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Protein

Ras-related protein Rab-6B

Gene

RAB6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45GTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTP8
Nucleotide bindingi68 – 72GTP5
Nucleotide bindingi126 – 129GTP4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • myosin V binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6B
Gene namesi
Name:RAB6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000154917.10
HGNCiHGNC:14902 RAB6B
MIMi615852 gene
neXtProtiNX_Q9NRW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27T → N: Loss of APBA1-binding. 1 Publication1
Mutagenesisi72Q → L: Interacts with APBA1. 1 Publication1

Organism-specific databases

DisGeNETi51560
OpenTargetsiENSG00000154917
PharmGKBiPA34147

Polymorphism and mutation databases

BioMutaiRAB6B
DMDMi13633595

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211151 – 208Ras-related protein Rab-6BAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82O-AMP-tyrosine; by Legionella DrrA1 Publication1
Lipidationi206S-geranylgeranyl cysteineBy similarity1
Modified residuei208Cysteine methyl esterBy similarity1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9NRW1
MaxQBiQ9NRW1
PaxDbiQ9NRW1
PeptideAtlasiQ9NRW1
PRIDEiQ9NRW1
ProteomicsDBi82427

PTM databases

iPTMnetiQ9NRW1
PhosphoSitePlusiQ9NRW1
SwissPalmiQ9NRW1

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSG00000154917 Expressed in 192 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9NRW1 baseline and differential
GenevisibleiQ9NRW1 HS

Organism-specific databases

HPAiCAB017713
HPA059131

Interactioni

Subunit structurei

Interacts with BICDL1/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119610, 50 interactors
IntActiQ9NRW1, 12 interactors
STRINGi9606.ENSP00000285208

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NRW1
SMRiQ9NRW1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NRW1

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9NRW1
KOiK07894
OMAiKIGHALP
OrthoDBiEOG091G0ORZ
PhylomeDBiQ9NRW1
TreeFamiTF300803

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS
110 120 130 140 150
FQQTSKWIDD VRTERGSDVI IMLVGNKTDL ADKRQITIEE GEQRAKELSV
160 170 180 190 200
MFIETSAKTG YNVKQLFRRV ASALPGMENV QEKSKEGMID IKLDKPQEPP

ASEGGCSC
Length:208
Mass (Da):23,462
Last modified:October 1, 2000 - v1
Checksum:iE81C831996E2446D
GO
Isoform 2 (identifier: Q9NRW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSAGGDFGNPLRKFKLVFLGEQSV → MWHMTRNWPLV

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,334
Checksum:iE772D44D7E9D2C2C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JU14C9JU14_HUMAN
Ras-related protein Rab-6B
RAB6B
83Annotation score:
J3KR73J3KR73_HUMAN
Ras-related protein Rab-6B
RAB6B
124Annotation score:
C9JB90C9JB90_HUMAN
Ras-related protein Rab-6B
RAB6B
49Annotation score:
C9J0I2C9J0I2_HUMAN
Ras-related protein Rab-6B
RAB6B
71Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558311 – 24MSAGG…GEQSV → MWHMTRNWPLV in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166492 mRNA Translation: AAF61637.1
AF498940 mRNA Translation: AAM21088.1
BT007263 mRNA Translation: AAP35927.1
AK295451 mRNA Translation: BAH12073.1
AK312378 mRNA Translation: BAG35296.1
AC080128 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79158.1
CH471052 Genomic DNA Translation: EAW79159.1
BC002510 mRNA Translation: AAH02510.1
U66623 mRNA Translation: AAC51198.1
CCDSiCCDS3082.1 [Q9NRW1-1]
CCDS87137.1 [Q9NRW1-2]
RefSeqiNP_057661.3, NM_016577.3 [Q9NRW1-1]
XP_011511195.1, XM_011512893.2
UniGeneiHs.715344

Genome annotation databases

EnsembliENST00000285208; ENSP00000285208; ENSG00000154917 [Q9NRW1-1]
ENST00000486858; ENSP00000419381; ENSG00000154917 [Q9NRW1-2]
ENST00000543906; ENSP00000437797; ENSG00000154917 [Q9NRW1-1]
GeneIDi51560
KEGGihsa:51560
UCSCiuc003epy.4 human [Q9NRW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166492 mRNA Translation: AAF61637.1
AF498940 mRNA Translation: AAM21088.1
BT007263 mRNA Translation: AAP35927.1
AK295451 mRNA Translation: BAH12073.1
AK312378 mRNA Translation: BAG35296.1
AC080128 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79158.1
CH471052 Genomic DNA Translation: EAW79159.1
BC002510 mRNA Translation: AAH02510.1
U66623 mRNA Translation: AAC51198.1
CCDSiCCDS3082.1 [Q9NRW1-1]
CCDS87137.1 [Q9NRW1-2]
RefSeqiNP_057661.3, NM_016577.3 [Q9NRW1-1]
XP_011511195.1, XM_011512893.2
UniGeneiHs.715344

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9SX-ray1.78A/B/C13-174[»]
2FE4X-ray2.30A13-174[»]
2FFQX-ray1.78A13-174[»]
ProteinModelPortaliQ9NRW1
SMRiQ9NRW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119610, 50 interactors
IntActiQ9NRW1, 12 interactors
STRINGi9606.ENSP00000285208

PTM databases

iPTMnetiQ9NRW1
PhosphoSitePlusiQ9NRW1
SwissPalmiQ9NRW1

Polymorphism and mutation databases

BioMutaiRAB6B
DMDMi13633595

Proteomic databases

EPDiQ9NRW1
MaxQBiQ9NRW1
PaxDbiQ9NRW1
PeptideAtlasiQ9NRW1
PRIDEiQ9NRW1
ProteomicsDBi82427

Protocols and materials databases

DNASUi51560
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285208; ENSP00000285208; ENSG00000154917 [Q9NRW1-1]
ENST00000486858; ENSP00000419381; ENSG00000154917 [Q9NRW1-2]
ENST00000543906; ENSP00000437797; ENSG00000154917 [Q9NRW1-1]
GeneIDi51560
KEGGihsa:51560
UCSCiuc003epy.4 human [Q9NRW1-1]

Organism-specific databases

CTDi51560
DisGeNETi51560
EuPathDBiHostDB:ENSG00000154917.10
GeneCardsiRAB6B
HGNCiHGNC:14902 RAB6B
HPAiCAB017713
HPA059131
MIMi615852 gene
neXtProtiNX_Q9NRW1
OpenTargetsiENSG00000154917
PharmGKBiPA34147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9NRW1
KOiK07894
OMAiKIGHALP
OrthoDBiEOG091G0ORZ
PhylomeDBiQ9NRW1
TreeFamiTF300803

Enzyme and pathway databases

ReactomeiR-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRAB6B human
EvolutionaryTraceiQ9NRW1
GeneWikiiRAB6B
GenomeRNAii51560
PROiPR:Q9NRW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154917 Expressed in 192 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9NRW1 baseline and differential
GenevisibleiQ9NRW1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB6B_HUMAN
AccessioniPrimary (citable) accession number: Q9NRW1
Secondary accession number(s): B2R5Z9
, B7Z337, D3DND3, Q92929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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