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Entry version 178 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Glutaredoxin-2, mitochondrial

Gene

GLRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

4 Publications

Miscellaneous

The absence of GLRX2 dramatically sensitizes cells to cell death induced by doxorubicin/adriamycin and phenylarsine oxide.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The 2Fe-2S present in the homodimer leads to inactivation of the enzyme. The 2Fe-2S may serve as a redox sensor: the presence of one-electron oxidants or reductants leading to the loss of the 2Fe-2S cluster, subsequent monomerization and activation of the enzyme. Unlike other glutaredoxins, it is not inhibited by oxidation of structural Cys residues.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.9 mM for GSH1 Publication
  2. KM=0.77 mM for glutathionylated ribonuclease A1 Publication
  3. KM=4.3 mM for glutathionylated BSA1 Publication
  4. KM=0.11 mM for glutathionylated beta-mercaptoethanol1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi68Iron-sulfur (2Fe-2S); shared with dimeric partner; in inactive formCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei74Glutathione1 Publication1
Binding sitei109Glutathione1 Publication1
Binding sitei121Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1
Metal bindingi153Iron-sulfur (2Fe-2S); shared with dimeric partner; in inactive formCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NS18

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9NS18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutaredoxin-2, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLRX2
Synonyms:GRX2
ORF Names:CGI-133
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16065, GLRX2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606820, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NS18

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000023572

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68C → S: Abolishes absorption at 320 nm and 420 nm suggesting the loss of 2Fe-2S-binding. 1 Publication1
Mutagenesisi78S → P: Specifically increases the specific activity but decreases affinity for glutathionylated substrates. 1 Publication1
Mutagenesisi80C → S: Strongly impairs enzymatic activity. 1 Publication1
Mutagenesisi153C → S: Abolishes absorption at 320 nm and 420 nm suggesting the loss of 2Fe-2S-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51022

Open Targets

More...
OpenTargetsi
ENSG00000023572

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28732

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NS18, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00143, Glutathione

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLRX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73919686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001162820 – 164Glutaredoxin-2, mitochondrialAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 80Redox-active; alternateBy similarity
Modified residuei77S-glutathionyl cysteine; alternate1 Publication1

Keywords - PTMi

Disulfide bond, Glutathionylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NS18

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NS18

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NS18

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NS18

PeptideAtlas

More...
PeptideAtlasi
Q9NS18

PRoteomics IDEntifications database

More...
PRIDEi
Q9NS18

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82463 [Q9NS18-1]
82464 [Q9NS18-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NS18

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NS18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000023572, Expressed in sperm and 239 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NS18, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000023572, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119228, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NS18, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356410

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NS18, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NS18

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NS18

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 157GlutaredoxinPROSITE-ProRule annotationAdd BLAST101

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1752, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000162420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026126_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NS18

Identification of Orthologs from Complete Genome Data

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OMAi
DSTHAQF

Database of Orthologous Groups

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OrthoDBi
1535999at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NS18

TreeFam database of animal gene trees

More...
TreeFami
TF319627

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002109, Glutaredoxin
IPR011899, Glutaredoxin_euk/vir
IPR014025, Glutaredoxin_subgr
IPR036249, Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00462, Glutaredoxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00160, GLUTAREDOXIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02180, GRX_euk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51354, GLUTAREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NS18-1) [UniParc]FASTAAdd to basket
Also known as: Grx2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIWRRAALAG TRLVWSRSGS AGWLDRAAGA AGAAAAAASG MESNTSSSLE
60 70 80 90 100
NLATAPVNQI QETISDNCVV IFSKTSCSYC TMAKKLFHDM NVNYKVVELD
110 120 130 140 150
LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL HKEGKLLPLV
160
HQCYLKKSKR KEFQ
Length:164
Mass (Da):18,052
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9798A01BB532A5D
GO
Isoform 2 (identifier: Q9NS18-2) [UniParc]FASTAAdd to basket
Also known as: Grx2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MIWRRAALAG...AGAAAAAASG → MNPRDKQVSR...PGRTRSAARR

Show »
Length:165
Mass (Da):18,726
Checksum:iD4A1F78015B516D4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34128 differs from that shown. Reason: Frameshift.Curated
The sequence AAH28113 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02523495K → E1 PublicationCorresponds to variant dbSNP:rs34237236Ensembl.1
Isoform 2 (identifier: Q9NS18-2)
Natural variantiVAR_08282540R → WCuratedCorresponds to variant dbSNP:rs10921310Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152211 – 40MIWRR…AAASG → MNPRDKQVSRFSPLKDVYTW VALAGIQRSGSPGRTRSAAR R in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF132495 mRNA Translation: AAF37320.2
AF290514 mRNA Translation: AAK83089.1
AY038988 mRNA Translation: AAK72499.1
DQ194815 Genomic DNA Translation: ABA03170.1
AL136370 Genomic DNA No translation available.
AF151891 mRNA Translation: AAD34128.1 Frameshift.
BC028113 mRNA Translation: AAH28113.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1380.1 [Q9NS18-2]
CCDS1381.1 [Q9NS18-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001230328.1, NM_001243399.1
NP_001306220.1, NM_001319291.1
NP_057150.2, NM_016066.4 [Q9NS18-2]
NP_932066.1, NM_197962.2 [Q9NS18-1]
XP_016856886.1, XM_017001397.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367439; ENSP00000356409; ENSG00000023572 [Q9NS18-1]
ENST00000367440; ENSP00000356410; ENSG00000023572 [Q9NS18-2]
ENST00000608166; ENSP00000494652; ENSG00000023572 [Q9NS18-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51022

UCSC genome browser

More...
UCSCi
uc001gsz.3, human [Q9NS18-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132495 mRNA Translation: AAF37320.2
AF290514 mRNA Translation: AAK83089.1
AY038988 mRNA Translation: AAK72499.1
DQ194815 Genomic DNA Translation: ABA03170.1
AL136370 Genomic DNA No translation available.
AF151891 mRNA Translation: AAD34128.1 Frameshift.
BC028113 mRNA Translation: AAH28113.1 Different initiation.
CCDSiCCDS1380.1 [Q9NS18-2]
CCDS1381.1 [Q9NS18-1]
RefSeqiNP_001230328.1, NM_001243399.1
NP_001306220.1, NM_001319291.1
NP_057150.2, NM_016066.4 [Q9NS18-2]
NP_932066.1, NM_197962.2 [Q9NS18-1]
XP_016856886.1, XM_017001397.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQ9NMR-A48-164[»]
2FLSX-ray2.05A56-164[»]
2HT9X-ray1.90A/B41-164[»]
SMRiQ9NS18
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119228, 10 interactors
IntActiQ9NS18, 3 interactors
STRINGi9606.ENSP00000356410

Chemistry databases

DrugBankiDB00143, Glutathione

PTM databases

iPTMnetiQ9NS18
PhosphoSitePlusiQ9NS18

Genetic variation databases

BioMutaiGLRX2
DMDMi73919686

Proteomic databases

EPDiQ9NS18
jPOSTiQ9NS18
MassIVEiQ9NS18
MaxQBiQ9NS18
PeptideAtlasiQ9NS18
PRIDEiQ9NS18
ProteomicsDBi82463 [Q9NS18-1]
82464 [Q9NS18-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
20620, 180 antibodies

The DNASU plasmid repository

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DNASUi
51022

Genome annotation databases

EnsembliENST00000367439; ENSP00000356409; ENSG00000023572 [Q9NS18-1]
ENST00000367440; ENSP00000356410; ENSG00000023572 [Q9NS18-2]
ENST00000608166; ENSP00000494652; ENSG00000023572 [Q9NS18-1]
GeneIDi51022
KEGGihsa:51022
UCSCiuc001gsz.3, human [Q9NS18-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51022
DisGeNETi51022

GeneCards: human genes, protein and diseases

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GeneCardsi
GLRX2
HGNCiHGNC:16065, GLRX2
HPAiENSG00000023572, Low tissue specificity
MIMi606820, gene
neXtProtiNX_Q9NS18
OpenTargetsiENSG00000023572
PharmGKBiPA28732
VEuPathDBiHostDB:ENSG00000023572

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1752, Eukaryota
GeneTreeiENSGT00940000162420
HOGENOMiCLU_026126_7_0_1
InParanoidiQ9NS18
OMAiDSTHAQF
OrthoDBi1535999at2759
PhylomeDBiQ9NS18
TreeFamiTF319627

Enzyme and pathway databases

PathwayCommonsiQ9NS18
SABIO-RKiQ9NS18

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51022, 10 hits in 1019 CRISPR screens
EvolutionaryTraceiQ9NS18

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GLRX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51022
PharosiQ9NS18, Tbio

Protein Ontology

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PROi
PR:Q9NS18
RNActiQ9NS18, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000023572, Expressed in sperm and 239 other tissues
GenevisibleiQ9NS18, HS

Family and domain databases

InterProiView protein in InterPro
IPR002109, Glutaredoxin
IPR011899, Glutaredoxin_euk/vir
IPR014025, Glutaredoxin_subgr
IPR036249, Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462, Glutaredoxin, 1 hit
PRINTSiPR00160, GLUTAREDOXIN
SUPFAMiSSF52833, SSF52833, 1 hit
TIGRFAMsiTIGR02180, GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS51354, GLUTAREDOXIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLRX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NS18
Secondary accession number(s): Q3LR69
, Q7L1N7, Q96JC0, Q9Y3D4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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