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Entry version 157 (22 Apr 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Sorting nexin-15

Gene

SNX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei51Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei53Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei87Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei96Phosphatidylinositol 3-phosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14978 SNX15

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605964 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRS6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000110025

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRS6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNX15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138621 – 342Sorting nexin-15Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105Omega-N-methylarginineBy similarity1
Modified residuei201PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NRS6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NRS6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NRS6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NRS6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NRS6

PeptideAtlas

More...
PeptideAtlasi
Q9NRS6

PRoteomics IDEntifications database

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PRIDEi
Q9NRS6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
15302
82421 [Q9NRS6-1]
82422 [Q9NRS6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110025 Expressed in cerebellum and 92 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NRS6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NRS6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110025 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with SNX1, SNX2 and SNX4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118955, 11 interactors

Protein interaction database and analysis system

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IntActi
Q9NRS6, 9 interactors

Molecular INTeraction database

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MINTi
Q9NRS6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366452

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NRS6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NRS6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 130PXPROSITE-ProRule annotationAdd BLAST130
Domaini265 – 342MITAdd BLAST78

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0603 Eukaryota
KOG2101 Eukaryota
ENOG4111HIS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160125

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRS6

KEGG Orthology (KO)

More...
KOi
K17927

Identification of Orthologs from Complete Genome Data

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OMAi
SPTHIGE

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NRS6

TreeFam database of animal gene trees

More...
TreeFami
TF323964

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04212 MIT, 1 hit
PF00787 PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF116846 SSF116846, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK
60 70 80 90 100
RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA
110 120 130 140 150
EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP
160 170 180 190 200
PDDPRLSQLL PAERRGLEEL EVPVDPPPSS PAQEALDLLF NCESTEEASG
210 220 230 240 250
SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE SARLDQEPWE
260 270 280 290 300
PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH
310 320 330 340
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP
Length:342
Mass (Da):38,291
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33F64A79EAF6BBDC
GO
Isoform 2 (identifier: Q9NRS6-2) [UniParc]FASTAAdd to basket
Also known as: SNX15A

The sequence of this isoform differs from the canonical sequence as follows:
     222-308: EGAAPSPTHV...VHVLLQGVPS → G

Show »
Length:256
Mass (Da):29,220
Checksum:iB2044AFF5C09059B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNI5E9PNI5_HUMAN
Sorting nexin-15
SNX15
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMW6E9PMW6_HUMAN
Sorting nexin-15
SNX15
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR81E9PR81_HUMAN
Sorting nexin-15
SNX15
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK26E9PK26_HUMAN
Sorting nexin-15
SNX15
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221Missing in AAF89956 (PubMed:11085978).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052478334R → C. Corresponds to variant dbSNP:rs495820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006193222 – 308EGAAP…QGVPS → G in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF175267 mRNA Translation: AAF89955.1
AF175268 mRNA Translation: AAF89956.1
HQ205586 Genomic DNA Translation: ADP91255.1
HQ205587 Genomic DNA Translation: ADP91257.1
HQ205588 Genomic DNA Translation: ADP91259.1
HQ205589 Genomic DNA Translation: ADP91261.1
HQ205590 Genomic DNA Translation: ADP91263.1
HQ205591 Genomic DNA Translation: ADP91265.1
HQ205592 Genomic DNA Translation: ADP91267.1
HQ205593 Genomic DNA Translation: ADP91269.1
HQ205594 Genomic DNA Translation: ADP91271.1
HQ205595 Genomic DNA Translation: ADP91273.1
HQ205596 Genomic DNA Translation: ADP91275.1
HQ205597 Genomic DNA Translation: ADP91277.1
HQ205598 Genomic DNA Translation: ADP91279.1
HQ205599 Genomic DNA Translation: ADP91281.1
HQ205600 Genomic DNA Translation: ADP91283.1
HQ205601 Genomic DNA Translation: ADP91285.1
HQ205602 Genomic DNA Translation: ADP91287.1
HQ205603 Genomic DNA Translation: ADP91289.1
HQ205604 Genomic DNA Translation: ADP91291.1
HQ205605 Genomic DNA Translation: ADP91293.1
HQ205606 Genomic DNA Translation: ADP91295.1
HQ205607 Genomic DNA Translation: ADP91297.1
HQ205608 Genomic DNA Translation: ADP91299.1
HQ205609 Genomic DNA Translation: ADP91301.1
HQ205610 Genomic DNA Translation: ADP91303.1
HQ205611 Genomic DNA Translation: ADP91305.1
HQ205612 Genomic DNA Translation: ADP91307.1
HQ205613 Genomic DNA Translation: ADP91309.1
HQ205614 Genomic DNA Translation: ADP91311.1
HQ205615 Genomic DNA Translation: ADP91313.1
HQ205616 Genomic DNA Translation: ADP91315.1
HQ205617 Genomic DNA Translation: ADP91317.1
HQ205618 Genomic DNA Translation: ADP91319.1
HQ205619 Genomic DNA Translation: ADP91321.1
HQ205620 Genomic DNA Translation: ADP91323.1
HQ205621 Genomic DNA Translation: ADP91325.1
HQ205622 Genomic DNA Translation: ADP91327.1
HQ205623 Genomic DNA Translation: ADP91329.1
HQ205624 Genomic DNA Translation: ADP91331.1
HQ205625 Genomic DNA Translation: ADP91333.1
BT006631 mRNA Translation: AAP35277.1
AP000436 Genomic DNA No translation available.
AP003068 Genomic DNA No translation available.
BC009897 mRNA Translation: AAH09897.1
BC012767 mRNA Translation: AAH12767.1
BC014520 mRNA Translation: AAH14520.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8089.1 [Q9NRS6-1]
CCDS8090.1 [Q9NRS6-2]

NCBI Reference Sequences

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RefSeqi
NP_037438.2, NM_013306.4 [Q9NRS6-1]
NP_680086.2, NM_147777.3 [Q9NRS6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000352068; ENSP00000316410; ENSG00000110025 [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025 [Q9NRS6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29907

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29907

UCSC genome browser

More...
UCSCi
uc001ock.4 human [Q9NRS6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175267 mRNA Translation: AAF89955.1
AF175268 mRNA Translation: AAF89956.1
HQ205586 Genomic DNA Translation: ADP91255.1
HQ205587 Genomic DNA Translation: ADP91257.1
HQ205588 Genomic DNA Translation: ADP91259.1
HQ205589 Genomic DNA Translation: ADP91261.1
HQ205590 Genomic DNA Translation: ADP91263.1
HQ205591 Genomic DNA Translation: ADP91265.1
HQ205592 Genomic DNA Translation: ADP91267.1
HQ205593 Genomic DNA Translation: ADP91269.1
HQ205594 Genomic DNA Translation: ADP91271.1
HQ205595 Genomic DNA Translation: ADP91273.1
HQ205596 Genomic DNA Translation: ADP91275.1
HQ205597 Genomic DNA Translation: ADP91277.1
HQ205598 Genomic DNA Translation: ADP91279.1
HQ205599 Genomic DNA Translation: ADP91281.1
HQ205600 Genomic DNA Translation: ADP91283.1
HQ205601 Genomic DNA Translation: ADP91285.1
HQ205602 Genomic DNA Translation: ADP91287.1
HQ205603 Genomic DNA Translation: ADP91289.1
HQ205604 Genomic DNA Translation: ADP91291.1
HQ205605 Genomic DNA Translation: ADP91293.1
HQ205606 Genomic DNA Translation: ADP91295.1
HQ205607 Genomic DNA Translation: ADP91297.1
HQ205608 Genomic DNA Translation: ADP91299.1
HQ205609 Genomic DNA Translation: ADP91301.1
HQ205610 Genomic DNA Translation: ADP91303.1
HQ205611 Genomic DNA Translation: ADP91305.1
HQ205612 Genomic DNA Translation: ADP91307.1
HQ205613 Genomic DNA Translation: ADP91309.1
HQ205614 Genomic DNA Translation: ADP91311.1
HQ205615 Genomic DNA Translation: ADP91313.1
HQ205616 Genomic DNA Translation: ADP91315.1
HQ205617 Genomic DNA Translation: ADP91317.1
HQ205618 Genomic DNA Translation: ADP91319.1
HQ205619 Genomic DNA Translation: ADP91321.1
HQ205620 Genomic DNA Translation: ADP91323.1
HQ205621 Genomic DNA Translation: ADP91325.1
HQ205622 Genomic DNA Translation: ADP91327.1
HQ205623 Genomic DNA Translation: ADP91329.1
HQ205624 Genomic DNA Translation: ADP91331.1
HQ205625 Genomic DNA Translation: ADP91333.1
BT006631 mRNA Translation: AAP35277.1
AP000436 Genomic DNA No translation available.
AP003068 Genomic DNA No translation available.
BC009897 mRNA Translation: AAH09897.1
BC012767 mRNA Translation: AAH12767.1
BC014520 mRNA Translation: AAH14520.1
CCDSiCCDS8089.1 [Q9NRS6-1]
CCDS8090.1 [Q9NRS6-2]
RefSeqiNP_037438.2, NM_013306.4 [Q9NRS6-1]
NP_680086.2, NM_147777.3 [Q9NRS6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ECMX-ray2.35A1-126[»]
6MBIX-ray2.83A1-126[»]
SMRiQ9NRS6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118955, 11 interactors
IntActiQ9NRS6, 9 interactors
MINTiQ9NRS6
STRINGi9606.ENSP00000366452

PTM databases

iPTMnetiQ9NRS6
PhosphoSitePlusiQ9NRS6

Polymorphism and mutation databases

BioMutaiSNX15
DMDMi13124562

Proteomic databases

EPDiQ9NRS6
jPOSTiQ9NRS6
MassIVEiQ9NRS6
MaxQBiQ9NRS6
PaxDbiQ9NRS6
PeptideAtlasiQ9NRS6
PRIDEiQ9NRS6
ProteomicsDBi15302
82421 [Q9NRS6-1]
82422 [Q9NRS6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29586 212 antibodies

The DNASU plasmid repository

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DNASUi
29907

Genome annotation databases

EnsembliENST00000352068; ENSP00000316410; ENSG00000110025 [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025 [Q9NRS6-1]
GeneIDi29907
KEGGihsa:29907
UCSCiuc001ock.4 human [Q9NRS6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29907

GeneCards: human genes, protein and diseases

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GeneCardsi
SNX15
HGNCiHGNC:14978 SNX15
HPAiENSG00000110025 Low tissue specificity
MIMi605964 gene
neXtProtiNX_Q9NRS6
OpenTargetsiENSG00000110025
PharmGKBiPA37953

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0603 Eukaryota
KOG2101 Eukaryota
ENOG4111HIS LUCA
GeneTreeiENSGT00940000160125
InParanoidiQ9NRS6
KOiK17927
OMAiSPTHIGE
PhylomeDBiQ9NRS6
TreeFamiTF323964

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNX15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29907
PharosiQ9NRS6 Tdark

Protein Ontology

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PROi
PR:Q9NRS6
RNActiQ9NRS6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110025 Expressed in cerebellum and 92 other tissues
ExpressionAtlasiQ9NRS6 baseline and differential
GenevisibleiQ9NRS6 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF04212 MIT, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRS6
Secondary accession number(s): E5KQS6, Q9NRS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: April 22, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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