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UniProtKB - Q9NS64 (RPRM_HUMAN)
Protein
Protein reprimo
Gene
RPRM
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
By similarityMiscellaneous
'Reprimo' signifies stop/repress.
GO - Biological processi
- regulation of cell cycle Source: ProtInc
- regulation of mitotic cell cycle Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9NS64 |
SignaLinki | Q9NS64 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein reprimo |
Gene namesi | Name:RPRM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24201, RPRM |
MIMi | 612171, gene |
neXtProti | NX_Q9NS64 |
VEuPathDBi | HostDB:ENSG00000177519 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56475 |
OpenTargetsi | ENSG00000177519 |
PharmGKBi | PA134937494 |
Miscellaneous databases
Pharosi | Q9NS64, Tbio |
Genetic variation databases
BioMutai | RPRM |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312752 | 1 – 109 | Protein reprimoAdd BLAST | 109 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 98 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9NS64 |
PeptideAtlasi | Q9NS64 |
PRIDEi | Q9NS64 |
PTM databases
GlyGeni | Q9NS64, 2 sites |
PhosphoSitePlusi | Q9NS64 |
Expressioni
Inductioni
By p53/TP53, following X-ray irradiation.1 Publication
Gene expression databases
Bgeei | ENSG00000177519, Expressed in frontal cortex and 147 other tissues |
Genevisiblei | Q9NS64, HS |
Organism-specific databases
HPAi | ENSG00000177519, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NS64
Protein-protein interaction databases
BioGRIDi | 121145, 96 interactors |
IntActi | Q9NS64, 77 interactors |
MINTi | Q9NS64 |
STRINGi | 9606.ENSP00000314946 |
Miscellaneous databases
RNActi | Q9NS64, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the reprimo family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S262, Eukaryota |
GeneTreei | ENSGT00390000010523 |
HOGENOMi | CLU_170456_0_0_1 |
InParanoidi | Q9NS64 |
OMAi | EEFFCCN |
OrthoDBi | 1529294at2759 |
PhylomeDBi | Q9NS64 |
TreeFami | TF332720 |
Family and domain databases
InterProi | View protein in InterPro IPR033356, Reprimo IPR043383, Reprimo_fam |
PANTHERi | PTHR28649, PTHR28649, 1 hit PTHR28649:SF2, PTHR28649:SF2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NS64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPALGNQTD VAGLFLANSS EALERAVRCC TQASVVTDDG FAEGGPDERS
60 70 80 90 100
LYIMRVVQIA VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE
VEAVVVGPY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB043585 mRNA Translation: BAB01513.1 AK311958 mRNA Translation: BAG34898.1 AK074808 mRNA Translation: BAG52007.1 AC012501 Genomic DNA Translation: AAY14783.1 CH471058 Genomic DNA Translation: EAX11467.1 BC002908 mRNA Translation: AAH02908.1 |
CCDSi | CCDS2198.1 |
RefSeqi | NP_062819.1, NM_019845.2 |
Genome annotation databases
Ensembli | ENST00000325926; ENSP00000314946; ENSG00000177519 |
GeneIDi | 56475 |
KEGGi | hsa:56475 |
MANE-Selecti | ENST00000325926.4; ENSP00000314946.3; NM_019845.3; NP_062819.1 |
UCSCi | uc002tyq.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB043585 mRNA Translation: BAB01513.1 AK311958 mRNA Translation: BAG34898.1 AK074808 mRNA Translation: BAG52007.1 AC012501 Genomic DNA Translation: AAY14783.1 CH471058 Genomic DNA Translation: EAX11467.1 BC002908 mRNA Translation: AAH02908.1 |
CCDSi | CCDS2198.1 |
RefSeqi | NP_062819.1, NM_019845.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121145, 96 interactors |
IntActi | Q9NS64, 77 interactors |
MINTi | Q9NS64 |
STRINGi | 9606.ENSP00000314946 |
PTM databases
GlyGeni | Q9NS64, 2 sites |
PhosphoSitePlusi | Q9NS64 |
Genetic variation databases
BioMutai | RPRM |
Proteomic databases
PaxDbi | Q9NS64 |
PeptideAtlasi | Q9NS64 |
PRIDEi | Q9NS64 |
Protocols and materials databases
Antibodypediai | 54148, 87 antibodies from 14 providers |
DNASUi | 56475 |
Genome annotation databases
Ensembli | ENST00000325926; ENSP00000314946; ENSG00000177519 |
GeneIDi | 56475 |
KEGGi | hsa:56475 |
MANE-Selecti | ENST00000325926.4; ENSP00000314946.3; NM_019845.3; NP_062819.1 |
UCSCi | uc002tyq.1, human |
Organism-specific databases
CTDi | 56475 |
DisGeNETi | 56475 |
GeneCardsi | RPRM |
HGNCi | HGNC:24201, RPRM |
HPAi | ENSG00000177519, Low tissue specificity |
MIMi | 612171, gene |
neXtProti | NX_Q9NS64 |
OpenTargetsi | ENSG00000177519 |
PharmGKBi | PA134937494 |
VEuPathDBi | HostDB:ENSG00000177519 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S262, Eukaryota |
GeneTreei | ENSGT00390000010523 |
HOGENOMi | CLU_170456_0_0_1 |
InParanoidi | Q9NS64 |
OMAi | EEFFCCN |
OrthoDBi | 1529294at2759 |
PhylomeDBi | Q9NS64 |
TreeFami | TF332720 |
Enzyme and pathway databases
PathwayCommonsi | Q9NS64 |
SignaLinki | Q9NS64 |
Miscellaneous databases
BioGRID-ORCSi | 56475, 2 hits in 1043 CRISPR screens |
GenomeRNAii | 56475 |
Pharosi | Q9NS64, Tbio |
PROi | PR:Q9NS64 |
RNActi | Q9NS64, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177519, Expressed in frontal cortex and 147 other tissues |
Genevisiblei | Q9NS64, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033356, Reprimo IPR043383, Reprimo_fam |
PANTHERi | PTHR28649, PTHR28649, 1 hit PTHR28649:SF2, PTHR28649:SF2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RPRM_HUMAN | |
Accessioni | Q9NS64Primary (citable) accession number: Q9NS64 Secondary accession number(s): B2R4V1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families