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Protein

39S ribosomal protein L17, mitochondrial

Gene

MRPL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L17, mitochondrial
Short name:
L17mt
Short name:
MRP-L17
Alternative name(s):
LYST-interacting protein 2
Mitochondrial large ribosomal subunit protein bL17m1 Publication
Gene namesi
Name:MRPL17
Synonyms:LIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000158042.8
HGNCiHGNC:14053 MRPL17
MIMi611830 gene
neXtProtiNX_Q9NRX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi63875
OpenTargetsiENSG00000158042
PharmGKBiPA30946

Polymorphism and mutation databases

BioMutaiMRPL17
DMDMi74752931

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8MitochondrionBy similarity8
ChainiPRO_00002373319 – 17539S ribosomal protein L17, mitochondrialAdd BLAST167

Proteomic databases

EPDiQ9NRX2
MaxQBiQ9NRX2
PaxDbiQ9NRX2
PeptideAtlasiQ9NRX2
PRIDEiQ9NRX2
ProteomicsDBi82433
TopDownProteomicsiQ9NRX2

PTM databases

iPTMnetiQ9NRX2
PhosphoSitePlusiQ9NRX2

Expressioni

Tissue specificityi

Detected in adrenal gland, mammary gland and adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000158042 Expressed in 205 organ(s), highest expression level in placenta
CleanExiHS_MRPL17
ExpressionAtlasiQ9NRX2 baseline and differential
GenevisibleiQ9NRX2 HS

Organism-specific databases

HPAiHPA043666
HPA050552

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121968, 53 interactors
CORUMiQ9NRX2
IntActiQ9NRX2, 16 interactors
MINTiQ9NRX2
STRINGi9606.ENSP00000288937

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NRX2
SMRiQ9NRX2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NRX2

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3280 Eukaryota
COG0203 LUCA
GeneTreeiENSGT00390000010698
HOGENOMiHOG000019780
HOVERGENiHBG056029
InParanoidiQ9NRX2
KOiK02879
OMAiTMEMADY
OrthoDBiEOG091G0PQG
PhylomeDBiQ9NRX2
TreeFamiTF105844

Family and domain databases

Gene3Di3.90.1030.10, 1 hit
InterProiView protein in InterPro
IPR000456 Ribosomal_L17
IPR036373 Ribosomal_L17_sf
PANTHERiPTHR14413 PTHR14413, 1 hit
PfamiView protein in Pfam
PF01196 Ribosomal_L17, 1 hit
SUPFAMiSSF64263 SSF64263, 1 hit
TIGRFAMsiTIGR00059 L17, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD
60 70 80 90 100
EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ
110 120 130 140 150
TGGYTRMLQI PNRSLDRAKM AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ
160 170
GLRQDLRQSQ EASNHSSHTA QTPGI
Length:175
Mass (Da):20,050
Last modified:October 1, 2000 - v1
Checksum:i48C73425104200EA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKV2E9PKV2_HUMAN
39S ribosomal protein L17, mitochon...
MRPL17
142Annotation score:

Sequence cautioni

The sequence AAG49441 differs from that shown. Reason: Frameshift at position 8.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105T → A in CAG33458 (PubMed:11984006).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164797 mRNA Translation: AAF80761.1
AF141338 mRNA Translation: AAG49441.1 Frameshift.
AK026857 mRNA Translation: BAB15575.1
CR457177 mRNA Translation: CAG33458.1
CH471064 Genomic DNA Translation: EAW68681.1
CH471064 Genomic DNA Translation: EAW68682.1
BC012306 mRNA Translation: AAH12306.1
AB051620 Genomic DNA Translation: BAB54948.1
CCDSiCCDS31412.1
RefSeqiNP_071344.1, NM_022061.3
UniGeneiHs.523456
Hs.708782

Genome annotation databases

EnsembliENST00000288937; ENSP00000288937; ENSG00000158042
GeneIDi63875
KEGGihsa:63875
UCSCiuc001men.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164797 mRNA Translation: AAF80761.1
AF141338 mRNA Translation: AAG49441.1 Frameshift.
AK026857 mRNA Translation: BAB15575.1
CR457177 mRNA Translation: CAG33458.1
CH471064 Genomic DNA Translation: EAW68681.1
CH471064 Genomic DNA Translation: EAW68682.1
BC012306 mRNA Translation: AAH12306.1
AB051620 Genomic DNA Translation: BAB54948.1
CCDSiCCDS31412.1
RefSeqiNP_071344.1, NM_022061.3
UniGeneiHs.523456
Hs.708782

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQMNMR-A28-136[»]
3J7Yelectron microscopy3.40O1-175[»]
3J9Melectron microscopy3.50O1-175[»]
5OOLelectron microscopy3.06O1-175[»]
5OOMelectron microscopy3.03O1-175[»]
ProteinModelPortaliQ9NRX2
SMRiQ9NRX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121968, 53 interactors
CORUMiQ9NRX2
IntActiQ9NRX2, 16 interactors
MINTiQ9NRX2
STRINGi9606.ENSP00000288937

PTM databases

iPTMnetiQ9NRX2
PhosphoSitePlusiQ9NRX2

Polymorphism and mutation databases

BioMutaiMRPL17
DMDMi74752931

Proteomic databases

EPDiQ9NRX2
MaxQBiQ9NRX2
PaxDbiQ9NRX2
PeptideAtlasiQ9NRX2
PRIDEiQ9NRX2
ProteomicsDBi82433
TopDownProteomicsiQ9NRX2

Protocols and materials databases

DNASUi63875
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288937; ENSP00000288937; ENSG00000158042
GeneIDi63875
KEGGihsa:63875
UCSCiuc001men.3 human

Organism-specific databases

CTDi63875
DisGeNETi63875
EuPathDBiHostDB:ENSG00000158042.8
GeneCardsiMRPL17
HGNCiHGNC:14053 MRPL17
HPAiHPA043666
HPA050552
MIMi611830 gene
neXtProtiNX_Q9NRX2
OpenTargetsiENSG00000158042
PharmGKBiPA30946
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3280 Eukaryota
COG0203 LUCA
GeneTreeiENSGT00390000010698
HOGENOMiHOG000019780
HOVERGENiHBG056029
InParanoidiQ9NRX2
KOiK02879
OMAiTMEMADY
OrthoDBiEOG091G0PQG
PhylomeDBiQ9NRX2
TreeFamiTF105844

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

EvolutionaryTraceiQ9NRX2
GeneWikiiMRPL17
GenomeRNAii63875
PROiPR:Q9NRX2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158042 Expressed in 205 organ(s), highest expression level in placenta
CleanExiHS_MRPL17
ExpressionAtlasiQ9NRX2 baseline and differential
GenevisibleiQ9NRX2 HS

Family and domain databases

Gene3Di3.90.1030.10, 1 hit
InterProiView protein in InterPro
IPR000456 Ribosomal_L17
IPR036373 Ribosomal_L17_sf
PANTHERiPTHR14413 PTHR14413, 1 hit
PfamiView protein in Pfam
PF01196 Ribosomal_L17, 1 hit
SUPFAMiSSF64263 SSF64263, 1 hit
TIGRFAMsiTIGR00059 L17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM17_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX2
Secondary accession number(s): D3DQU3
, Q6IAH8, Q96Q53, Q9C066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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