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Entry version 159 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Serine incorporator 1

Gene

SERINC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977347 Serine biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERINC1
Synonyms:KIAA1253, TDE1L, TDE2
ORF Names:UNQ396/PRO732
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13464 SERINC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614548 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRX5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88LumenalSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 123CytoplasmicSequence analysisAdd BLAST14
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 151LumenalSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 197CytoplasmicSequence analysisAdd BLAST25
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231LumenalSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 259CytoplasmicSequence analysis7
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 309LumenalSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 387CytoplasmicSequence analysisAdd BLAST57
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 426LumenalSequence analysisAdd BLAST18
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 453CytoplasmicSequence analysis6

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57515

Open Targets

More...
OpenTargetsi
ENSG00000111897

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973249

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERINC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25453298

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189662 – 453Serine incorporator 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi298N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei351PhosphoserineCombined sources1
Modified residuei352PhosphothreonineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRX5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NRX5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRX5

PeptideAtlas

More...
PeptideAtlasi
Q9NRX5

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRX5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82437

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRX5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NRX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111897 Expressed in 237 organ(s), highest expression level in substantia nigra

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRX5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035738
HPA035739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SPTLC1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PAX8Q067102EBI-2683145,EBI-2683132

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121579, 48 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9NRX5

Protein interaction database and analysis system

More...
IntActi
Q9NRX5, 17 interactors

Molecular INTeraction database

More...
MINTi
Q9NRX5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342962

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2592 Eukaryota
ENOG410XP7K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182793

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRX5

Identification of Orthologs from Complete Genome Data

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OMAi
VCFGMAM

Database of Orthologous Groups

More...
OrthoDBi
1276632at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRX5

TreeFam database of animal gene trees

More...
TreeFami
TF312881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029557 Serinc1/3
IPR005016 TDE1/TMS

The PANTHER Classification System

More...
PANTHERi
PTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03348 Serinc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSVLGLCSM ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF AAAIAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAIVLFFVYY THPASCSENK AFISVNMLLC VGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGYNTT
310 320 330 340 350
STVPKEGQSV QWWHAQGIIG LILFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGGAR SDGSLEDGDD VHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGIVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,495
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3868DBF38165B78C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86567 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89A → S in AAH28607 (PubMed:15489334).Curated1
Sequence conflicti247S → F in AAP97200 (Ref. 1) Curated1
Sequence conflicti247S → F in AAP97211 (Ref. 1) Curated1
Sequence conflicti408Y → S in AAQ88795 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052275199L → V. Corresponds to variant dbSNP:rs13210569Ensembl.1
Natural variantiVAR_052276216F → V. Corresponds to variant dbSNP:rs13210446Ensembl.1
Natural variantiVAR_052277225S → G. Corresponds to variant dbSNP:rs17260829Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF087902 mRNA Translation: AAP97200.1
AF092436 Genomic DNA Translation: AAP97211.1
AB033079 mRNA Translation: BAA86567.1 Different initiation.
AL137261 mRNA Translation: CAB70662.2
AF164794 mRNA Translation: AAF80758.1
AY358429 mRNA Translation: AAQ88795.1
AK128781 mRNA Translation: BAG54731.1
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48172.1
CH471051 Genomic DNA Translation: EAW48173.1
BC028607 mRNA Translation: AAH28607.1
BC033029 mRNA Translation: AAH33029.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5125.1

NCBI Reference Sequences

More...
RefSeqi
NP_065806.1, NM_020755.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339697; ENSP00000342962; ENSG00000111897

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57515

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57515

UCSC genome browser

More...
UCSCi
uc003pyy.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA Translation: AAP97200.1
AF092436 Genomic DNA Translation: AAP97211.1
AB033079 mRNA Translation: BAA86567.1 Different initiation.
AL137261 mRNA Translation: CAB70662.2
AF164794 mRNA Translation: AAF80758.1
AY358429 mRNA Translation: AAQ88795.1
AK128781 mRNA Translation: BAG54731.1
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48172.1
CH471051 Genomic DNA Translation: EAW48173.1
BC028607 mRNA Translation: AAH28607.1
BC033029 mRNA Translation: AAH33029.1
CCDSiCCDS5125.1
RefSeqiNP_065806.1, NM_020755.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121579, 48 interactors
ELMiQ9NRX5
IntActiQ9NRX5, 17 interactors
MINTiQ9NRX5
STRINGi9606.ENSP00000342962

PTM databases

iPTMnetiQ9NRX5
PhosphoSitePlusiQ9NRX5
SwissPalmiQ9NRX5

Polymorphism and mutation databases

BioMutaiSERINC1
DMDMi25453298

Proteomic databases

EPDiQ9NRX5
jPOSTiQ9NRX5
MaxQBiQ9NRX5
PaxDbiQ9NRX5
PeptideAtlasiQ9NRX5
PRIDEiQ9NRX5
ProteomicsDBi82437

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57515
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897
GeneIDi57515
KEGGihsa:57515
UCSCiuc003pyy.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57515
DisGeNETi57515

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SERINC1
HGNCiHGNC:13464 SERINC1
HPAiHPA035738
HPA035739
MIMi614548 gene
neXtProtiNX_Q9NRX5
OpenTargetsiENSG00000111897
PharmGKBiPA134973249

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00950000182793
InParanoidiQ9NRX5
OMAiVCFGMAM
OrthoDBi1276632at2759
PhylomeDBiQ9NRX5
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SERINC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SERINC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57515

Protein Ontology

More...
PROi
PR:Q9NRX5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111897 Expressed in 237 organ(s), highest expression level in substantia nigra
GenevisibleiQ9NRX5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029557 Serinc1/3
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRX5
Secondary accession number(s): B3KY69
, E1P565, O75655, Q7Z2F5, Q8TAG1, Q9NTH8, Q9ULG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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