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UniProtKB - Q9NS73 (MBIP1_HUMAN)

Entry version 164 (07 Apr 2021)
Sequence version 2 (13 Nov 2007)
Previous versions | rss
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Protein

MAP3K12-binding inhibitory protein 1

Gene

MBIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NS73

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847, HATs acetylate histones

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NS73

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAP3K12-binding inhibitory protein 1
Alternative name(s):
MAPK upstream kinase-binding inhibitory protein
Short name:
MUK-binding inhibitory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBIP
ORF Names:BM-015
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20427, MBIP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609431, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NS73

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151332.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51562

Open Targets

More...OpenTargetsi		ENSG00000151332

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134929415

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NS73, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MBIP

Domain mapping of disease mutations (DMDM)

More...DMDMi		160112798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962691 – 344MAP3K12-binding inhibitory protein 1Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki235Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei301N6-acetyllysine; alternateBy similarity1
Cross-linki301Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NS73

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NS73

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NS73

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NS73

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NS73

PeptideAtlas

More...PeptideAtlasi		Q9NS73

PRoteomics IDEntifications database

More...PRIDEi		Q9NS73

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82502 [Q9NS73-1]
82503 [Q9NS73-2]
82504 [Q9NS73-3]
82505 [Q9NS73-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NS73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NS73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. High expression seen in the heart and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151332, Expressed in left lobe of thyroid gland and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NS73, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NS73, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151332, Tissue enhanced (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9NS73
With#Exp.IntAct
EPB41L3 [Q96HL7]3EBI-741953,EBI-749393
FXR2 [P51116]3EBI-741953,EBI-740459
KAT14 [Q9H8E8]6EBI-741953,EBI-750907
itself3EBI-741953,EBI-741953
PLEKHF2 [Q9H8W4]3EBI-741953,EBI-742388
PPFIA1 [Q13136]3EBI-741953,EBI-745426
TXLNB [Q8N3L3]4EBI-741953,EBI-6116822
WDR5 [P61964]6EBI-741953,EBI-540834
Isoform 4 [Q9NS73-5]
With#Exp.IntAct
BFSP2 [Q13515]6EBI-10182361,EBI-10229433
CCNC [P24863]3EBI-10182361,EBI-395261
DIP2A - isoform 6 [Q14689-6]3EBI-10182361,EBI-10233719
DRC7 [Q8IY82]3EBI-10182361,EBI-10262896
EXOC8 [Q8IYI6]3EBI-10182361,EBI-742102
FGFR3 [P22607]3EBI-10182361,EBI-348399
ING5 [Q8WYH8]3EBI-10182361,EBI-488533
KAT14 [Q9H8E8]3EBI-10182361,EBI-750907
KIF1B - isoform 2 [O60333-2]3EBI-10182361,EBI-10975473
KLC3 [Q6P597]3EBI-10182361,EBI-1643885
LMO2 [P25791]3EBI-10182361,EBI-739696
MCM7 [P33993]3EBI-10182361,EBI-355924
MIS18A [Q9NYP9]3EBI-10182361,EBI-1104552
MOAP1 [Q96BY2]3EBI-10182361,EBI-739825
NDEL1 [Q9GZM8]3EBI-10182361,EBI-928842
NEFL [P07196]3EBI-10182361,EBI-475646
PECAM1 [P16284]3EBI-10182361,EBI-716404
PEX1 [O43933]3EBI-10182361,EBI-988601
PLEKHF2 [Q9H8W4]3EBI-10182361,EBI-742388
POLR1C [O15160]3EBI-10182361,EBI-1055079
RAB5A [P20339]3EBI-10182361,EBI-399437
RAP1GDS1 [P52306]3EBI-10182361,EBI-746389
STX11 [O75558]3EBI-10182361,EBI-714135
TGIF2LY [Q8IUE0]3EBI-10182361,EBI-8063723
TXLNA [P40222]3EBI-10182361,EBI-359793
TXLNB [Q8N3L3]3EBI-10182361,EBI-6116822
VIM [P08670]3EBI-10182361,EBI-353844
VPS28 [Q548N1]3EBI-10182361,EBI-10243107
VPS28 [Q9UK41]3EBI-10182361,EBI-727424
WDR5 [P61964]4EBI-10182361,EBI-540834
WFS1 [O76024]3EBI-10182361,EBI-720609
Q9Y6493EBI-10182361,EBI-25900580

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119612, 99 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1004, PCAF-containing ATAC complex
CPX-997, GCN5-containing ATAC complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NS73

Protein interaction database and analysis system

More...IntActi		Q9NS73, 98 interactors

Molecular INTeraction database

More...MINTi		Q9NS73

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000399718

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NS73, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni172 – 344Interaction with MAP3K12Add BLAST173
Regioni271 – 285Leucine-zipper 1Sequence analysisAdd BLAST15
Regioni314 – 329Leucine-zipper 2Sequence analysisAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R8QG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000047831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069631_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NS73

Identification of Orthologs from Complete Genome Data

More...OMAi		HKSNSML

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NS73

TreeFam database of animal gene trees

More...TreeFami		TF331763

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026062, MBIP

The PANTHER Classification System

More...PANTHERi		PTHR23404:SF3, PTHR23404:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NS73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV 
        60         70         80         90        100
VKITIDWNKL QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA 
       110        120        130        140        150
VEEIGRTEMG NKNEVNDKFS IGDLQEEEKH KESDLRDVKK TQIHFDPEVV 
       160        170        180        190        200
QIKAGKAEID RRISAFIERK QAEINENNVR EFCNVIDCNQ ENSCARTDAI 
       210        220        230        240        250
FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML RDCGNQAVEE 
       260        270        280        290        300
RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG 
       310        320        330        340 
KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP
Length:344
Mass (Da):39,281
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DABB35CA8695C02
GO
Isoform 2 (identifier: Q9NS73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-344: FSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP → L

Show »
Length:298
Mass (Da):34,023
Checksum:i00856BC8902FA9B3
GO
Isoform 3 (identifier: Q9NS73-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-344: GGPVPRDIYQ...AESMATHHLP → ELFWKKKKSSTTSTELFTG

Show »
Length:282
Mass (Da):32,223
Checksum:i4BD1C926F718E3B7
GO
Isoform 4 (identifier: Q9NS73-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-309: Missing.

Show »
Length:343
Mass (Da):39,153
Checksum:i97D44D5E8AB7DE60
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2X9S4R2X9_HUMAN
MAP3K12-binding inhibitory protein ...
MBIP
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1L0A0A087X1L0_HUMAN
MAP3K12-binding inhibitory protein ...
MBIP
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3Y0S4R3Y0_HUMAN
MAP3K12-binding inhibitory protein ...
MBIP
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3N2S4R3N2_HUMAN
MAP3K12-binding inhibitory protein ...
MBIP
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3P6S4R3P6_HUMAN
MAP3K12-binding inhibitory protein ...
MBIP
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62615 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218N → Y in AAH05197 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0184497L → H3 PublicationsCorresponds to variant dbSNP:rs2899849Ensembl.1
Natural variantiVAR_03409322R → S3 PublicationsCorresponds to variant dbSNP:rs3168891Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010265264 – 344GGPVP…THHLP → ELFWKKKKSSTTSTELFTG in isoform 3. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_010266298 – 344FSGKR…THHLP → L in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_040134309Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB038523 mRNA Translation: BAA94083.1
AF208857 mRNA Translation: AAF64271.1
BX248287 mRNA Translation: CAD62615.1 Different initiation.
AL137226 Genomic DNA No translation available.
BC005197 mRNA Translation: AAH05197.1
BC016821 mRNA Translation: AAH16821.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45096.1 [Q9NS73-5]
CCDS76672.1 [Q9NS73-3]
CCDS9658.1 [Q9NS73-1]

NCBI Reference Sequences

More...RefSeqi		NP_001138363.1, NM_001144891.1 [Q9NS73-5]
NP_001295039.1, NM_001308110.1 [Q9NS73-3]
NP_057670.2, NM_016586.2 [Q9NS73-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000318473; ENSP00000324444; ENSG00000151332 [Q9NS73-5]
ENST00000359527; ENSP00000352517; ENSG00000151332 [Q9NS73-3]
ENST00000416007; ENSP00000399718; ENSG00000151332 [Q9NS73-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51562

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51562

UCSC genome browser

More...UCSCi		uc001wtm.2, human [Q9NS73-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038523 mRNA Translation: BAA94083.1
AF208857 mRNA Translation: AAF64271.1
BX248287 mRNA Translation: CAD62615.1 Different initiation.
AL137226 Genomic DNA No translation available.
BC005197 mRNA Translation: AAH05197.1
BC016821 mRNA Translation: AAH16821.1
CCDSiCCDS45096.1 [Q9NS73-5]
CCDS76672.1 [Q9NS73-3]
CCDS9658.1 [Q9NS73-1]
RefSeqiNP_001138363.1, NM_001144891.1 [Q9NS73-5]
NP_001295039.1, NM_001308110.1 [Q9NS73-3]
NP_057670.2, NM_016586.2 [Q9NS73-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119612, 99 interactors
ComplexPortaliCPX-1004, PCAF-containing ATAC complex
CPX-997, GCN5-containing ATAC complex
CORUMiQ9NS73
IntActiQ9NS73, 98 interactors
MINTiQ9NS73
STRINGi9606.ENSP00000399718

PTM databases

iPTMnetiQ9NS73
PhosphoSitePlusiQ9NS73

Genetic variation databases

BioMutaiMBIP
DMDMi160112798

Proteomic databases

EPDiQ9NS73
jPOSTiQ9NS73
MassIVEiQ9NS73
MaxQBiQ9NS73
PaxDbiQ9NS73
PeptideAtlasiQ9NS73
PRIDEiQ9NS73
ProteomicsDBi82502 [Q9NS73-1]
82503 [Q9NS73-2]
82504 [Q9NS73-3]
82505 [Q9NS73-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		166, 138 antibodies

The DNASU plasmid repository

More...DNASUi		51562

Genome annotation databases

EnsembliENST00000318473; ENSP00000324444; ENSG00000151332 [Q9NS73-5]
ENST00000359527; ENSP00000352517; ENSG00000151332 [Q9NS73-3]
ENST00000416007; ENSP00000399718; ENSG00000151332 [Q9NS73-1]
GeneIDi51562
KEGGihsa:51562
UCSCiuc001wtm.2, human [Q9NS73-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51562
DisGeNETi51562

GeneCards: human genes, protein and diseases

More...GeneCardsi		MBIP
HGNCiHGNC:20427, MBIP
HPAiENSG00000151332, Tissue enhanced (thyroid)
MIMi609431, gene
neXtProtiNX_Q9NS73
OpenTargetsiENSG00000151332
PharmGKBiPA134929415
VEuPathDBiHostDB:ENSG00000151332.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R8QG, Eukaryota
GeneTreeiENSGT00510000047831
HOGENOMiCLU_069631_0_0_1
InParanoidiQ9NS73
OMAiHKSNSML
PhylomeDBiQ9NS73
TreeFamiTF331763

Enzyme and pathway databases

PathwayCommonsiQ9NS73
ReactomeiR-HSA-3214847, HATs acetylate histones
SignaLinkiQ9NS73

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51562, 10 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MBIP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51562
PharosiQ9NS73, Tbio

Protein Ontology

More...PROi		PR:Q9NS73
RNActiQ9NS73, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151332, Expressed in left lobe of thyroid gland and 229 other tissues
ExpressionAtlasiQ9NS73, baseline and differential
GenevisibleiQ9NS73, HS

Family and domain databases

InterProiView protein in InterPro
IPR026062, MBIP
PANTHERiPTHR23404:SF3, PTHR23404:SF3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS73
Secondary accession number(s): Q86TZ2
, Q96AS5, Q9BS93, Q9NZE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 13, 2007
Last modified: April 7, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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