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Entry version 150 (16 Oct 2019)
Sequence version 2 (09 Jul 2014)
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Protein

Phospholipid scramblase 2

Gene

PLSCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • phospholipid scramblase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.99.B1 2681

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.36.1.5 the ca(2+)-dependent phospholipid scramblase (scramblase) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid scramblase 2
Short name:
PL scramblase 2
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLSCR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16494 PLSCR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607610 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRY7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 276CytoplasmicBy similarityAdd BLAST276
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei277 – 293HelicalSequence analysisAdd BLAST17
Topological domaini294 – 297ExtracellularBy similarity4

Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57047

Open Targets

More...
OpenTargetsi
ENSG00000163746

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33420

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRY7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLSCR2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007871 – 297Phospholipid scramblase 2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei149Phosphothreonine; by PKCBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi172S-palmitoyl cysteineBy similarity1
Lipidationi173S-palmitoyl cysteineBy similarity1
Lipidationi174S-palmitoyl cysteineBy similarity1
Lipidationi176S-palmitoyl cysteineBy similarity1
Lipidationi177S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NRY7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRY7

PeptideAtlas

More...
PeptideAtlasi
Q9NRY7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRY7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
82445 [Q9NRY7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRY7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression of isoform 1 seems restricted to testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163746 Expressed in 80 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRY7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRY7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121340, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9NRY7, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420132

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 72Proline-rich domain (PRD)By similarityAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 80Poly-Pro6
Compositional biasi169 – 177Cys-rich9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0621 Eukaryota
ENOG410XSYS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164933

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237356

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NRY7

Identification of Orthologs from Complete Genome Data

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OMAi
QNWHLWR

Database of Orthologous Groups

More...
OrthoDBi
664813at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314939

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005552 Scramblase

The PANTHER Classification System

More...
PANTHERi
PTHR23248 PTHR23248, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03803 Scramblase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9NRY7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSWNSLFCL NSSRPPGHIV YPKHQAGHTG KQADHLGSQA FYPGRQHDYL
60 70 80 90 100
VPPAGTAGIP VQNQPGRPEG VPWMPAPPPP LNCPPGLEYL SQIDMILIHQ
110 120 130 140 150
QIELLEVLFS FESSNMYEIK NSFGQRIYFA AEDTNFCIRN CCGRSRPFTL
160 170 180 190 200
RITDNVGREV ITLERPLRCN CCCCPCCLQE IEIQAPPGVP VGYVTQTWHP
210 220 230 240 250
CLTKFTIKNQ KREDVLKISG PCIVCSCIAG VDFEITSLDE QIVVGRISKH
260 270 280 290
WSGFLREAFT DADNFGIQFP RDLDVKMKAV MIGACFLIDY MFFERTR
Note: No experimental confirmation available.
Length:297
Mass (Da):33,504
Last modified:July 9, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58F50C24AB438729
GO
Isoform 1 (identifier: Q9NRY7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:224
Mass (Da):25,523
Checksum:iFD218C63C59D239A
GO
Isoform 3 (identifier: Q9NRY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MRSWNSLFCLNSSR → MKPFQIHLPG

Note: No experimental confirmation available.
Show »
Length:293
Mass (Da):32,970
Checksum:iD4FFE4925247787F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J636C9J636_HUMAN
Phospholipid scramblase
PLSCR2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEZ1F8WEZ1_HUMAN
Phospholipid scramblase
PLSCR2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH55415 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti272 – 274DLD → NLN in BAG63335 (PubMed:14702039).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552391 – 73Missing in isoform 1. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0552401 – 14MRSWN…LNSSR → MKPFQIHLPG in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF159441 mRNA Translation: AAF91082.1
AK301909 mRNA Translation: BAG63335.1
AC069528 Genomic DNA No translation available.
BC055415 mRNA Translation: AAH55415.1 Different initiation.
BC069785 mRNA Translation: AAH69785.2
BC120969 mRNA Translation: AAI20970.1
BC141969 mRNA Translation: AAI41970.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3134.1 [Q9NRY7-1]
CCDS56284.1 [Q9NRY7-2]
CCDS75029.1 [Q9NRY7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001186907.1, NM_001199978.1 [Q9NRY7-2]
NP_001186908.1, NM_001199979.1 [Q9NRY7-3]
NP_065092.1, NM_020359.2 [Q9NRY7-1]
XP_016862394.1, XM_017006905.1
XP_016862395.1, XM_017006906.1
XP_016862396.1, XM_017006907.1
XP_016862397.1, XM_017006908.1
XP_016862398.1, XM_017006909.1
XP_016862399.1, XM_017006910.1 [Q9NRY7-1]
XP_016862400.1, XM_017006911.1 [Q9NRY7-1]
XP_016862403.1, XM_017006914.1
XP_016862404.1, XM_017006915.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336685; ENSP00000338707; ENSG00000163746 [Q9NRY7-1]
ENST00000497985; ENSP00000420132; ENSG00000163746 [Q9NRY7-2]
ENST00000610787; ENSP00000478044; ENSG00000163746 [Q9NRY7-1]
ENST00000613069; ENSP00000478902; ENSG00000163746 [Q9NRY7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57047

UCSC genome browser

More...
UCSCi
uc003evv.3 human [Q9NRY7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Scramblase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159441 mRNA Translation: AAF91082.1
AK301909 mRNA Translation: BAG63335.1
AC069528 Genomic DNA No translation available.
BC055415 mRNA Translation: AAH55415.1 Different initiation.
BC069785 mRNA Translation: AAH69785.2
BC120969 mRNA Translation: AAI20970.1
BC141969 mRNA Translation: AAI41970.1
CCDSiCCDS3134.1 [Q9NRY7-1]
CCDS56284.1 [Q9NRY7-2]
CCDS75029.1 [Q9NRY7-3]
RefSeqiNP_001186907.1, NM_001199978.1 [Q9NRY7-2]
NP_001186908.1, NM_001199979.1 [Q9NRY7-3]
NP_065092.1, NM_020359.2 [Q9NRY7-1]
XP_016862394.1, XM_017006905.1
XP_016862395.1, XM_017006906.1
XP_016862396.1, XM_017006907.1
XP_016862397.1, XM_017006908.1
XP_016862398.1, XM_017006909.1
XP_016862399.1, XM_017006910.1 [Q9NRY7-1]
XP_016862400.1, XM_017006911.1 [Q9NRY7-1]
XP_016862403.1, XM_017006914.1
XP_016862404.1, XM_017006915.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121340, 1 interactor
IntActiQ9NRY7, 14 interactors
STRINGi9606.ENSP00000420132

Protein family/group databases

TCDBi9.A.36.1.5 the ca(2+)-dependent phospholipid scramblase (scramblase) family

PTM databases

iPTMnetiQ9NRY7
PhosphoSitePlusiQ9NRY7

Polymorphism and mutation databases

BioMutaiPLSCR2

Proteomic databases

MassIVEiQ9NRY7
PaxDbiQ9NRY7
PeptideAtlasiQ9NRY7
PRIDEiQ9NRY7
ProteomicsDBi82445 [Q9NRY7-2]

Genome annotation databases

EnsembliENST00000336685; ENSP00000338707; ENSG00000163746 [Q9NRY7-1]
ENST00000497985; ENSP00000420132; ENSG00000163746 [Q9NRY7-2]
ENST00000610787; ENSP00000478044; ENSG00000163746 [Q9NRY7-1]
ENST00000613069; ENSP00000478902; ENSG00000163746 [Q9NRY7-3]
GeneIDi57047
KEGGihsa:57047
UCSCiuc003evv.3 human [Q9NRY7-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57047
DisGeNETi57047

GeneCards: human genes, protein and diseases

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GeneCardsi
PLSCR2
HGNCiHGNC:16494 PLSCR2
MIMi607610 gene
neXtProtiNX_Q9NRY7
OpenTargetsiENSG00000163746
PharmGKBiPA33420

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00940000164933
HOGENOMiHOG000237356
InParanoidiQ9NRY7
OMAiQNWHLWR
OrthoDBi664813at2759
TreeFamiTF314939

Enzyme and pathway databases

BRENDAi3.6.99.B1 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLSCR2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PLSCR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57047
PharosiQ9NRY7

Protein Ontology

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PROi
PR:Q9NRY7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163746 Expressed in 80 organ(s), highest expression level in sperm
ExpressionAtlasiQ9NRY7 baseline and differential
GenevisibleiQ9NRY7 HS

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRY7
Secondary accession number(s): B4DXC3
, J3KR76, Q0VAQ1, Q6NSW9, Q7Z4L7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 9, 2014
Last modified: October 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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