Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene

TOMM22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM22 homolog
Short name:
hTom22
Alternative name(s):
1C9-2
Translocase of outer membrane 22 kDa subunit homolog
Gene namesi
Name:TOMM22
Synonyms:TOM22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100216.5
HGNCiHGNC:18002 TOMM22
MIMi607046 gene
neXtProtiNX_Q9NS69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 83CytoplasmicSequence analysisAdd BLAST82
Transmembranei84 – 103HelicalSequence analysisAdd BLAST20
Topological domaini104 – 142Mitochondrial intermembraneSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100216
PharmGKBiPA38275

Polymorphism and mutation databases

BioMutaiTOMM22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000761062 – 142Mitochondrial import receptor subunit TOM22 homologAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei15PhosphoserineCombined sources1
Modified residuei43PhosphothreonineCombined sources1
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NS69
MaxQBiQ9NS69
PaxDbiQ9NS69
PeptideAtlasiQ9NS69
PRIDEiQ9NS69
ProteomicsDBi82500
TopDownProteomicsiQ9NS69

PTM databases

iPTMnetiQ9NS69
PhosphoSitePlusiQ9NS69

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100216 Expressed in 220 organ(s), highest expression level in prostate gland
CleanExiHS_TOMM22
ExpressionAtlasiQ9NS69 baseline and differential
GenevisibleiQ9NS69 HS

Organism-specific databases

HPAiHPA003037

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi121308, 86 interactors
CORUMiQ9NS69
IntActiQ9NS69, 127 interactors
MINTiQ9NS69
STRINGi9606.ENSP00000216034

Structurei

3D structure databases

ProteinModelPortaliQ9NS69
SMRiQ9NS69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 50Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarity10
Regioni83 – 103TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST21
Regioni123 – 142C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi110 – 118Poly-Gln9

Domaini

Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.By similarity

Sequence similaritiesi

Belongs to the Tom22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4111 Eukaryota
ENOG41122K3 LUCA
GeneTreeiENSGT00390000016475
HOGENOMiHOG000067816
HOVERGENiHBG061819
InParanoidiQ9NS69
KOiK17769
OMAiEPVRNFG
OrthoDBiEOG091G0XN1
PhylomeDBiQ9NS69
TreeFamiTF106201

Family and domain databases

InterProiView protein in InterPro
IPR005683 Tom22
PANTHERiPTHR12504:SF0 PTHR12504:SF0, 1 hit
PfamiView protein in Pfam
PF04281 Tom22, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG
60 70 80 90 100
LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV
110 120 130 140
FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPSLPG KI
Length:142
Mass (Da):15,522
Last modified:January 23, 2007 - v3
Checksum:iC957232F8420F34D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040119 mRNA Translation: BAB03306.1
AB041906 mRNA Translation: BAB16408.1
AK024731 mRNA Translation: BAB14979.1
CR456475 mRNA Translation: CAG30361.1
BC009363 mRNA Translation: AAH09363.1
CCDSiCCDS13975.1
RefSeqiNP_064628.1, NM_020243.4
UniGeneiHs.595072

Genome annotation databases

EnsembliENST00000216034; ENSP00000216034; ENSG00000100216
GeneIDi56993
KEGGihsa:56993
UCSCiuc003awe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040119 mRNA Translation: BAB03306.1
AB041906 mRNA Translation: BAB16408.1
AK024731 mRNA Translation: BAB14979.1
CR456475 mRNA Translation: CAG30361.1
BC009363 mRNA Translation: AAH09363.1
CCDSiCCDS13975.1
RefSeqiNP_064628.1, NM_020243.4
UniGeneiHs.595072

3D structure databases

ProteinModelPortaliQ9NS69
SMRiQ9NS69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121308, 86 interactors
CORUMiQ9NS69
IntActiQ9NS69, 127 interactors
MINTiQ9NS69
STRINGi9606.ENSP00000216034

PTM databases

iPTMnetiQ9NS69
PhosphoSitePlusiQ9NS69

Polymorphism and mutation databases

BioMutaiTOMM22

Proteomic databases

EPDiQ9NS69
MaxQBiQ9NS69
PaxDbiQ9NS69
PeptideAtlasiQ9NS69
PRIDEiQ9NS69
ProteomicsDBi82500
TopDownProteomicsiQ9NS69

Protocols and materials databases

DNASUi56993
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216034; ENSP00000216034; ENSG00000100216
GeneIDi56993
KEGGihsa:56993
UCSCiuc003awe.4 human

Organism-specific databases

CTDi56993
EuPathDBiHostDB:ENSG00000100216.5
GeneCardsiTOMM22
HGNCiHGNC:18002 TOMM22
HPAiHPA003037
MIMi607046 gene
neXtProtiNX_Q9NS69
OpenTargetsiENSG00000100216
PharmGKBiPA38275
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4111 Eukaryota
ENOG41122K3 LUCA
GeneTreeiENSGT00390000016475
HOGENOMiHOG000067816
HOVERGENiHBG061819
InParanoidiQ9NS69
KOiK17769
OMAiEPVRNFG
OrthoDBiEOG091G0XN1
PhylomeDBiQ9NS69
TreeFamiTF106201

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Miscellaneous databases

ChiTaRSiTOMM22 human
GeneWikiiTOMM22
GenomeRNAii56993
PROiPR:Q9NS69
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100216 Expressed in 220 organ(s), highest expression level in prostate gland
CleanExiHS_TOMM22
ExpressionAtlasiQ9NS69 baseline and differential
GenevisibleiQ9NS69 HS

Family and domain databases

InterProiView protein in InterPro
IPR005683 Tom22
PANTHERiPTHR12504:SF0 PTHR12504:SF0, 1 hit
PfamiView protein in Pfam
PF04281 Tom22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOM22_HUMAN
AccessioniPrimary (citable) accession number: Q9NS69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again