UniProtKB - Q9NRY5 (F1142_HUMAN)

BLAST

>sp|Q9NRY5|F1142_HUMAN Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4
MSDKDDIETPLLTEAAPILEDGNCEPAKNSESVDQGAKPESKSEPVVSTRKRPETKPSSD
LETSKVLPIQDNVSKDVPQTRWGYWGSWGKSILSSASATVATVGQGISNVIEKAETSLGI
PGPSEISTEVKYVAGETNAKENENSSPVAGAFGVFSTISTAVQSTGKSVISGGLDALEFI
GKKTMDVIAEGDPGFKRTKGLMNRNATLSQVLREAKEKEEIRTSNEVTVETDKKTHYGLL
FDEFQGLSHLEALEMLSQESEIKVKSILNSLSGEELETLKVELEQLKETFSLAEFCEEEE
EEKKGDEDFTKDITELFSQLHVSSKPEKLARARNTAHEWIRKSLTKPLAENEEGEKQSEA
ENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQM
TIVLCKELSSLSKEFTTCLTTAGVKEMADVLNPLITAVFLEASNSASYIQDAFQLLLPVL
EISLIENKIESHRHELQGQKPLLEH

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History
Entry version 116 (07 Nov 2018)
Sequence version 4 (18 May 2010)
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Protein

Protein FAM114A2

Gene

FAM114A2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

purine nucleotide binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10843801

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6802952 Signaling by BRAF and RAF fusions

Reactomeⁱ

R-HSA-6802952 Signaling by BRAF and RAF fusions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM114A2
Gene namesⁱ	Name:FAM114A2 Synonyms:C5orf3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000055147.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1333 FAM114A2
neXtProtⁱ	NX_Q9NRY5

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000055147
PharmGKBⁱ	PA162385716

Polymorphism and mutation databases

BioMutaⁱ	FAM114A2
DMDMⁱ	296439475

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274564	1 – 505	Protein FAM114A2Add BLAST		505

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	87	PhosphoserineCombined sources	1
Modified residueⁱ	146	PhosphoserineCombined sources	1
Modified residueⁱ	209	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NRY5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NRY5
PaxDbⁱ	Q9NRY5
PeptideAtlas More...PeptideAtlasⁱ	Q9NRY5
PRIDEⁱ	Q9NRY5
ProteomicsDBⁱ	82443

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00329662

REPRODUCTION-2DPAGEⁱ

IPI00329662

PTM databases

iPTMnetⁱ	Q9NRY5
PhosphoSitePlusⁱ	Q9NRY5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000055147 Expressed in 212 organ(s), highest expression level in kidney
CleanExⁱ	HS_FAM114A2
ExpressionAtlasⁱ	Q9NRY5 baseline and differential
Genevisibleⁱ	Q9NRY5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035869 HPA035870

HPAⁱ

HPA035869
HPA035870

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116040, 21 interactors
IntActⁱ	Q9NRY5, 12 interactors
STRINGⁱ	9606.ENSP00000341597

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NRY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	268 – 295	Sequence analysisAdd BLAST		28

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	297 – 302	Poly-Glu		6

Sequence similaritiesⁱ

Belongs to the FAM114 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IHQB Eukaryota ENOG411029H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010054
HOGENOMⁱ	HOG000059573
HOVERGENⁱ	HBG056879
InParanoidⁱ	Q9NRY5
OMAⁱ	LFENYCG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FS
PhylomeDBⁱ	Q9NRY5
TreeFamⁱ	TF324360

Family and domain databases

InterProⁱ	View protein in InterPro IPR007998 DUF719
PANTHERⁱ	PTHR12842 PTHR12842, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05334 DUF719, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q9NRY5-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR 
        60         70         80         90        100
KRPETKPSSD LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV 
       110        120        130        140        150
ATVGQGISNV IEKAETSLGI PGPSEISTEV KYVAGETNAK ENENSSPVAG 
       160        170        180        190        200
AFGVFSTIST AVQSTGKSVI SGGLDALEFI GKKTMDVIAE GDPGFKRTKG 
       210        220        230        240        250
LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL FDEFQGLSHL 
       260        270        280        290        300
EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE 
       310        320        330        340        350
EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE 
       360        370        380        390        400
NEEGEKQSEA ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV 
       410        420        430        440        450
LHGRKQEVTA IERSQTLSQM TIVLCKELSS LSKEFTTCLT TAGVKEMADV 
       460        470        480        490        500
LNPLITAVFL EASNSASYIQ DAFQLLLPVL EISLIENKIE SHRHELQGQK 

PLLEH

Length:505

Mass (Da):55,468

Last modified:May 18, 2010 - v4

Checksum:ⁱE3991C42F8DCF606

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ESJ7	E7ESJ7_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	435	Annotation score:
E5RGF9	E5RGF9_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	210	Annotation score:
E5RHP2	E5RHP2_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	103	Annotation score:
E5RFK2	E5RFK2_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	166	Annotation score:
E5RHI8	E5RHI8_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	125	Annotation score:
E5RK42	E5RK42_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	79	Annotation score:
E5RH43	E5RH43_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	63	Annotation score:
E5RIK7	E5RIK7_HUMAN	Protein FAM114A2 Protein FAM114A2	FAM114A2	15	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	68	P → S in AAF76523 (PubMed:10843801).Curated	1
Sequence conflictⁱ	122	G → S in AAF76523 (PubMed:10843801).Curated	1
Sequence conflictⁱ	122	G → S in BAB14952 (PubMed:14702039).Curated	1
Sequence conflictⁱ	122	G → S in AAH11414 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159700 mRNA Translation: AAF76523.1 AK024664 mRNA Translation: BAB14952.1 AK313331 mRNA Translation: BAG36135.1 AC010232 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61646.1 CH471062 Genomic DNA Translation: EAW61647.1 CH471062 Genomic DNA Translation: EAW61648.1 BC011414 mRNA Translation: AAH11414.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4323.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001304922.1, NM_001317993.1 NP_001304923.1, NM_001317994.1 NP_001304924.1, NM_001317995.1 NP_061161.2, NM_018691.3 XP_005268417.1, XM_005268360.4 XP_005268418.1, XM_005268361.4 XP_011535842.1, XM_011537540.2 XP_011535843.1, XM_011537541.2 XP_011535844.1, XM_011537542.2 XP_016864456.1, XM_017008967.1 XP_016864457.1, XM_017008968.1
UniGeneⁱ	Hs.166551

Genome annotation databases

Ensemblⁱ	ENST00000351797; ENSP00000341597; ENSG00000055147 ENST00000520667; ENSP00000430384; ENSG00000055147 ENST00000522858; ENSP00000430489; ENSG00000055147
GeneIDⁱ	10827
KEGGⁱ	hsa:10827
UCSC genome browser More...UCSCⁱ	uc003lvb.5 human

Protein	Similar proteins		Species	Score	Length	Source
Q9NRY5	Testis tissue sperm-binding protein Li 81P		HUMAN		505	UniRef100_Q9NRY5
Protein FAM114A2 (Fragment)		HUMAN		125
Protein FAM114A2 (Fragment)		HUMAN		166
Protein FAM114A2 (Fragment)		HUMAN		210

Protein	Similar proteins		Species	Score	Length	Source
Q9NRY5	Testis tissue sperm-binding protein Li 81P		HUMAN		505	UniRef90_Q9NRY5
Uncharacterized protein		PANPA		516
Family with sequence similarity 114 member A2		PANTR		516
Uncharacterized protein		MACFA		512
Uncharacterized protein		MACMU		512
+50

Protein	Similar proteins		Species	Score	Length	Source
Q9NRY5	Testis tissue sperm-binding protein Li 81P		HUMAN		505	UniRef50_Q9NRY5
Family with sequence similarity 114 member A2		PANTR		516
Uncharacterized protein		PANPA		516
Uncharacterized protein		MACFA		512
Uncharacterized protein		MACMU		512
+148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159700 mRNA Translation: AAF76523.1 AK024664 mRNA Translation: BAB14952.1 AK313331 mRNA Translation: BAG36135.1 AC010232 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61646.1 CH471062 Genomic DNA Translation: EAW61647.1 CH471062 Genomic DNA Translation: EAW61648.1 BC011414 mRNA Translation: AAH11414.1
CCDSⁱ	CCDS4323.1
RefSeqⁱ	NP_001304922.1, NM_001317993.1 NP_001304923.1, NM_001317994.1 NP_001304924.1, NM_001317995.1 NP_061161.2, NM_018691.3 XP_005268417.1, XM_005268360.4 XP_005268418.1, XM_005268361.4 XP_011535842.1, XM_011537540.2 XP_011535843.1, XM_011537541.2 XP_011535844.1, XM_011537542.2 XP_016864456.1, XM_017008967.1 XP_016864457.1, XM_017008968.1
UniGeneⁱ	Hs.166551

3D structure databases

ProteinModelPortalⁱ	Q9NRY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116040, 21 interactors
IntActⁱ	Q9NRY5, 12 interactors
STRINGⁱ	9606.ENSP00000341597

PTM databases

iPTMnetⁱ	Q9NRY5
PhosphoSitePlusⁱ	Q9NRY5

Polymorphism and mutation databases

BioMutaⁱ	FAM114A2
DMDMⁱ	296439475

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00329662

REPRODUCTION-2DPAGEⁱ

IPI00329662

Proteomic databases

EPDⁱ	Q9NRY5
MaxQBⁱ	Q9NRY5
PaxDbⁱ	Q9NRY5
PeptideAtlasⁱ	Q9NRY5
PRIDEⁱ	Q9NRY5
ProteomicsDBⁱ	82443

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10827
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000351797; ENSP00000341597; ENSG00000055147 ENST00000520667; ENSP00000430384; ENSG00000055147 ENST00000522858; ENSP00000430489; ENSG00000055147
GeneIDⁱ	10827
KEGGⁱ	hsa:10827
UCSCⁱ	uc003lvb.5 human

Organism-specific databases

CTDⁱ	10827
EuPathDBⁱ	HostDB:ENSG00000055147.17
GeneCardsⁱ	FAM114A2
H-InvDBⁱ	HIX0005337
HGNCⁱ	HGNC:1333 FAM114A2
HPAⁱ	HPA035869 HPA035870
neXtProtⁱ	NX_Q9NRY5
OpenTargetsⁱ	ENSG00000055147
PharmGKBⁱ	PA162385716
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHQB Eukaryota ENOG411029H LUCA
GeneTreeⁱ	ENSGT00390000010054
HOGENOMⁱ	HOG000059573
HOVERGENⁱ	HBG056879
InParanoidⁱ	Q9NRY5
OMAⁱ	LFENYCG
OrthoDBⁱ	EOG091G06FS
PhylomeDBⁱ	Q9NRY5
TreeFamⁱ	TF324360

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6802952 Signaling by BRAF and RAF fusions

Reactomeⁱ

R-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRSⁱ	FAM114A2 human
GeneWikiⁱ	C5orf3
GenomeRNAiⁱ	10827
Protein Ontology More...PROⁱ	PR:Q9NRY5

Gene expression databases

Bgeeⁱ	ENSG00000055147 Expressed in 212 organ(s), highest expression level in kidney
CleanExⁱ	HS_FAM114A2
ExpressionAtlasⁱ	Q9NRY5 baseline and differential
Genevisibleⁱ	Q9NRY5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007998 DUF719
PANTHERⁱ	PTHR12842 PTHR12842, 1 hit
Pfamⁱ	View protein in Pfam PF05334 DUF719, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1142_HUMAN
Accessionⁱ	Q9NRY5Primary (citable) accession number: Q9NRY5 Secondary accession number(s): B2R8D8, Q9H7E0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NRY5 (F1142_HUMAN)

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Protein FAM114A2

FAM114A2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ