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UniProtKB - Q9NRX3 (NUA4L_HUMAN)

Entry version 137 (07 Apr 2021)
Sequence version 1 (01 Oct 2000)
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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Gene

NDUFA4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:G66-33023-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRX3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Alternative name(s):
NADH-ubiquinone oxidoreductase MLRQ subunit homolog
Short name:
NUOMS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFA4L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29836, NDUFA4L2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRX3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185633.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56901

Open Targets

More...OpenTargetsi		ENSG00000185633

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596402

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRX3, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363065

Drug and drug target database

More...DrugBanki		DB00157, NADH

DrugCentral

More...DrugCentrali		Q9NRX3

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NDUFA4L2

Domain mapping of disease mutations (DMDM)

More...DMDMi		23396790

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188251 – 87NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Add BLAST87

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRX3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRX3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRX3

PeptideAtlas

More...PeptideAtlasi		Q9NRX3

PRoteomics IDEntifications database

More...PRIDEi		Q9NRX3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82434

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185633, Expressed in ectocervix and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRX3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRX3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185633, Tissue enhanced (esophagus, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121231, 22 interactors

Protein interaction database and analysis system

More...IntActi		Q9NRX3, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377411

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NRX3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRX3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRX3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SG4Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161040

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_181002_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRX3

Identification of Orthologs from Complete Genome Data

More...OMAi		EPWNNLD

Database of Orthologous Groups

More...OrthoDBi		1552648at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRX3

TreeFam database of animal gene trees

More...TreeFami		TF106383

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010530, B12D

The PANTHER Classification System

More...PANTHERi		PTHR14256, PTHR14256, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06522, B12D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW 
        60         70         80 
DRKNNPEPWN RLSPNDQYKF LAVSTDYKKL KKDRPDF
Length:87
Mass (Da):9,966
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA08D7182A0A3CA87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V560G3V560_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA4L2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF164796 mRNA Translation: AAF80760.1
CR457176 mRNA Translation: CAG33457.1
BC011910 mRNA Translation: AAH11910.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8935.1

NCBI Reference Sequences

More...RefSeqi		NP_064527.1, NM_020142.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393825; ENSP00000377411; ENSG00000185633
ENST00000554503; ENSP00000450664; ENSG00000185633

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56901

UCSC genome browser

More...UCSCi		uc001sno.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164796 mRNA Translation: AAF80760.1
CR457176 mRNA Translation: CAG33457.1
BC011910 mRNA Translation: AAH11910.1
CCDSiCCDS8935.1
RefSeqiNP_064527.1, NM_020142.3

3D structure databases

SMRiQ9NRX3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121231, 22 interactors
IntActiQ9NRX3, 19 interactors
STRINGi9606.ENSP00000377411

Chemistry databases

BindingDBiQ9NRX3
ChEMBLiCHEMBL2363065
DrugBankiDB00157, NADH
DrugCentraliQ9NRX3

PTM databases

iPTMnetiQ9NRX3
PhosphoSitePlusiQ9NRX3

Genetic variation databases

BioMutaiNDUFA4L2
DMDMi23396790

Proteomic databases

MassIVEiQ9NRX3
MaxQBiQ9NRX3
PaxDbiQ9NRX3
PeptideAtlasiQ9NRX3
PRIDEiQ9NRX3
ProteomicsDBi82434

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43977, 131 antibodies

Genome annotation databases

EnsembliENST00000393825; ENSP00000377411; ENSG00000185633
ENST00000554503; ENSP00000450664; ENSG00000185633
GeneIDi56901
KEGGihsa:56901
UCSCiuc001sno.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56901
DisGeNETi56901

GeneCards: human genes, protein and diseases

More...GeneCardsi		NDUFA4L2
HGNCiHGNC:29836, NDUFA4L2
HPAiENSG00000185633, Tissue enhanced (esophagus, skin)
neXtProtiNX_Q9NRX3
OpenTargetsiENSG00000185633
PharmGKBiPA144596402
VEuPathDBiHostDB:ENSG00000185633.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SG4Q, Eukaryota
GeneTreeiENSGT00940000161040
HOGENOMiCLU_181002_0_0_1
InParanoidiQ9NRX3
OMAiEPWNNLD
OrthoDBi1552648at2759
PhylomeDBiQ9NRX3
TreeFamiTF106383

Enzyme and pathway databases

BioCyciMetaCyc:G66-33023-MONOMER
PathwayCommonsiQ9NRX3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56901, 6 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDUFA4L2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56901
PharosiQ9NRX3, Tclin

Protein Ontology

More...PROi		PR:Q9NRX3
RNActiQ9NRX3, protein

Gene expression databases

BgeeiENSG00000185633, Expressed in ectocervix and 186 other tissues
ExpressionAtlasiQ9NRX3, baseline and differential
GenevisibleiQ9NRX3, HS

Family and domain databases

InterProiView protein in InterPro
IPR010530, B12D
PANTHERiPTHR14256, PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522, B12D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUA4L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRX3
Secondary accession number(s): Q6IAH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: April 7, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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