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Protein

RNA-binding protein PNO1

Gene

PNO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein PNO1
Gene namesi
Name:PNO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115946.7
HGNCiHGNC:32790 PNO1
neXtProtiNX_Q9NRX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56902
OpenTargetsiENSG00000115946
PharmGKBiPA162399854

Polymorphism and mutation databases

BioMutaiPNO1
DMDMi74734328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705401 – 252RNA-binding protein PNO1Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NRX1
MaxQBiQ9NRX1
PaxDbiQ9NRX1
PeptideAtlasiQ9NRX1
PRIDEiQ9NRX1
ProteomicsDBi82432

PTM databases

iPTMnetiQ9NRX1
PhosphoSitePlusiQ9NRX1

Expressioni

Tissue specificityi

Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000115946
CleanExiHS_PNO1
ExpressionAtlasiQ9NRX1 baseline and differential
GenevisibleiQ9NRX1 HS

Organism-specific databases

HPAiHPA056928

Interactioni

Protein-protein interaction databases

BioGridi121232, 59 interactors
IntActiQ9NRX1, 26 interactors
MINTiQ9NRX1
STRINGi9606.ENSP00000263657

Structurei

3D structure databases

ProteinModelPortaliQ9NRX1
SMRiQ9NRX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 225KHAdd BLAST53

Sequence similaritiesi

Belongs to the PNO1 family.Curated

Phylogenomic databases

eggNOGiKOG3273 Eukaryota
COG1094 LUCA
GeneTreeiENSGT00390000018052
HOGENOMiHOG000181708
HOVERGENiHBG055635
InParanoidiQ9NRX1
KOiK11884
OMAiQLQVRFN
OrthoDBiEOG091G0L5I
PhylomeDBiQ9NRX1
TreeFamiTF300114

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR036612 KH_dom_type_1_sf
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NRX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEMETQSA RAEEGFTQVT RKGGRRAKKR QAEQLSAAGE GGDAGRMDTE
60 70 80 90 100
EARPAKRPVF PPLCGDGLLS GKEETRKIPV PANRYTPLKE NWMKIFTPIV
110 120 130 140 150
EHLGLQIRFN LKSRNVEIRT CKETKDVSAL TKAADFVKAF ILGFQVEDAL
160 170 180 190 200
ALIRLDDLFL ESFEITDVKP LKGDHLSRAI GRIAGKGGKT KFTIENVTRT
210 220 230 240 250
RIVLADVKVH ILGSFQNIKM ARTAICNLIL GNPPSKVYGN IRAVASRSAD

RF
Length:252
Mass (Da):27,924
Last modified:October 1, 2000 - v1
Checksum:iDDF2285D95D3D232
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02981411R → G3 PublicationsCorresponds to variant dbSNP:rs2044693Ensembl.1
Natural variantiVAR_02981571G → A. Corresponds to variant dbSNP:rs7590838Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349314 mRNA Translation: AAK29434.1
AF164799 mRNA Translation: AAF80763.1
AC017083 Genomic DNA Translation: AAY14714.1
CH471053 Genomic DNA Translation: EAW99879.1
BC008304 mRNA Translation: AAH08304.1
BC018152 mRNA Translation: AAH18152.1
AK223118 mRNA Translation: BAD96838.1
AK291715 mRNA Translation: BAF84404.1
CCDSiCCDS1885.1
RefSeqiNP_064528.1, NM_020143.3
UniGeneiHs.262858

Genome annotation databases

EnsembliENST00000263657; ENSP00000263657; ENSG00000115946
GeneIDi56902
KEGGihsa:56902
UCSCiuc002seh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPNO1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX1
Secondary accession number(s): A8K6Q0, Q53G13, Q8WVB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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