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Protein

Protein FAM114A2

Gene

FAM114A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • purine nucleotide binding Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM114A2
Gene namesi
Name:FAM114A2
Synonyms:C5orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000055147.17
HGNCiHGNC:1333 FAM114A2
neXtProtiNX_Q9NRY5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000055147
PharmGKBiPA162385716

Polymorphism and mutation databases

BioMutaiFAM114A2
DMDMi296439475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745641 – 505Protein FAM114A2Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NRY5
MaxQBiQ9NRY5
PaxDbiQ9NRY5
PeptideAtlasiQ9NRY5
PRIDEiQ9NRY5
ProteomicsDBi82443

2D gel databases

REPRODUCTION-2DPAGEiIPI00329662

PTM databases

iPTMnetiQ9NRY5
PhosphoSitePlusiQ9NRY5

Expressioni

Gene expression databases

BgeeiENSG00000055147 Expressed in 212 organ(s), highest expression level in kidney
CleanExiHS_FAM114A2
ExpressionAtlasiQ9NRY5 baseline and differential
GenevisibleiQ9NRY5 HS

Organism-specific databases

HPAiHPA035869
HPA035870

Interactioni

Protein-protein interaction databases

BioGridi116040, 21 interactors
IntActiQ9NRY5, 12 interactors
STRINGi9606.ENSP00000341597

Structurei

3D structure databases

ProteinModelPortaliQ9NRY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili268 – 295Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi297 – 302Poly-Glu6

Sequence similaritiesi

Belongs to the FAM114 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHQB Eukaryota
ENOG411029H LUCA
GeneTreeiENSGT00390000010054
HOGENOMiHOG000059573
HOVERGENiHBG056879
InParanoidiQ9NRY5
OMAiLFENYCG
OrthoDBiEOG091G06FS
PhylomeDBiQ9NRY5
TreeFamiTF324360

Family and domain databases

InterProiView protein in InterPro
IPR007998 DUF719
PANTHERiPTHR12842 PTHR12842, 1 hit
PfamiView protein in Pfam
PF05334 DUF719, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9NRY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR
60 70 80 90 100
KRPETKPSSD LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV
110 120 130 140 150
ATVGQGISNV IEKAETSLGI PGPSEISTEV KYVAGETNAK ENENSSPVAG
160 170 180 190 200
AFGVFSTIST AVQSTGKSVI SGGLDALEFI GKKTMDVIAE GDPGFKRTKG
210 220 230 240 250
LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL FDEFQGLSHL
260 270 280 290 300
EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE
310 320 330 340 350
EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE
360 370 380 390 400
NEEGEKQSEA ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV
410 420 430 440 450
LHGRKQEVTA IERSQTLSQM TIVLCKELSS LSKEFTTCLT TAGVKEMADV
460 470 480 490 500
LNPLITAVFL EASNSASYIQ DAFQLLLPVL EISLIENKIE SHRHELQGQK

PLLEH
Length:505
Mass (Da):55,468
Last modified:May 18, 2010 - v4
Checksum:iE3991C42F8DCF606
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESJ7E7ESJ7_HUMAN
Protein FAM114A2
FAM114A2
435Annotation score:
E5RGF9E5RGF9_HUMAN
Protein FAM114A2
FAM114A2
210Annotation score:
E5RHP2E5RHP2_HUMAN
Protein FAM114A2
FAM114A2
103Annotation score:
E5RFK2E5RFK2_HUMAN
Protein FAM114A2
FAM114A2
166Annotation score:
E5RHI8E5RHI8_HUMAN
Protein FAM114A2
FAM114A2
125Annotation score:
E5RK42E5RK42_HUMAN
Protein FAM114A2
FAM114A2
79Annotation score:
E5RH43E5RH43_HUMAN
Protein FAM114A2
FAM114A2
63Annotation score:
E5RIK7E5RIK7_HUMAN
Protein FAM114A2
FAM114A2
15Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68P → S in AAF76523 (PubMed:10843801).Curated1
Sequence conflicti122G → S in AAF76523 (PubMed:10843801).Curated1
Sequence conflicti122G → S in BAB14952 (PubMed:14702039).Curated1
Sequence conflicti122G → S in AAH11414 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159700 mRNA Translation: AAF76523.1
AK024664 mRNA Translation: BAB14952.1
AK313331 mRNA Translation: BAG36135.1
AC010232 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61646.1
CH471062 Genomic DNA Translation: EAW61647.1
CH471062 Genomic DNA Translation: EAW61648.1
BC011414 mRNA Translation: AAH11414.1
CCDSiCCDS4323.1
RefSeqiNP_001304922.1, NM_001317993.1
NP_001304923.1, NM_001317994.1
NP_001304924.1, NM_001317995.1
NP_061161.2, NM_018691.3
XP_005268417.1, XM_005268360.4
XP_005268418.1, XM_005268361.4
XP_011535842.1, XM_011537540.2
XP_011535843.1, XM_011537541.2
XP_011535844.1, XM_011537542.2
XP_016864456.1, XM_017008967.1
XP_016864457.1, XM_017008968.1
UniGeneiHs.166551

Genome annotation databases

EnsembliENST00000351797; ENSP00000341597; ENSG00000055147
ENST00000520667; ENSP00000430384; ENSG00000055147
ENST00000522858; ENSP00000430489; ENSG00000055147
GeneIDi10827
KEGGihsa:10827
UCSCiuc003lvb.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159700 mRNA Translation: AAF76523.1
AK024664 mRNA Translation: BAB14952.1
AK313331 mRNA Translation: BAG36135.1
AC010232 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61646.1
CH471062 Genomic DNA Translation: EAW61647.1
CH471062 Genomic DNA Translation: EAW61648.1
BC011414 mRNA Translation: AAH11414.1
CCDSiCCDS4323.1
RefSeqiNP_001304922.1, NM_001317993.1
NP_001304923.1, NM_001317994.1
NP_001304924.1, NM_001317995.1
NP_061161.2, NM_018691.3
XP_005268417.1, XM_005268360.4
XP_005268418.1, XM_005268361.4
XP_011535842.1, XM_011537540.2
XP_011535843.1, XM_011537541.2
XP_011535844.1, XM_011537542.2
XP_016864456.1, XM_017008967.1
XP_016864457.1, XM_017008968.1
UniGeneiHs.166551

3D structure databases

ProteinModelPortaliQ9NRY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116040, 21 interactors
IntActiQ9NRY5, 12 interactors
STRINGi9606.ENSP00000341597

PTM databases

iPTMnetiQ9NRY5
PhosphoSitePlusiQ9NRY5

Polymorphism and mutation databases

BioMutaiFAM114A2
DMDMi296439475

2D gel databases

REPRODUCTION-2DPAGEiIPI00329662

Proteomic databases

EPDiQ9NRY5
MaxQBiQ9NRY5
PaxDbiQ9NRY5
PeptideAtlasiQ9NRY5
PRIDEiQ9NRY5
ProteomicsDBi82443

Protocols and materials databases

DNASUi10827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351797; ENSP00000341597; ENSG00000055147
ENST00000520667; ENSP00000430384; ENSG00000055147
ENST00000522858; ENSP00000430489; ENSG00000055147
GeneIDi10827
KEGGihsa:10827
UCSCiuc003lvb.5 human

Organism-specific databases

CTDi10827
EuPathDBiHostDB:ENSG00000055147.17
GeneCardsiFAM114A2
H-InvDBiHIX0005337
HGNCiHGNC:1333 FAM114A2
HPAiHPA035869
HPA035870
neXtProtiNX_Q9NRY5
OpenTargetsiENSG00000055147
PharmGKBiPA162385716
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHQB Eukaryota
ENOG411029H LUCA
GeneTreeiENSGT00390000010054
HOGENOMiHOG000059573
HOVERGENiHBG056879
InParanoidiQ9NRY5
OMAiLFENYCG
OrthoDBiEOG091G06FS
PhylomeDBiQ9NRY5
TreeFamiTF324360

Enzyme and pathway databases

ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRSiFAM114A2 human
GeneWikiiC5orf3
GenomeRNAii10827
PROiPR:Q9NRY5

Gene expression databases

BgeeiENSG00000055147 Expressed in 212 organ(s), highest expression level in kidney
CleanExiHS_FAM114A2
ExpressionAtlasiQ9NRY5 baseline and differential
GenevisibleiQ9NRY5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007998 DUF719
PANTHERiPTHR12842 PTHR12842, 1 hit
PfamiView protein in Pfam
PF05334 DUF719, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1142_HUMAN
AccessioniPrimary (citable) accession number: Q9NRY5
Secondary accession number(s): B2R8D8, Q9H7E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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