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Entry version 158 (03 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

Gene

AGPAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.78 µM for LPA sn-1 C18:11 Publication
  2. KM=21.53 µM for C18:1-CoA1 Publication
  1. Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:11 Publication
  2. Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), Lysocardiolipin acyltransferase 1 (LCLAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS08470-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.1.51 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1483166 Synthesis of PA
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9NRZ7

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00557;UER00613

Chemistry databases

SwissLipids knowledge resource for lipid biology

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SwissLipidsi
SLP:000000823

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC:2.3.1.511 Publication)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 3
Short name:
1-AGP acyltransferase 3
Short name:
1-AGPAT 3
Lysophosphatidic acid acyltransferase gamma
Short name:
LPAAT-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGPAT3
Synonyms:LPAAT3
ORF Names:UNQ759/PRO1490
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:326 AGPAT3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614794 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NRZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 124Cytoplasmic1 PublicationAdd BLAST124
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 316Lumenal1 PublicationAdd BLAST171
Transmembranei317 – 339HelicalSequence analysisAdd BLAST23
Topological domaini340 – 376Cytoplasmic1 PublicationAdd BLAST37

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
56894

Open Targets

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OpenTargetsi
ENSG00000160216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24623

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AGPAT3

Domain mapping of disease mutations (DMDM)

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DMDMi
12643817

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002081941 – 3761-acyl-sn-glycerol-3-phosphate acyltransferase gammaAdd BLAST376

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NRZ7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NRZ7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NRZ7

PeptideAtlas

More...
PeptideAtlasi
Q9NRZ7

PRoteomics IDEntifications database

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PRIDEi
Q9NRZ7

ProteomicsDB human proteome resource

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ProteomicsDBi
82447
82448 [Q9NRZ7-2]
82449 [Q9NRZ7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NRZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NRZ7

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9NRZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160216 Expressed in 204 organ(s), highest expression level in primary visual cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NRZ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NRZ7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121224, 36 interactors

Protein interaction database and analysis system

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IntActi
Q9NRZ7, 18 interactors

Molecular INTeraction database

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MINTi
Q9NRZ7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381140

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 101HXXXXD motifBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1505 Eukaryota
COG0204 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182836

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NRZ7

KEGG Orthology (KO)

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KOi
K13523

Identification of Orthologs from Complete Genome Data

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OMAi
INFIQLC

Database of Orthologous Groups

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OrthoDBi
959325at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NRZ7

TreeFam database of animal gene trees

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TreeFami
TF314065

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032098 Acyltransf_C
IPR002123 Plipid/glycerol_acylTrfase

Pfam protein domain database

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Pfami
View protein in Pfam
PF16076 Acyltransf_C, 1 hit
PF01553 Acyltransferase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00563 PlsC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRZ7-1) [UniParc]FASTAAdd to basket
Also known as: Gamma-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLAFLKTQ FVLHLLVGFV FVVSGLVINF VQLCTLALWP VSKQLYRRLN
60 70 80 90 100
CRLAYSLWSQ LVMLLEWWSC TECTLFTDQA TVERFGKEHA VIILNHNFEI
110 120 130 140 150
DFLCGWTMCE RFGVLGSSKV LAKKELLYVP LIGWTWYFLE IVFCKRKWEE
160 170 180 190 200
DRDTVVEGLR RLSDYPEYMW FLLYCEGTRF TETKHRVSME VAAAKGLPVL
210 220 230 240 250
KYHLLPRTKG FTTAVKCLRG TVAAVYDVTL NFRGNKNPSL LGILYGKKYE
260 270 280 290 300
ADMCVRRFPL EDIPLDEKEA AQWLHKLYQE KDALQEIYNQ KGMFPGEQFK
310 320 330 340 350
PARRPWTLLN FLSWATILLS PLFSFVLGVF ASGSPLLILT FLGFVGAASF
360 370
GVRRLIGVTE IEKGSSYGNQ EFKKKE
Length:376
Mass (Da):43,381
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC12CDBB7CC363852
GO
Isoform 2 (identifier: Q9NRZ7-2) [UniParc]FASTAAdd to basket
Also known as: Gamma-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:314
Mass (Da):36,271
Checksum:iFFB9EA98F4F5C204
GO
Isoform 3 (identifier: Q9NRZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MGLLAFLKTQ...CRLAYSLWSQ → MQSGGSLPFC...SANALPLSAE

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):45,514
Checksum:i9729B3AE9FB5E518
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JL26C9JL26_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J184C9J184_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQX8C9JQX8_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JK35C9JK35_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74T → P in CAD38635 (PubMed:14702039).Curated1
Sequence conflicti358 – 376VTEIE…FKKKE → ESLEPGRWRLQ in AAQ89067 (PubMed:12975309).CuratedAdd BLAST19

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0050721 – 62Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0131441 – 60MGLLA…SLWSQ → MQSGGSLPFCCYLPSVSSQL LLRESYCNFIKRTQCKSSKL MFSRDFLSGQKYCRCLLWAL PDHPRRRGPTSANALPLSAE in isoform 3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF156774 mRNA Translation: AAF80336.1
AF156775 mRNA Translation: AAF80337.1
AB040138 mRNA Translation: BAB18943.1
AY358704 mRNA Translation: AAQ89067.1
AP001054 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09461.1
CH471079 Genomic DNA Translation: EAX09463.1
CH471079 Genomic DNA Translation: EAX09464.1
CH471079 Genomic DNA Translation: EAX09465.1
BC011971 mRNA Translation: AAH11971.1
BC040603 mRNA Translation: AAH40603.1
BC063552 mRNA Translation: AAH63552.1
AK125804 mRNA Translation: BAC86299.1
AL832919 mRNA Translation: CAD38635.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS13703.1 [Q9NRZ7-1]

NCBI Reference Sequences

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RefSeqi
NP_001032642.1, NM_001037553.1 [Q9NRZ7-1]
NP_064517.1, NM_020132.4 [Q9NRZ7-1]
XP_005261217.1, XM_005261160.4 [Q9NRZ7-1]
XP_006724092.1, XM_006724029.3 [Q9NRZ7-1]
XP_006724093.1, XM_006724030.3 [Q9NRZ7-1]
XP_006724094.1, XM_006724031.3 [Q9NRZ7-2]
XP_011527967.1, XM_011529665.2 [Q9NRZ7-1]
XP_016883898.1, XM_017028409.1 [Q9NRZ7-1]
XP_016883899.1, XM_017028410.1 [Q9NRZ7-1]
XP_016883900.1, XM_017028411.1 [Q9NRZ7-2]
XP_016883901.1, XM_017028412.1 [Q9NRZ7-2]
XP_016883902.1, XM_017028413.1 [Q9NRZ7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291572; ENSP00000291572; ENSG00000160216 [Q9NRZ7-1]
ENST00000327505; ENSP00000332989; ENSG00000160216 [Q9NRZ7-1]
ENST00000398058; ENSP00000381135; ENSG00000160216 [Q9NRZ7-1]
ENST00000398061; ENSP00000381138; ENSG00000160216 [Q9NRZ7-1]
ENST00000398063; ENSP00000381140; ENSG00000160216 [Q9NRZ7-1]
ENST00000546158; ENSP00000443510; ENSG00000160216 [Q9NRZ7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56894

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56894

UCSC genome browser

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UCSCi
uc002zdv.4 human [Q9NRZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156774 mRNA Translation: AAF80336.1
AF156775 mRNA Translation: AAF80337.1
AB040138 mRNA Translation: BAB18943.1
AY358704 mRNA Translation: AAQ89067.1
AP001054 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09461.1
CH471079 Genomic DNA Translation: EAX09463.1
CH471079 Genomic DNA Translation: EAX09464.1
CH471079 Genomic DNA Translation: EAX09465.1
BC011971 mRNA Translation: AAH11971.1
BC040603 mRNA Translation: AAH40603.1
BC063552 mRNA Translation: AAH63552.1
AK125804 mRNA Translation: BAC86299.1
AL832919 mRNA Translation: CAD38635.2
CCDSiCCDS13703.1 [Q9NRZ7-1]
RefSeqiNP_001032642.1, NM_001037553.1 [Q9NRZ7-1]
NP_064517.1, NM_020132.4 [Q9NRZ7-1]
XP_005261217.1, XM_005261160.4 [Q9NRZ7-1]
XP_006724092.1, XM_006724029.3 [Q9NRZ7-1]
XP_006724093.1, XM_006724030.3 [Q9NRZ7-1]
XP_006724094.1, XM_006724031.3 [Q9NRZ7-2]
XP_011527967.1, XM_011529665.2 [Q9NRZ7-1]
XP_016883898.1, XM_017028409.1 [Q9NRZ7-1]
XP_016883899.1, XM_017028410.1 [Q9NRZ7-1]
XP_016883900.1, XM_017028411.1 [Q9NRZ7-2]
XP_016883901.1, XM_017028412.1 [Q9NRZ7-2]
XP_016883902.1, XM_017028413.1 [Q9NRZ7-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121224, 36 interactors
IntActiQ9NRZ7, 18 interactors
MINTiQ9NRZ7
STRINGi9606.ENSP00000381140

Chemistry databases

SwissLipidsiSLP:000000823

PTM databases

iPTMnetiQ9NRZ7
PhosphoSitePlusiQ9NRZ7
SwissPalmiQ9NRZ7

Polymorphism and mutation databases

BioMutaiAGPAT3
DMDMi12643817

Proteomic databases

jPOSTiQ9NRZ7
MaxQBiQ9NRZ7
PaxDbiQ9NRZ7
PeptideAtlasiQ9NRZ7
PRIDEiQ9NRZ7
ProteomicsDBi82447
82448 [Q9NRZ7-2]
82449 [Q9NRZ7-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56894
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291572; ENSP00000291572; ENSG00000160216 [Q9NRZ7-1]
ENST00000327505; ENSP00000332989; ENSG00000160216 [Q9NRZ7-1]
ENST00000398058; ENSP00000381135; ENSG00000160216 [Q9NRZ7-1]
ENST00000398061; ENSP00000381138; ENSG00000160216 [Q9NRZ7-1]
ENST00000398063; ENSP00000381140; ENSG00000160216 [Q9NRZ7-1]
ENST00000546158; ENSP00000443510; ENSG00000160216 [Q9NRZ7-1]
GeneIDi56894
KEGGihsa:56894
UCSCiuc002zdv.4 human [Q9NRZ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56894
DisGeNETi56894

GeneCards: human genes, protein and diseases

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GeneCardsi
AGPAT3
HGNCiHGNC:326 AGPAT3
MIMi614794 gene
neXtProtiNX_Q9NRZ7
OpenTargetsiENSG00000160216
PharmGKBiPA24623

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1505 Eukaryota
COG0204 LUCA
GeneTreeiENSGT00950000182836
InParanoidiQ9NRZ7
KOiK13523
OMAiINFIQLC
OrthoDBi959325at2759
PhylomeDBiQ9NRZ7
TreeFamiTF314065

Enzyme and pathway databases

UniPathwayiUPA00557;UER00613
BioCyciMetaCyc:HS08470-MONOMER
BRENDAi2.3.1.51 2681
ReactomeiR-HSA-1483166 Synthesis of PA
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
SIGNORiQ9NRZ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AGPAT3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AGPAT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56894

Protein Ontology

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PROi
PR:Q9NRZ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160216 Expressed in 204 organ(s), highest expression level in primary visual cortex
ExpressionAtlasiQ9NRZ7 baseline and differential
GenevisibleiQ9NRZ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR032098 Acyltransf_C
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF16076 Acyltransf_C, 1 hit
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRZ7
Secondary accession number(s): D3DSL2
, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 3, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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