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Protein

Regulator of G-protein signaling 18

Gene

RGS18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:RGS18
Synonyms:RGS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000150681.9
HGNCiHGNC:14261 RGS18
MIMi607192 gene
neXtProtiNX_Q9NS28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi64407
OpenTargetsiENSG00000150681
PharmGKBiPA34369

Polymorphism and mutation databases

BioMutaiRGS18
DMDMi15214228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042271 – 235Regulator of G-protein signaling 18Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Phosphoserine1 Publication1
Modified residuei216PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NS28
PaxDbiQ9NS28
PeptideAtlasiQ9NS28
PRIDEiQ9NS28
ProteomicsDBi82475

2D gel databases

OGPiQ9NS28

PTM databases

iPTMnetiQ9NS28
PhosphoSitePlusiQ9NS28

Expressioni

Tissue specificityi

Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.2 Publications

Gene expression databases

BgeeiENSG00000150681
CleanExiHS_RGS13
HS_RGS18
GenevisibleiQ9NS28 HS

Organism-specific databases

HPAiHPA028727
HPA045780

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Gnao1P592152EBI-15933052,EBI-8071125From Rattus norvegicus.

Protein-protein interaction databases

BioGridi122160, 7 interactors
DIPiDIP-59096N
IntActiQ9NS28, 1 interactor
STRINGi9606.ENSP00000356430

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi77 – 83Combined sources7
Helixi87 – 92Combined sources6
Helixi94 – 106Combined sources13
Helixi111 – 122Combined sources12
Helixi127 – 141Combined sources15
Beta strandi144 – 147Combined sources4
Helixi155 – 163Combined sources9
Helixi164 – 166Combined sources3
Turni170 – 173Combined sources4
Helixi174 – 186Combined sources13
Helixi188 – 193Combined sources6
Helixi196 – 202Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLVNMR-A76-202[»]
2JM5NMR-A75-223[»]
2OWINMR-A75-223[»]
ProteinModelPortaliQ9NS28
SMRiQ9NS28
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NS28

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 202RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ9NS28
KOiK16449
OMAiLMEQDSY
OrthoDBiEOG091G0BDG
PhylomeDBiQ9NS28
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034950 RGS18
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF155 PTHR10845:SF155, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NS28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL
60 70 80 90 100
LVQKPEFHED TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF
110 120 130 140 150
TRFLKTEFSE ENIEFWIACE DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE
160 170 180 190 200
VNLDFHTKEV ITNSITQPTL HSFDAAQSRV YQLMEQDSYT RFLKSDIYLD
210 220 230
LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL
Length:235
Mass (Da):27,582
Last modified:October 1, 2000 - v1
Checksum:i973ABDE8EC7DE3D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226 – 227DV → ML (PubMed:11042171).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076642 mRNA Translation: AAF80227.1
AF268036 mRNA Translation: AAK58589.1
AL596342, AL513175 Genomic DNA Translation: CAH71160.1
AK315377 mRNA Translation: BAG37770.1
AL513175, AL596342 Genomic DNA Translation: CAH70529.1
CH471067 Genomic DNA Translation: EAW91223.1
BC020632 mRNA Translation: AAH20632.1
CCDSiCCDS1374.1
RefSeqiNP_570138.1, NM_130782.2
UniGeneiHs.440890

Genome annotation databases

EnsembliENST00000367460; ENSP00000356430; ENSG00000150681
GeneIDi64407
KEGGihsa:64407
UCSCiuc001gsg.4 human

Similar proteinsi

Entry informationi

Entry nameiRGS18_HUMAN
AccessioniPrimary (citable) accession number: Q9NS28
Secondary accession number(s): B2RD23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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