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Protein

Serine incorporator 1

Gene

SERINC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:SERINC1
Synonyms:KIAA1253, TDE1L, TDE2
ORF Names:UNQ396/PRO732
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111897.6
HGNCiHGNC:13464 SERINC1
MIMi614548 gene
neXtProtiNX_Q9NRX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88LumenalSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 123CytoplasmicSequence analysisAdd BLAST14
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 151LumenalSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 197CytoplasmicSequence analysisAdd BLAST25
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231LumenalSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 259CytoplasmicSequence analysis7
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 309LumenalSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 387CytoplasmicSequence analysisAdd BLAST57
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 426LumenalSequence analysisAdd BLAST18
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 453CytoplasmicSequence analysis6

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57515
OpenTargetsiENSG00000111897
PharmGKBiPA134973249

Polymorphism and mutation databases

BioMutaiSERINC1
DMDMi25453298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002189662 – 453Serine incorporator 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Glycosylationi298N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei351PhosphoserineCombined sources1
Modified residuei352PhosphothreonineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9NRX5
MaxQBiQ9NRX5
PaxDbiQ9NRX5
PeptideAtlasiQ9NRX5
PRIDEiQ9NRX5
ProteomicsDBi82437

PTM databases

iPTMnetiQ9NRX5
PhosphoSitePlusiQ9NRX5
SwissPalmiQ9NRX5

Expressioni

Gene expression databases

BgeeiENSG00000111897 Expressed in 237 organ(s), highest expression level in substantia nigra
CleanExiHS_SERINC1
GenevisibleiQ9NRX5 HS

Organism-specific databases

HPAiHPA035738
HPA035739

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PAX8Q067102EBI-2683145,EBI-2683132

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121579, 48 interactors
ELMiQ9NRX5
IntActiQ9NRX5, 17 interactors
MINTiQ9NRX5
STRINGi9606.ENSP00000342962

Structurei

3D structure databases

ProteinModelPortaliQ9NRX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOVERGENiHBG025699
InParanoidiQ9NRX5
OMAiVCFGMAM
OrthoDBiEOG091G07WS
PhylomeDBiQ9NRX5
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029552 SERINC1
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSVLGLCSM ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF AAAIAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAIVLFFVYY THPASCSENK AFISVNMLLC VGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGYNTT
310 320 330 340 350
STVPKEGQSV QWWHAQGIIG LILFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGGAR SDGSLEDGDD VHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGIVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,495
Last modified:October 1, 2000 - v1
Checksum:i3868DBF38165B78C
GO

Sequence cautioni

The sequence BAA86567 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89A → S in AAH28607 (PubMed:15489334).Curated1
Sequence conflicti247S → F in AAP97200 (Ref. 1) Curated1
Sequence conflicti247S → F in AAP97211 (Ref. 1) Curated1
Sequence conflicti408Y → S in AAQ88795 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052275199L → V. Corresponds to variant dbSNP:rs13210569Ensembl.1
Natural variantiVAR_052276216F → V. Corresponds to variant dbSNP:rs13210446Ensembl.1
Natural variantiVAR_052277225S → G. Corresponds to variant dbSNP:rs17260829Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA Translation: AAP97200.1
AF092436 Genomic DNA Translation: AAP97211.1
AB033079 mRNA Translation: BAA86567.1 Different initiation.
AL137261 mRNA Translation: CAB70662.2
AF164794 mRNA Translation: AAF80758.1
AY358429 mRNA Translation: AAQ88795.1
AK128781 mRNA Translation: BAG54731.1
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48172.1
CH471051 Genomic DNA Translation: EAW48173.1
BC028607 mRNA Translation: AAH28607.1
BC033029 mRNA Translation: AAH33029.1
CCDSiCCDS5125.1
RefSeqiNP_065806.1, NM_020755.3
UniGeneiHs.146668

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897
GeneIDi57515
KEGGihsa:57515
UCSCiuc003pyy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA Translation: AAP97200.1
AF092436 Genomic DNA Translation: AAP97211.1
AB033079 mRNA Translation: BAA86567.1 Different initiation.
AL137261 mRNA Translation: CAB70662.2
AF164794 mRNA Translation: AAF80758.1
AY358429 mRNA Translation: AAQ88795.1
AK128781 mRNA Translation: BAG54731.1
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48172.1
CH471051 Genomic DNA Translation: EAW48173.1
BC028607 mRNA Translation: AAH28607.1
BC033029 mRNA Translation: AAH33029.1
CCDSiCCDS5125.1
RefSeqiNP_065806.1, NM_020755.3
UniGeneiHs.146668

3D structure databases

ProteinModelPortaliQ9NRX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121579, 48 interactors
ELMiQ9NRX5
IntActiQ9NRX5, 17 interactors
MINTiQ9NRX5
STRINGi9606.ENSP00000342962

PTM databases

iPTMnetiQ9NRX5
PhosphoSitePlusiQ9NRX5
SwissPalmiQ9NRX5

Polymorphism and mutation databases

BioMutaiSERINC1
DMDMi25453298

Proteomic databases

EPDiQ9NRX5
MaxQBiQ9NRX5
PaxDbiQ9NRX5
PeptideAtlasiQ9NRX5
PRIDEiQ9NRX5
ProteomicsDBi82437

Protocols and materials databases

DNASUi57515
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897
GeneIDi57515
KEGGihsa:57515
UCSCiuc003pyy.2 human

Organism-specific databases

CTDi57515
DisGeNETi57515
EuPathDBiHostDB:ENSG00000111897.6
GeneCardsiSERINC1
HGNCiHGNC:13464 SERINC1
HPAiHPA035738
HPA035739
MIMi614548 gene
neXtProtiNX_Q9NRX5
OpenTargetsiENSG00000111897
PharmGKBiPA134973249
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOVERGENiHBG025699
InParanoidiQ9NRX5
OMAiVCFGMAM
OrthoDBiEOG091G07WS
PhylomeDBiQ9NRX5
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRSiSERINC1 human
GeneWikiiSERINC1
GenomeRNAii57515
PROiPR:Q9NRX5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111897 Expressed in 237 organ(s), highest expression level in substantia nigra
CleanExiHS_SERINC1
GenevisibleiQ9NRX5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029552 SERINC1
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSERC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX5
Secondary accession number(s): B3KY69
, E1P565, O75655, Q7Z2F5, Q8TAG1, Q9NTH8, Q9ULG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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