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Protein

Phospholipid scramblase 2

Gene

PLSCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.

Cofactori

Ca2+By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • phospholipid scramblase activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.99.B1 2681

Protein family/group databases

TCDBi9.A.36.1.5 the ca(2+)-dependent phospholipid scramblase (scramblase) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase 2
Short name:
PL scramblase 2
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 2
Gene namesi
Name:PLSCR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163746.11
HGNCiHGNC:16494 PLSCR2
MIMi607610 gene
neXtProtiNX_Q9NRY7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 276CytoplasmicBy similarityAdd BLAST276
Transmembranei277 – 293HelicalSequence analysisAdd BLAST17
Topological domaini294 – 297ExtracellularBy similarity4

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57047
OpenTargetsiENSG00000163746
PharmGKBiPA33420

Polymorphism and mutation databases

BioMutaiPLSCR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007871 – 297Phospholipid scramblase 2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149Phosphothreonine; by PKCBy similarity1
Lipidationi172S-palmitoyl cysteineBy similarity1
Lipidationi173S-palmitoyl cysteineBy similarity1
Lipidationi174S-palmitoyl cysteineBy similarity1
Lipidationi176S-palmitoyl cysteineBy similarity1
Lipidationi177S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9NRY7
PeptideAtlasiQ9NRY7
PRIDEiQ9NRY7
ProteomicsDBi82445

PTM databases

iPTMnetiQ9NRY7
PhosphoSitePlusiQ9NRY7

Expressioni

Tissue specificityi

Expression of isoform 1 seems restricted to testis.1 Publication

Gene expression databases

BgeeiENSG00000163746 Expressed in 80 organ(s), highest expression level in sperm
CleanExiHS_PLSCR2
ExpressionAtlasiQ9NRY7 baseline and differential
GenevisibleiQ9NRY7 HS

Interactioni

Protein-protein interaction databases

BioGridi121340, 1 interactor
IntActiQ9NRY7, 14 interactors
STRINGi9606.ENSP00000420132

Structurei

3D structure databases

ProteinModelPortaliQ9NRY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 72Proline-rich domain (PRD)By similarityAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Pro6
Compositional biasi169 – 177Cys-rich9

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356
HOVERGENiHBG019157
InParanoidiQ9NRY7
OMAiMGQNVFY
OrthoDBiEOG091G0CUL
TreeFamiTF314939

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9NRY7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSWNSLFCL NSSRPPGHIV YPKHQAGHTG KQADHLGSQA FYPGRQHDYL
60 70 80 90 100
VPPAGTAGIP VQNQPGRPEG VPWMPAPPPP LNCPPGLEYL SQIDMILIHQ
110 120 130 140 150
QIELLEVLFS FESSNMYEIK NSFGQRIYFA AEDTNFCIRN CCGRSRPFTL
160 170 180 190 200
RITDNVGREV ITLERPLRCN CCCCPCCLQE IEIQAPPGVP VGYVTQTWHP
210 220 230 240 250
CLTKFTIKNQ KREDVLKISG PCIVCSCIAG VDFEITSLDE QIVVGRISKH
260 270 280 290
WSGFLREAFT DADNFGIQFP RDLDVKMKAV MIGACFLIDY MFFERTR
Note: No experimental confirmation available.
Length:297
Mass (Da):33,504
Last modified:July 9, 2014 - v2
Checksum:i58F50C24AB438729
GO
Isoform 1 (identifier: Q9NRY7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:224
Mass (Da):25,523
Checksum:iFD218C63C59D239A
GO
Isoform 3 (identifier: Q9NRY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MRSWNSLFCLNSSR → MKPFQIHLPG

Note: No experimental confirmation available.
Show »
Length:293
Mass (Da):32,970
Checksum:iD4FFE4925247787F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J636C9J636_HUMAN
Phospholipid scramblase
PLSCR2
161Annotation score:
F8WEZ1F8WEZ1_HUMAN
Phospholipid scramblase
PLSCR2
38Annotation score:

Sequence cautioni

The sequence AAH55415 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272 – 274DLD → NLN in BAG63335 (PubMed:14702039).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552391 – 73Missing in isoform 1. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0552401 – 14MRSWN…LNSSR → MKPFQIHLPG in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159441 mRNA Translation: AAF91082.1
AK301909 mRNA Translation: BAG63335.1
AC069528 Genomic DNA No translation available.
BC055415 mRNA Translation: AAH55415.1 Different initiation.
BC069785 mRNA Translation: AAH69785.2
BC120969 mRNA Translation: AAI20970.1
BC141969 mRNA Translation: AAI41970.1
CCDSiCCDS3134.1 [Q9NRY7-1]
CCDS56284.1 [Q9NRY7-2]
CCDS75029.1 [Q9NRY7-3]
RefSeqiNP_001186907.1, NM_001199978.1 [Q9NRY7-2]
NP_001186908.1, NM_001199979.1 [Q9NRY7-3]
NP_065092.1, NM_020359.2 [Q9NRY7-1]
XP_016862394.1, XM_017006905.1
XP_016862395.1, XM_017006906.1
XP_016862396.1, XM_017006907.1
XP_016862397.1, XM_017006908.1
XP_016862398.1, XM_017006909.1
XP_016862399.1, XM_017006910.1 [Q9NRY7-1]
XP_016862400.1, XM_017006911.1 [Q9NRY7-1]
XP_016862403.1, XM_017006914.1
XP_016862404.1, XM_017006915.1
UniGeneiHs.744414

Genome annotation databases

EnsembliENST00000336685; ENSP00000338707; ENSG00000163746 [Q9NRY7-1]
ENST00000497985; ENSP00000420132; ENSG00000163746 [Q9NRY7-2]
ENST00000610787; ENSP00000478044; ENSG00000163746 [Q9NRY7-1]
ENST00000613069; ENSP00000478902; ENSG00000163746 [Q9NRY7-3]
GeneIDi57047
KEGGihsa:57047
UCSCiuc003evv.3 human [Q9NRY7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Scramblase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159441 mRNA Translation: AAF91082.1
AK301909 mRNA Translation: BAG63335.1
AC069528 Genomic DNA No translation available.
BC055415 mRNA Translation: AAH55415.1 Different initiation.
BC069785 mRNA Translation: AAH69785.2
BC120969 mRNA Translation: AAI20970.1
BC141969 mRNA Translation: AAI41970.1
CCDSiCCDS3134.1 [Q9NRY7-1]
CCDS56284.1 [Q9NRY7-2]
CCDS75029.1 [Q9NRY7-3]
RefSeqiNP_001186907.1, NM_001199978.1 [Q9NRY7-2]
NP_001186908.1, NM_001199979.1 [Q9NRY7-3]
NP_065092.1, NM_020359.2 [Q9NRY7-1]
XP_016862394.1, XM_017006905.1
XP_016862395.1, XM_017006906.1
XP_016862396.1, XM_017006907.1
XP_016862397.1, XM_017006908.1
XP_016862398.1, XM_017006909.1
XP_016862399.1, XM_017006910.1 [Q9NRY7-1]
XP_016862400.1, XM_017006911.1 [Q9NRY7-1]
XP_016862403.1, XM_017006914.1
XP_016862404.1, XM_017006915.1
UniGeneiHs.744414

3D structure databases

ProteinModelPortaliQ9NRY7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121340, 1 interactor
IntActiQ9NRY7, 14 interactors
STRINGi9606.ENSP00000420132

Protein family/group databases

TCDBi9.A.36.1.5 the ca(2+)-dependent phospholipid scramblase (scramblase) family

PTM databases

iPTMnetiQ9NRY7
PhosphoSitePlusiQ9NRY7

Polymorphism and mutation databases

BioMutaiPLSCR2

Proteomic databases

PaxDbiQ9NRY7
PeptideAtlasiQ9NRY7
PRIDEiQ9NRY7
ProteomicsDBi82445

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336685; ENSP00000338707; ENSG00000163746 [Q9NRY7-1]
ENST00000497985; ENSP00000420132; ENSG00000163746 [Q9NRY7-2]
ENST00000610787; ENSP00000478044; ENSG00000163746 [Q9NRY7-1]
ENST00000613069; ENSP00000478902; ENSG00000163746 [Q9NRY7-3]
GeneIDi57047
KEGGihsa:57047
UCSCiuc003evv.3 human [Q9NRY7-2]

Organism-specific databases

CTDi57047
DisGeNETi57047
EuPathDBiHostDB:ENSG00000163746.11
GeneCardsiPLSCR2
H-InvDBiHIX0200552
HGNCiHGNC:16494 PLSCR2
MIMi607610 gene
neXtProtiNX_Q9NRY7
OpenTargetsiENSG00000163746
PharmGKBiPA33420
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356
HOVERGENiHBG019157
InParanoidiQ9NRY7
OMAiMGQNVFY
OrthoDBiEOG091G0CUL
TreeFamiTF314939

Enzyme and pathway databases

BRENDAi3.6.99.B1 2681

Miscellaneous databases

GeneWikiiPLSCR2
GenomeRNAii57047
PROiPR:Q9NRY7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163746 Expressed in 80 organ(s), highest expression level in sperm
CleanExiHS_PLSCR2
ExpressionAtlasiQ9NRY7 baseline and differential
GenevisibleiQ9NRY7 HS

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLS2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRY7
Secondary accession number(s): B4DXC3
, J3KR76, Q0VAQ1, Q6NSW9, Q7Z4L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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