UniProtKB - Q9NRY4 (RHG35_HUMAN)
Rho GTPase-activating protein 35
ARHGAP35
Functioni
Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085).
Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492).
This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492).
Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity).
Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity).
Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity).
Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity).
During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity).
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621).
By similarity3 PublicationsActivity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 28 | GTPCombined sources1 Publication | 1 | |
Binding sitei | 52 | GTP; via carbonyl oxygenCombined sources1 Publication | 1 | |
Binding sitei | 56 | GTPCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 37 | GTPCombined sources1 Publication | 5 | |
Nucleotide bindingi | 95 – 97 | GTPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 201 – 203 | GTPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 229 – 231 | GTPCombined sources1 Publication | 3 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- GTPase activating protein binding Source: Ensembl
- GTPase activator activity Source: UniProtKB
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- phospholipid binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- axonal fasciculation Source: UniProtKB
- axon guidance Source: UniProtKB
- camera-type eye development Source: Ensembl
- cell migration Source: UniProtKB
- cellular response to extracellular stimulus Source: UniProtKB
- central nervous system neuron axonogenesis Source: UniProtKB
- establishment or maintenance of actin cytoskeleton polarity Source: UniProtKB
- forebrain development Source: Ensembl
- mammary gland development Source: UniProtKB
- negative regulation of Rho protein signal transduction Source: ARUK-UCL
- negative regulation of vascular permeability Source: Ensembl
- neural tube closure Source: Ensembl
- neuron projection guidance Source: UniProtKB
- positive regulation of cilium assembly Source: UniProtKB
- positive regulation of GTPase activity Source: Ensembl
- positive regulation of neuron projection development Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of actin polymerization or depolymerization Source: UniProtKB
- regulation of axonogenesis Source: UniProtKB
- regulation of cell shape Source: Ensembl
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
- wound healing, spreading of cells Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, GTPase activation, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | GTP-binding, Lipid-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NRY4 |
Reactomei | R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8980692, RHOA GTPase cycle R-HSA-9013026, RHOB GTPase cycle R-HSA-9013106, RHOC GTPase cycle R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013405, RHOD GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9696264, RND3 GTPase cycle R-HSA-9696270, RND2 GTPase cycle R-HSA-9696273, RND1 GTPase cycle |
SignaLinki | Q9NRY4 |
SIGNORi | Q9NRY4 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 35ImportedAlternative name(s): Glucocorticoid receptor DNA-binding factor 1 Glucocorticoid receptor repression factor 1 Short name: GRF-1 Rho GAP p190A Short name: p190-A1 Publication |
Gene namesi | Name:ARHGAP35Imported Synonyms:GRF11 Publication, GRLF11 Publication, KIAA1722, P190A1 Publication, p190ARHOGAP1 Publication |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4591, ARHGAP35 |
MIMi | 605277, gene |
neXtProti | NX_Q9NRY4 |
VEuPathDBi | HostDB:ENSG00000160007 |
Subcellular locationi
Cytoskeleton
- cilium basal body By similarity
Plasma membrane
- Cell membrane By similarity
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin.By similarity
Cytoskeleton
- actin cytoskeleton Source: Ensembl
- ciliary basal body Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1221 | S → A: No effect on total phosphorylation levels. Abolishes inhibition of phospholipid binding by PRKCA phosphorylation. Decreases phosphorylation by PRKCA; when associated with A-1226. Abolishes phosphorylation by PRKCA; when associated with A-1126 and A-1236. 1 Publication | 1 | |
Mutagenesisi | 1221 | S → D: Enhances Rac GAP activity. 1 Publication | 1 | |
Mutagenesisi | 1226 | T → A: No effect on total phosphorylation levels. Abolishes inhibition of phospholipid binding by PRKCA phosphorylation. Decreases phosphorylation by PRKCA; when associated with A-1221. Abolishes phosphorylation by PRKCA; when associated with A-1121 and A-1236. 1 Publication | 1 | |
Mutagenesisi | 1226 | T → D: Enhances Rac GAP activity. 1 Publication | 1 | |
Mutagenesisi | 1236 | S → A: No effect on total phosphorylation levels. No effect on inhibition of phospholipid binding by PRKCA phosphorylation. Abolishes phosphorylation by PRKCA; when associated with A-1121 and A-1226. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2909 |
OpenTargetsi | ENSG00000160007 |
PharmGKBi | PA28988 |
Miscellaneous databases
Pharosi | Q9NRY4, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523646 |
Genetic variation databases
BioMutai | ARHGAP35 |
DMDMi | 408360250 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056730 | 1 – 1499 | Rho GTPase-activating protein 35Add BLAST | 1499 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 308 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 589 | PhosphoserineCombined sources | 1 | |
Modified residuei | 770 | PhosphoserineCombined sources | 1 | |
Modified residuei | 773 | PhosphoserineCombined sources | 1 | |
Modified residuei | 970 | PhosphoserineCombined sources | 1 | |
Modified residuei | 975 | PhosphoserineCombined sources | 1 | |
Modified residuei | 985 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1001 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1072 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1087 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1105 | Phosphotyrosine; by ABL2 and PTK6Combined sources1 Publication | 1 | |
Modified residuei | 1134 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1142 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1150 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1176 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1179 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1221 | Phosphoserine; by PKC/PRKCA1 Publication | 1 | |
Modified residuei | 1226 | Phosphothreonine; by PKC/PRKCA1 Publication | 1 | |
Modified residuei | 1236 | Phosphoserine; by PKC/PRKCA1 Publication | 1 | |
Modified residuei | 1472 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1476 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1480 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1483 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NRY4 |
jPOSTi | Q9NRY4 |
MassIVEi | Q9NRY4 |
MaxQBi | Q9NRY4 |
PaxDbi | Q9NRY4 |
PeptideAtlasi | Q9NRY4 |
PRIDEi | Q9NRY4 |
ProteomicsDBi | 82441 |
PTM databases
iPTMneti | Q9NRY4 |
PhosphoSitePlusi | Q9NRY4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160007, Expressed in frontal cortex and 242 other tissues |
Genevisiblei | Q9NRY4, HS |
Organism-specific databases
HPAi | ENSG00000160007, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RASA1 (By similarity).
Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm (PubMed:19393245).
By similarity1 PublicationGO - Molecular functioni
- GTPase activating protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109166, 90 interactors |
DIPi | DIP-34578N |
IntActi | Q9NRY4, 21 interactors |
MINTi | Q9NRY4 |
STRINGi | 9606.ENSP00000385720 |
Chemistry databases
BindingDBi | Q9NRY4 |
Miscellaneous databases
RNActi | Q9NRY4, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9NRY4 |
BMRBi | Q9NRY4 |
SMRi | Q9NRY4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NRY4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 270 – 327 | FF 1Add BLAST | 58 | |
Domaini | 368 – 422 | FF 2Add BLAST | 55 | |
Domaini | 429 – 483 | FF 3Add BLAST | 55 | |
Domaini | 485 – 550 | FF 4Add BLAST | 66 | |
Domaini | 592 – 767 | pG1 pseudoGTPasePROSITE-ProRule annotationAdd BLAST | 176 | |
Domaini | 783 – 947 | pG2 pseudoGTPasePROSITE-ProRule annotationAdd BLAST | 165 | |
Domaini | 1249 – 1436 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 188 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 266 | Has GTPase activity, required for proper localizationBy similarityAdd BLAST | 266 | |
Regioni | 1058 – 1089 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1124 – 1146 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1177 – 1207 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1213 – 1236 | Required for phospholipid binding and regulation of the substrate preference1 PublicationAdd BLAST | 24 | |
Regioni | 1446 – 1499 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1124 – 1139 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1182 – 1196 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1451 – 1469 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1470 – 1486 | Pro residuesSequence analysisAdd BLAST | 17 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4271, Eukaryota |
GeneTreei | ENSGT01030000234635 |
HOGENOMi | CLU_004268_0_0_1 |
InParanoidi | Q9NRY4 |
OMAi | YWGEVVR |
OrthoDBi | 110157at2759 |
PhylomeDBi | Q9NRY4 |
TreeFami | TF324451 |
Family and domain databases
Gene3Di | 1.10.10.440, 2 hits 1.10.555.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR002713, FF_domain IPR036517, FF_domain_sf IPR027417, P-loop_NTPase IPR039007, pG1 IPR008936, Rho_GTPase_activation_prot IPR032835, RhoGAP-FF1 IPR000198, RhoGAP_dom IPR045786, RhoGAP_pG1_pG2 IPR039006, RhoGAP_pG2 IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF01846, FF, 1 hit PF00071, Ras, 1 hit PF00620, RhoGAP, 1 hit PF16512, RhoGAP-FF1, 1 hit PF19518, RhoGAP_pG1_pG2, 1 hit |
SMARTi | View protein in SMART SM00441, FF, 4 hits SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF52540, SSF52540, 1 hit SSF81698, SSF81698, 1 hit |
PROSITEi | View protein in PROSITE PS51676, FF, 4 hits PS51852, PG1, 1 hit PS51853, PG2, 1 hit PS50238, RHOGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF
60 70 80 90 100
HLDHTSVLST SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHIVEQTEFI
110 120 130 140 150
DDQTFQPHRS TALQPYIKRA AATKLASAEK LMYFCTDQLG LEQDFEQKQM
160 170 180 190 200
PDGKLLVDGF LLGIDVSRGM NRNFDDQLKF VSNLYNQLAK TKKPIVVVLT
210 220 230 240 250
KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF STLVQLIDKS
260 270 280 290 300
RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWLSVSRKMQ
310 320 330 340 350
ASPEYQDYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA
360 370 380 390 400
LIPNLDEIDH LSCIKAKKLL ETKPEFLKWF VVLEETPWDA TSHIDNMENE
410 420 430 440 450
RIPFDLMDTV PAEQLYEAHL EKLRNERKRV EMRRAFKENL ETSPFITPGK
460 470 480 490 500
PWEEARSFIM NEDFYQWLEE SVYMDIYGKH QKQIIDKAKE EFQELLLEYS
510 520 530 540 550
ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER DALILKHIHF
560 570 580 590 600
VYHPTKETCP SCPACVDAKI EHLISSRFIR PSDRNQKNSL SDPNIDRINL
610 620 630 640 650
VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS
660 670 680 690 700
FQTPTFQPHG CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL
710 720 730 740 750
ILVNKRGDTS GETLHSLIQQ GQQIASKLQC VFLDPASAGI GYGRNINEKQ
760 770 780 790 800
ISQVLKGLLD SKRNLNLVSS TASIKDLADV DLRIVMCLMC GDPFSADDIL
810 820 830 840 850
FPVLQSQTCK SSHCGSNNSV LLELPIGLHK KRIELSVLSY HSSFSIRKSR
860 870 880 890 900
LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPIQLVALTD GAVDVLDNDL
910 920 930 940 950
SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LEIFHPFFKD VVEKKNIIEA
960 970 980 990 1000
THMYDNAAEA CSTTEEVFNS PRAGSPLCNS NLQDSEEDIE PSYSLFREDT
1010 1020 1030 1040 1050
SLPSLSKDHS KLSMELEGND GLSFIMSNFE SKLNNKVPPP VKPKPPVHFE
1060 1070 1080 1090 1100
ITKGDLSYLD QGHRDGQRKS VSSSPWLPQD GFDPSDYAEP MDAVVKPRNE
1110 1120 1130 1140 1150
EENIYSVPHD STQGKIITIR NINKAQSNGS GNGSDSEMDT SSLERGRKVS
1160 1170 1180 1190 1200
IVSKPVLYRT RCTRLGRFAS YRTSFSVGSD DELGPIRKKE EDQASQGYKG
1210 1220 1230 1240 1250
DNAVIPYETD EDPRRRNILR SLRRNTKKPK PKPRPSITKA TWESNYFGVP
1260 1270 1280 1290 1300
LTTVVTPEKP IPIFIERCIE YIEATGLSTE GIYRVSGNKS EMESLQRQFD
1310 1320 1330 1340 1350
QDHNLDLAEK DFTVNTVAGA MKSFFSELPD PLVPYNMQID LVEAHKINDR
1360 1370 1380 1390 1400
EQKLHALKEV LKKFPKENHE VFKYVISHLN KVSHNNKVNL MTSENLSICF
1410 1420 1430 1440 1450
WPTLMRPDFS TMDALTATRT YQTIIELFIQ QCPFFFYNRP ITEPPGARPS
1460 1470 1480 1490
SPSAVASTVP FLTSTPVTSQ PSPPQSPPPT PQSPMQPLLP SQLQAEHTL
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 251 | R → P in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 309 | V → D in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 362 | S → G in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 414 | Q → A in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 414 | Q → A in AAA58618 (PubMed:1894621).Curated | 1 | |
Sequence conflicti | 474 | M → T in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 474 | M → T in AAA58618 (PubMed:1894621).Curated | 1 | |
Sequence conflicti | 978 | C → S in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 1292 | M → I in AAF80386 (PubMed:11054565).Curated | 1 | |
Sequence conflicti | 1452 – 1453 | PS → RN in AAA58618 (PubMed:1894621).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051509 mRNA Translation: BAB21813.2 CH471126 Genomic DNA Translation: EAW57450.1 BC150257 mRNA Translation: AAI50258.1 AF159851 mRNA Translation: AAF80386.1 Sequence problems. M73077 mRNA Translation: AAA58618.1 Frameshift. |
CCDSi | CCDS46127.1 |
RefSeqi | NP_004482.4, NM_004491.4 XP_016882203.1, XM_017026714.1 |
Genome annotation databases
Ensembli | ENST00000404338.8; ENSP00000385720.2; ENSG00000160007.19 ENST00000614079.1; ENSP00000483730.1; ENSG00000160007.19 ENST00000672722.1; ENSP00000500409.1; ENSG00000160007.19 |
GeneIDi | 2909 |
KEGGi | hsa:2909 |
MANE-Selecti | ENST00000672722.1; ENSP00000500409.1; NM_004491.5; NP_004482.4 |
UCSCi | uc010ekv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051509 mRNA Translation: BAB21813.2 CH471126 Genomic DNA Translation: EAW57450.1 BC150257 mRNA Translation: AAI50258.1 AF159851 mRNA Translation: AAF80386.1 Sequence problems. M73077 mRNA Translation: AAA58618.1 Frameshift. |
CCDSi | CCDS46127.1 |
RefSeqi | NP_004482.4, NM_004491.4 XP_016882203.1, XM_017026714.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K85 | NMR | - | A | 267-331 | [»] | |
3C5H | X-ray | 1.80 | A | 13-249 | [»] | |
3FK2 | X-ray | 2.80 | A/B/C/D | 1212-1439 | [»] | |
6PXC | X-ray | 1.60 | U | 1100-1112 | [»] | |
6WAY | X-ray | 1.50 | V | 1086-1093 | [»] | |
AlphaFoldDBi | Q9NRY4 | |||||
BMRBi | Q9NRY4 | |||||
SMRi | Q9NRY4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109166, 90 interactors |
DIPi | DIP-34578N |
IntActi | Q9NRY4, 21 interactors |
MINTi | Q9NRY4 |
STRINGi | 9606.ENSP00000385720 |
Chemistry databases
BindingDBi | Q9NRY4 |
ChEMBLi | CHEMBL4523646 |
PTM databases
iPTMneti | Q9NRY4 |
PhosphoSitePlusi | Q9NRY4 |
Genetic variation databases
BioMutai | ARHGAP35 |
DMDMi | 408360250 |
Proteomic databases
EPDi | Q9NRY4 |
jPOSTi | Q9NRY4 |
MassIVEi | Q9NRY4 |
MaxQBi | Q9NRY4 |
PaxDbi | Q9NRY4 |
PeptideAtlasi | Q9NRY4 |
PRIDEi | Q9NRY4 |
ProteomicsDBi | 82441 |
Protocols and materials databases
Antibodypediai | 31509, 275 antibodies from 29 providers |
DNASUi | 2909 |
Genome annotation databases
Ensembli | ENST00000404338.8; ENSP00000385720.2; ENSG00000160007.19 ENST00000614079.1; ENSP00000483730.1; ENSG00000160007.19 ENST00000672722.1; ENSP00000500409.1; ENSG00000160007.19 |
GeneIDi | 2909 |
KEGGi | hsa:2909 |
MANE-Selecti | ENST00000672722.1; ENSP00000500409.1; NM_004491.5; NP_004482.4 |
UCSCi | uc010ekv.4, human |
Organism-specific databases
CTDi | 2909 |
DisGeNETi | 2909 |
GeneCardsi | ARHGAP35 |
HGNCi | HGNC:4591, ARHGAP35 |
HPAi | ENSG00000160007, Low tissue specificity |
MIMi | 605277, gene |
neXtProti | NX_Q9NRY4 |
OpenTargetsi | ENSG00000160007 |
PharmGKBi | PA28988 |
VEuPathDBi | HostDB:ENSG00000160007 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4271, Eukaryota |
GeneTreei | ENSGT01030000234635 |
HOGENOMi | CLU_004268_0_0_1 |
InParanoidi | Q9NRY4 |
OMAi | YWGEVVR |
OrthoDBi | 110157at2759 |
PhylomeDBi | Q9NRY4 |
TreeFami | TF324451 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRY4 |
Reactomei | R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8980692, RHOA GTPase cycle R-HSA-9013026, RHOB GTPase cycle R-HSA-9013106, RHOC GTPase cycle R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013405, RHOD GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9696264, RND3 GTPase cycle R-HSA-9696270, RND2 GTPase cycle R-HSA-9696273, RND1 GTPase cycle |
SignaLinki | Q9NRY4 |
SIGNORi | Q9NRY4 |
Miscellaneous databases
BioGRID-ORCSi | 2909, 31 hits in 1091 CRISPR screens |
ChiTaRSi | ARHGAP35, human |
EvolutionaryTracei | Q9NRY4 |
GeneWikii | GRLF1 |
GenomeRNAii | 2909 |
Pharosi | Q9NRY4, Tbio |
PROi | PR:Q9NRY4 |
RNActi | Q9NRY4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160007, Expressed in frontal cortex and 242 other tissues |
Genevisiblei | Q9NRY4, HS |
Family and domain databases
Gene3Di | 1.10.10.440, 2 hits 1.10.555.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR002713, FF_domain IPR036517, FF_domain_sf IPR027417, P-loop_NTPase IPR039007, pG1 IPR008936, Rho_GTPase_activation_prot IPR032835, RhoGAP-FF1 IPR000198, RhoGAP_dom IPR045786, RhoGAP_pG1_pG2 IPR039006, RhoGAP_pG2 IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF01846, FF, 1 hit PF00071, Ras, 1 hit PF00620, RhoGAP, 1 hit PF16512, RhoGAP-FF1, 1 hit PF19518, RhoGAP_pG1_pG2, 1 hit |
SMARTi | View protein in SMART SM00441, FF, 4 hits SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF52540, SSF52540, 1 hit SSF81698, SSF81698, 1 hit |
PROSITEi | View protein in PROSITE PS51676, FF, 4 hits PS51852, PG1, 1 hit PS51853, PG2, 1 hit PS50238, RHOGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG35_HUMAN | |
Accessioni | Q9NRY4Primary (citable) accession number: Q9NRY4 Secondary accession number(s): A7E2A4, Q14452, Q9C0E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2003 |
Last sequence update: | October 3, 2012 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references