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UniProtKB - Q9NS23 (RASF1_HUMAN)

Entry version 165 (13 Feb 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Ras association domain-containing protein 1

Gene

RASSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.9 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri51 – 105Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST55

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: CAFA
  • protein N-terminus binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NS23

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NS23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras association domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASSF1Imported
Synonyms:RDA32Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000068028.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:9882 RASSF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605082 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NS23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		11186

MalaCards human disease database

More...MalaCardsi		RASSF1

Open Targets

More...OpenTargetsi		ENSG00000068028

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34245

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RASSF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		50401686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688912 – 344Ras association domain-containing protein 1Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei36Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NS23

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NS23

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NS23

PeptideAtlas

More...PeptideAtlasi		Q9NS23

PRoteomics IDEntifications database

More...PRIDEi		Q9NS23

ProteomicsDB human proteome resource

More...ProteomicsDBi		82465
82466 [Q9NS23-2]
82467 [Q9NS23-3]
82468 [Q9NS23-4]
82469 [Q9NS23-5]
82470 [Q9NS23-6]
82471 [Q9NS23-7]
82472 [Q9NS23-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NS23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NS23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000068028 Expressed in 170 organ(s), highest expression level in small intestine Peyer's patch

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NS23 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA040735

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53.11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116356, 91 interactors

Database of interacting proteins

More...DIPi		DIP-31270N

Protein interaction database and analysis system

More...IntActi		Q9NS23, 39 interactors

Molecular INTeraction database

More...MINTi		Q9NS23

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349547

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KZUNMR-B-[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9NS23

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NS23

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NS23

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 292Ras-associatingPROSITE-ProRule annotationAdd BLAST95
Domaini294 – 341SARAHPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 119Mediates interaction with E4F11 PublicationAdd BLAST118
Regioni315 – 318MOAP1-binding4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 105Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IPAE Eukaryota
ENOG4111HS2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155664

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013025

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG054362

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NS23

KEGG Orthology (KO)

More...KOi		K09850

Identification of Orthologs from Complete Genome Data

More...OMAi		TPSFEMT

Database of Orthologous Groups

More...OrthoDBi		1120975at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NS23

TreeFam database of animal gene trees

More...TreeFami		TF319243

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029 C1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033614 C-RASSF
IPR002219 PE/DAG-bd
IPR000159 RA_dom
IPR033600 RASSF1
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR22738 PTHR22738, 1 hit
PTHR22738:SF12 PTHR22738:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109 C1, 1 hit
SM00314 RA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform D1 Publication (identifier: Q9NS23-1) [UniParc]FASTAAdd to basket
Also known as: RASSF1D, Cardiac-specific1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGEPELIEL RELAPAGRAG KGRTRLERAN ALRIARGTAC NPTRQLVPGR 
        60         70         80         90        100
GHRFQPAGPA THTWCDLCGD FIWGVVRKGL QCARLSADCK FTCHYRCRAL 
       110        120        130        140        150
VCLDCCGPRD LGWEPAVERD TNVDEPVEWE TPDLSQAEIE QKIKEYNAQI 
       160        170        180        190        200
NSNLFMSLNK DGSYTGFIKV QLKLVRPVSV PSSKKPPSLQ DARRGPGRGT 
       210        220        230        240        250
SVRRRTSFYL PKDAVKHLHV LSRTRAREVI EALLRKFLVV DDPRKFALFE 
       260        270        280        290        300
RAERHGQVYL RKLLDDEQPL RLRLLAGPSD KALSFVLKEN DSGEVNWDAF 
       310        320        330        340 
SMPELHNFLR ILQREEEEHL RQILQKYSYC RQKIQEALHA CPLG
Note: Produced by alternative promoter usage.
Length:344
Mass (Da):39,219
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4071B8D044C1DB2D
GO
Isoform A2 Publications (identifier: Q9NS23-2) [UniParc]FASTAAdd to basket
Also known as: RASSF1A

The sequence of this isoform differs from the canonical sequence as follows:
     84-88: RLSAD → H

Note: Produced by alternative splicing of isoform D.
Show »
Length:340
Mass (Da):38,814
Checksum:i73FB7C7D87507D9F
GO
Isoform B1 Publication (identifier: Q9NS23-3) [UniParc]FASTAAdd to basket
Also known as: RASSF1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Note: Produced by alternative splicing of isoform D.
Show »
Length:189
Mass (Da):21,899
Checksum:i2D7C1F632EA7A23B
GO
Isoform C2 Publications (identifier: Q9NS23-4) [UniParc]FASTAAdd to basket
Also known as: RASSF1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-123: VVRKGLQCAR...EPAVERDTNV → MGEAEAPSFE...SLARRPRRDQ

Note: Produced by alternative promoter usage.
Show »
Length:270
Mass (Da):31,226
Checksum:i2E7006EA16A38D25
GO
Isoform E1 Publication (identifier: Q9NS23-5) [UniParc]FASTAAdd to basket
Also known as: RASSF1E, Pancreas-specific1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     84-88: RLSAD → H
     123-123: V → VPILQ

Note: Produced by alternative splicing of isoform D.
Show »
Length:344
Mass (Da):39,265
Checksum:iDB422771EB2AB7B2
GO
Isoform F1 Publication (identifier: Q9NS23-6) [UniParc]FASTAAdd to basket
Also known as: RASSF1F

The sequence of this isoform differs from the canonical sequence as follows:
     85-91: LSADCKF → RACGVGD
     93-344: Missing.

Note: Produced by alternative splicing of isoform D.
Show »
Length:92
Mass (Da):9,937
Checksum:iC8FEFAAD37425A01
GO
Isoform G1 Publication (identifier: Q9NS23-7) [UniParc]FASTAAdd to basket
Also known as: RASSF1G

The sequence of this isoform differs from the canonical sequence as follows:
     84-149: RLSADCKFTC...EQKIKEYNAQ → QQGRFLHRLH...PACAVTHKGT
     150-344: Missing.

Note: Produced by alternative splicing of isoform D.
Show »
Length:152
Mass (Da):16,120
Checksum:i18403EEC734C2695
GO
Isoform H (identifier: Q9NS23-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-123: VVRKGLQCAR...EPAVERDTNV → MGEAEAPSFE...SLARRPRRDQ
     150-344: Missing.

Note: Produced by alternative splicing of isoform C.
Show »
Length:75
Mass (Da):8,656
Checksum:i5B7A6F7C7409E740
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB67312 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01954221K → Q2 PublicationsCorresponds to variant dbSNP:rs4688725Ensembl.1
Natural variantiVAR_01954353R → C1 PublicationCorresponds to variant dbSNP:rs201618726Ensembl.1
Natural variantiVAR_019544133D → E1 PublicationCorresponds to variant dbSNP:rs76335415Ensembl.1
Natural variantiVAR_019545135S → F Prevents G1 cell cycle arrest; reduced protein phosphorylation. 1 PublicationCorresponds to variant dbSNP:rs934370004Ensembl.1
Natural variantiVAR_019546137A → S Prevents G1 cell cycle arrest; reduced protein phosphorylation. 2 PublicationsCorresponds to variant dbSNP:rs2073498Ensembl.1
Natural variantiVAR_059794319H → R. Corresponds to variant dbSNP:rs12488879Ensembl.1
Natural variantiVAR_019547329Y → C1 PublicationCorresponds to variant dbSNP:rs782655006Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0507701 – 155Missing in isoform B. 2 PublicationsAdd BLAST155
Alternative sequenceiVSP_0507731 – 74Missing in isoform C and isoform H. 3 PublicationsAdd BLAST74
Alternative sequenceiVSP_05077475 – 123VVRKG…RDTNV → MGEAEAPSFEMTWSSTTSSG YCSQEDSDSELEQYFTARTS LARRPRRDQ in isoform C and isoform H. 3 PublicationsAdd BLAST49
Alternative sequenceiVSP_05077584 – 149RLSAD…EYNAQ → QQGRFLHRLHQGSAEAGAPC LCALQQEATLLAGCPAGPRT GHKCQAPHFLLPAQGCCQAP ACAVTHKGT in isoform G. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_05077184 – 88RLSAD → H in isoform A and isoform E. 3 Publications5
Alternative sequenceiVSP_05077685 – 91LSADCKF → RACGVGD in isoform F. 1 Publication7
Alternative sequenceiVSP_05077793 – 344Missing in isoform F. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_050772123V → VPILQ in isoform E. 1 Publication1
Alternative sequenceiVSP_050778150 – 344Missing in isoform G and isoform H. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF061836 mRNA Translation: AAC16001.1
AF132675 mRNA Translation: AAD44174.1
AF132676 mRNA Translation: AAD44175.1
AF132677 mRNA Translation: AAD44176.1
AF040703 mRNA Translation: AAC70910.2
AF102770 mRNA Translation: AAF35127.2
AF102771 mRNA Translation: AAF35128.2
AF102772 mRNA Translation: AAF35129.2
BT020047 mRNA Translation: AAV38850.1
BT020048 mRNA Translation: AAV38851.1
AF286217 mRNA Translation: AAG10038.1
AF291719 mRNA Translation: AAG10064.1
AC002455 Genomic DNA No translation available.
AC002481 Genomic DNA Translation: AAB67312.1 Sequence problems.
CH471055 Genomic DNA Translation: EAW65098.1
CH471055 Genomic DNA Translation: EAW65101.1
CH471055 Genomic DNA Translation: EAW65102.1
BC110412 mRNA Translation: AAI10413.1
BC143879 mRNA Translation: AAI43880.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2820.1 [Q9NS23-1]
CCDS2821.1 [Q9NS23-4]
CCDS2822.1 [Q9NS23-3]
CCDS43096.1 [Q9NS23-2]

NCBI Reference Sequences

More...RefSeqi		NP_001193886.1, NM_001206957.1 [Q9NS23-3]
NP_009113.3, NM_007182.4 [Q9NS23-2]
NP_733830.1, NM_170712.2 [Q9NS23-3]
NP_733831.1, NM_170713.2 [Q9NS23-4]
NP_733832.1, NM_170714.1 [Q9NS23-1]
XP_011531617.1, XM_011533315.1
XP_011531618.1, XM_011533316.2 [Q9NS23-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.476270

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327761; ENSP00000333327; ENSG00000068028 [Q9NS23-4]
ENST00000357043; ENSP00000349547; ENSG00000068028 [Q9NS23-1]
ENST00000359365; ENSP00000352323; ENSG00000068028 [Q9NS23-2]
ENST00000395117; ENSP00000378549; ENSG00000068028 [Q9NS23-6]
ENST00000395126; ENSP00000378558; ENSG00000068028 [Q9NS23-3]
ENST00000482447; ENSP00000433000; ENSG00000068028 [Q9NS23-7]
ENST00000616212; ENSP00000482696; ENSG00000068028 [Q9NS23-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11186

UCSC genome browser

More...UCSCi		uc003dab.2 human [Q9NS23-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061836 mRNA Translation: AAC16001.1
AF132675 mRNA Translation: AAD44174.1
AF132676 mRNA Translation: AAD44175.1
AF132677 mRNA Translation: AAD44176.1
AF040703 mRNA Translation: AAC70910.2
AF102770 mRNA Translation: AAF35127.2
AF102771 mRNA Translation: AAF35128.2
AF102772 mRNA Translation: AAF35129.2
BT020047 mRNA Translation: AAV38850.1
BT020048 mRNA Translation: AAV38851.1
AF286217 mRNA Translation: AAG10038.1
AF291719 mRNA Translation: AAG10064.1
AC002455 Genomic DNA No translation available.
AC002481 Genomic DNA Translation: AAB67312.1 Sequence problems.
CH471055 Genomic DNA Translation: EAW65098.1
CH471055 Genomic DNA Translation: EAW65101.1
CH471055 Genomic DNA Translation: EAW65102.1
BC110412 mRNA Translation: AAI10413.1
BC143879 mRNA Translation: AAI43880.1
CCDSiCCDS2820.1 [Q9NS23-1]
CCDS2821.1 [Q9NS23-4]
CCDS2822.1 [Q9NS23-3]
CCDS43096.1 [Q9NS23-2]
RefSeqiNP_001193886.1, NM_001206957.1 [Q9NS23-3]
NP_009113.3, NM_007182.4 [Q9NS23-2]
NP_733830.1, NM_170712.2 [Q9NS23-3]
NP_733831.1, NM_170713.2 [Q9NS23-4]
NP_733832.1, NM_170714.1 [Q9NS23-1]
XP_011531617.1, XM_011533315.1
XP_011531618.1, XM_011533316.2 [Q9NS23-3]
UniGeneiHs.476270

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KZUNMR-B-[»]
ProteinModelPortaliQ9NS23
SMRiQ9NS23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116356, 91 interactors
DIPiDIP-31270N
IntActiQ9NS23, 39 interactors
MINTiQ9NS23
STRINGi9606.ENSP00000349547

PTM databases

iPTMnetiQ9NS23
PhosphoSitePlusiQ9NS23

Polymorphism and mutation databases

BioMutaiRASSF1
DMDMi50401686

Proteomic databases

jPOSTiQ9NS23
MaxQBiQ9NS23
PaxDbiQ9NS23
PeptideAtlasiQ9NS23
PRIDEiQ9NS23
ProteomicsDBi82465
82466 [Q9NS23-2]
82467 [Q9NS23-3]
82468 [Q9NS23-4]
82469 [Q9NS23-5]
82470 [Q9NS23-6]
82471 [Q9NS23-7]
82472 [Q9NS23-9]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		11186
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327761; ENSP00000333327; ENSG00000068028 [Q9NS23-4]
ENST00000357043; ENSP00000349547; ENSG00000068028 [Q9NS23-1]
ENST00000359365; ENSP00000352323; ENSG00000068028 [Q9NS23-2]
ENST00000395117; ENSP00000378549; ENSG00000068028 [Q9NS23-6]
ENST00000395126; ENSP00000378558; ENSG00000068028 [Q9NS23-3]
ENST00000482447; ENSP00000433000; ENSG00000068028 [Q9NS23-7]
ENST00000616212; ENSP00000482696; ENSG00000068028 [Q9NS23-3]
GeneIDi11186
KEGGihsa:11186
UCSCiuc003dab.2 human [Q9NS23-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11186
DisGeNETi11186
EuPathDBiHostDB:ENSG00000068028.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		RASSF1
HGNCiHGNC:9882 RASSF1
HPAiHPA040735
MalaCardsiRASSF1
MIMi605082 gene
neXtProtiNX_Q9NS23
OpenTargetsiENSG00000068028
PharmGKBiPA34245

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IPAE Eukaryota
ENOG4111HS2 LUCA
GeneTreeiENSGT00940000155664
HOGENOMiHOG000013025
HOVERGENiHBG054362
InParanoidiQ9NS23
KOiK09850
OMAiTPSFEMT
OrthoDBi1120975at2759
PhylomeDBiQ9NS23
TreeFamiTF319243

Enzyme and pathway databases

SignaLinkiQ9NS23
SIGNORiQ9NS23

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RASSF1 human
EvolutionaryTraceiQ9NS23

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RASSF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11186

Protein Ontology

More...PROi		PR:Q9NS23

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000068028 Expressed in 170 organ(s), highest expression level in small intestine Peyer's patch
GenevisibleiQ9NS23 HS

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR033614 C-RASSF
IPR002219 PE/DAG-bd
IPR000159 RA_dom
IPR033600 RASSF1
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF12 PTHR22738:SF12, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS23
Secondary accession number(s): B7ZLL1
, O14571, O60539, O60710, Q0VGC6, Q5TZT2, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: February 13, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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