885
LMO2	P25791	3	EBI-10182361,EBI-739696
MCM7	P33993	3	EBI-10182361,EBI-355924
MIS18A	Q9NYP9	3	EBI-10182361,EBI-1104552
MOAP1	Q96BY2	3	EBI-10182361,EBI-739825
NDEL1	Q9GZM8	3	EBI-10182361,EBI-928842
PLEKHF2	Q9H8W4	3	EBI-741953,EBI-742388
POLR1C	O15160	3	EBI-10182361,EBI-1055079
PPFIA1	Q13136	3	EBI-741953,EBI-745426
RAP1GDS1	P52306	3	EBI-10182361,EBI-746389
STX11	O75558	3	EBI-10182361,EBI-714135
TGIF2LY	Q8IUE0	3	EBI-10182361,EBI-8063723
TXLNA	P40222	3	EBI-10182361,EBI-359793
TXLNB	Q8N3L3	3	EBI-10182361,EBI-6116822
VPS28	Q548N1	3	EBI-10182361,EBI-10243107
VPS28	Q9UK41	3	EBI-10182361,EBI-727424
WDR5	P61964	4	EBI-741953,EBI-540834

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 19060904

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119612, 91 interactors
ComplexPortalⁱ	CPX-1004 PCAF-containing ATAC complex CPX-997 GCN5-containing ATAC complex
CORUMⁱ	Q9NS73
IntActⁱ	Q9NS73, 48 interactors
Molecular INTeraction database More...MINTⁱ	Q9NS73
STRINGⁱ	9606.ENSP00000399718

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NS73
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	172 – 344	Interaction with MAP3K12Add BLAST	173
Regionⁱ	271 – 285	Leucine-zipper 1Sequence analysisAdd BLAST	15
Regionⁱ	314 – 329	Leucine-zipper 2Sequence analysisAdd BLAST	16

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IFXK Eukaryota ENOG410Y0HB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047831
HOGENOMⁱ	HOG000113491
HOVERGENⁱ	HBG052420
InParanoidⁱ	Q9NS73
OMAⁱ	EYFQSVN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CV5
PhylomeDBⁱ	Q9NS73
TreeFamⁱ	TF331763

Family and domain databases

InterProⁱ	View protein in InterPro IPR026062 MBIP
PANTHERⁱ	PTHR23404:SF3 PTHR23404:SF3, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NS73-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV 
        60         70         80         90        100
VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA 
       110        120        130        140        150
VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV 
       160        170        180        190        200
QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI 
       210        220        230        240        250
FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE 
       260        270        280        290        300
RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG 
       310        320        330        340 
KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP

Length:344

Mass (Da):39,281

Last modified:November 13, 2007 - v2

Checksum:ⁱ9DABB35CA8695C02

GO

Isoform 2 (identifier: Q9NS73-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
298-344: FSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP → L

« Hide

        10         20         30         40         50
MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV 
        60         70         80         90        100
VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA 
       110        120        130        140        150
VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV 
       160        170        180        190        200
QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI 
       210        220        230        240        250
FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE 
       260        270        280        290 
RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSL

Note: No experimental confirmation available.

Show »

Length:298

Mass (Da):34,023

Checksum:ⁱ00856BC8902FA9B3

GO

Isoform 3 (identifier: Q9NS73-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
264-344: GGPVPRDIYQ...AESMATHHLP → ELFWKKKKSSTTSTELFTG

« Hide

        10         20         30         40         50
MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV 
        60         70         80         90        100
VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA 
       110        120        130        140        150
VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV 
       160        170        180        190        200
QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI 
       210        220        230        240        250
FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE 
       260        270        280 
RLQNIEAHLR LQTELFWKKK KSSTTSTELF TG

Show »

Length:282

Mass (Da):32,223

Checksum:ⁱ4BD1C926F718E3B7

GO

Isoform 4 (identifier: Q9NS73-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
309-309: Missing.

« Hide

        10         20         30         40         50
MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV 
        60         70         80         90        100
VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA 
       110        120        130        140        150
VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV 
       160        170        180        190        200
QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI 
       210        220        230        240        250
FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE 
       260        270        280        290        300
RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG 
       310        320        330        340 
KRRKVQPPQN YSLAELDEKI SALKQALLRK SREAESMATH HLP

Show »

Length:343

Mass (Da):39,153

Checksum:ⁱ97D44D5E8AB7DE60

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R2X9	S4R2X9_HUMAN	MAP3K12-binding inhibitory protein ... MAP3K12-binding inhibitory protein 1	MBIP	299	Annotation score:
A0A087X1L0	A0A087X1L0_HUMAN	MAP3K12-binding inhibitory protein ... MAP3K12-binding inhibitory protein 1	MBIP	298	Annotation score:
S4R3N2	S4R3N2_HUMAN	MAP3K12-binding inhibitory protein ... MAP3K12-binding inhibitory protein 1	MBIP	281	Annotation score:
S4R3P6	S4R3P6_HUMAN	MAP3K12-binding inhibitory protein ... MAP3K12-binding inhibitory protein 1	MBIP	222	Annotation score:
S4R3Y0	S4R3Y0_HUMAN	MAP3K12-binding inhibitory protein ... MAP3K12-binding inhibitory protein 1	MBIP	112	Annotation score:

Sequence cautionⁱ

The sequence CAD62615 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	218	N → Y in AAH05197 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_018449	7	L → H3 PublicationsCorresponds to variant dbSNP:rs2899849Ensembl.		1
Natural variantⁱVAR_034093	22	R → S3 PublicationsCorresponds to variant dbSNP:rs3168891Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010265	264 – 344	GGPVP…THHLP → ELFWKKKKSSTTSTELFTG in isoform 3. 1 PublicationAdd BLAST	81
Alternative sequenceⁱVSP_010266	298 – 344	FSGKR…THHLP → L in isoform 2. 1 PublicationAdd BLAST	47
Alternative sequenceⁱVSP_040134	309	Missing in isoform 4. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB038523 mRNA Translation: BAA94083.1 AF208857 mRNA Translation: AAF64271.1 BX248287 mRNA Translation: CAD62615.1 Different initiation. AL137226 Genomic DNA No translation available. BC005197 mRNA Translation: AAH05197.1 BC016821 mRNA Translation: AAH16821.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45096.1 [Q9NS73-5] CCDS76672.1 [Q9NS73-3] CCDS9658.1 [Q9NS73-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138363.1, NM_001144891.1 [Q9NS73-5] NP_001295039.1, NM_001308110.1 [Q9NS73-3] NP_057670.2, NM_016586.2 [Q9NS73-1]
UniGeneⁱ	Hs.368647

Genome annotation databases

Ensemblⁱ	ENST00000318473; ENSP00000324444; ENSG00000151332 [Q9NS73-5] ENST00000359527; ENSP00000352517; ENSG00000151332 [Q9NS73-3] ENST00000416007; ENSP00000399718; ENSG00000151332 [Q9NS73-1]
GeneIDⁱ	51562
KEGGⁱ	hsa:51562
UCSC genome browser More...UCSCⁱ	uc001wtm.2 human [Q9NS73-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NS73	MAP3K12 binding inhibitory protein 1		PANTR		344	UniRef90_Q9NS73
MAP3K12 binding inhibitory protein 1		GORGO		344
MAP3K12 binding inhibitory protein 1		CALJA		344
MAP3K12-binding inhibitory protein 1 isoform X1		Enhydra lutris kenyoni		344
Uncharacterized protein		PANPA		344
+50
Q9NS73-3	MAP3K12 binding inhibitory protein 1		PANTR		282	UniRef90_Q9NS73-3
MAP3K12 binding inhibitory protein 1		SAIBB		282
Uncharacterized protein		CALJA		282
Uncharacterized protein		MACMU		282
Uncharacterized protein		CERAT		282
+26

Protein	Similar proteins		Species	Score	Length	Source
Q9NS73	MAP3K12-binding inhibitory protein 1		MOUSE		341	UniRef50_Q9NS73
MAP3K12 binding inhibitory protein 1		GORGO		344
MAP3K12 binding inhibitory protein 1		CALJA		344
MAP3K12 binding inhibitory protein 1, isoform CRA_b		HUMAN		344
MAP3K12-binding inhibitory protein 1 isoform X1		Enhydra lutris kenyoni		344
+480
Q9NS73-3	MBIP isoform 4		PONAB		282	UniRef50_Q9NS73-3
Uncharacterized protein		MACMU		282
Uncharacterized protein		CERAT		282
Uncharacterized protein		MACFA		282
Uncharacterized protein		MACNE		282
+94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB038523 mRNA Translation: BAA94083.1 AF208857 mRNA Translation: AAF64271.1 BX248287 mRNA Translation: CAD62615.1 Different initiation. AL137226 Genomic DNA No translation available. BC005197 mRNA Translation: AAH05197.1 BC016821 mRNA Translation: AAH16821.1
CCDSⁱ	CCDS45096.1 [Q9NS73-5] CCDS76672.1 [Q9NS73-3] CCDS9658.1 [Q9NS73-1]
RefSeqⁱ	NP_001138363.1, NM_001144891.1 [Q9NS73-5] NP_001295039.1, NM_001308110.1 [Q9NS73-3] NP_057670.2, NM_016586.2 [Q9NS73-1]
UniGeneⁱ	Hs.368647

3D structure databases

ProteinModelPortalⁱ	Q9NS73
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119612, 91 interactors
ComplexPortalⁱ	CPX-1004 PCAF-containing ATAC complex CPX-997 GCN5-containing ATAC complex
CORUMⁱ	Q9NS73
IntActⁱ	Q9NS73, 48 interactors
MINTⁱ	Q9NS73
STRINGⁱ	9606.ENSP00000399718

PTM databases

iPTMnetⁱ	Q9NS73
PhosphoSitePlusⁱ	Q9NS73

Polymorphism and mutation databases

BioMutaⁱ	MBIP
DMDMⁱ	160112798

Proteomic databases

EPDⁱ	Q9NS73
MaxQBⁱ	Q9NS73
PaxDbⁱ	Q9NS73
PeptideAtlasⁱ	Q9NS73
PRIDEⁱ	Q9NS73
ProteomicsDBⁱ	82502 82503 [Q9NS73-2] 82504 [Q9NS73-3] 82505 [Q9NS73-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51562
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000318473; ENSP00000324444; ENSG00000151332 [Q9NS73-5] ENST00000359527; ENSP00000352517; ENSG00000151332 [Q9NS73-3] ENST00000416007; ENSP00000399718; ENSG00000151332 [Q9NS73-1]
GeneIDⁱ	51562
KEGGⁱ	hsa:51562
UCSCⁱ	uc001wtm.2 human [Q9NS73-1]

Organism-specific databases

CTDⁱ	51562
EuPathDBⁱ	HostDB:ENSG00000151332.18
GeneCardsⁱ	MBIP
H-InvDBⁱ	HIX0011602
HGNCⁱ	HGNC:20427 MBIP
HPAⁱ	HPA003388
MIMⁱ	609431 gene
neXtProtⁱ	NX_Q9NS73
OpenTargetsⁱ	ENSG00000151332
PharmGKBⁱ	PA134929415
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFXK Eukaryota ENOG410Y0HB LUCA
GeneTreeⁱ	ENSGT00510000047831
HOGENOMⁱ	HOG000113491
HOVERGENⁱ	HBG052420
InParanoidⁱ	Q9NS73
OMAⁱ	EYFQSVN
OrthoDBⁱ	EOG091G0CV5
PhylomeDBⁱ	Q9NS73
TreeFamⁱ	TF331763

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones
SignaLinkⁱ	Q9NS73

Miscellaneous databases

GenomeRNAiⁱ	51562
Protein Ontology More...PROⁱ	PR:Q9NS73
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151332 Expressed in 216 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_MBIP
ExpressionAtlasⁱ	Q9NS73 baseline and differential
Genevisibleⁱ	Q9NS73 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026062 MBIP
PANTHERⁱ	PTHR23404:SF3 PTHR23404:SF3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MBIP1_HUMAN
Accessionⁱ	Q9NS73Primary (citable) accession number: Q9NS73 Secondary accession number(s): Q86TZ2 , Q96AS5, Q9BS93, Q9NZE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	November 13, 2007
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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UniProtKB - Q9NS73 (MBIP1_HUMAN)

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MAP3K12-binding inhibitory protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ