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UniProtKB - Q9NRZ7 (PLCC_HUMAN)

Entry version 166 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

Gene

AGPAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.78 µM for LPA sn-1 C18:11 Publication
  2. KM=21.53 µM for C18:1-CoA1 Publication
  1. Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:11 Publication
  2. Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4), Lysocardiolipin acyltransferase 1 (LCLAT1)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), CDP-diacylglycerol synthase (TAMM41), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), CDP-diacylglycerol synthase (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, CDP-diacylglycerol synthase (TAMM41), CDP-diacylglycerol synthase (TAMM41), Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS08470-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.51, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRZ7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1483166, Synthesis of PA
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NRZ7

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00557;UER00613

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000823

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC:2.3.1.511 Publication)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 3
Short name:
1-AGP acyltransferase 3
Short name:
1-AGPAT 3
Lysophosphatidic acid acyltransferase gamma
Short name:
LPAAT-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGPAT3
Synonyms:LPAAT3
ORF Names:UNQ759/PRO1490
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000160216.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:326, AGPAT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614794, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 124Cytoplasmic1 PublicationAdd BLAST124
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 316Lumenal1 PublicationAdd BLAST171
Transmembranei317 – 339HelicalSequence analysisAdd BLAST23
Topological domaini340 – 376Cytoplasmic1 PublicationAdd BLAST37

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56894

Open Targets

More...OpenTargetsi		ENSG00000160216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24623

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRZ7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AGPAT3

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643817

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002081941 – 3761-acyl-sn-glycerol-3-phosphate acyltransferase gammaAdd BLAST376

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NRZ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRZ7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRZ7

PeptideAtlas

More...PeptideAtlasi		Q9NRZ7

PRoteomics IDEntifications database

More...PRIDEi		Q9NRZ7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82447 [Q9NRZ7-1]
82448 [Q9NRZ7-2]
82449 [Q9NRZ7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRZ7

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NRZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160216, Expressed in primary visual cortex and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRZ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRZ7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160216, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 101HXXXXD motifBy similarity6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1505, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182836

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRZ7

KEGG Orthology (KO)

More...KOi		K13523

Identification of Orthologs from Complete Genome Data

More...OMAi		EQECANW

Database of Orthologous Groups

More...OrthoDBi		959325at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRZ7

TreeFam database of animal gene trees

More...TreeFami		TF314065

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032098, Acyltransf_C
IPR002123, Plipid/glycerol_acylTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16076, Acyltransf_C, 1 hit
PF01553, Acyltransferase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00563, PlsC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRZ7-1) [UniParc]FASTAAdd to basket
Also known as: Gamma-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLAFLKTQ FVLHLLVGFV FVVSGLVINF VQLCTLALWP VSKQLYRRLN 
        60         70         80         90        100
CRLAYSLWSQ LVMLLEWWSC TECTLFTDQA TVERFGKEHA VIILNHNFEI 
       110        120        130        140        150
DFLCGWTMCE RFGVLGSSKV LAKKELLYVP LIGWTWYFLE IVFCKRKWEE 
       160        170        180        190        200
DRDTVVEGLR RLSDYPEYMW FLLYCEGTRF TETKHRVSME VAAAKGLPVL 
       210        220        230        240        250
KYHLLPRTKG FTTAVKCLRG TVAAVYDVTL NFRGNKNPSL LGILYGKKYE 
       260        270        280        290        300
ADMCVRRFPL EDIPLDEKEA AQWLHKLYQE KDALQEIYNQ KGMFPGEQFK 
       310        320        330        340        350
PARRPWTLLN FLSWATILLS PLFSFVLGVF ASGSPLLILT FLGFVGAASF 
       360        370 
GVRRLIGVTE IEKGSSYGNQ EFKKKE
Length:376
Mass (Da):43,381
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC12CDBB7CC363852
GO
Isoform 2 (identifier: Q9NRZ7-2) [UniParc]FASTAAdd to basket
Also known as: Gamma-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:314
Mass (Da):36,271
Checksum:iFFB9EA98F4F5C204
GO
Isoform 3 (identifier: Q9NRZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MGLLAFLKTQ...CRLAYSLWSQ → MQSGGSLPFC...SANALPLSAE

Show »
Length:396
Mass (Da):45,514
Checksum:i9729B3AE9FB5E518
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JL26C9JL26_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J184C9J184_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JK35C9JK35_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQX8C9JQX8_HUMAN
1-acyl-sn-glycerol-3-phosphate acyl...
AGPAT3
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74T → P in CAD38635 (PubMed:14702039).Curated1
Sequence conflicti358 – 376VTEIE…FKKKE → ESLEPGRWRLQ in AAQ89067 (PubMed:12975309).CuratedAdd BLAST19

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0050721 – 62Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0131441 – 60MGLLA…SLWSQ → MQSGGSLPFCCYLPSVSSQL LLRESYCNFIKRTQCKSSKL MFSRDFLSGQKYCRCLLWAL PDHPRRRGPTSANALPLSAE in isoform 3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF156774 mRNA Translation: AAF80336.1
AF156775 mRNA Translation: AAF80337.1
AB040138 mRNA Translation: BAB18943.1
AY358704 mRNA Translation: AAQ89067.1
AP001054 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09461.1
CH471079 Genomic DNA Translation: EAX09463.1
CH471079 Genomic DNA Translation: EAX09464.1
CH471079 Genomic DNA Translation: EAX09465.1
BC011971 mRNA Translation: AAH11971.1
BC040603 mRNA Translation: AAH40603.1
BC063552 mRNA Translation: AAH63552.1
AK125804 mRNA Translation: BAC86299.1
AL832919 mRNA Translation: CAD38635.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13703.1 [Q9NRZ7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001032642.1, NM_001037553.1 [Q9NRZ7-1]
NP_064517.1, NM_020132.4 [Q9NRZ7-1]
XP_005261217.1, XM_005261160.4 [Q9NRZ7-1]
XP_006724092.1, XM_006724029.3 [Q9NRZ7-1]
XP_006724093.1, XM_006724030.3 [Q9NRZ7-1]
XP_006724094.1, XM_006724031.3 [Q9NRZ7-2]
XP_011527967.1, XM_011529665.2 [Q9NRZ7-1]
XP_016883898.1, XM_017028409.1
XP_016883899.1, XM_017028410.1
XP_016883900.1, XM_017028411.1 [Q9NRZ7-2]
XP_016883901.1, XM_017028412.1 [Q9NRZ7-2]
XP_016883902.1, XM_017028413.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000291572; ENSP00000291572; ENSG00000160216 [Q9NRZ7-1]
ENST00000327505; ENSP00000332989; ENSG00000160216 [Q9NRZ7-1]
ENST00000398058; ENSP00000381135; ENSG00000160216 [Q9NRZ7-1]
ENST00000398061; ENSP00000381138; ENSG00000160216 [Q9NRZ7-1]
ENST00000398063; ENSP00000381140; ENSG00000160216 [Q9NRZ7-1]
ENST00000546158; ENSP00000443510; ENSG00000160216 [Q9NRZ7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56894

UCSC genome browser

More...UCSCi		uc002zdv.4, human [Q9NRZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156774 mRNA Translation: AAF80336.1
AF156775 mRNA Translation: AAF80337.1
AB040138 mRNA Translation: BAB18943.1
AY358704 mRNA Translation: AAQ89067.1
AP001054 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09461.1
CH471079 Genomic DNA Translation: EAX09463.1
CH471079 Genomic DNA Translation: EAX09464.1
CH471079 Genomic DNA Translation: EAX09465.1
BC011971 mRNA Translation: AAH11971.1
BC040603 mRNA Translation: AAH40603.1
BC063552 mRNA Translation: AAH63552.1
AK125804 mRNA Translation: BAC86299.1
AL832919 mRNA Translation: CAD38635.2
CCDSiCCDS13703.1 [Q9NRZ7-1]
RefSeqiNP_001032642.1, NM_001037553.1 [Q9NRZ7-1]
NP_064517.1, NM_020132.4 [Q9NRZ7-1]
XP_005261217.1, XM_005261160.4 [Q9NRZ7-1]
XP_006724092.1, XM_006724029.3 [Q9NRZ7-1]
XP_006724093.1, XM_006724030.3 [Q9NRZ7-1]
XP_006724094.1, XM_006724031.3 [Q9NRZ7-2]
XP_011527967.1, XM_011529665.2 [Q9NRZ7-1]
XP_016883898.1, XM_017028409.1
XP_016883899.1, XM_017028410.1
XP_016883900.1, XM_017028411.1 [Q9NRZ7-2]
XP_016883901.1, XM_017028412.1 [Q9NRZ7-2]
XP_016883902.1, XM_017028413.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121224, 36 interactors
IntActiQ9NRZ7, 31 interactors
MINTiQ9NRZ7
STRINGi9606.ENSP00000381140

Chemistry databases

SwissLipidsiSLP:000000823

PTM databases

iPTMnetiQ9NRZ7
PhosphoSitePlusiQ9NRZ7
SwissPalmiQ9NRZ7

Polymorphism and mutation databases

BioMutaiAGPAT3
DMDMi12643817

Proteomic databases

jPOSTiQ9NRZ7
MassIVEiQ9NRZ7
MaxQBiQ9NRZ7
PaxDbiQ9NRZ7
PeptideAtlasiQ9NRZ7
PRIDEiQ9NRZ7
ProteomicsDBi82447 [Q9NRZ7-1]
82448 [Q9NRZ7-2]
82449 [Q9NRZ7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24081, 156 antibodies

The DNASU plasmid repository

More...DNASUi		56894

Genome annotation databases

EnsembliENST00000291572; ENSP00000291572; ENSG00000160216 [Q9NRZ7-1]
ENST00000327505; ENSP00000332989; ENSG00000160216 [Q9NRZ7-1]
ENST00000398058; ENSP00000381135; ENSG00000160216 [Q9NRZ7-1]
ENST00000398061; ENSP00000381138; ENSG00000160216 [Q9NRZ7-1]
ENST00000398063; ENSP00000381140; ENSG00000160216 [Q9NRZ7-1]
ENST00000546158; ENSP00000443510; ENSG00000160216 [Q9NRZ7-1]
GeneIDi56894
KEGGihsa:56894
UCSCiuc002zdv.4, human [Q9NRZ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56894
DisGeNETi56894
EuPathDBiHostDB:ENSG00000160216.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		AGPAT3
HGNCiHGNC:326, AGPAT3
HPAiENSG00000160216, Tissue enhanced (skeletal)
MIMi614794, gene
neXtProtiNX_Q9NRZ7
OpenTargetsiENSG00000160216
PharmGKBiPA24623

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1505, Eukaryota
GeneTreeiENSGT00950000182836
InParanoidiQ9NRZ7
KOiK13523
OMAiEQECANW
OrthoDBi959325at2759
PhylomeDBiQ9NRZ7
TreeFamiTF314065

Enzyme and pathway databases

UniPathwayiUPA00557;UER00613
BioCyciMetaCyc:HS08470-MONOMER
BRENDAi2.3.1.51, 2681
PathwayCommonsiQ9NRZ7
ReactomeiR-HSA-1483166, Synthesis of PA
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
SIGNORiQ9NRZ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56894, 7 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AGPAT3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AGPAT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56894
PharosiQ9NRZ7, Tbio

Protein Ontology

More...PROi		PR:Q9NRZ7
RNActiQ9NRZ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160216, Expressed in primary visual cortex and 220 other tissues
ExpressionAtlasiQ9NRZ7, baseline and differential
GenevisibleiQ9NRZ7, HS

Family and domain databases

InterProiView protein in InterPro
IPR032098, Acyltransf_C
IPR002123, Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF16076, Acyltransf_C, 1 hit
PF01553, Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563, PlsC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRZ7
Secondary accession number(s): D3DSL2
, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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