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UniProtKB - Q9NRV9 (HEBP1_HUMAN)
Protein
Heme-binding protein 1
Gene
HEBP1
Organism
Homo sapiens (Human)
Status
Functioni
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
1 PublicationGO - Molecular functioni
- heme binding Source: UniProtKB
GO - Biological processi
- circadian rhythm Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q9NRV9 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
SignaLinki | Q9NRV9 |
Names & Taxonomyi
Protein namesi | Recommended name: Heme-binding protein 1Alternative name(s): p22HBP |
Gene namesi | Name:HEBP1 Synonyms:HBP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17176, HEBP1 |
MIMi | 605826, gene |
neXtProti | NX_Q9NRV9 |
VEuPathDBi | HostDB:ENSG00000013583 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 50865 |
OpenTargetsi | ENSG00000013583 |
PharmGKBi | PA29236 |
Miscellaneous databases
Pharosi | Q9NRV9, Tbio |
Genetic variation databases
BioMutai | HEBP1 |
DMDMi | 74734327 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000116897 | 1 – 189 | Heme-binding protein 1Add BLAST | 189 |
Proteomic databases
EPDi | Q9NRV9 |
jPOSTi | Q9NRV9 |
MassIVEi | Q9NRV9 |
MaxQBi | Q9NRV9 |
PaxDbi | Q9NRV9 |
PeptideAtlasi | Q9NRV9 |
PRIDEi | Q9NRV9 |
ProteomicsDBi | 82426 |
TopDownProteomicsi | Q9NRV9 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00148063 |
PTM databases
iPTMneti | Q9NRV9 |
MetOSitei | Q9NRV9 |
PhosphoSitePlusi | Q9NRV9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000013583, Expressed in duodenum and 235 other tissues |
ExpressionAtlasi | Q9NRV9, baseline and differential |
Genevisiblei | Q9NRV9, HS |
Organism-specific databases
HPAi | ENSG00000013583, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 119164, 17 interactors |
IntActi | Q9NRV9, 7 interactors |
STRINGi | 9606.ENSP00000014930 |
Miscellaneous databases
RNActi | Q9NRV9, protein |
Family & Domainsi
Domaini
Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).By similarity
Sequence similaritiesi
Belongs to the HEBP family.Curated
Phylogenomic databases
eggNOGi | ENOG502RYZW, Eukaryota |
GeneTreei | ENSGT00940000160320 |
HOGENOMi | CLU_068699_3_0_1 |
InParanoidi | Q9NRV9 |
OMAi | YVNYAAK |
OrthoDBi | 1611913at2759 |
PhylomeDBi | Q9NRV9 |
TreeFami | TF328887 |
Family and domain databases
Gene3Di | 3.20.80.10, 1 hit |
InterProi | View protein in InterPro IPR011256, Reg_factor_effector_dom_sf IPR006917, SOUL_haem-bd |
PANTHERi | PTHR11220, PTHR11220, 1 hit |
Pfami | View protein in Pfam PF04832, SOUL, 1 hit |
SUPFAMi | SSF55136, SSF55136, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9NRV9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGMIKNSLF GSVETWPWQV LSKGDKEEVA YEERACEGGK FATVEVTDKP
60 70 80 90 100
VDEALREAMP KVAKYAGGTN DKGIGMGMTV PISFAVFPNE DGSLQKKLKV
110 120 130 140 150
WFRIPNQFQS DPPAPSDKSV KIEEREGITV YSMQFGGYAK EADYVAQATR
160 170 180
LRAALEGTAT YRGDIYFCTG YDPPMKPYGR RNEIWLLKT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IRV5 | A0A3B3IRV5_HUMAN | Heme-binding protein 1 | HEBP1 | 207 | Annotation score: | ||
F5GWX2 | F5GWX2_HUMAN | Heme-binding protein 1 | HEBP1 | 133 | Annotation score: | ||
H0YG71 | H0YG71_HUMAN | Heme-binding protein 1 | HEBP1 | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 158 | T → P in AAD32098 (PubMed:10640688).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053363 | 183 | E → D. Corresponds to variant dbSNP:rs1941Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117615 mRNA Translation: AAD32098.1 AF167473 mRNA Translation: AAF89618.1 BT007294 mRNA Translation: AAP35958.1 AK289877 mRNA Translation: BAF82566.1 CH471094 Genomic DNA Translation: EAW96295.1 BC016277 mRNA Translation: AAH16277.1 |
CCDSi | CCDS31749.1 |
RefSeqi | NP_057071.2, NM_015987.4 |
Genome annotation databases
Ensembli | ENST00000014930; ENSP00000014930; ENSG00000013583 |
GeneIDi | 50865 |
KEGGi | hsa:50865 |
MANE-Selecti | ENST00000014930.9; ENSP00000014930.4; NM_015987.5; NP_057071.2 |
UCSCi | uc001rbd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117615 mRNA Translation: AAD32098.1 AF167473 mRNA Translation: AAF89618.1 BT007294 mRNA Translation: AAP35958.1 AK289877 mRNA Translation: BAF82566.1 CH471094 Genomic DNA Translation: EAW96295.1 BC016277 mRNA Translation: AAH16277.1 |
CCDSi | CCDS31749.1 |
RefSeqi | NP_057071.2, NM_015987.4 |
3D structure databases
SMRi | Q9NRV9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119164, 17 interactors |
IntActi | Q9NRV9, 7 interactors |
STRINGi | 9606.ENSP00000014930 |
PTM databases
iPTMneti | Q9NRV9 |
MetOSitei | Q9NRV9 |
PhosphoSitePlusi | Q9NRV9 |
Genetic variation databases
BioMutai | HEBP1 |
DMDMi | 74734327 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00148063 |
Proteomic databases
EPDi | Q9NRV9 |
jPOSTi | Q9NRV9 |
MassIVEi | Q9NRV9 |
MaxQBi | Q9NRV9 |
PaxDbi | Q9NRV9 |
PeptideAtlasi | Q9NRV9 |
PRIDEi | Q9NRV9 |
ProteomicsDBi | 82426 |
TopDownProteomicsi | Q9NRV9 |
Protocols and materials databases
Antibodypediai | 23570, 165 antibodies from 23 providers |
DNASUi | 50865 |
Genome annotation databases
Ensembli | ENST00000014930; ENSP00000014930; ENSG00000013583 |
GeneIDi | 50865 |
KEGGi | hsa:50865 |
MANE-Selecti | ENST00000014930.9; ENSP00000014930.4; NM_015987.5; NP_057071.2 |
UCSCi | uc001rbd.4, human |
Organism-specific databases
CTDi | 50865 |
DisGeNETi | 50865 |
GeneCardsi | HEBP1 |
HGNCi | HGNC:17176, HEBP1 |
HPAi | ENSG00000013583, Tissue enhanced (intestine) |
MIMi | 605826, gene |
neXtProti | NX_Q9NRV9 |
OpenTargetsi | ENSG00000013583 |
PharmGKBi | PA29236 |
VEuPathDBi | HostDB:ENSG00000013583 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYZW, Eukaryota |
GeneTreei | ENSGT00940000160320 |
HOGENOMi | CLU_068699_3_0_1 |
InParanoidi | Q9NRV9 |
OMAi | YVNYAAK |
OrthoDBi | 1611913at2759 |
PhylomeDBi | Q9NRV9 |
TreeFami | TF328887 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRV9 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
SignaLinki | Q9NRV9 |
Miscellaneous databases
BioGRID-ORCSi | 50865, 8 hits in 1047 CRISPR screens |
ChiTaRSi | HEBP1, human |
GenomeRNAii | 50865 |
Pharosi | Q9NRV9, Tbio |
PROi | PR:Q9NRV9 |
RNActi | Q9NRV9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000013583, Expressed in duodenum and 235 other tissues |
ExpressionAtlasi | Q9NRV9, baseline and differential |
Genevisiblei | Q9NRV9, HS |
Family and domain databases
Gene3Di | 3.20.80.10, 1 hit |
InterProi | View protein in InterPro IPR011256, Reg_factor_effector_dom_sf IPR006917, SOUL_haem-bd |
PANTHERi | PTHR11220, PTHR11220, 1 hit |
Pfami | View protein in Pfam PF04832, SOUL, 1 hit |
SUPFAMi | SSF55136, SSF55136, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HEBP1_HUMAN | |
Accessioni | Q9NRV9Primary (citable) accession number: Q9NRV9 Secondary accession number(s): A8K1G2, Q9Y5Z5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families