Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 19

Gene

TNFRSF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • tumor necrosis factor-activated receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NS68

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF19
Synonyms:TAJ, TROY
ORF Names:UNQ1888/PRO4333
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127863.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11915 TNFRSF19

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606122 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NS68

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 170ExtracellularSequence analysisAdd BLAST141
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 423CytoplasmicSequence analysisAdd BLAST232

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55504

Open Targets

More...
OpenTargetsi
ENSG00000127863

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36608

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21264102

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003459730 – 423Tumor necrosis factor receptor superfamily member 19Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NS68

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NS68

PeptideAtlas

More...
PeptideAtlasi
Q9NS68

PRoteomics IDEntifications database

More...
PRIDEi
Q9NS68

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82498
82499 [Q9NS68-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NS68

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NS68

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127863 Expressed in 169 organ(s), highest expression level in upper arm skin

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNFRSF19

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NS68 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NS68 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010135

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120684, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NS68

Protein interaction database and analysis system

More...
IntActi
Q9NS68, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NS68

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NS68

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati33 – 72TNFR-Cys 1Add BLAST40
Repeati74 – 114TNFR-Cys 2Add BLAST41
Repeati116 – 149TNFR-Cys 3Add BLAST34

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFRK Eukaryota
ENOG410ZU96 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049070

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069143

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NS68

KEGG Orthology (KO)

More...
KOi
K05155

Identification of Orthologs from Complete Genome Data

More...
OMAi
CVTCRPH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0ADI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NS68

TreeFam database of animal gene trees

More...
TreeFami
TF331385

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13418 TNFRSF19, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022342 TNFR_19
IPR034047 TNFRSF19_N

The PANTHER Classification System

More...
PANTHERi
PTHR12120:SF1 PTHR12120:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01969 TNFACTORR19

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NS68-1) [UniParc]FASTAAdd to basket
Also known as: TAJ-alpha, TRADEalpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN
60 70 80 90 100
QCGPGMELSK ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR
110 120 130 140 150
FQKANCSATS DAICGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCA
160 170 180 190 200
SKVNLVKIAS TASSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK
210 220 230 240 250
KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD SVQTCGPVRL
260 270 280 290 300
LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI
310 320 330 340 350
CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN
360 370 380 390 400
SSQDLVGGAV PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ
410 420
ESGAVIHPAT QTSLQVRQRL GSL
Length:423
Mass (Da):46,015
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5891CEA9ED45361
GO
Isoform 2 (identifier: Q9NS68-2) [UniParc]FASTAAdd to basket
Also known as: TRADEbeta

The sequence of this isoform differs from the canonical sequence as follows:
     416-423: VRQRLGSL → EA

Show »
Length:417
Mass (Da):45,305
Checksum:i3AA85D783F0835C4
GO
Isoform 3 (identifier: Q9NS68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     416-423: VRQRLGSL → EA

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):30,542
Checksum:i4798BE078A891985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74T → A in AAF71828 (PubMed:10809768).Curated1
Sequence conflicti215 – 216GS → ET in AAF71828 (PubMed:10809768).Curated2
Sequence conflicti221F → L in AAK28396 (Ref. 3) Curated1
Sequence conflicti330T → A in AAK28396 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02427831S → T1 PublicationCorresponds to variant dbSNP:rs9550987Ensembl.1
Natural variantiVAR_070812159A → V1 PublicationCorresponds to variant dbSNP:rs61756242Ensembl.1
Natural variantiVAR_024279405V → I2 PublicationsCorresponds to variant dbSNP:rs3751362Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0448861 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_006512416 – 423VRQRLGSL → EA in isoform 2 and isoform 3. 4 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF167555 mRNA Translation: AAF71828.1
AB040434 mRNA Translation: BAB03269.1
AF246998 mRNA Translation: AAK28395.1
AF246999 mRNA Translation: AAK28396.1
AY358888 mRNA Translation: AAQ89247.1
AK292874 mRNA Translation: BAF85563.1
AK292891 mRNA Translation: BAF85580.1
AK304290 mRNA Translation: BAG65148.1
AL161422 Genomic DNA No translation available.
AL354815 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08326.1
BC047321 mRNA Translation: AAH47321.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55893.1 [Q9NS68-3]
CCDS9301.1 [Q9NS68-2]
CCDS9302.1 [Q9NS68-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191387.1, NM_001204458.1 [Q9NS68-2]
NP_001191388.1, NM_001204459.1 [Q9NS68-3]
NP_061117.2, NM_018647.3 [Q9NS68-1]
NP_683760.1, NM_148957.3 [Q9NS68-2]
XP_005266502.1, XM_005266445.2 [Q9NS68-1]
XP_011533448.1, XM_011535146.1 [Q9NS68-1]
XP_016876140.1, XM_017020651.1 [Q9NS68-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.149168
Hs.730848

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000248484; ENSP00000248484; ENSG00000127863 [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863 [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863 [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863 [Q9NS68-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55504

UCSC genome browser

More...
UCSCi
uc001uot.4 human [Q9NS68-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167555 mRNA Translation: AAF71828.1
AB040434 mRNA Translation: BAB03269.1
AF246998 mRNA Translation: AAK28395.1
AF246999 mRNA Translation: AAK28396.1
AY358888 mRNA Translation: AAQ89247.1
AK292874 mRNA Translation: BAF85563.1
AK292891 mRNA Translation: BAF85580.1
AK304290 mRNA Translation: BAG65148.1
AL161422 Genomic DNA No translation available.
AL354815 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08326.1
BC047321 mRNA Translation: AAH47321.1
CCDSiCCDS55893.1 [Q9NS68-3]
CCDS9301.1 [Q9NS68-2]
CCDS9302.1 [Q9NS68-1]
RefSeqiNP_001191387.1, NM_001204458.1 [Q9NS68-2]
NP_001191388.1, NM_001204459.1 [Q9NS68-3]
NP_061117.2, NM_018647.3 [Q9NS68-1]
NP_683760.1, NM_148957.3 [Q9NS68-2]
XP_005266502.1, XM_005266445.2 [Q9NS68-1]
XP_011533448.1, XM_011535146.1 [Q9NS68-1]
XP_016876140.1, XM_017020651.1 [Q9NS68-1]
UniGeneiHs.149168
Hs.730848

3D structure databases

ProteinModelPortaliQ9NS68
SMRiQ9NS68
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120684, 46 interactors
CORUMiQ9NS68
IntActiQ9NS68, 7 interactors
STRINGi9606.ENSP00000371693

PTM databases

iPTMnetiQ9NS68
PhosphoSitePlusiQ9NS68

Polymorphism and mutation databases

BioMutaiTNFRSF19
DMDMi21264102

Proteomic databases

MaxQBiQ9NS68
PaxDbiQ9NS68
PeptideAtlasiQ9NS68
PRIDEiQ9NS68
ProteomicsDBi82498
82499 [Q9NS68-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248484; ENSP00000248484; ENSG00000127863 [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863 [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863 [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863 [Q9NS68-3]
GeneIDi55504
KEGGihsa:55504
UCSCiuc001uot.4 human [Q9NS68-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55504
DisGeNETi55504
EuPathDBiHostDB:ENSG00000127863.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFRSF19
HGNCiHGNC:11915 TNFRSF19
HPAiHPA010135
MIMi606122 gene
neXtProtiNX_Q9NS68
OpenTargetsiENSG00000127863
PharmGKBiPA36608

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFRK Eukaryota
ENOG410ZU96 LUCA
GeneTreeiENSGT00940000153259
HOGENOMiHOG000049070
HOVERGENiHBG069143
InParanoidiQ9NS68
KOiK05155
OMAiCVTCRPH
OrthoDBiEOG091G0ADI
PhylomeDBiQ9NS68
TreeFamiTF331385

Enzyme and pathway databases

SignaLinkiQ9NS68

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNFRSF19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55504

Protein Ontology

More...
PROi
PR:Q9NS68

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127863 Expressed in 169 organ(s), highest expression level in upper arm skin
CleanExiHS_TNFRSF19
ExpressionAtlasiQ9NS68 baseline and differential
GenevisibleiQ9NS68 HS

Family and domain databases

CDDicd13418 TNFRSF19, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022342 TNFR_19
IPR034047 TNFRSF19_N
PANTHERiPTHR12120:SF1 PTHR12120:SF1, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01969 TNFACTORR19
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR19_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS68
Secondary accession number(s): A8KA09
, A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NZV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again