UniProtKB - Q9NRW1 (RAB6B_HUMAN)
Protein
Ras-related protein Rab-6B
Gene
RAB6B
Organism
Homo sapiens (Human)
Status
Functioni
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 45 | GTP | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 20 – 27 | GTP | 8 | |
Nucleotide bindingi | 68 – 72 | GTP | 5 | |
Nucleotide bindingi | 126 – 129 | GTP | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- myosin V binding Source: UniProtKB
GO - Biological processi
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: GO_Central
- Rab protein signal transduction Source: GO_Central
- retrograde transport, endosome to Golgi Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8854214 TBC/RABGAPs R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-6B |
Gene namesi | Name:RAB6B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000154917.10 |
HGNCi | HGNC:14902 RAB6B |
MIMi | 615852 gene |
neXtProti | NX_Q9NRW1 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 2 Publications; Lipid-anchor Curated
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment 1 Publication
- Cytoplasmic vesicle 1 Publication
Note: Colocalizes with BICD1 at vesicular structures that align along microtubules.1 Publication
Cytosol
- cytosol Source: GOC
Golgi apparatus
- Golgi apparatus Source: HPA
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- presynapse Source: Ensembl
Keywords - Cellular componenti
Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 27 | T → N: Loss of APBA1-binding. 1 Publication | 1 | |
Mutagenesisi | 72 | Q → L: Interacts with APBA1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51560 |
OpenTargetsi | ENSG00000154917 |
PharmGKBi | PA34147 |
Polymorphism and mutation databases
BioMutai | RAB6B |
DMDMi | 13633595 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121115 | 1 – 208 | Ras-related protein Rab-6BAdd BLAST | 208 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 82 | O-AMP-tyrosine; by Legionella DrrA1 Publication | 1 | |
Lipidationi | 206 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 208 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 208 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
EPDi | Q9NRW1 |
jPOSTi | Q9NRW1 |
MaxQBi | Q9NRW1 |
PaxDbi | Q9NRW1 |
PeptideAtlasi | Q9NRW1 |
PRIDEi | Q9NRW1 |
ProteomicsDBi | 82427 |
PTM databases
iPTMneti | Q9NRW1 |
PhosphoSitePlusi | Q9NRW1 |
SwissPalmi | Q9NRW1 |
Expressioni
Tissue specificityi
Predominantly expressed in brain.
Gene expression databases
Bgeei | ENSG00000154917 Expressed in 192 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | Q9NRW1 baseline and differential |
Genevisiblei | Q9NRW1 HS |
Organism-specific databases
HPAi | CAB017713 HPA059131 |
Interactioni
Subunit structurei
Interacts with BICDL1/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.By similarity3 Publications
Binary interactionsi
GO - Molecular functioni
- myosin V binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 119610, 52 interactors |
IntActi | Q9NRW1, 12 interactors |
STRINGi | 9606.ENSP00000285208 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E9S | X-ray | 1.78 | A/B/C | 13-174 | [»] | |
2FE4 | X-ray | 2.30 | A | 13-174 | [»] | |
2FFQ | X-ray | 1.78 | A | 13-174 | [»] | |
ProteinModelPortali | Q9NRW1 | |||||
SMRi | Q9NRW1 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NRW1 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 42 – 50 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0094 Eukaryota ENOG410XPBI LUCA |
GeneTreei | ENSGT00940000159656 |
HOGENOMi | HOG000233968 |
HOVERGENi | HBG009351 |
InParanoidi | Q9NRW1 |
KOi | K07894 |
OMAi | KIGHALP |
OrthoDBi | 1277051at2759 |
PhylomeDBi | Q9NRW1 |
TreeFami | TF300803 |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase |
Pfami | View protein in Pfam PF00071 Ras, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00231 small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419 RAB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NRW1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS
110 120 130 140 150
FQQTSKWIDD VRTERGSDVI IMLVGNKTDL ADKRQITIEE GEQRAKELSV
160 170 180 190 200
MFIETSAKTG YNVKQLFRRV ASALPGMENV QEKSKEGMID IKLDKPQEPP
ASEGGCSC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JU14 | C9JU14_HUMAN | Ras-related protein Rab-6B | RAB6B | 83 | Annotation score: | ||
J3KR73 | J3KR73_HUMAN | Ras-related protein Rab-6B | RAB6B | 124 | Annotation score: | ||
C9JB90 | C9JB90_HUMAN | Ras-related protein Rab-6B | RAB6B | 49 | Annotation score: | ||
C9J0I2 | C9J0I2_HUMAN | Ras-related protein Rab-6B | RAB6B | 71 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055831 | 1 – 24 | MSAGG…GEQSV → MWHMTRNWPLV in isoform 2. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF166492 mRNA Translation: AAF61637.1 AF498940 mRNA Translation: AAM21088.1 BT007263 mRNA Translation: AAP35927.1 AK295451 mRNA Translation: BAH12073.1 AK312378 mRNA Translation: BAG35296.1 AC080128 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79158.1 CH471052 Genomic DNA Translation: EAW79159.1 BC002510 mRNA Translation: AAH02510.1 U66623 mRNA Translation: AAC51198.1 |
CCDSi | CCDS3082.1 [Q9NRW1-1] CCDS87137.1 [Q9NRW1-2] |
RefSeqi | NP_057661.3, NM_016577.3 [Q9NRW1-1] XP_011511195.1, XM_011512893.2 |
UniGenei | Hs.715344 |
Genome annotation databases
Ensembli | ENST00000285208; ENSP00000285208; ENSG00000154917 [Q9NRW1-1] ENST00000486858; ENSP00000419381; ENSG00000154917 [Q9NRW1-2] ENST00000543906; ENSP00000437797; ENSG00000154917 [Q9NRW1-1] |
GeneIDi | 51560 |
KEGGi | hsa:51560 |
UCSCi | uc003epy.4 human [Q9NRW1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF166492 mRNA Translation: AAF61637.1 AF498940 mRNA Translation: AAM21088.1 BT007263 mRNA Translation: AAP35927.1 AK295451 mRNA Translation: BAH12073.1 AK312378 mRNA Translation: BAG35296.1 AC080128 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79158.1 CH471052 Genomic DNA Translation: EAW79159.1 BC002510 mRNA Translation: AAH02510.1 U66623 mRNA Translation: AAC51198.1 |
CCDSi | CCDS3082.1 [Q9NRW1-1] CCDS87137.1 [Q9NRW1-2] |
RefSeqi | NP_057661.3, NM_016577.3 [Q9NRW1-1] XP_011511195.1, XM_011512893.2 |
UniGenei | Hs.715344 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E9S | X-ray | 1.78 | A/B/C | 13-174 | [»] | |
2FE4 | X-ray | 2.30 | A | 13-174 | [»] | |
2FFQ | X-ray | 1.78 | A | 13-174 | [»] | |
ProteinModelPortali | Q9NRW1 | |||||
SMRi | Q9NRW1 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 119610, 52 interactors |
IntActi | Q9NRW1, 12 interactors |
STRINGi | 9606.ENSP00000285208 |
PTM databases
iPTMneti | Q9NRW1 |
PhosphoSitePlusi | Q9NRW1 |
SwissPalmi | Q9NRW1 |
Polymorphism and mutation databases
BioMutai | RAB6B |
DMDMi | 13633595 |
Proteomic databases
EPDi | Q9NRW1 |
jPOSTi | Q9NRW1 |
MaxQBi | Q9NRW1 |
PaxDbi | Q9NRW1 |
PeptideAtlasi | Q9NRW1 |
PRIDEi | Q9NRW1 |
ProteomicsDBi | 82427 |
Protocols and materials databases
DNASUi | 51560 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000285208; ENSP00000285208; ENSG00000154917 [Q9NRW1-1] ENST00000486858; ENSP00000419381; ENSG00000154917 [Q9NRW1-2] ENST00000543906; ENSP00000437797; ENSG00000154917 [Q9NRW1-1] |
GeneIDi | 51560 |
KEGGi | hsa:51560 |
UCSCi | uc003epy.4 human [Q9NRW1-1] |
Organism-specific databases
CTDi | 51560 |
DisGeNETi | 51560 |
EuPathDBi | HostDB:ENSG00000154917.10 |
GeneCardsi | RAB6B |
HGNCi | HGNC:14902 RAB6B |
HPAi | CAB017713 HPA059131 |
MIMi | 615852 gene |
neXtProti | NX_Q9NRW1 |
OpenTargetsi | ENSG00000154917 |
PharmGKBi | PA34147 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0094 Eukaryota ENOG410XPBI LUCA |
GeneTreei | ENSGT00940000159656 |
HOGENOMi | HOG000233968 |
HOVERGENi | HBG009351 |
InParanoidi | Q9NRW1 |
KOi | K07894 |
OMAi | KIGHALP |
OrthoDBi | 1277051at2759 |
PhylomeDBi | Q9NRW1 |
TreeFami | TF300803 |
Enzyme and pathway databases
Reactomei | R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8854214 TBC/RABGAPs R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
ChiTaRSi | RAB6B human |
EvolutionaryTracei | Q9NRW1 |
GeneWikii | RAB6B |
GenomeRNAii | 51560 |
PROi | PR:Q9NRW1 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154917 Expressed in 192 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | Q9NRW1 baseline and differential |
Genevisiblei | Q9NRW1 HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase |
Pfami | View protein in Pfam PF00071 Ras, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00231 small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419 RAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | RAB6B_HUMAN | |
Accessioni | Q9NRW1Primary (citable) accession number: Q9NRW1 Secondary accession number(s): B2R5Z9 Q92929 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 13, 2019 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot