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UniProtKB - Q9NRX4 (PHP14_HUMAN)
Protein
14 kDa phosphohistidine phosphatase
Gene
PHPT1
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits phosphohistidine phosphatase activity.
2 PublicationsCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 21 | Substrate1 Publication | 1 | |
Active sitei | 53 | Proton acceptor1 Publication | 1 |
GO - Molecular functioni
- calcium channel inhibitor activity Source: BHF-UCL
- protein histidine phosphatase activity Source: BHF-UCL
- transmembrane transporter binding Source: BHF-UCL
GO - Biological processi
- negative regulation of ATP citrate synthase activity Source: BHF-UCL
- negative regulation of lyase activity Source: BHF-UCL
- negative regulation of T cell receptor signaling pathway Source: BHF-UCL
- peptidyl-histidine dephosphorylation Source: BHF-UCL
- positive regulation of cell motility Source: BHF-UCL
- protein dephosphorylation Source: BHF-UCL
- regulation of actin cytoskeleton reorganization Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.9.1.3, 2681 |
PathwayCommonsi | Q9NRX4 |
SignaLinki | Q9NRX4 |
Names & Taxonomyi
Protein namesi | Recommended name: 14 kDa phosphohistidine phosphatase1 Publication (EC:3.9.1.32 Publications)Alternative name(s): Phosphohistidine phosphatase 11 Publication Short name: PHPT11 Publication Protein histidine phosphatase1 Publication Short name: PHP1 Publication Protein janus-A homolog |
Gene namesi | Name:PHPT1 Synonyms:PHP14 ORF Names:CGI-202, HSPC141 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30033, PHPT1 |
MIMi | 610167, gene |
neXtProti | NX_Q9NRX4 |
VEuPathDBi | HostDB:ENSG00000054148 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 21 | K → A: Decreased affinity for substrate and strongly reduced catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 45 | R → A: Slightly decreased affinity for substrate, but no effect on catalytic activity. 2 Publications | 1 | |
Mutagenesisi | 53 | H → A: Loss of activity. 2 Publications | 1 | |
Mutagenesisi | 78 | R → A: Decreased affinity for substrate and reduced catalytic activity. 2 Publications | 1 | |
Mutagenesisi | 94 | S → A: Decreased affinity for substrate and strongly reduced catalytic activity. | 1 | |
Mutagenesisi | 102 | H → A: Decreased affinity for substrate and slightly reduced catalytic activity. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 29085 |
OpenTargetsi | ENSG00000054148 |
PharmGKBi | PA134948141 |
Miscellaneous databases
Pharosi | Q9NRX4, Tbio |
Genetic variation databases
BioMutai | PHPT1 |
DMDMi | 25008934 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000206152 | 2 – 125 | 14 kDa phosphohistidine phosphataseAdd BLAST | 124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9NRX4 |
jPOSTi | Q9NRX4 |
MassIVEi | Q9NRX4 |
MaxQBi | Q9NRX4 |
PaxDbi | Q9NRX4 |
PeptideAtlasi | Q9NRX4 |
PRIDEi | Q9NRX4 |
ProteomicsDBi | 82435 [Q9NRX4-1] 82436 [Q9NRX4-2] |
TopDownProteomicsi | Q9NRX4-1 [Q9NRX4-1] |
PTM databases
DEPODi | PHPT1 |
iPTMneti | Q9NRX4 |
MetOSitei | Q9NRX4 |
PhosphoSitePlusi | Q9NRX4 |
Expressioni
Tissue specificityi
Expressed abundantly in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000054148, Expressed in apex of heart and 196 other tissues |
ExpressionAtlasi | Q9NRX4, baseline and differential |
Genevisiblei | Q9NRX4, HS |
Organism-specific databases
HPAi | ENSG00000054148, Tissue enhanced (tongue) |
Interactioni
Subunit structurei
Monomer.
1 PublicationBinary interactionsi
GO - Molecular functioni
- transmembrane transporter binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 118854, 40 interactors |
DIPi | DIP-48597N |
IntActi | Q9NRX4, 8 interactors |
STRINGi | 9606.ENSP00000247665 |
Miscellaneous databases
RNActi | Q9NRX4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9NRX4 |
SMRi | Q9NRX4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NRX4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 96 | Substrate binding1 Publication | 3 |
Sequence similaritiesi
Belongs to the janus family.Curated
Phylogenomic databases
eggNOGi | ENOG502S4DR, Eukaryota |
GeneTreei | ENSGT00390000002738 |
HOGENOMi | CLU_120717_0_1_1 |
InParanoidi | Q9NRX4 |
OMAi | VRYPDYE |
OrthoDBi | 1529401at2759 |
PhylomeDBi | Q9NRX4 |
TreeFami | TF315158 |
Family and domain databases
Gene3Di | 3.50.20.20, 1 hit |
InterProi | View protein in InterPro IPR007702, Janus IPR038596, Janus_sf IPR028441, PHPT1 |
PANTHERi | PTHR12258, PTHR12258, 1 hit PTHR12258:SF10, PTHR12258:SF10, 1 hit |
Pfami | View protein in Pfam PF05005, Ocnus, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9NRX4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVADLALIP DVDIDSDGVF KYVLIRVHSA PRSGAPAAES KEIVRGYKWA
60 70 80 90 100
EYHADIYDKV SGDMQKQGCD CECLGGGRIS HQSQDKKIHV YGYSMAYGPA
110 120
QHAISTEKIK AKYPDYEVTW ANDGY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | I → T in CAB66579 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 27 | V → I in CAB66579 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 79 | I → T in CAB66579 (PubMed:11230166).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041159 | 96 – 125 | AYGPA…ANDGY → MRPTCVPLGASGPRIHHQGL WSCPARHFN in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF393504 mRNA Translation: AAN52504.1 AF164795 mRNA Translation: AAF80759.1 AF285119 mRNA Translation: AAG01156.1 AL136644 mRNA Translation: CAB66579.1 AL355987 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88289.1 BC024648 mRNA Translation: AAH24648.1 BQ922335 mRNA No translation available. |
CCDSi | CCDS48060.1 [Q9NRX4-2] CCDS7009.1 [Q9NRX4-1] |
RefSeqi | NP_001129333.1, NM_001135861.2 [Q9NRX4-2] NP_054891.2, NM_014172.5 [Q9NRX4-1] |
Genome annotation databases
Ensembli | ENST00000247665; ENSP00000247665; ENSG00000054148 ENST00000371661; ENSP00000360724; ENSG00000054148 [Q9NRX4-2] |
GeneIDi | 29085 |
KEGGi | hsa:29085 |
MANE-Selecti | ENST00000247665.12; ENSP00000247665.10; NM_014172.6; NP_054891.2 |
UCSCi | uc064xew.1, human [Q9NRX4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF393504 mRNA Translation: AAN52504.1 AF164795 mRNA Translation: AAF80759.1 AF285119 mRNA Translation: AAG01156.1 AL136644 mRNA Translation: CAB66579.1 AL355987 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88289.1 BC024648 mRNA Translation: AAH24648.1 BQ922335 mRNA No translation available. |
CCDSi | CCDS48060.1 [Q9NRX4-2] CCDS7009.1 [Q9NRX4-1] |
RefSeqi | NP_001129333.1, NM_001135861.2 [Q9NRX4-2] NP_054891.2, NM_014172.5 [Q9NRX4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2AI6 | NMR | - | A | 1-125 | [»] | |
2HW4 | X-ray | 1.90 | A | 5-125 | [»] | |
2NMM | X-ray | 2.70 | A/B/C | 1-125 | [»] | |
2OZW | NMR | - | A | 1-125 | [»] | |
2OZX | NMR | - | A | 1-125 | [»] | |
BMRBi | Q9NRX4 | |||||
SMRi | Q9NRX4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118854, 40 interactors |
DIPi | DIP-48597N |
IntActi | Q9NRX4, 8 interactors |
STRINGi | 9606.ENSP00000247665 |
PTM databases
DEPODi | PHPT1 |
iPTMneti | Q9NRX4 |
MetOSitei | Q9NRX4 |
PhosphoSitePlusi | Q9NRX4 |
Genetic variation databases
BioMutai | PHPT1 |
DMDMi | 25008934 |
Proteomic databases
EPDi | Q9NRX4 |
jPOSTi | Q9NRX4 |
MassIVEi | Q9NRX4 |
MaxQBi | Q9NRX4 |
PaxDbi | Q9NRX4 |
PeptideAtlasi | Q9NRX4 |
PRIDEi | Q9NRX4 |
ProteomicsDBi | 82435 [Q9NRX4-1] 82436 [Q9NRX4-2] |
TopDownProteomicsi | Q9NRX4-1 [Q9NRX4-1] |
Protocols and materials databases
Antibodypediai | 18807, 382 antibodies from 31 providers |
DNASUi | 29085 |
Genome annotation databases
Ensembli | ENST00000247665; ENSP00000247665; ENSG00000054148 ENST00000371661; ENSP00000360724; ENSG00000054148 [Q9NRX4-2] |
GeneIDi | 29085 |
KEGGi | hsa:29085 |
MANE-Selecti | ENST00000247665.12; ENSP00000247665.10; NM_014172.6; NP_054891.2 |
UCSCi | uc064xew.1, human [Q9NRX4-1] |
Organism-specific databases
CTDi | 29085 |
DisGeNETi | 29085 |
GeneCardsi | PHPT1 |
HGNCi | HGNC:30033, PHPT1 |
HPAi | ENSG00000054148, Tissue enhanced (tongue) |
MIMi | 610167, gene |
neXtProti | NX_Q9NRX4 |
OpenTargetsi | ENSG00000054148 |
PharmGKBi | PA134948141 |
VEuPathDBi | HostDB:ENSG00000054148 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4DR, Eukaryota |
GeneTreei | ENSGT00390000002738 |
HOGENOMi | CLU_120717_0_1_1 |
InParanoidi | Q9NRX4 |
OMAi | VRYPDYE |
OrthoDBi | 1529401at2759 |
PhylomeDBi | Q9NRX4 |
TreeFami | TF315158 |
Enzyme and pathway databases
BRENDAi | 3.9.1.3, 2681 |
PathwayCommonsi | Q9NRX4 |
SignaLinki | Q9NRX4 |
Miscellaneous databases
BioGRID-ORCSi | 29085, 18 hits in 1046 CRISPR screens |
ChiTaRSi | PHPT1, human |
EvolutionaryTracei | Q9NRX4 |
GeneWikii | PHPT1 |
GenomeRNAii | 29085 |
Pharosi | Q9NRX4, Tbio |
PROi | PR:Q9NRX4 |
RNActi | Q9NRX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000054148, Expressed in apex of heart and 196 other tissues |
ExpressionAtlasi | Q9NRX4, baseline and differential |
Genevisiblei | Q9NRX4, HS |
Family and domain databases
Gene3Di | 3.50.20.20, 1 hit |
InterProi | View protein in InterPro IPR007702, Janus IPR038596, Janus_sf IPR028441, PHPT1 |
PANTHERi | PTHR12258, PTHR12258, 1 hit PTHR12258:SF10, PTHR12258:SF10, 1 hit |
Pfami | View protein in Pfam PF05005, Ocnus, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PHP14_HUMAN | |
Accessioni | Q9NRX4Primary (citable) accession number: Q9NRX4 Secondary accession number(s): B1AMX0, B1AMX1, Q9H0Y3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families