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Entry version 167 (11 Dec 2019)
Sequence version 3 (28 Jun 2011)
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Protein

Kv channel-interacting protein 2

Gene

KCNIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi189 – 2001PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi237 – 2482PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Metal-binding, Potassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.82.2.4 the calmodulin calcium binding protein (calmodulin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kv channel-interacting protein 2
Short name:
KChIP21 Publication
Alternative name(s):
A-type potassium channel modulatory protein 2
Cardiac voltage-gated potassium channel modulatory subunit
Potassium channel-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNIP2
Synonyms:KCHIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000120049.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15522 KCNIP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604661 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NS61

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
30819

Open Targets

More...
OpenTargetsi
ENSG00000120049

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30042

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NS61 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3885598

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
338817979

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000738211 – 270Kv channel-interacting protein 2Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi45S-palmitoyl cysteineBy similarity1
Lipidationi46S-palmitoyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated. Palmitoylation enhances association with the plasma membrane.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NS61

PeptideAtlas

More...
PeptideAtlasi
Q9NS61

PRoteomics IDEntifications database

More...
PRIDEi
Q9NS61

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82483 [Q9NS61-1]
82484 [Q9NS61-2]
82485 [Q9NS61-3]
82486 [Q9NS61-4]
82487 [Q9NS61-5]
82488 [Q9NS61-6]
82489 [Q9NS61-7]
82490 [Q9NS61-8]
82491 [Q9NS61-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NS61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NS61

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NS61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120049 Expressed in 157 organ(s), highest expression level in right atrium auricular region

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NS61 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NS61 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066717

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits (PubMed:14623880, PubMed:14980201).

Interacts with KCND2 (PubMed:10676964, PubMed:14623880, PubMed:14980201). Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and homotetramers.

Isoform 3 interacts with KCNIP1 in a calcium-dependent manner.

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119043, 12 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3239 Kv4.2-KChIP2 channel complex

Protein interaction database and analysis system

More...
IntActi
Q9NS61, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420040

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NS61 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NS61

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 137EF-hand 1; degeneratePROSITE-ProRule annotationAdd BLAST57
Domaini140 – 175EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini176 – 211EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini224 – 259EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni257 – 270Interaction with KCND2By similarityAdd BLAST14

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157798

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NS61

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECPDGVV

Database of Orthologous Groups

More...
OrthoDBi
1271942at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318560

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028846 Recoverin

The PANTHER Classification System

More...
PANTHERi
PTHR23055 PTHR23055, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NS61-1) [UniParc]FASTAAdd to basket
Also known as: KChIP2a, KChIP2b, KCHIP2.4, KCHIP2L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGQGRKESL SDSRDLDGSY DQLTGHPPGP TKKALKQRFL KLLPCCGPQA
60 70 80 90 100
LPSVSETLAA PASLRPHRPR LLDPDSVDDE FELSTVCHRP EGLEQLQEQT
110 120 130 140 150
KFTRKELQVL YRGFKNECPS GIVNEENFKQ IYSQFFPQGD SSTYATFLFN
160 170 180 190 200
AFDTNHDGSV SFEDFVAGLS VILRGTVDDR LNWAFNLYDL NKDGCITKEE
210 220 230 240 250
MLDIMKSIYD MMGKYTYPAL REEAPREHVE SFFQKMDRNK DGVVTIEEFI
260 270
ESCQKDENIM RSMQLFDNVI
Length:270
Mass (Da):30,907
Last modified:June 28, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB75AD02B9E273243
GO
Isoform 2 (identifier: Q9NS61-2) [UniParc]FASTAAdd to basket
Also known as: 3, KChIP2.1, KChIP2b

The sequence of this isoform differs from the canonical sequence as follows:
     57-75: TLAAPASLRPHRPRLLDPD → N

Show »
Length:252
Mass (Da):28,943
Checksum:i7502F0C69D2B35FE
GO
Isoform 3 (identifier: Q9NS61-3) [UniParc]FASTAAdd to basket
Also known as: 2, KChIP2.2, KChIP2c, KCHIP2S

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.

Show »
Length:220
Mass (Da):25,562
Checksum:i52FD8C601356338F
GO
Isoform 4 (identifier: Q9NS61-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MRGQGRKESL...LRPHRPRLLD → MNRCPRRCRSPLGQAARSLYQLVTGSLS

Show »
Length:225
Mass (Da):26,066
Checksum:i7919AFDD3A5FACF1
GO
Isoform 5 (identifier: Q9NS61-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.
     160-163: Missing.

Show »
Length:216
Mass (Da):25,100
Checksum:iEDDF7A3B16108F08
GO
Isoform 6 (identifier: Q9NS61-6) [UniParc]FASTAAdd to basket
Also known as: KCHIP4.2

The sequence of this isoform differs from the canonical sequence as follows:
     57-57: T → IGRVFRFLGDSSLPSA

Show »
Length:285
Mass (Da):32,510
Checksum:i38A62414577BCF49
GO
Isoform 7 (identifier: Q9NS61-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.
     116-116: N → NPGALSFQ

Show »
Length:227
Mass (Da):26,263
Checksum:i7F1D2B8E7F85D8B9
GO
Isoform 8 (identifier: Q9NS61-8) [UniParc]FASTAAdd to basket
Also known as: KCHIP2.6

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.
     94-162: EQLQEQTKFT...DTNHDGSVSF → MWLSWTAWTM...SRFTPSSFLK

Show »
Length:177
Mass (Da):20,482
Checksum:i8CF26C549F293353
GO
Isoform 9 (identifier: Q9NS61-9) [UniParc]FASTAAdd to basket
Also known as: KCHIP2.5

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.
     163-198: Missing.
     256-270: DENIMRSMQLFDNVI → VQLPALYITLTWTQA

Show »
Length:184
Mass (Da):21,401
Checksum:i4B810CA98F45A052
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6D7A0A2R8Y6D7_HUMAN
Kv channel-interacting protein 2
KCNIP2
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NFF4A6NFF4_HUMAN
Kv channel-interacting protein 2
KCNIP2
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50A → V in BAA96740 (PubMed:11263977).Curated1
Sequence conflicti71L → P in BAA96740 (PubMed:11263977).Curated1
Sequence conflicti75D → V in BAA96741 (PubMed:11263977).Curated1
Sequence conflicti76S → R in BAB55052 (PubMed:14702039).Curated1
Sequence conflicti78D → E in BAA96740 (PubMed:11263977).Curated1
Sequence conflicti83L → S in CAB66656 (PubMed:11230166).Curated1
Sequence conflicti224A → P in BAA96740 (PubMed:11263977).Curated1
Sequence conflicti224A → P in BAA96741 (PubMed:11263977).Curated1
Sequence conflicti239N → S in AAP57633 (Ref. 9) Curated1
Sequence conflicti246I → N in CAB66656 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0150491 – 93Missing in isoform 8. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0150501 – 73MRGQG…PRLLD → MNRCPRRCRSPLGQAARSLY QLVTGSLS in isoform 4. 3 PublicationsAdd BLAST73
Alternative sequenceiVSP_01505125 – 74Missing in isoform 3, isoform 5, isoform 7 and isoform 9. 10 PublicationsAdd BLAST50
Alternative sequenceiVSP_01505257 – 75TLAAP…LLDPD → N in isoform 2. 8 PublicationsAdd BLAST19
Alternative sequenceiVSP_01505357T → IGRVFRFLGDSSLPSA in isoform 6. 1 Publication1
Alternative sequenceiVSP_01505494 – 162EQLQE…GSVSF → MWLSWTAWTMNLNCPPCVTG LRVWSSCRSKPNSRARSCRS CTGASRTNVPAELSMRRTSS RFTPSSFLK in isoform 8. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_015055116N → NPGALSFQ in isoform 7. 1 Publication1
Alternative sequenceiVSP_015056160 – 163Missing in isoform 5. 1 Publication4
Alternative sequenceiVSP_015057163 – 198Missing in isoform 9. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_015058256 – 270DENIM…FDNVI → VQLPALYITLTWTQA in isoform 9. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF199598 mRNA Translation: AAF33683.1
AB044584 mRNA Translation: BAA96740.1
AB044585 mRNA Translation: BAA96741.1
AY026328 mRNA Translation: AAK07674.1
AY026331, AY026329, AY026330 Genomic DNA Translation: AAK21972.1
AF347114 mRNA Translation: AAK70356.1
AF295076 mRNA Translation: AAG02120.1
AF295530 mRNA Translation: AAG02121.1
AF367018 mRNA Translation: AAK53707.1
AF367019 mRNA Translation: AAK53708.1
AF367020 mRNA Translation: AAK53709.1
AF367021 mRNA Translation: AAK53710.1
DQ148480 mRNA Translation: AAZ77797.1
DQ148481 mRNA Translation: AAZ77798.1
DQ148483 mRNA Translation: AAZ77800.1
AL136722 mRNA Translation: CAB66656.1
AY302141 mRNA Translation: AAP57633.1
AK027347 mRNA Translation: BAB55052.1
AK315042 mRNA Translation: BAG37523.1
AC010789 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49733.1
BC034685 mRNA Translation: AAH34685.1
AJ276317 mRNA Translation: CAB77054.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41562.1 [Q9NS61-2]
CCDS7521.1 [Q9NS61-6]
CCDS7522.1 [Q9NS61-1]
CCDS7523.1 [Q9NS61-7]
CCDS7524.1 [Q9NS61-3]
CCDS7525.1 [Q9NS61-4]
CCDS7526.1 [Q9NS61-9]

NCBI Reference Sequences

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RefSeqi
NP_055406.2, NM_014591.4 [Q9NS61-6]
NP_775283.1, NM_173191.2 [Q9NS61-1]
NP_775284.1, NM_173192.2 [Q9NS61-2]
NP_775285.1, NM_173193.2 [Q9NS61-7]
NP_775286.1, NM_173194.2 [Q9NS61-4]
NP_775287.1, NM_173195.2 [Q9NS61-3]
NP_775289.1, NM_173197.2 [Q9NS61-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000239117; ENSP00000239117; ENSG00000120049 [Q9NS61-9]
ENST00000343195; ENSP00000344169; ENSG00000120049 [Q9NS61-3]
ENST00000348850; ENSP00000239118; ENSG00000120049 [Q9NS61-4]
ENST00000353068; ENSP00000341624; ENSG00000120049 [Q9NS61-7]
ENST00000356640; ENSP00000349055; ENSG00000120049 [Q9NS61-1]
ENST00000358038; ENSP00000350733; ENSG00000120049 [Q9NS61-2]
ENST00000434163; ENSP00000411679; ENSG00000120049 [Q9NS61-8]
ENST00000461105; ENSP00000420040; ENSG00000120049 [Q9NS61-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
30819

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:30819

UCSC genome browser

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UCSCi
uc001ktz.4 human [Q9NS61-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199598 mRNA Translation: AAF33683.1
AB044584 mRNA Translation: BAA96740.1
AB044585 mRNA Translation: BAA96741.1
AY026328 mRNA Translation: AAK07674.1
AY026331, AY026329, AY026330 Genomic DNA Translation: AAK21972.1
AF347114 mRNA Translation: AAK70356.1
AF295076 mRNA Translation: AAG02120.1
AF295530 mRNA Translation: AAG02121.1
AF367018 mRNA Translation: AAK53707.1
AF367019 mRNA Translation: AAK53708.1
AF367020 mRNA Translation: AAK53709.1
AF367021 mRNA Translation: AAK53710.1
DQ148480 mRNA Translation: AAZ77797.1
DQ148481 mRNA Translation: AAZ77798.1
DQ148483 mRNA Translation: AAZ77800.1
AL136722 mRNA Translation: CAB66656.1
AY302141 mRNA Translation: AAP57633.1
AK027347 mRNA Translation: BAB55052.1
AK315042 mRNA Translation: BAG37523.1
AC010789 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49733.1
BC034685 mRNA Translation: AAH34685.1
AJ276317 mRNA Translation: CAB77054.1
CCDSiCCDS41562.1 [Q9NS61-2]
CCDS7521.1 [Q9NS61-6]
CCDS7522.1 [Q9NS61-1]
CCDS7523.1 [Q9NS61-7]
CCDS7524.1 [Q9NS61-3]
CCDS7525.1 [Q9NS61-4]
CCDS7526.1 [Q9NS61-9]
RefSeqiNP_055406.2, NM_014591.4 [Q9NS61-6]
NP_775283.1, NM_173191.2 [Q9NS61-1]
NP_775284.1, NM_173192.2 [Q9NS61-2]
NP_775285.1, NM_173193.2 [Q9NS61-7]
NP_775286.1, NM_173194.2 [Q9NS61-4]
NP_775287.1, NM_173195.2 [Q9NS61-3]
NP_775289.1, NM_173197.2 [Q9NS61-9]

3D structure databases

SMRiQ9NS61
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119043, 12 interactors
ComplexPortaliCPX-3239 Kv4.2-KChIP2 channel complex
IntActiQ9NS61, 9 interactors
STRINGi9606.ENSP00000420040

Chemistry databases

ChEMBLiCHEMBL3885598

Protein family/group databases

TCDBi8.A.82.2.4 the calmodulin calcium binding protein (calmodulin) family

PTM databases

iPTMnetiQ9NS61
PhosphoSitePlusiQ9NS61
SwissPalmiQ9NS61

Polymorphism and mutation databases

BioMutaiKCNIP2
DMDMi338817979

Proteomic databases

MassIVEiQ9NS61
PeptideAtlasiQ9NS61
PRIDEiQ9NS61
ProteomicsDBi82483 [Q9NS61-1]
82484 [Q9NS61-2]
82485 [Q9NS61-3]
82486 [Q9NS61-4]
82487 [Q9NS61-5]
82488 [Q9NS61-6]
82489 [Q9NS61-7]
82490 [Q9NS61-8]
82491 [Q9NS61-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
30819

Genome annotation databases

EnsembliENST00000239117; ENSP00000239117; ENSG00000120049 [Q9NS61-9]
ENST00000343195; ENSP00000344169; ENSG00000120049 [Q9NS61-3]
ENST00000348850; ENSP00000239118; ENSG00000120049 [Q9NS61-4]
ENST00000353068; ENSP00000341624; ENSG00000120049 [Q9NS61-7]
ENST00000356640; ENSP00000349055; ENSG00000120049 [Q9NS61-1]
ENST00000358038; ENSP00000350733; ENSG00000120049 [Q9NS61-2]
ENST00000434163; ENSP00000411679; ENSG00000120049 [Q9NS61-8]
ENST00000461105; ENSP00000420040; ENSG00000120049 [Q9NS61-6]
GeneIDi30819
KEGGihsa:30819
UCSCiuc001ktz.4 human [Q9NS61-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30819
DisGeNETi30819
EuPathDBiHostDB:ENSG00000120049.18

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNIP2
HGNCiHGNC:15522 KCNIP2
HPAiHPA066717
MIMi604661 gene
neXtProtiNX_Q9NS61
OpenTargetsiENSG00000120049
PharmGKBiPA30042

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157798
InParanoidiQ9NS61
OMAiECPDGVV
OrthoDBi1271942at2759
TreeFamiTF318560

Enzyme and pathway databases

ReactomeiR-HSA-5576894 Phase 1 - inactivation of fast Na+ channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCNIP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNIP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
30819
PharosiQ9NS61 Tbio

Protein Ontology

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PROi
PR:Q9NS61
RNActiQ9NS61 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120049 Expressed in 157 organ(s), highest expression level in right atrium auricular region
ExpressionAtlasiQ9NS61 baseline and differential
GenevisibleiQ9NS61 HS

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028846 Recoverin
PANTHERiPTHR23055 PTHR23055, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCIP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS61
Secondary accession number(s): A6NJE5
, A8MQ75, Q3YAC6, Q3YAC8, Q3YAC9, Q7Z6F1, Q96K86, Q96T41, Q96T42, Q96T43, Q96T44, Q9H0N4, Q9HD10, Q9HD11, Q9NS60, Q9NY10, Q9NZI1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 28, 2011
Last modified: December 11, 2019
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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