DUSP22

Functionⁱ

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).By similarity1 Publication

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	88	Phosphocysteine intermediateBy similarity		1

GO - Molecular functionⁱ

non-membrane spanning protein tyrosine phosphatase activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 20018849
protein tyrosine/serine/threonine phosphatase activity Source: InterPro
protein tyrosine kinase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 24714587
protein tyrosine phosphatase activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 24714587

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9205128
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 9205128
cellular response to epidermal growth factor stimulus
Source: ARUK-UCL
Inferred from direct assayⁱ
- 20018849
inactivation of MAPK activity
Source: ProtInc
Traceable author statementⁱ
- 9205128
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 9205128
negative regulation of cell migration
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 20018849
negative regulation of focal adhesion assembly
Source: ARUK-UCL
Inferred from direct assayⁱ
- 20018849
negative regulation of non-membrane spanning protein tyrosine kinase activity
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 20018849
negative regulation of T cell activation Source: Ensembl
negative regulation of T cell mediated immunity Source: Ensembl
negative regulation of T cell receptor signaling pathway Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from mutant phenotypeⁱ
- 16636663
peptidyl-tyrosine dephosphorylation
Source: ARUK-UCL
Inferred from direct assayⁱ
- 20018849
positive regulation of JNK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein dephosphorylation
Source: ProtInc
Traceable author statementⁱ
- 9205128
regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transforming growth factor beta receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SABIO-RKⁱ	Q9NRW4
SignaLinkⁱ	Q9NRW4
SIGNORⁱ	Q9NRW4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity protein phosphatase 22 (EC:3.1.3.16, EC:3.1.3.48) Alternative name(s): JNK-stimulatory phosphatase-1 Short name: JSP-1 Low molecular weight dual specificity phosphatase 2 Short name: LMW-DSP2 Mitogen-activated protein kinase phosphatase x Short name: MAP kinase phosphatase x Short name: MKP-x
Gene namesⁱ	Name:DUSP22 Synonyms:JSP1, LMWDSP2, MKPX
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112679.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16077 DUSP22
neXtProtⁱ	NX_Q9NRW4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56940
Open Targets More...OpenTargetsⁱ	ENSG00000112679
PharmGKBⁱ	PA134991025

Chemistry databases

ChEMBLⁱ	CHEMBL3924

ChEMBLⁱ

CHEMBL3924

Polymorphism and mutation databases

BioMutaⁱ	DUSP22
DMDMⁱ	74752929

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000244751	2 – 184	Dual specificity protein phosphatase 22Add BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication		1
Modified residueⁱ	58	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Myristoylation regulates subcellular location, and is necessary for activation of JNK.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NRW4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NRW4
PaxDbⁱ	Q9NRW4
PeptideAtlas More...PeptideAtlasⁱ	Q9NRW4
PRIDEⁱ	Q9NRW4
ProteomicsDBⁱ	82429 82430 [Q9NRW4-2]

PTM databases

DEPODⁱ	Q9NRW4
iPTMnetⁱ	Q9NRW4
PhosphoSitePlusⁱ	Q9NRW4

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000112679 Expressed in 224 organ(s), highest expression level in epithelium of mammary gland
CleanExⁱ	HS_DUSP22
ExpressionAtlasⁱ	Q9NRW4 baseline and differential
Genevisibleⁱ	Q9NRW4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031394

HPAⁱ

HPA031394

Interactionⁱ

Subunit structureⁱ

Monomer.1 Publication

GO - Molecular functionⁱ

protein tyrosine kinase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 24714587

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121264, 112 interactors
IntActⁱ	Q9NRW4, 6 interactors
STRINGⁱ	9606.ENSP00000345281

Chemistry databases

BindingDBⁱ

Q9NRW4

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 9	Combined sources	4
Beta strandⁱ	12 – 15	Combined sources	4
Helixⁱ	19 – 21	Combined sources	3
Helixⁱ	23 – 28	Combined sources	6
Beta strandⁱ	31 – 38	Combined sources	8
Beta strandⁱ	49 – 54	Combined sources	6
Helixⁱ	64 – 66	Combined sources	3
Helixⁱ	67 – 79	Combined sources	13
Beta strandⁱ	83 – 87	Combined sources	5
Beta strandⁱ	89 – 93	Combined sources	5
Helixⁱ	94 – 106	Combined sources	13
Helixⁱ	111 – 121	Combined sources	11
Helixⁱ	129 – 141	Combined sources	13
Helixⁱ	143 – 154	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NRW4
SMRⁱ	Q9NRW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NRW4

EvolutionaryTraceⁱ

Q9NRW4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	65 – 133	Tyrosine-protein phosphataseAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1716 Eukaryota COG2453 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118853
HOGENOMⁱ	HOG000007880
HOVERGENⁱ	HBG054344
InParanoidⁱ	Q9NRW4
KEGG Orthology (KO) More...KOⁱ	K14165
OMAⁱ	LFIGNFK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NE0
PhylomeDBⁱ	Q9NRW4
TreeFamⁱ	TF105126

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00127 DSPc, 1 hit
Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR020417 Atypical_DUSP IPR000340 Dual-sp_phosphatase_cat-dom IPR024950 DUSP IPR029021 Prot-tyrosine_phosphatase-like IPR000387 TYR_PHOSPHATASE_dom IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERⁱ	PTHR10159 PTHR10159, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00782 DSPc, 1 hit
PRINTSⁱ	PR01908 ADSPHPHTASE
SMARTⁱ	View protein in SMART SM00195 DSPc, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS50056 TYR_PHOSPHATASE_2, 1 hit PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NRW4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY 
        60         70         80         90        100
LCIPAADSPS QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI 
       110        120        130        140        150
AYIMTVTDFG WEDALHTVRA GRSCANPNVG FQRQLQEFEK HEVHQYRQWL 
       160        170        180 
KEEYGESPLQ DAEEAKNILA APGILKFWAF LRRL

Length:184

Mass (Da):20,910

Last modified:October 1, 2000 - v1

Checksum:ⁱB3F962A087C2BA20

GO

Isoform 2 (identifier: Q9NRW4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
170-184: AAPGILKFWAFLRRL → GKYKEQGRTEPQPGARRWSSFPALAPLTYDNYTTET

« Hide

        10         20         30         40         50
MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY 
        60         70         80         90        100
LCIPAADSPS QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI 
       110        120        130        140        150
AYIMTVTDFG WEDALHTVRA GRSCANPNVG FQRQLQEFEK HEVHQYRQWL 
       160        170        180        190        200
KEEYGESPLQ DAEEAKNILG KYKEQGRTEP QPGARRWSSF PALAPLTYDN 

YTTET

Show »

Length:205

Mass (Da):23,268

Checksum:ⁱ48334A97991FCFF8

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R3A4	S4R3A4_HUMAN	Dual-specificity protein phosphatas... Dual-specificity protein phosphatase 22	DUSP22	75	Annotation score:
S4R3M1	S4R3M1_HUMAN	Dual-specificity protein phosphatas... Dual-specificity protein phosphatase 22	DUSP22	102	Annotation score:
S4R459	S4R459_HUMAN	Dual-specificity protein phosphatas... Dual-specificity protein phosphatase 22	DUSP22	54	Annotation score:
S4R378	S4R378_HUMAN	Dual-specificity protein phosphatas... Dual-specificity protein phosphatase 22	DUSP22	46	Annotation score:
S4R3K1	S4R3K1_HUMAN	Dual-specificity protein phosphatas... Dual-specificity protein phosphatase 22	DUSP22	18	Annotation score:

Sequence cautionⁱ

The sequence AAH16844 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026912	119	R → H. Corresponds to variant dbSNP:rs7768224Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019614	170 – 184	AAPGI…FLRRL → GKYKEQGRTEPQPGARRWSS FPALAPLTYDNYTTET in isoform 2. 2 PublicationsAdd BLAST		15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF424702 mRNA Translation: AAL18850.1 AF165519 mRNA Translation: AAF86649.1 AY249859 mRNA Translation: AAP76376.1 AK296402 mRNA Translation: BAG59068.1 AL365272 Genomic DNA No translation available. BC016844 mRNA Translation: AAH16844.1 Different initiation. BC022847 mRNA Translation: AAH22847.1 AB208997 mRNA Translation: BAD92234.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4468.1 [Q9NRW4-1] CCDS69035.1 [Q9NRW4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273484.1, NM_001286555.1 [Q9NRW4-2] NP_064570.1, NM_020185.4 [Q9NRW4-1]
UniGeneⁱ	Hs.29106

Genome annotation databases

Ensemblⁱ	ENST00000344450; ENSP00000345281; ENSG00000112679 [Q9NRW4-1] ENST00000419235; ENSP00000397459; ENSG00000112679 [Q9NRW4-2]
GeneIDⁱ	56940
KEGGⁱ	hsa:56940
UCSC genome browser More...UCSCⁱ	uc003msx.5 human [Q9NRW4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NRW4	DUSP22 isoform 1		PANTR		184	UniRef100_Q9NRW4
Uncharacterized protein		PANPA		184
Dual specificity phosphatase 22		GORGO		184
Q9NRW4-2	Dual-specificity protein phosphatase 22		HUMAN		102	UniRef100_S4R3M1
DUSP22 isoform 3		PANTR		205
Uncharacterized protein		PANPA		205
Dual specificity phosphatase 22		GORGO		205
cDNA FLJ35864 fis, clone TESTI2007657, highly similar to Dual specificity protein phosphatase 22		HUMAN		162
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9NRW4	DUSP22 isoform 1		PANTR		184	UniRef90_Q9NRW4
Uncharacterized protein		PANPA		184
Dual specificity phosphatase 22		GORGO		184
Uncharacterized protein		CALJA		205
Uncharacterized protein		Cebus capucinus imitator		205
+64

Protein	Similar proteins		Species	Score	Length	Source
Q9NRW4	DUSP22 isoform 1		PANTR		184	UniRef50_Q9NRW4
Uncharacterized protein		PANPA		184
Dual specificity phosphatase 22		GORGO		184
Uncharacterized protein		MACFA		205
Uncharacterized protein (Fragment)		MACMU		198
+81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF424702 mRNA Translation: AAL18850.1 AF165519 mRNA Translation: AAF86649.1 AY249859 mRNA Translation: AAP76376.1 AK296402 mRNA Translation: BAG59068.1 AL365272 Genomic DNA No translation available. BC016844 mRNA Translation: AAH16844.1 Different initiation. BC022847 mRNA Translation: AAH22847.1 AB208997 mRNA Translation: BAD92234.1
CCDSⁱ	CCDS4468.1 [Q9NRW4-1] CCDS69035.1 [Q9NRW4-2]
RefSeqⁱ	NP_001273484.1, NM_001286555.1 [Q9NRW4-2] NP_064570.1, NM_020185.4 [Q9NRW4-1]
UniGeneⁱ	Hs.29106

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WRM	X-ray	1.50	A	1-163	[»]
	4WOH	X-ray	1.34	A	1-163	[»]
ProteinModelPortalⁱ	Q9NRW4
SMRⁱ	Q9NRW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121264, 112 interactors
IntActⁱ	Q9NRW4, 6 interactors
STRINGⁱ	9606.ENSP00000345281

Chemistry databases

BindingDBⁱ	Q9NRW4
ChEMBLⁱ	CHEMBL3924

PTM databases

DEPODⁱ	Q9NRW4
iPTMnetⁱ	Q9NRW4
PhosphoSitePlusⁱ	Q9NRW4

Polymorphism and mutation databases

BioMutaⁱ	DUSP22
DMDMⁱ	74752929

Proteomic databases

EPDⁱ	Q9NRW4
MaxQBⁱ	Q9NRW4
PaxDbⁱ	Q9NRW4
PeptideAtlasⁱ	Q9NRW4
PRIDEⁱ	Q9NRW4
ProteomicsDBⁱ	82429 82430 [Q9NRW4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56940
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344450; ENSP00000345281; ENSG00000112679 [Q9NRW4-1] ENST00000419235; ENSP00000397459; ENSG00000112679 [Q9NRW4-2]
GeneIDⁱ	56940
KEGGⁱ	hsa:56940
UCSCⁱ	uc003msx.5 human [Q9NRW4-1]

Organism-specific databases

CTDⁱ	56940
DisGeNETⁱ	56940
EuPathDBⁱ	HostDB:ENSG00000112679.14
GeneCardsⁱ	DUSP22
HGNCⁱ	HGNC:16077 DUSP22
HPAⁱ	HPA031394
neXtProtⁱ	NX_Q9NRW4
OpenTargetsⁱ	ENSG00000112679
PharmGKBⁱ	PA134991025
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1716 Eukaryota COG2453 LUCA
GeneTreeⁱ	ENSGT00760000118853
HOGENOMⁱ	HOG000007880
HOVERGENⁱ	HBG054344
InParanoidⁱ	Q9NRW4
KOⁱ	K14165
OMAⁱ	LFIGNFK
OrthoDBⁱ	EOG091G0NE0
PhylomeDBⁱ	Q9NRW4
TreeFamⁱ	TF105126

Enzyme and pathway databases

SABIO-RKⁱ	Q9NRW4
SignaLinkⁱ	Q9NRW4
SIGNORⁱ	Q9NRW4

Miscellaneous databases

ChiTaRSⁱ	DUSP22 human
EvolutionaryTraceⁱ	Q9NRW4
GeneWikiⁱ	DUSP22
GenomeRNAiⁱ	56940
Protein Ontology More...PROⁱ	PR:Q9NRW4

Gene expression databases

Bgeeⁱ	ENSG00000112679 Expressed in 224 organ(s), highest expression level in epithelium of mammary gland
CleanExⁱ	HS_DUSP22
ExpressionAtlasⁱ	Q9NRW4 baseline and differential
Genevisibleⁱ	Q9NRW4 HS

Family and domain databases

CDDⁱ	cd00127 DSPc, 1 hit
Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR020417 Atypical_DUSP IPR000340 Dual-sp_phosphatase_cat-dom IPR024950 DUSP IPR029021 Prot-tyrosine_phosphatase-like IPR000387 TYR_PHOSPHATASE_dom IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERⁱ	PTHR10159 PTHR10159, 1 hit
Pfamⁱ	View protein in Pfam PF00782 DSPc, 1 hit
PRINTSⁱ	PR01908 ADSPHPHTASE
SMARTⁱ	View protein in SMART SM00195 DSPc, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS50056 TYR_PHOSPHATASE_2, 1 hit PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DUS22_HUMAN
Accessionⁱ	Q9NRW4Primary (citable) accession number: Q9NRW4 Secondary accession number(s): B4DK56 , Q59GW2, Q5VWR2, Q96AR1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q9NRW4 (DUS22_HUMAN)

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Dual specificity protein phosphatase 22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ