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Protein

Ras association domain-containing protein 1

Gene

RASSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.9 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 105Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: CAFA
  • protein N-terminus binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9NS23
SIGNORiQ9NS23

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 1
Gene namesi
Name:RASSF1Imported
Synonyms:RDA32Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000068028.17
HGNCiHGNC:9882 RASSF1
MIMi605082 gene
neXtProtiNX_Q9NS23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi11186
MalaCardsiRASSF1
OpenTargetsiENSG00000068028
PharmGKBiPA34245

Polymorphism and mutation databases

BioMutaiRASSF1
DMDMi50401686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000688912 – 344Ras association domain-containing protein 1Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei36Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NS23
PaxDbiQ9NS23
PeptideAtlasiQ9NS23
PRIDEiQ9NS23
ProteomicsDBi82465
82466 [Q9NS23-2]
82467 [Q9NS23-3]
82468 [Q9NS23-4]
82469 [Q9NS23-5]
82470 [Q9NS23-6]
82471 [Q9NS23-7]
82472 [Q9NS23-9]

PTM databases

iPTMnetiQ9NS23
PhosphoSitePlusiQ9NS23

Expressioni

Tissue specificityi

Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.2 Publications

Gene expression databases

BgeeiENSG00000068028 Expressed in 170 organ(s), highest expression level in small intestine Peyer's patch
GenevisibleiQ9NS23 HS

Organism-specific databases

HPAiHPA040735

Interactioni

Subunit structurei

Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53.11 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116356, 60 interactors
DIPiDIP-31270N
IntActiQ9NS23, 39 interactors
MINTiQ9NS23
STRINGi9606.ENSP00000349547

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NS23
SMRiQ9NS23
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NS23

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 292Ras-associatingPROSITE-ProRule annotationAdd BLAST95
Domaini294 – 341SARAHPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 119Mediates interaction with E4F11 PublicationAdd BLAST118
Regioni315 – 318MOAP1-binding4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 105Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPAE Eukaryota
ENOG4111HS2 LUCA
GeneTreeiENSGT00390000003367
HOGENOMiHOG000013025
HOVERGENiHBG054362
InParanoidiQ9NS23
KOiK09850
OMAiTPSFEMT
OrthoDBiEOG091G0EPB
PhylomeDBiQ9NS23
TreeFamiTF319243

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR033614 C-RASSF
IPR002219 PE/DAG-bd
IPR000159 RA_dom
IPR033600 RASSF1
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF12 PTHR22738:SF12, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform D1 Publication (identifier: Q9NS23-1) [UniParc]FASTAAdd to basket
Also known as: RASSF1D, Cardiac-specific1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGEPELIEL RELAPAGRAG KGRTRLERAN ALRIARGTAC NPTRQLVPGR
60 70 80 90 100
GHRFQPAGPA THTWCDLCGD FIWGVVRKGL QCARLSADCK FTCHYRCRAL
110 120 130 140 150
VCLDCCGPRD LGWEPAVERD TNVDEPVEWE TPDLSQAEIE QKIKEYNAQI
160 170 180 190 200
NSNLFMSLNK DGSYTGFIKV QLKLVRPVSV PSSKKPPSLQ DARRGPGRGT
210 220 230 240 250
SVRRRTSFYL PKDAVKHLHV LSRTRAREVI EALLRKFLVV DDPRKFALFE
260 270 280 290 300
RAERHGQVYL RKLLDDEQPL RLRLLAGPSD KALSFVLKEN DSGEVNWDAF
310 320 330 340
SMPELHNFLR ILQREEEEHL RQILQKYSYC RQKIQEALHA CPLG
Note: Produced by alternative promoter usage.
Length:344
Mass (Da):39,219
Last modified:October 1, 2000 - v1
Checksum:i4071B8D044C1DB2D
GO
Isoform A2 Publications (identifier: Q9NS23-2) [UniParc]FASTAAdd to basket
Also known as: RASSF1A

The sequence of this isoform differs from the canonical sequence as follows:
     84-88: RLSAD → H

Note: Produced by alternative splicing of isoform D.
Show »
Length:340
Mass (Da):38,814
Checksum:i73FB7C7D87507D9F
GO
Isoform B1 Publication (identifier: Q9NS23-3) [UniParc]FASTAAdd to basket
Also known as: RASSF1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Note: Produced by alternative splicing of isoform D.
Show »
Length:189
Mass (Da):21,899
Checksum:i2D7C1F632EA7A23B
GO
Isoform C2 Publications (identifier: Q9NS23-4) [UniParc]FASTAAdd to basket
Also known as: RASSF1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-123: VVRKGLQCAR...EPAVERDTNV → MGEAEAPSFE...SLARRPRRDQ

Note: Produced by alternative promoter usage.
Show »
Length:270
Mass (Da):31,226
Checksum:i2E7006EA16A38D25
GO
Isoform E1 Publication (identifier: Q9NS23-5) [UniParc]FASTAAdd to basket
Also known as: RASSF1E, Pancreas-specific1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     84-88: RLSAD → H
     123-123: V → VPILQ

Note: Produced by alternative splicing of isoform D.
Show »
Length:344
Mass (Da):39,265
Checksum:iDB422771EB2AB7B2
GO
Isoform F1 Publication (identifier: Q9NS23-6) [UniParc]FASTAAdd to basket
Also known as: RASSF1F

The sequence of this isoform differs from the canonical sequence as follows:
     85-91: LSADCKF → RACGVGD
     93-344: Missing.

Note: Produced by alternative splicing of isoform D.
Show »
Length:92
Mass (Da):9,937
Checksum:iC8FEFAAD37425A01
GO
Isoform G1 Publication (identifier: Q9NS23-7) [UniParc]FASTAAdd to basket
Also known as: RASSF1G

The sequence of this isoform differs from the canonical sequence as follows:
     84-149: RLSADCKFTC...EQKIKEYNAQ → QQGRFLHRLH...PACAVTHKGT
     150-344: Missing.

Note: Produced by alternative splicing of isoform D.
Show »
Length:152
Mass (Da):16,120
Checksum:i18403EEC734C2695
GO
Isoform H (identifier: Q9NS23-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-123: VVRKGLQCAR...EPAVERDTNV → MGEAEAPSFE...SLARRPRRDQ
     150-344: Missing.

Note: Produced by alternative splicing of isoform C.
Show »
Length:75
Mass (Da):8,656
Checksum:i5B7A6F7C7409E740
GO

Sequence cautioni

The sequence AAB67312 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01954221K → Q2 PublicationsCorresponds to variant dbSNP:rs4688725Ensembl.1
Natural variantiVAR_01954353R → C1 PublicationCorresponds to variant dbSNP:rs201618726Ensembl.1
Natural variantiVAR_019544133D → E1 PublicationCorresponds to variant dbSNP:rs76335415Ensembl.1
Natural variantiVAR_019545135S → F Prevents G1 cell cycle arrest; reduced protein phosphorylation. 1 PublicationCorresponds to variant dbSNP:rs934370004Ensembl.1
Natural variantiVAR_019546137A → S Prevents G1 cell cycle arrest; reduced protein phosphorylation. 2 PublicationsCorresponds to variant dbSNP:rs2073498Ensembl.1
Natural variantiVAR_059794319H → R. Corresponds to variant dbSNP:rs12488879Ensembl.1
Natural variantiVAR_019547329Y → C1 PublicationCorresponds to variant dbSNP:rs782655006Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0507701 – 155Missing in isoform B. 2 PublicationsAdd BLAST155
Alternative sequenceiVSP_0507731 – 74Missing in isoform C and isoform H. 3 PublicationsAdd BLAST74
Alternative sequenceiVSP_05077475 – 123VVRKG…RDTNV → MGEAEAPSFEMTWSSTTSSG YCSQEDSDSELEQYFTARTS LARRPRRDQ in isoform C and isoform H. 3 PublicationsAdd BLAST49
Alternative sequenceiVSP_05077584 – 149RLSAD…EYNAQ → QQGRFLHRLHQGSAEAGAPC LCALQQEATLLAGCPAGPRT GHKCQAPHFLLPAQGCCQAP ACAVTHKGT in isoform G. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_05077184 – 88RLSAD → H in isoform A and isoform E. 3 Publications5
Alternative sequenceiVSP_05077685 – 91LSADCKF → RACGVGD in isoform F. 1 Publication7
Alternative sequenceiVSP_05077793 – 344Missing in isoform F. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_050772123V → VPILQ in isoform E. 1 Publication1
Alternative sequenceiVSP_050778150 – 344Missing in isoform G and isoform H. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061836 mRNA Translation: AAC16001.1
AF132675 mRNA Translation: AAD44174.1
AF132676 mRNA Translation: AAD44175.1
AF132677 mRNA Translation: AAD44176.1
AF040703 mRNA Translation: AAC70910.2
AF102770 mRNA Translation: AAF35127.2
AF102771 mRNA Translation: AAF35128.2
AF102772 mRNA Translation: AAF35129.2
BT020047 mRNA Translation: AAV38850.1
BT020048 mRNA Translation: AAV38851.1
AF286217 mRNA Translation: AAG10038.1
AF291719 mRNA Translation: AAG10064.1
AC002455 Genomic DNA No translation available.
AC002481 Genomic DNA Translation: AAB67312.1 Sequence problems.
CH471055 Genomic DNA Translation: EAW65098.1
CH471055 Genomic DNA Translation: EAW65101.1
CH471055 Genomic DNA Translation: EAW65102.1
BC110412 mRNA Translation: AAI10413.1
BC143879 mRNA Translation: AAI43880.1
CCDSiCCDS2820.1 [Q9NS23-1]
CCDS2821.1 [Q9NS23-4]
CCDS2822.1 [Q9NS23-3]
CCDS43096.1 [Q9NS23-2]
RefSeqiNP_001193886.1, NM_001206957.1 [Q9NS23-3]
NP_009113.3, NM_007182.4 [Q9NS23-2]
NP_733830.1, NM_170712.2 [Q9NS23-3]
NP_733831.1, NM_170713.2 [Q9NS23-4]
NP_733832.1, NM_170714.1 [Q9NS23-1]
XP_011531617.1, XM_011533315.1
XP_011531618.1, XM_011533316.2 [Q9NS23-3]
UniGeneiHs.476270

Genome annotation databases

EnsembliENST00000327761; ENSP00000333327; ENSG00000068028 [Q9NS23-4]
ENST00000357043; ENSP00000349547; ENSG00000068028 [Q9NS23-1]
ENST00000359365; ENSP00000352323; ENSG00000068028 [Q9NS23-2]
ENST00000395117; ENSP00000378549; ENSG00000068028 [Q9NS23-6]
ENST00000395126; ENSP00000378558; ENSG00000068028 [Q9NS23-3]
ENST00000482447; ENSP00000433000; ENSG00000068028 [Q9NS23-7]
ENST00000616212; ENSP00000482696; ENSG00000068028 [Q9NS23-3]
GeneIDi11186
KEGGihsa:11186
UCSCiuc003dab.2 human [Q9NS23-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061836 mRNA Translation: AAC16001.1
AF132675 mRNA Translation: AAD44174.1
AF132676 mRNA Translation: AAD44175.1
AF132677 mRNA Translation: AAD44176.1
AF040703 mRNA Translation: AAC70910.2
AF102770 mRNA Translation: AAF35127.2
AF102771 mRNA Translation: AAF35128.2
AF102772 mRNA Translation: AAF35129.2
BT020047 mRNA Translation: AAV38850.1
BT020048 mRNA Translation: AAV38851.1
AF286217 mRNA Translation: AAG10038.1
AF291719 mRNA Translation: AAG10064.1
AC002455 Genomic DNA No translation available.
AC002481 Genomic DNA Translation: AAB67312.1 Sequence problems.
CH471055 Genomic DNA Translation: EAW65098.1
CH471055 Genomic DNA Translation: EAW65101.1
CH471055 Genomic DNA Translation: EAW65102.1
BC110412 mRNA Translation: AAI10413.1
BC143879 mRNA Translation: AAI43880.1
CCDSiCCDS2820.1 [Q9NS23-1]
CCDS2821.1 [Q9NS23-4]
CCDS2822.1 [Q9NS23-3]
CCDS43096.1 [Q9NS23-2]
RefSeqiNP_001193886.1, NM_001206957.1 [Q9NS23-3]
NP_009113.3, NM_007182.4 [Q9NS23-2]
NP_733830.1, NM_170712.2 [Q9NS23-3]
NP_733831.1, NM_170713.2 [Q9NS23-4]
NP_733832.1, NM_170714.1 [Q9NS23-1]
XP_011531617.1, XM_011533315.1
XP_011531618.1, XM_011533316.2 [Q9NS23-3]
UniGeneiHs.476270

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KZUNMR-B-[»]
ProteinModelPortaliQ9NS23
SMRiQ9NS23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116356, 60 interactors
DIPiDIP-31270N
IntActiQ9NS23, 39 interactors
MINTiQ9NS23
STRINGi9606.ENSP00000349547

PTM databases

iPTMnetiQ9NS23
PhosphoSitePlusiQ9NS23

Polymorphism and mutation databases

BioMutaiRASSF1
DMDMi50401686

Proteomic databases

MaxQBiQ9NS23
PaxDbiQ9NS23
PeptideAtlasiQ9NS23
PRIDEiQ9NS23
ProteomicsDBi82465
82466 [Q9NS23-2]
82467 [Q9NS23-3]
82468 [Q9NS23-4]
82469 [Q9NS23-5]
82470 [Q9NS23-6]
82471 [Q9NS23-7]
82472 [Q9NS23-9]

Protocols and materials databases

DNASUi11186
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327761; ENSP00000333327; ENSG00000068028 [Q9NS23-4]
ENST00000357043; ENSP00000349547; ENSG00000068028 [Q9NS23-1]
ENST00000359365; ENSP00000352323; ENSG00000068028 [Q9NS23-2]
ENST00000395117; ENSP00000378549; ENSG00000068028 [Q9NS23-6]
ENST00000395126; ENSP00000378558; ENSG00000068028 [Q9NS23-3]
ENST00000482447; ENSP00000433000; ENSG00000068028 [Q9NS23-7]
ENST00000616212; ENSP00000482696; ENSG00000068028 [Q9NS23-3]
GeneIDi11186
KEGGihsa:11186
UCSCiuc003dab.2 human [Q9NS23-1]

Organism-specific databases

CTDi11186
DisGeNETi11186
EuPathDBiHostDB:ENSG00000068028.17
GeneCardsiRASSF1
HGNCiHGNC:9882 RASSF1
HPAiHPA040735
MalaCardsiRASSF1
MIMi605082 gene
neXtProtiNX_Q9NS23
OpenTargetsiENSG00000068028
PharmGKBiPA34245
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPAE Eukaryota
ENOG4111HS2 LUCA
GeneTreeiENSGT00390000003367
HOGENOMiHOG000013025
HOVERGENiHBG054362
InParanoidiQ9NS23
KOiK09850
OMAiTPSFEMT
OrthoDBiEOG091G0EPB
PhylomeDBiQ9NS23
TreeFamiTF319243

Enzyme and pathway databases

SignaLinkiQ9NS23
SIGNORiQ9NS23

Miscellaneous databases

ChiTaRSiRASSF1 human
EvolutionaryTraceiQ9NS23
GeneWikiiRASSF1
GenomeRNAii11186
PROiPR:Q9NS23
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068028 Expressed in 170 organ(s), highest expression level in small intestine Peyer's patch
GenevisibleiQ9NS23 HS

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR033614 C-RASSF
IPR002219 PE/DAG-bd
IPR000159 RA_dom
IPR033600 RASSF1
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF12 PTHR22738:SF12, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASF1_HUMAN
AccessioniPrimary (citable) accession number: Q9NS23
Secondary accession number(s): B7ZLL1
, O14571, O60539, O60710, Q0VGC6, Q5TZT2, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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