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Protein

Double-stranded RNA-specific editase B2

Gene

ADARB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi432ZincPROSITE-ProRule annotation1
Active sitei434Proton donorPROSITE-ProRule annotation1
Metal bindingi490ZincPROSITE-ProRule annotation1
Metal bindingi555ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processmRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-specific editase B2 (EC:3.5.-.-)
Alternative name(s):
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
dsRNA adenosine deaminase B2
Gene namesi
Name:ADARB2
Synonyms:ADAR3, RED2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000185736.15
HGNCiHGNC:227 ADARB2
MIMi602065 gene
neXtProtiNX_Q9NS39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi105
OpenTargetsiENSG00000185736
PharmGKBiPA24557

Polymorphism and mutation databases

BioMutaiADARB2
DMDMi33112436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717821 – 739Double-stranded RNA-specific editase B2Add BLAST739

Proteomic databases

EPDiQ9NS39
PaxDbiQ9NS39
PeptideAtlasiQ9NS39
PRIDEiQ9NS39
ProteomicsDBi82477

2D gel databases

SWISS-2DPAGEiQ9NS39

PTM databases

iPTMnetiQ9NS39
PhosphoSitePlusiQ9NS39

Expressioni

Tissue specificityi

Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain tissue.2 Publications

Gene expression databases

BgeeiENSG00000185736 Expressed in 121 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_ADARB2
ExpressionAtlasiQ9NS39 baseline and differential
GenevisibleiQ9NS39 HS

Interactioni

Protein-protein interaction databases

BioGridi106619, 9 interactors
IntActiQ9NS39, 5 interactors
STRINGi9606.ENSP00000370713

Structurei

3D structure databases

ProteinModelPortaliQ9NS39
SMRiQ9NS39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 191DRBM 1PROSITE-ProRule annotationAdd BLAST67
Domaini274 – 341DRBM 2PROSITE-ProRule annotationAdd BLAST68
Domaini408 – 735A to I editasePROSITE-ProRule annotationAdd BLAST328

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 35R-domain (ssRNA-binding)Add BLAST13

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2777 Eukaryota
ENOG410XT0Z LUCA
GeneTreeiENSGT00550000074412
HOGENOMiHOG000290164
HOVERGENiHBG003836
InParanoidiQ9NS39
KOiK13194
OMAiCKLQLIW
OrthoDBiEOG091G0MZP
PhylomeDBiQ9NS39
TreeFamiTF315806

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR002466 A_deamin
IPR014720 dsRBD_dom
PfamiView protein in Pfam
PF02137 A_deamin, 1 hit
PF00035 dsrm, 2 hits
SMARTiView protein in SMART
SM00552 ADEAMc, 1 hit
SM00358 DSRM, 2 hits
PROSITEiView protein in PROSITE
PS50141 A_DEAMIN_EDITASE, 1 hit
PS50137 DS_RBD, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9NS39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKHLS
60 70 80 90 100
PGITNTEDDD TLSTSSAEVK ENRNVGNLAA RPPPSGDRAR GGAPGAKRKR
110 120 130 140 150
PLEEGNGGHL CKLQLVWKKL SWSVAPKNAL VQLHELRPGL QYRTVSQTGP
160 170 180 190 200
VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR AAELALRSFV QFPNACQAHL
210 220 230 240 250
AMGGGPGPGT DFTSDQADFP DTLFQEFEPP APRPGLAGGR PGDAALLSAA
260 270 280 290 300
YGRRRLLCRA LDLVGPTPAT PAAPGERNPV VLLNRLRAGL RYVCLAEPAE
310 320 330 340 350
RRARSFVMAV SVDGRTFEGS GRSKKLARGQ AAQAALQELF DIQMPGHAPG
360 370 380 390 400
RARRTPMPQE FADSISQLVT QKFREVTTDL TPMHARHKAL AGIVMTKGLD
410 420 430 440 450
ARQAQVVALS SGTKCISGEH LSDQGLVVND CHAEVVARRA FLHFLYTQLE
460 470 480 490 500
LHLSKRREDS ERSIFVRLKE GGYRLRENIL FHLYVSTSPC GDARLHSPYE
510 520 530 540 550
ITTDLHSSKH LVRKFRGHLR TKIESGEGTV PVRGPSAVQT WDGVLLGEQL
560 570 580 590 600
ITMSCTDKIA RWNVLGLQGA LLSHFVEPVY LQSIVVGSLH HTGHLARVMS
610 620 630 640 650
HRMEGVGQLP ASYRHNRPLL SGVSDAEARQ PGKSPPFSMN WVVGSADLEI
660 670 680 690 700
INATTGRRSC GGPSRLCKHV LSARWARLYG RLSTRTPSPG DTPSMYCEAK
710 720 730
LGAHTYQSVK QQLFKAFQKA GLGTWVRKPP EQQQFLLTL
Length:739
Mass (Da):80,621
Last modified:October 1, 2000 - v1
Checksum:iA158A81D35894F79
GO
Isoform 2 (identifier: Q9NS39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MASVLGSGRG...DTLSTSSAEV → MGLWSPVPGN...GAPLTAGSPH
     70-560: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):26,723
Checksum:i370AD0A469831419
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VW43Q5VW43_HUMAN
Double-stranded RNA-specific editas...
ADARB2
141Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02043844A → T. Corresponds to variant dbSNP:rs3793733Ensembl.1
Natural variantiVAR_035806210T → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035807512V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138734198Ensembl.1
Natural variantiVAR_048726626A → T1 PublicationCorresponds to variant dbSNP:rs2271275Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569261 – 69MASVL…SSAEV → MGLWSPVPGNSVPRAPVMAG LGLGHSQGAPQGPHDGKTDR SSGPGRRRTERTRLPGLLGG APLTAGSPH in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_05692770 – 560Missing in isoform 2. 1 PublicationAdd BLAST491

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034837 mRNA Translation: AAF78094.1
AK055107 mRNA Translation: BAG51468.1
AL442069 Genomic DNA No translation available.
AL450386 Genomic DNA No translation available.
AC026224 Genomic DNA No translation available.
AL392083 Genomic DNA No translation available.
AL513304 Genomic DNA No translation available.
BC137477 mRNA Translation: AAI37478.1
BC140852 mRNA Translation: AAI40853.1
CCDSiCCDS7058.1 [Q9NS39-1]
RefSeqiNP_061172.1, NM_018702.3 [Q9NS39-1]
UniGeneiHs.586663

Genome annotation databases

EnsembliENST00000381310; ENSP00000370711; ENSG00000185736 [Q9NS39-2]
ENST00000381312; ENSP00000370713; ENSG00000185736 [Q9NS39-1]
GeneIDi105
KEGGihsa:105
UCSCiuc001igm.5 human [Q9NS39-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRED2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS39
Secondary accession number(s): B2RPJ5, Q5VUT6, Q5VW42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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