NDUFA4L2

Functionⁱ

GO - Biological processⁱ

electron transport chain Source: GOC
proton transmembrane transport Source: GOC

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 Alternative name(s): NADH-ubiquinone oxidoreductase MLRQ subunit homolog Short name: NUOMS
Gene namesⁱ	Name:NDUFA4L2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185633.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29836 NDUFA4L2
neXtProtⁱ	NX_Q9NRX3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56901
Open Targets More...OpenTargetsⁱ	ENSG00000185633
PharmGKBⁱ	PA144596402

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
Drug and drug target database More...DrugBankⁱ	DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	NDUFA4L2
DMDMⁱ	23396790

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118825	1 – 87	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Add BLAST		87

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NRX3
PaxDbⁱ	Q9NRX3
PeptideAtlas More...PeptideAtlasⁱ	Q9NRX3
PRIDEⁱ	Q9NRX3
ProteomicsDBⁱ	82434

PTM databases

iPTMnetⁱ	Q9NRX3
PhosphoSitePlusⁱ	Q9NRX3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185633 Expressed in 169 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_NDUFA4L2
ExpressionAtlasⁱ	Q9NRX3 baseline and differential
Genevisibleⁱ	Q9NRX3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055323

HPAⁱ

HPA055323

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	121231, 15 interactors
IntActⁱ	Q9NRX3, 14 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NRX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J463 Eukaryota ENOG410XWHY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010457
HOGENOMⁱ	HOG000261679
HOVERGENⁱ	HBG006548
InParanoidⁱ	Q9NRX3
KEGG Orthology (KO) More...KOⁱ	K03948
OMAⁱ	FFFICLG
PhylomeDBⁱ	Q9NRX3
TreeFamⁱ	TF106383

Family and domain databases

InterProⁱ	View protein in InterPro IPR010530 B12D
PANTHERⁱ	PTHR14256 PTHR14256, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06522 B12D, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9NRX3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW 
        60         70         80 
DRKNNPEPWN RLSPNDQYKF LAVSTDYKKL KKDRPDF

Length:87

Mass (Da):9,966

Last modified:October 1, 2000 - v1

Checksum:ⁱA08D7182A0A3CA87

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V560	G3V560_HUMAN		NADH dehydrogenase [ubiquinone] 1 a... NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	93	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF164796 mRNA Translation: AAF80760.1 CR457176 mRNA Translation: CAG33457.1 BC011910 mRNA Translation: AAH11910.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8935.1
NCBI Reference Sequences More...RefSeqⁱ	NP_064527.1, NM_020142.3
UniGeneⁱ	Hs.75069

Genome annotation databases

Ensemblⁱ	ENST00000393825; ENSP00000377411; ENSG00000185633 ENST00000554503; ENSP00000450664; ENSG00000185633
GeneIDⁱ	56901
KEGGⁱ	hsa:56901
UCSC genome browser More...UCSCⁱ	uc001sno.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q9NRX3	NADH:ubiquinone oxidoreductase MLRQ subunit homolog, isoform CRA_a		HUMAN		87	UniRef100_Q9NRX3
NDUFA4, mitochondrial complex associated like 2		PANTR		87
NDUFA4, mitochondrial complex associated like 2		PONAB		87
Uncharacterized protein		PANPA		87
NDUFA4, mitochondrial complex associated like 2		GORGO		87
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9NRX3	NADH:ubiquinone oxidoreductase MLRQ subunit homolog, isoform CRA_a		HUMAN		87	UniRef90_Q9NRX3
NDUFA4, mitochondrial complex associated like 2		PANTR		87
NDUFA4, mitochondrial complex associated like 2		PONAB		87
Uncharacterized protein		PANPA		87
NDUFA4, mitochondrial complex associated like 2		GORGO		87
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9NRX3	NADH:ubiquinone oxidoreductase MLRQ subunit homolog, isoform CRA_a		HUMAN		87	UniRef50_Q9NRX3
NDUFA4, mitochondrial complex associated like 2		PANTR		87
NDUFA4, mitochondrial complex associated like 2		PONAB		87
Uncharacterized protein		PANPA		87
NDUFA4, mitochondrial complex associated like 2		GORGO		87
+6

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF164796 mRNA Translation: AAF80760.1 CR457176 mRNA Translation: CAG33457.1 BC011910 mRNA Translation: AAH11910.1
CCDSⁱ	CCDS8935.1
RefSeqⁱ	NP_064527.1, NM_020142.3
UniGeneⁱ	Hs.75069

3D structure databases

ProteinModelPortalⁱ	Q9NRX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121231, 15 interactors
IntActⁱ	Q9NRX3, 14 interactors

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
DrugBankⁱ	DB00157 NADH

PTM databases

iPTMnetⁱ	Q9NRX3
PhosphoSitePlusⁱ	Q9NRX3

Polymorphism and mutation databases

BioMutaⁱ	NDUFA4L2
DMDMⁱ	23396790

Proteomic databases

MaxQBⁱ	Q9NRX3
PaxDbⁱ	Q9NRX3
PeptideAtlasⁱ	Q9NRX3
PRIDEⁱ	Q9NRX3
ProteomicsDBⁱ	82434

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000393825; ENSP00000377411; ENSG00000185633 ENST00000554503; ENSP00000450664; ENSG00000185633
GeneIDⁱ	56901
KEGGⁱ	hsa:56901
UCSCⁱ	uc001sno.4 human

Organism-specific databases

CTDⁱ	56901
DisGeNETⁱ	56901
EuPathDBⁱ	HostDB:ENSG00000185633.10
GeneCardsⁱ	NDUFA4L2
HGNCⁱ	HGNC:29836 NDUFA4L2
HPAⁱ	HPA055323
neXtProtⁱ	NX_Q9NRX3
OpenTargetsⁱ	ENSG00000185633
PharmGKBⁱ	PA144596402
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J463 Eukaryota ENOG410XWHY LUCA
GeneTreeⁱ	ENSGT00390000010457
HOGENOMⁱ	HOG000261679
HOVERGENⁱ	HBG006548
InParanoidⁱ	Q9NRX3
KOⁱ	K03948
OMAⁱ	FFFICLG
PhylomeDBⁱ	Q9NRX3
TreeFamⁱ	TF106383

Miscellaneous databases

GenomeRNAiⁱ	56901
Protein Ontology More...PROⁱ	PR:Q9NRX3

Gene expression databases

Bgeeⁱ	ENSG00000185633 Expressed in 169 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_NDUFA4L2
ExpressionAtlasⁱ	Q9NRX3 baseline and differential
Genevisibleⁱ	Q9NRX3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010530 B12D
PANTHERⁱ	PTHR14256 PTHR14256, 1 hit
Pfamⁱ	View protein in Pfam PF06522 B12D, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUA4L_HUMAN
Accessionⁱ	Q9NRX3Primary (citable) accession number: Q9NRX3 Secondary accession number(s): Q6IAH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NRX3 (NUA4L_HUMAN)

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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ