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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Gene

NDUFA4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Alternative name(s):
NADH-ubiquinone oxidoreductase MLRQ subunit homolog
Short name:
NUOMS
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185633.10
HGNCiHGNC:29836 NDUFA4L2
neXtProtiNX_Q9NRX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi56901
OpenTargetsiENSG00000185633
PharmGKBiPA144596402

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFA4L2
DMDMi23396790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188251 – 87NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Add BLAST87

Proteomic databases

MaxQBiQ9NRX3
PaxDbiQ9NRX3
PeptideAtlasiQ9NRX3
PRIDEiQ9NRX3
ProteomicsDBi82434

PTM databases

iPTMnetiQ9NRX3
PhosphoSitePlusiQ9NRX3

Expressioni

Gene expression databases

BgeeiENSG00000185633 Expressed in 169 organ(s), highest expression level in ectocervix
CleanExiHS_NDUFA4L2
ExpressionAtlasiQ9NRX3 baseline and differential
GenevisibleiQ9NRX3 HS

Organism-specific databases

HPAiHPA055323

Interactioni

Protein-protein interaction databases

BioGridi121231, 15 interactors
IntActiQ9NRX3, 14 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NRX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J463 Eukaryota
ENOG410XWHY LUCA
GeneTreeiENSGT00390000010457
HOGENOMiHOG000261679
HOVERGENiHBG006548
InParanoidiQ9NRX3
KOiK03948
OMAiFFFICLG
PhylomeDBiQ9NRX3
TreeFamiTF106383

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW
60 70 80
DRKNNPEPWN RLSPNDQYKF LAVSTDYKKL KKDRPDF
Length:87
Mass (Da):9,966
Last modified:October 1, 2000 - v1
Checksum:iA08D7182A0A3CA87
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V560G3V560_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA4L2
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164796 mRNA Translation: AAF80760.1
CR457176 mRNA Translation: CAG33457.1
BC011910 mRNA Translation: AAH11910.1
CCDSiCCDS8935.1
RefSeqiNP_064527.1, NM_020142.3
UniGeneiHs.75069

Genome annotation databases

EnsembliENST00000393825; ENSP00000377411; ENSG00000185633
ENST00000554503; ENSP00000450664; ENSG00000185633
GeneIDi56901
KEGGihsa:56901
UCSCiuc001sno.4 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164796 mRNA Translation: AAF80760.1
CR457176 mRNA Translation: CAG33457.1
BC011910 mRNA Translation: AAH11910.1
CCDSiCCDS8935.1
RefSeqiNP_064527.1, NM_020142.3
UniGeneiHs.75069

3D structure databases

ProteinModelPortaliQ9NRX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121231, 15 interactors
IntActiQ9NRX3, 14 interactors

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

PTM databases

iPTMnetiQ9NRX3
PhosphoSitePlusiQ9NRX3

Polymorphism and mutation databases

BioMutaiNDUFA4L2
DMDMi23396790

Proteomic databases

MaxQBiQ9NRX3
PaxDbiQ9NRX3
PeptideAtlasiQ9NRX3
PRIDEiQ9NRX3
ProteomicsDBi82434

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393825; ENSP00000377411; ENSG00000185633
ENST00000554503; ENSP00000450664; ENSG00000185633
GeneIDi56901
KEGGihsa:56901
UCSCiuc001sno.4 human

Organism-specific databases

CTDi56901
DisGeNETi56901
EuPathDBiHostDB:ENSG00000185633.10
GeneCardsiNDUFA4L2
HGNCiHGNC:29836 NDUFA4L2
HPAiHPA055323
neXtProtiNX_Q9NRX3
OpenTargetsiENSG00000185633
PharmGKBiPA144596402
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J463 Eukaryota
ENOG410XWHY LUCA
GeneTreeiENSGT00390000010457
HOGENOMiHOG000261679
HOVERGENiHBG006548
InParanoidiQ9NRX3
KOiK03948
OMAiFFFICLG
PhylomeDBiQ9NRX3
TreeFamiTF106383

Miscellaneous databases

GenomeRNAii56901
PROiPR:Q9NRX3

Gene expression databases

BgeeiENSG00000185633 Expressed in 169 organ(s), highest expression level in ectocervix
CleanExiHS_NDUFA4L2
ExpressionAtlasiQ9NRX3 baseline and differential
GenevisibleiQ9NRX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUA4L_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX3
Secondary accession number(s): Q6IAH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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