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UniProtKB - Q9NRX3 (NUA4L_HUMAN)
Protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Gene
NDUFA4L2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Alternative name(s): NADH-ubiquinone oxidoreductase MLRQ subunit homolog Short name: NUOMS |
Gene namesi | Name:NDUFA4L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29836, NDUFA4L2 |
neXtProti | NX_Q9NRX3 |
VEuPathDBi | HostDB:ENSG00000185633 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56901 |
OpenTargetsi | ENSG00000185633 |
PharmGKBi | PA144596402 |
Miscellaneous databases
Pharosi | Q9NRX3, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | Q9NRX3 |
Genetic variation databases
BioMutai | NDUFA4L2 |
DMDMi | 23396790 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118825 | 1 – 87 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Add BLAST | 87 |
Proteomic databases
MassIVEi | Q9NRX3 |
MaxQBi | Q9NRX3 |
PaxDbi | Q9NRX3 |
PeptideAtlasi | Q9NRX3 |
PRIDEi | Q9NRX3 |
ProteomicsDBi | 82434 |
PTM databases
iPTMneti | Q9NRX3 |
PhosphoSitePlusi | Q9NRX3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185633, Expressed in ectocervix and 186 other tissues |
ExpressionAtlasi | Q9NRX3, baseline and differential |
Genevisiblei | Q9NRX3, HS |
Organism-specific databases
HPAi | ENSG00000185633, Tissue enhanced (esophagus) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121231, 22 interactors |
IntActi | Q9NRX3, 19 interactors |
MINTi | Q9NRX3 |
STRINGi | 9606.ENSP00000377411 |
Chemistry databases
BindingDBi | Q9NRX3 |
Miscellaneous databases
RNActi | Q9NRX3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFA4 subunit family.Curated
Phylogenomic databases
eggNOGi | ENOG502SG4Q, Eukaryota |
GeneTreei | ENSGT00940000161040 |
HOGENOMi | CLU_181002_0_0_1 |
InParanoidi | Q9NRX3 |
OMAi | TWNKTDN |
OrthoDBi | 1552648at2759 |
PhylomeDBi | Q9NRX3 |
TreeFami | TF106383 |
Family and domain databases
InterProi | View protein in InterPro IPR010530, B12D |
PANTHERi | PTHR14256, PTHR14256, 1 hit |
Pfami | View protein in Pfam PF06522, B12D, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NRX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW
60 70 80
DRKNNPEPWN RLSPNDQYKF LAVSTDYKKL KKDRPDF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V560 | G3V560_HUMAN | NADH dehydrogenase [ubiquinone] 1 a... | NDUFA4L2 | 93 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF164796 mRNA Translation: AAF80760.1 CR457176 mRNA Translation: CAG33457.1 BC011910 mRNA Translation: AAH11910.1 |
CCDSi | CCDS8935.1 |
RefSeqi | NP_064527.1, NM_020142.3 |
Genome annotation databases
Ensembli | ENST00000393825; ENSP00000377411; ENSG00000185633 ENST00000554503; ENSP00000450664; ENSG00000185633 |
GeneIDi | 56901 |
KEGGi | hsa:56901 |
MANE-Selecti | ENST00000554503.6; ENSP00000450664.1; NM_001394961.1; NP_001381890.1 |
UCSCi | uc001sno.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF164796 mRNA Translation: AAF80760.1 CR457176 mRNA Translation: CAG33457.1 BC011910 mRNA Translation: AAH11910.1 |
CCDSi | CCDS8935.1 |
RefSeqi | NP_064527.1, NM_020142.3 |
3D structure databases
SMRi | Q9NRX3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121231, 22 interactors |
IntActi | Q9NRX3, 19 interactors |
MINTi | Q9NRX3 |
STRINGi | 9606.ENSP00000377411 |
Chemistry databases
BindingDBi | Q9NRX3 |
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | Q9NRX3 |
PTM databases
iPTMneti | Q9NRX3 |
PhosphoSitePlusi | Q9NRX3 |
Genetic variation databases
BioMutai | NDUFA4L2 |
DMDMi | 23396790 |
Proteomic databases
MassIVEi | Q9NRX3 |
MaxQBi | Q9NRX3 |
PaxDbi | Q9NRX3 |
PeptideAtlasi | Q9NRX3 |
PRIDEi | Q9NRX3 |
ProteomicsDBi | 82434 |
Protocols and materials databases
Antibodypediai | 43977, 143 antibodies from 23 providers |
DNASUi | 56901 |
Genome annotation databases
Ensembli | ENST00000393825; ENSP00000377411; ENSG00000185633 ENST00000554503; ENSP00000450664; ENSG00000185633 |
GeneIDi | 56901 |
KEGGi | hsa:56901 |
MANE-Selecti | ENST00000554503.6; ENSP00000450664.1; NM_001394961.1; NP_001381890.1 |
UCSCi | uc001sno.4, human |
Organism-specific databases
CTDi | 56901 |
DisGeNETi | 56901 |
GeneCardsi | NDUFA4L2 |
HGNCi | HGNC:29836, NDUFA4L2 |
HPAi | ENSG00000185633, Tissue enhanced (esophagus) |
neXtProti | NX_Q9NRX3 |
OpenTargetsi | ENSG00000185633 |
PharmGKBi | PA144596402 |
VEuPathDBi | HostDB:ENSG00000185633 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SG4Q, Eukaryota |
GeneTreei | ENSGT00940000161040 |
HOGENOMi | CLU_181002_0_0_1 |
InParanoidi | Q9NRX3 |
OMAi | TWNKTDN |
OrthoDBi | 1552648at2759 |
PhylomeDBi | Q9NRX3 |
TreeFami | TF106383 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRX3 |
SignaLinki | Q9NRX3 |
Miscellaneous databases
BioGRID-ORCSi | 56901, 7 hits in 1038 CRISPR screens |
ChiTaRSi | NDUFA4L2, human |
GenomeRNAii | 56901 |
Pharosi | Q9NRX3, Tclin |
PROi | PR:Q9NRX3 |
RNActi | Q9NRX3, protein |
Gene expression databases
Bgeei | ENSG00000185633, Expressed in ectocervix and 186 other tissues |
ExpressionAtlasi | Q9NRX3, baseline and differential |
Genevisiblei | Q9NRX3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010530, B12D |
PANTHERi | PTHR14256, PTHR14256, 1 hit |
Pfami | View protein in Pfam PF06522, B12D, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NUA4L_HUMAN | |
Accessioni | Q9NRX3Primary (citable) accession number: Q9NRX3 Secondary accession number(s): Q6IAH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families