UniProtKB - Q9NS73 (MBIP1_HUMAN)
Protein
MAP3K12-binding inhibitory protein 1
Gene
MBIP
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase inhibitor activity Source: ProtInc
GO - Biological processi
- histone H3 acetylation Source: BHF-UCL
- inactivation of MAPK activity involved in osmosensory signaling pathway Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q9NS73 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q9NS73 |
Names & Taxonomyi
Protein namesi | Recommended name: MAP3K12-binding inhibitory protein 1Alternative name(s): MAPK upstream kinase-binding inhibitory protein Short name: MUK-binding inhibitory protein |
Gene namesi | Name:MBIP ORF Names:BM-015 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20427, MBIP |
MIMi | 609431, gene |
neXtProti | NX_Q9NS73 |
VEuPathDBi | HostDB:ENSG00000151332.18 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51562 |
OpenTargetsi | ENSG00000151332 |
PharmGKBi | PA134929415 |
Miscellaneous databases
Pharosi | Q9NS73, Tbio |
Genetic variation databases
BioMutai | MBIP |
DMDMi | 160112798 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096269 | 1 – 344 | MAP3K12-binding inhibitory protein 1Add BLAST | 344 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 91 | PhosphoserineCombined sources | 1 | |
Cross-linki | 94 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 129 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 153 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 235 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 301 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 301 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 325 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NS73 |
jPOSTi | Q9NS73 |
MassIVEi | Q9NS73 |
MaxQBi | Q9NS73 |
PaxDbi | Q9NS73 |
PeptideAtlasi | Q9NS73 |
PRIDEi | Q9NS73 |
ProteomicsDBi | 82502 [Q9NS73-1] 82503 [Q9NS73-2] 82504 [Q9NS73-3] 82505 [Q9NS73-5] |
PTM databases
iPTMneti | Q9NS73 |
PhosphoSitePlusi | Q9NS73 |
Expressioni
Tissue specificityi
Ubiquitous. High expression seen in the heart and lung.
Gene expression databases
Bgeei | ENSG00000151332, Expressed in left lobe of thyroid gland and 229 other tissues |
ExpressionAtlasi | Q9NS73, baseline and differential |
Genevisiblei | Q9NS73, HS |
Organism-specific databases
HPAi | ENSG00000151332, Tissue enhanced (thyroid) |
Interactioni
Subunit structurei
Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.
1 PublicationBinary interactionsi
Hide detailsQ9NS73
Isoform 4 [Q9NS73-5]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 119612, 99 interactors |
ComplexPortali | CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex |
CORUMi | Q9NS73 |
IntActi | Q9NS73, 98 interactors |
MINTi | Q9NS73 |
STRINGi | 9606.ENSP00000399718 |
Miscellaneous databases
RNActi | Q9NS73, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 172 – 344 | Interaction with MAP3K12Add BLAST | 173 | |
Regioni | 271 – 285 | Leucine-zipper 1Sequence analysisAdd BLAST | 15 | |
Regioni | 314 – 329 | Leucine-zipper 2Sequence analysisAdd BLAST | 16 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502R8QG, Eukaryota |
GeneTreei | ENSGT00510000047831 |
HOGENOMi | CLU_069631_0_0_1 |
InParanoidi | Q9NS73 |
OMAi | HKSNSML |
PhylomeDBi | Q9NS73 |
TreeFami | TF331763 |
Family and domain databases
InterProi | View protein in InterPro IPR026062, MBIP |
PANTHERi | PTHR23404:SF3, PTHR23404:SF3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NS73-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV
60 70 80 90 100
VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA
110 120 130 140 150
VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV
160 170 180 190 200
QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI
210 220 230 240 250
FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE
260 270 280 290 300
RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG
310 320 330 340
KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R2X9 | S4R2X9_HUMAN | MAP3K12-binding inhibitory protein ... | MBIP | 299 | Annotation score: | ||
A0A087X1L0 | A0A087X1L0_HUMAN | MAP3K12-binding inhibitory protein ... | MBIP | 298 | Annotation score: | ||
S4R3Y0 | S4R3Y0_HUMAN | MAP3K12-binding inhibitory protein ... | MBIP | 112 | Annotation score: | ||
S4R3N2 | S4R3N2_HUMAN | MAP3K12-binding inhibitory protein ... | MBIP | 281 | Annotation score: | ||
S4R3P6 | S4R3P6_HUMAN | MAP3K12-binding inhibitory protein ... | MBIP | 222 | Annotation score: |
Sequence cautioni
The sequence CAD62615 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | N → Y in AAH05197 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018449 | 7 | L → H3 PublicationsCorresponds to variant dbSNP:rs2899849Ensembl. | 1 | |
Natural variantiVAR_034093 | 22 | R → S3 PublicationsCorresponds to variant dbSNP:rs3168891Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010265 | 264 – 344 | GGPVP…THHLP → ELFWKKKKSSTTSTELFTG in isoform 3. 1 PublicationAdd BLAST | 81 | |
Alternative sequenceiVSP_010266 | 298 – 344 | FSGKR…THHLP → L in isoform 2. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_040134 | 309 | Missing in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB038523 mRNA Translation: BAA94083.1 AF208857 mRNA Translation: AAF64271.1 BX248287 mRNA Translation: CAD62615.1 Different initiation. AL137226 Genomic DNA No translation available. BC005197 mRNA Translation: AAH05197.1 BC016821 mRNA Translation: AAH16821.1 |
CCDSi | CCDS45096.1 [Q9NS73-5] CCDS76672.1 [Q9NS73-3] CCDS9658.1 [Q9NS73-1] |
RefSeqi | NP_001138363.1, NM_001144891.1 [Q9NS73-5] NP_001295039.1, NM_001308110.1 [Q9NS73-3] NP_057670.2, NM_016586.2 [Q9NS73-1] |
Genome annotation databases
Ensembli | ENST00000318473; ENSP00000324444; ENSG00000151332 [Q9NS73-5] ENST00000359527; ENSP00000352517; ENSG00000151332 [Q9NS73-3] ENST00000416007; ENSP00000399718; ENSG00000151332 [Q9NS73-1] |
GeneIDi | 51562 |
KEGGi | hsa:51562 |
UCSCi | uc001wtm.2, human [Q9NS73-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB038523 mRNA Translation: BAA94083.1 AF208857 mRNA Translation: AAF64271.1 BX248287 mRNA Translation: CAD62615.1 Different initiation. AL137226 Genomic DNA No translation available. BC005197 mRNA Translation: AAH05197.1 BC016821 mRNA Translation: AAH16821.1 |
CCDSi | CCDS45096.1 [Q9NS73-5] CCDS76672.1 [Q9NS73-3] CCDS9658.1 [Q9NS73-1] |
RefSeqi | NP_001138363.1, NM_001144891.1 [Q9NS73-5] NP_001295039.1, NM_001308110.1 [Q9NS73-3] NP_057670.2, NM_016586.2 [Q9NS73-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119612, 99 interactors |
ComplexPortali | CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex |
CORUMi | Q9NS73 |
IntActi | Q9NS73, 98 interactors |
MINTi | Q9NS73 |
STRINGi | 9606.ENSP00000399718 |
PTM databases
iPTMneti | Q9NS73 |
PhosphoSitePlusi | Q9NS73 |
Genetic variation databases
BioMutai | MBIP |
DMDMi | 160112798 |
Proteomic databases
EPDi | Q9NS73 |
jPOSTi | Q9NS73 |
MassIVEi | Q9NS73 |
MaxQBi | Q9NS73 |
PaxDbi | Q9NS73 |
PeptideAtlasi | Q9NS73 |
PRIDEi | Q9NS73 |
ProteomicsDBi | 82502 [Q9NS73-1] 82503 [Q9NS73-2] 82504 [Q9NS73-3] 82505 [Q9NS73-5] |
Protocols and materials databases
Antibodypediai | 166, 138 antibodies |
DNASUi | 51562 |
Genome annotation databases
Ensembli | ENST00000318473; ENSP00000324444; ENSG00000151332 [Q9NS73-5] ENST00000359527; ENSP00000352517; ENSG00000151332 [Q9NS73-3] ENST00000416007; ENSP00000399718; ENSG00000151332 [Q9NS73-1] |
GeneIDi | 51562 |
KEGGi | hsa:51562 |
UCSCi | uc001wtm.2, human [Q9NS73-1] |
Organism-specific databases
CTDi | 51562 |
DisGeNETi | 51562 |
GeneCardsi | MBIP |
HGNCi | HGNC:20427, MBIP |
HPAi | ENSG00000151332, Tissue enhanced (thyroid) |
MIMi | 609431, gene |
neXtProti | NX_Q9NS73 |
OpenTargetsi | ENSG00000151332 |
PharmGKBi | PA134929415 |
VEuPathDBi | HostDB:ENSG00000151332.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R8QG, Eukaryota |
GeneTreei | ENSGT00510000047831 |
HOGENOMi | CLU_069631_0_0_1 |
InParanoidi | Q9NS73 |
OMAi | HKSNSML |
PhylomeDBi | Q9NS73 |
TreeFami | TF331763 |
Enzyme and pathway databases
PathwayCommonsi | Q9NS73 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q9NS73 |
Miscellaneous databases
BioGRID-ORCSi | 51562, 10 hits in 994 CRISPR screens |
ChiTaRSi | MBIP, human |
GenomeRNAii | 51562 |
Pharosi | Q9NS73, Tbio |
PROi | PR:Q9NS73 |
RNActi | Q9NS73, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151332, Expressed in left lobe of thyroid gland and 229 other tissues |
ExpressionAtlasi | Q9NS73, baseline and differential |
Genevisiblei | Q9NS73, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026062, MBIP |
PANTHERi | PTHR23404:SF3, PTHR23404:SF3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBIP1_HUMAN | |
Accessioni | Q9NS73Primary (citable) accession number: Q9NS73 Secondary accession number(s): Q86TZ2 Q9NZE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | November 13, 2007 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot