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Protein

Gastrokine-1

Gene

GKN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.1 Publication

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

GO - Biological processi

  • digestion Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
  • regulation of cell proliferation Source: GO_Central

Keywordsi

Molecular functionMitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrokine-1
Alternative name(s):
18 kDa antrum mucosa protein
Short name:
AMP-18
Protein CA11
Gene namesi
Name:GKN1
Synonyms:AMP18, CA11
ORF Names:UNQ489/PRO1005
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169605.5
HGNCiHGNC:23217 GKN1
MIMi606402 gene
neXtProtiNX_Q9NS71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56287
OpenTargetsiENSG00000169605
PharmGKBiPA134898851

Polymorphism and mutation databases

BioMutaiGKN1
DMDMi223590223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34By similarityAdd BLAST34
ChainiPRO_000002133235 – 199Gastrokine-1Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 156By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NS71
PeptideAtlasiQ9NS71
PRIDEiQ9NS71
ProteomicsDBi82501

PTM databases

iPTMnetiQ9NS71
PhosphoSitePlusiQ9NS71

Expressioni

Tissue specificityi

Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000169605 Expressed in 80 organ(s), highest expression level in stomach
CleanExiHS_CA11
HS_GKN1
GenevisibleiQ9NS71 HS

Organism-specific databases

HPAiHPA047684

Interactioni

Protein-protein interaction databases

BioGridi121133, 11 interactors
IntActiQ9NS71, 12 interactors
STRINGi9606.ENSP00000367172

Structurei

3D structure databases

ProteinModelPortaliQ9NS71
SMRiQ9NS71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 164BRICHOSPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the gastrokine family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVWS Eukaryota
ENOG410YN1G LUCA
GeneTreeiENSGT00920000149130
HOGENOMiHOG000112728
HOVERGENiHBG009322
InParanoidiQ9NS71
OMAiCIVHKMN
OrthoDBiEOG091G0WZD
PhylomeDBiQ9NS71
TreeFamiTF335950

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAYSSVHCF REDKMKFTIV FAGLLGVFLA PALANYNINV NDDNNNAGSG
60 70 80 90 100
QQSVSVNNEH NVANVDNNNG WDSWNSIWDY GNGFAATRLF QKKTCIVHKM
110 120 130 140 150
NKEVMPSIQS LDALVKEKKL QGKGPGGPPP KGLMYSVNPN KVDDLSKFGK
160 170 180 190
NIANMCRGIP TYMAEEMQEA SLFFYSGTCY TTSVLWIVDI SFCGDTVEN
Length:199
Mass (Da):21,999
Last modified:February 10, 2009 - v3
Checksum:iC099B8B9A1338D7A
GO

Sequence cautioni

The sequence AAN75447 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAN75449 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89409 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035923118K → T in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039886 mRNA Translation: BAA92433.1
AY139182 Genomic DNA Translation: AAN75447.1 Different initiation.
AY139184 mRNA Translation: AAN75449.1 Different initiation.
AC114802 Genomic DNA No translation available.
BC059778 mRNA Translation: AAH59778.2
AY359050 mRNA Translation: AAQ89409.1 Different initiation.
CCDSiCCDS1891.2
RefSeqiNP_062563.3, NM_019617.3
UniGeneiHs.69319

Genome annotation databases

EnsembliENST00000377938; ENSP00000367172; ENSG00000169605
GeneIDi56287
KEGGihsa:56287
UCSCiuc002sfc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039886 mRNA Translation: BAA92433.1
AY139182 Genomic DNA Translation: AAN75447.1 Different initiation.
AY139184 mRNA Translation: AAN75449.1 Different initiation.
AC114802 Genomic DNA No translation available.
BC059778 mRNA Translation: AAH59778.2
AY359050 mRNA Translation: AAQ89409.1 Different initiation.
CCDSiCCDS1891.2
RefSeqiNP_062563.3, NM_019617.3
UniGeneiHs.69319

3D structure databases

ProteinModelPortaliQ9NS71
SMRiQ9NS71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121133, 11 interactors
IntActiQ9NS71, 12 interactors
STRINGi9606.ENSP00000367172

PTM databases

iPTMnetiQ9NS71
PhosphoSitePlusiQ9NS71

Polymorphism and mutation databases

BioMutaiGKN1
DMDMi223590223

Proteomic databases

PaxDbiQ9NS71
PeptideAtlasiQ9NS71
PRIDEiQ9NS71
ProteomicsDBi82501

Protocols and materials databases

DNASUi56287
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377938; ENSP00000367172; ENSG00000169605
GeneIDi56287
KEGGihsa:56287
UCSCiuc002sfc.4 human

Organism-specific databases

CTDi56287
DisGeNETi56287
EuPathDBiHostDB:ENSG00000169605.5
GeneCardsiGKN1
HGNCiHGNC:23217 GKN1
HPAiHPA047684
MIMi606402 gene
neXtProtiNX_Q9NS71
OpenTargetsiENSG00000169605
PharmGKBiPA134898851
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVWS Eukaryota
ENOG410YN1G LUCA
GeneTreeiENSGT00920000149130
HOGENOMiHOG000112728
HOVERGENiHBG009322
InParanoidiQ9NS71
OMAiCIVHKMN
OrthoDBiEOG091G0WZD
PhylomeDBiQ9NS71
TreeFamiTF335950

Miscellaneous databases

ChiTaRSiGKN1 human
GenomeRNAii56287
PROiPR:Q9NS71
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169605 Expressed in 80 organ(s), highest expression level in stomach
CleanExiHS_CA11
HS_GKN1
GenevisibleiQ9NS71 HS

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGKN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NS71
Secondary accession number(s): Q8IUA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: September 12, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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