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Protein

Heme-binding protein 1

Gene

HEBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.1 Publication

GO - Molecular functioni

GO - Biological processi

  • circadian rhythm Source: ProtInc
  • G protein-coupled receptor signaling pathway Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 1
Alternative name(s):
p22HBP
Gene namesi
Name:HEBP1
Synonyms:HBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000013583.8
HGNCiHGNC:17176 HEBP1
MIMi605826 gene
neXtProtiNX_Q9NRV9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi50865
OpenTargetsiENSG00000013583
PharmGKBiPA29236

Polymorphism and mutation databases

BioMutaiHEBP1
DMDMi74734327

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001168971 – 189Heme-binding protein 1Add BLAST189

Proteomic databases

EPDiQ9NRV9
MaxQBiQ9NRV9
PaxDbiQ9NRV9
PeptideAtlasiQ9NRV9
PRIDEiQ9NRV9
ProteomicsDBi82426
TopDownProteomicsiQ9NRV9

2D gel databases

REPRODUCTION-2DPAGEiIPI00148063

PTM databases

iPTMnetiQ9NRV9
PhosphoSitePlusiQ9NRV9

Expressioni

Gene expression databases

BgeeiENSG00000013583 Expressed in 225 organ(s), highest expression level in duodenum
CleanExiHS_HEBP1
ExpressionAtlasiQ9NRV9 baseline and differential
GenevisibleiQ9NRV9 HS

Organism-specific databases

HPAiHPA056417
HPA075277

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi119164, 8 interactors
IntActiQ9NRV9, 4 interactors
STRINGi9606.ENSP00000014930

Structurei

3D structure databases

ProteinModelPortaliQ9NRV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).By similarity

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IKQ6 Eukaryota
ENOG4111HGX LUCA
GeneTreeiENSGT00530000063312
HOGENOMiHOG000237638
HOVERGENiHBG053223
InParanoidiQ9NRV9
OMAiQRKQYFC
OrthoDBiEOG091G0ZIG
PhylomeDBiQ9NRV9
TreeFamiTF328887

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NRV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGMIKNSLF GSVETWPWQV LSKGDKEEVA YEERACEGGK FATVEVTDKP
60 70 80 90 100
VDEALREAMP KVAKYAGGTN DKGIGMGMTV PISFAVFPNE DGSLQKKLKV
110 120 130 140 150
WFRIPNQFQS DPPAPSDKSV KIEEREGITV YSMQFGGYAK EADYVAQATR
160 170 180
LRAALEGTAT YRGDIYFCTG YDPPMKPYGR RNEIWLLKT
Length:189
Mass (Da):21,097
Last modified:October 1, 2000 - v1
Checksum:i6ED12EA91B101B02
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YG71H0YG71_HUMAN
Heme-binding protein 1
HEBP1
62Annotation score:
F5GWX2F5GWX2_HUMAN
Heme-binding protein 1
HEBP1
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158T → P in AAD32098 (PubMed:10640688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053363183E → D. Corresponds to variant dbSNP:rs1941Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117615 mRNA Translation: AAD32098.1
AF167473 mRNA Translation: AAF89618.1
BT007294 mRNA Translation: AAP35958.1
AK289877 mRNA Translation: BAF82566.1
CH471094 Genomic DNA Translation: EAW96295.1
BC016277 mRNA Translation: AAH16277.1
CCDSiCCDS31749.1
RefSeqiNP_057071.2, NM_015987.4
UniGeneiHs.642618

Genome annotation databases

EnsembliENST00000014930; ENSP00000014930; ENSG00000013583
GeneIDi50865
KEGGihsa:50865
UCSCiuc001rbd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117615 mRNA Translation: AAD32098.1
AF167473 mRNA Translation: AAF89618.1
BT007294 mRNA Translation: AAP35958.1
AK289877 mRNA Translation: BAF82566.1
CH471094 Genomic DNA Translation: EAW96295.1
BC016277 mRNA Translation: AAH16277.1
CCDSiCCDS31749.1
RefSeqiNP_057071.2, NM_015987.4
UniGeneiHs.642618

3D structure databases

ProteinModelPortaliQ9NRV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119164, 8 interactors
IntActiQ9NRV9, 4 interactors
STRINGi9606.ENSP00000014930

PTM databases

iPTMnetiQ9NRV9
PhosphoSitePlusiQ9NRV9

Polymorphism and mutation databases

BioMutaiHEBP1
DMDMi74734327

2D gel databases

REPRODUCTION-2DPAGEiIPI00148063

Proteomic databases

EPDiQ9NRV9
MaxQBiQ9NRV9
PaxDbiQ9NRV9
PeptideAtlasiQ9NRV9
PRIDEiQ9NRV9
ProteomicsDBi82426
TopDownProteomicsiQ9NRV9

Protocols and materials databases

DNASUi50865
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000014930; ENSP00000014930; ENSG00000013583
GeneIDi50865
KEGGihsa:50865
UCSCiuc001rbd.4 human

Organism-specific databases

CTDi50865
DisGeNETi50865
EuPathDBiHostDB:ENSG00000013583.8
GeneCardsiHEBP1
H-InvDBiHIX0171642
HGNCiHGNC:17176 HEBP1
HPAiHPA056417
HPA075277
MIMi605826 gene
neXtProtiNX_Q9NRV9
OpenTargetsiENSG00000013583
PharmGKBiPA29236
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKQ6 Eukaryota
ENOG4111HGX LUCA
GeneTreeiENSGT00530000063312
HOGENOMiHOG000237638
HOVERGENiHBG053223
InParanoidiQ9NRV9
OMAiQRKQYFC
OrthoDBiEOG091G0ZIG
PhylomeDBiQ9NRV9
TreeFamiTF328887

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Miscellaneous databases

ChiTaRSiHEBP1 human
GenomeRNAii50865
PROiPR:Q9NRV9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000013583 Expressed in 225 organ(s), highest expression level in duodenum
CleanExiHS_HEBP1
ExpressionAtlasiQ9NRV9 baseline and differential
GenevisibleiQ9NRV9 HS

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRV9
Secondary accession number(s): A8K1G2, Q9Y5Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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