Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SOSS complex subunit C

Gene

INIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.2 Publications

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA repair Source: UniProtKB
  • response to ionizing radiation Source: UniProtKB

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
SOSS complex subunit C
Alternative name(s):
INTS3- and NABP-interacting protein
Sensor of single-strand DNA complex subunit C
Sensor of ssDNA subunit C
Short name:
SOSS-C
Single-stranded DNA-binding protein-interacting protein 1
Short name:
SSB-interacting protein 1
Short name:
hSSBIP1
Gene namesi
Name:INIP
Synonyms:C9orf80, SSBIP1
ORF Names:HSPC043, HSPC291
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148153.13
HGNCiHGNC:24994 INIP
MIMi613273 gene
neXtProtiNX_Q9NRY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148153
PharmGKBiPA134992982

Polymorphism and mutation databases

BioMutaiINIP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002794192 – 104SOSS complex subunit CAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei50PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NRY2
MaxQBiQ9NRY2
PaxDbiQ9NRY2
PeptideAtlasiQ9NRY2
PRIDEiQ9NRY2
ProteomicsDBi82439
82440 [Q9NRY2-2]

PTM databases

iPTMnetiQ9NRY2
PhosphoSitePlusiQ9NRY2

Expressioni

Gene expression databases

BgeeiENSG00000148153 Expressed in 204 organ(s), highest expression level in corpus callosum
CleanExiHS_C9orf80
ExpressionAtlasiQ9NRY2 baseline and differential
GenevisibleiQ9NRY2 HS

Organism-specific databases

HPAiHPA020382

Interactioni

Subunit structurei

Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121823, 13 interactors
ComplexPortaliCPX-482 SOSS1 complex
CPX-614 SOSS2 complex
IntActiQ9NRY2, 12 interactors
STRINGi9606.ENSP00000363360

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NRY2
SMRiQ9NRY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SOSS-C family.Curated

Phylogenomic databases

eggNOGiENOG410IXVU Eukaryota
ENOG4111QHU LUCA
GeneTreeiENSGT00390000006366
HOGENOMiHOG000007001
InParanoidiQ9NRY2
OMAiQSMNSPG
OrthoDBiEOG091G13NG
PhylomeDBiQ9NRY2
TreeFamiTF328613

Family and domain databases

InterProiView protein in InterPro
IPR031821 SOSSC
PANTHERiPTHR31526 PTHR31526, 1 hit
PfamiView protein in Pfam
PF15925 SOSSC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANSSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPS
60 70 80 90 100
LNKDFRDHAE QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR

LDPE
Length:104
Mass (Da):11,425
Last modified:October 1, 2000 - v1
Checksum:i87B2467920C58C1E
GO
Isoform 2 (identifier: Q9NRY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-44: SI → RY
     45-104: Missing.

Note: No experimental confirmation available.
Show »
Length:44
Mass (Da):4,904
Checksum:i1C28B5D5743145D1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8P6X6R8P6_HUMAN
SOSS complex subunit C
INIP
74Annotation score:
Q5VWJ6Q5VWJ6_HUMAN
SOSS complex subunit C
INIP
55Annotation score:

Sequence cautioni

The sequence AAF28969 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH13097 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02342343 – 44SI → RY in isoform 2. 1 Publication2
Alternative sequenceiVSP_02342445 – 104Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161409 mRNA Translation: AAF28969.1 Different initiation.
AF161411 mRNA Translation: AAF28971.2
AL390067 Genomic DNA No translation available.
BC013097 mRNA Translation: AAH13097.1 Different initiation.
BC014881 mRNA Translation: AAH14881.1
BC065210 mRNA Translation: AAH65210.1
CCDSiCCDS6785.1 [Q9NRY2-1]
RefSeqiNP_067041.1, NM_021218.2 [Q9NRY2-1]
UniGeneiHs.658575

Genome annotation databases

EnsembliENST00000374242; ENSP00000363360; ENSG00000148153 [Q9NRY2-1]
GeneIDi58493
KEGGihsa:58493
UCSCiuc004bgg.4 human [Q9NRY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161409 mRNA Translation: AAF28969.1 Different initiation.
AF161411 mRNA Translation: AAF28971.2
AL390067 Genomic DNA No translation available.
BC013097 mRNA Translation: AAH13097.1 Different initiation.
BC014881 mRNA Translation: AAH14881.1
BC065210 mRNA Translation: AAH65210.1
CCDSiCCDS6785.1 [Q9NRY2-1]
RefSeqiNP_067041.1, NM_021218.2 [Q9NRY2-1]
UniGeneiHs.658575

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OWTX-ray2.00C1-104[»]
4OWWX-ray2.30C1-104[»]
ProteinModelPortaliQ9NRY2
SMRiQ9NRY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121823, 13 interactors
ComplexPortaliCPX-482 SOSS1 complex
CPX-614 SOSS2 complex
IntActiQ9NRY2, 12 interactors
STRINGi9606.ENSP00000363360

PTM databases

iPTMnetiQ9NRY2
PhosphoSitePlusiQ9NRY2

Polymorphism and mutation databases

BioMutaiINIP

Proteomic databases

EPDiQ9NRY2
MaxQBiQ9NRY2
PaxDbiQ9NRY2
PeptideAtlasiQ9NRY2
PRIDEiQ9NRY2
ProteomicsDBi82439
82440 [Q9NRY2-2]

Protocols and materials databases

DNASUi58493
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374242; ENSP00000363360; ENSG00000148153 [Q9NRY2-1]
GeneIDi58493
KEGGihsa:58493
UCSCiuc004bgg.4 human [Q9NRY2-1]

Organism-specific databases

CTDi58493
EuPathDBiHostDB:ENSG00000148153.13
GeneCardsiINIP
HGNCiHGNC:24994 INIP
HPAiHPA020382
MIMi613273 gene
neXtProtiNX_Q9NRY2
OpenTargetsiENSG00000148153
PharmGKBiPA134992982
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXVU Eukaryota
ENOG4111QHU LUCA
GeneTreeiENSGT00390000006366
HOGENOMiHOG000007001
InParanoidiQ9NRY2
OMAiQSMNSPG
OrthoDBiEOG091G13NG
PhylomeDBiQ9NRY2
TreeFamiTF328613

Miscellaneous databases

ChiTaRSiINIP human
GenomeRNAii58493
PROiPR:Q9NRY2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148153 Expressed in 204 organ(s), highest expression level in corpus callosum
CleanExiHS_C9orf80
ExpressionAtlasiQ9NRY2 baseline and differential
GenevisibleiQ9NRY2 HS

Family and domain databases

InterProiView protein in InterPro
IPR031821 SOSSC
PANTHERiPTHR31526 PTHR31526, 1 hit
PfamiView protein in Pfam
PF15925 SOSSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOSSC_HUMAN
AccessioniPrimary (citable) accession number: Q9NRY2
Secondary accession number(s): Q5VWJ7, Q96E04, Q9P090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again