UniProtKB - Q9NRY5 (F1142_HUMAN)
Protein
Protein FAM114A2
Gene
FAM114A2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- purine nucleotide binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9NRY5 |
Reactomei | R-HSA-6802952, Signaling by BRAF and RAF fusions |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM114A2 |
Gene namesi | Name:FAM114A2 Synonyms:C5orf3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1333, FAM114A2 |
neXtProti | NX_Q9NRY5 |
VEuPathDBi | HostDB:ENSG00000055147.17 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10827 |
OpenTargetsi | ENSG00000055147 |
PharmGKBi | PA162385716 |
Miscellaneous databases
Pharosi | Q9NRY5, Tdark |
Genetic variation databases
BioMutai | FAM114A2 |
DMDMi | 296439475 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274564 | 1 – 505 | Protein FAM114A2Add BLAST | 505 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NRY5 |
jPOSTi | Q9NRY5 |
MassIVEi | Q9NRY5 |
MaxQBi | Q9NRY5 |
PaxDbi | Q9NRY5 |
PeptideAtlasi | Q9NRY5 |
PRIDEi | Q9NRY5 |
ProteomicsDBi | 82443 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00329662 |
PTM databases
iPTMneti | Q9NRY5 |
PhosphoSitePlusi | Q9NRY5 |
SwissPalmi | Q9NRY5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000055147, Expressed in stomach and 225 other tissues |
ExpressionAtlasi | Q9NRY5, baseline and differential |
Genevisiblei | Q9NRY5, HS |
Organism-specific databases
HPAi | ENSG00000055147, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NRY5
Protein-protein interaction databases
BioGRIDi | 116040, 34 interactors |
IntActi | Q9NRY5, 23 interactors |
STRINGi | 9606.ENSP00000341597 |
Miscellaneous databases
RNActi | Q9NRY5, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 268 – 295 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 297 – 302 | Poly-Glu | 6 |
Sequence similaritiesi
Belongs to the FAM114 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QS74, Eukaryota |
GeneTreei | ENSGT00390000010054 |
InParanoidi | Q9NRY5 |
OMAi | NDPKLMN |
OrthoDBi | 947469at2759 |
PhylomeDBi | Q9NRY5 |
TreeFami | TF324360 |
Family and domain databases
InterProi | View protein in InterPro IPR007998, DUF719 |
PANTHERi | PTHR12842, PTHR12842, 1 hit |
Pfami | View protein in Pfam PF05334, DUF719, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q9NRY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR
60 70 80 90 100
KRPETKPSSD LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV
110 120 130 140 150
ATVGQGISNV IEKAETSLGI PGPSEISTEV KYVAGETNAK ENENSSPVAG
160 170 180 190 200
AFGVFSTIST AVQSTGKSVI SGGLDALEFI GKKTMDVIAE GDPGFKRTKG
210 220 230 240 250
LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL FDEFQGLSHL
260 270 280 290 300
EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE
310 320 330 340 350
EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE
360 370 380 390 400
NEEGEKQSEA ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV
410 420 430 440 450
LHGRKQEVTA IERSQTLSQM TIVLCKELSS LSKEFTTCLT TAGVKEMADV
460 470 480 490 500
LNPLITAVFL EASNSASYIQ DAFQLLLPVL EISLIENKIE SHRHELQGQK
PLLEH
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ESJ7 | E7ESJ7_HUMAN | Protein FAM114A2 | FAM114A2 | 435 | Annotation score: | ||
E5RGF9 | E5RGF9_HUMAN | Protein FAM114A2 | FAM114A2 | 210 | Annotation score: | ||
E5RFK2 | E5RFK2_HUMAN | Protein FAM114A2 | FAM114A2 | 166 | Annotation score: | ||
E5RHI8 | E5RHI8_HUMAN | Protein FAM114A2 | FAM114A2 | 125 | Annotation score: | ||
E5RHP2 | E5RHP2_HUMAN | Protein FAM114A2 | FAM114A2 | 103 | Annotation score: | ||
E5RK42 | E5RK42_HUMAN | Protein FAM114A2 | FAM114A2 | 79 | Annotation score: | ||
E5RH43 | E5RH43_HUMAN | Protein FAM114A2 | FAM114A2 | 63 | Annotation score: | ||
E5RIK7 | E5RIK7_HUMAN | Protein FAM114A2 | FAM114A2 | 15 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | P → S in AAF76523 (PubMed:10843801).Curated | 1 | |
Sequence conflicti | 122 | G → S in AAF76523 (PubMed:10843801).Curated | 1 | |
Sequence conflicti | 122 | G → S in BAB14952 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 122 | G → S in AAH11414 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159700 mRNA Translation: AAF76523.1 AK024664 mRNA Translation: BAB14952.1 AK313331 mRNA Translation: BAG36135.1 AC010232 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61646.1 CH471062 Genomic DNA Translation: EAW61647.1 CH471062 Genomic DNA Translation: EAW61648.1 BC011414 mRNA Translation: AAH11414.1 |
CCDSi | CCDS4323.1 |
RefSeqi | NP_001304922.1, NM_001317993.1 NP_001304923.1, NM_001317994.1 NP_001304924.1, NM_001317995.1 NP_061161.2, NM_018691.3 XP_005268417.1, XM_005268360.4 XP_005268418.1, XM_005268361.4 XP_011535842.1, XM_011537540.2 XP_011535843.1, XM_011537541.2 XP_011535844.1, XM_011537542.2 XP_016864456.1, XM_017008967.1 XP_016864457.1, XM_017008968.1 |
Genome annotation databases
Ensembli | ENST00000351797; ENSP00000341597; ENSG00000055147 ENST00000520667; ENSP00000430384; ENSG00000055147 ENST00000522858; ENSP00000430489; ENSG00000055147 |
GeneIDi | 10827 |
KEGGi | hsa:10827 |
UCSCi | uc003lvb.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159700 mRNA Translation: AAF76523.1 AK024664 mRNA Translation: BAB14952.1 AK313331 mRNA Translation: BAG36135.1 AC010232 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61646.1 CH471062 Genomic DNA Translation: EAW61647.1 CH471062 Genomic DNA Translation: EAW61648.1 BC011414 mRNA Translation: AAH11414.1 |
CCDSi | CCDS4323.1 |
RefSeqi | NP_001304922.1, NM_001317993.1 NP_001304923.1, NM_001317994.1 NP_001304924.1, NM_001317995.1 NP_061161.2, NM_018691.3 XP_005268417.1, XM_005268360.4 XP_005268418.1, XM_005268361.4 XP_011535842.1, XM_011537540.2 XP_011535843.1, XM_011537541.2 XP_011535844.1, XM_011537542.2 XP_016864456.1, XM_017008967.1 XP_016864457.1, XM_017008968.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116040, 34 interactors |
IntActi | Q9NRY5, 23 interactors |
STRINGi | 9606.ENSP00000341597 |
PTM databases
iPTMneti | Q9NRY5 |
PhosphoSitePlusi | Q9NRY5 |
SwissPalmi | Q9NRY5 |
Genetic variation databases
BioMutai | FAM114A2 |
DMDMi | 296439475 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00329662 |
Proteomic databases
EPDi | Q9NRY5 |
jPOSTi | Q9NRY5 |
MassIVEi | Q9NRY5 |
MaxQBi | Q9NRY5 |
PaxDbi | Q9NRY5 |
PeptideAtlasi | Q9NRY5 |
PRIDEi | Q9NRY5 |
ProteomicsDBi | 82443 |
Protocols and materials databases
Antibodypediai | 48470, 64 antibodies |
DNASUi | 10827 |
Genome annotation databases
Ensembli | ENST00000351797; ENSP00000341597; ENSG00000055147 ENST00000520667; ENSP00000430384; ENSG00000055147 ENST00000522858; ENSP00000430489; ENSG00000055147 |
GeneIDi | 10827 |
KEGGi | hsa:10827 |
UCSCi | uc003lvb.5, human |
Organism-specific databases
CTDi | 10827 |
DisGeNETi | 10827 |
GeneCardsi | FAM114A2 |
HGNCi | HGNC:1333, FAM114A2 |
HPAi | ENSG00000055147, Low tissue specificity |
neXtProti | NX_Q9NRY5 |
OpenTargetsi | ENSG00000055147 |
PharmGKBi | PA162385716 |
VEuPathDBi | HostDB:ENSG00000055147.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS74, Eukaryota |
GeneTreei | ENSGT00390000010054 |
InParanoidi | Q9NRY5 |
OMAi | NDPKLMN |
OrthoDBi | 947469at2759 |
PhylomeDBi | Q9NRY5 |
TreeFami | TF324360 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRY5 |
Reactomei | R-HSA-6802952, Signaling by BRAF and RAF fusions |
Miscellaneous databases
BioGRID-ORCSi | 10827, 2 hits in 1001 CRISPR screens |
ChiTaRSi | FAM114A2, human |
GeneWikii | C5orf3 |
GenomeRNAii | 10827 |
Pharosi | Q9NRY5, Tdark |
PROi | PR:Q9NRY5 |
RNActi | Q9NRY5, protein |
Gene expression databases
Bgeei | ENSG00000055147, Expressed in stomach and 225 other tissues |
ExpressionAtlasi | Q9NRY5, baseline and differential |
Genevisiblei | Q9NRY5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007998, DUF719 |
PANTHERi | PTHR12842, PTHR12842, 1 hit |
Pfami | View protein in Pfam PF05334, DUF719, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1142_HUMAN | |
Accessioni | Q9NRY5Primary (citable) accession number: Q9NRY5 Secondary accession number(s): B2R8D8, Q9H7E0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families