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Protein

Sorting nexin-15

Gene

SNX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei53Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei87Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei96Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-15
Gene namesi
Name:SNX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110025.12
HGNCiHGNC:14978 SNX15
MIMi605964 gene
neXtProtiNX_Q9NRS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110025
PharmGKBiPA37953

Polymorphism and mutation databases

BioMutaiSNX15
DMDMi13124562

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138621 – 342Sorting nexin-15Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105Omega-N-methylarginineBy similarity1
Modified residuei201PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NRS6
MaxQBiQ9NRS6
PaxDbiQ9NRS6
PeptideAtlasiQ9NRS6
PRIDEiQ9NRS6
ProteomicsDBi82421
82422 [Q9NRS6-2]

PTM databases

iPTMnetiQ9NRS6
PhosphoSitePlusiQ9NRS6

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000110025 Expressed in 93 organ(s), highest expression level in cerebellum
CleanExiHS_SNX15
ExpressionAtlasiQ9NRS6 baseline and differential
GenevisibleiQ9NRS6 HS

Organism-specific databases

HPAiHPA038955

Interactioni

Subunit structurei

Homodimer. Interacts with SNX1, SNX2 and SNX4.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi118955, 10 interactors
IntActiQ9NRS6, 6 interactors
MINTiQ9NRS6
STRINGi9606.ENSP00000366452

Structurei

3D structure databases

ProteinModelPortaliQ9NRS6
SMRiQ9NRS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 130PXPROSITE-ProRule annotationAdd BLAST130
Domaini265 – 342MITAdd BLAST78

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG0603 Eukaryota
KOG2101 Eukaryota
ENOG4111HIS LUCA
GeneTreeiENSGT00890000139413
HOGENOMiHOG000154362
HOVERGENiHBG066336
InParanoidiQ9NRS6
KOiK17927
OMAiVSRDLHI
OrthoDBiEOG091G0CNL
PhylomeDBiQ9NRS6
TreeFamiTF323964

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR035048 SNX15
PANTHERiPTHR15508:SF7 PTHR15508:SF7, 1 hit
PfamiView protein in Pfam
PF04212 MIT, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK
60 70 80 90 100
RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA
110 120 130 140 150
EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP
160 170 180 190 200
PDDPRLSQLL PAERRGLEEL EVPVDPPPSS PAQEALDLLF NCESTEEASG
210 220 230 240 250
SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE SARLDQEPWE
260 270 280 290 300
PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH
310 320 330 340
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP
Length:342
Mass (Da):38,291
Last modified:October 1, 2000 - v1
Checksum:i33F64A79EAF6BBDC
GO
Isoform 2 (identifier: Q9NRS6-2) [UniParc]FASTAAdd to basket
Also known as: SNX15A

The sequence of this isoform differs from the canonical sequence as follows:
     222-308: EGAAPSPTHV...VHVLLQGVPS → G

Show »
Length:256
Mass (Da):29,220
Checksum:iB2044AFF5C09059B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMW6E9PMW6_HUMAN
Sorting nexin-15
SNX15
217Annotation score:
E9PK26E9PK26_HUMAN
Sorting nexin-15
SNX15
192Annotation score:
E9PNI5E9PNI5_HUMAN
Sorting nexin-15
SNX15
114Annotation score:
E9PR81E9PR81_HUMAN
Sorting nexin-15
SNX15
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221Missing in AAF89956 (PubMed:11085978).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052478334R → C. Corresponds to variant dbSNP:rs495820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006193222 – 308EGAAP…QGVPS → G in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175267 mRNA Translation: AAF89955.1
AF175268 mRNA Translation: AAF89956.1
HQ205586 Genomic DNA Translation: ADP91255.1
HQ205587 Genomic DNA Translation: ADP91257.1
HQ205588 Genomic DNA Translation: ADP91259.1
HQ205589 Genomic DNA Translation: ADP91261.1
HQ205590 Genomic DNA Translation: ADP91263.1
HQ205591 Genomic DNA Translation: ADP91265.1
HQ205592 Genomic DNA Translation: ADP91267.1
HQ205593 Genomic DNA Translation: ADP91269.1
HQ205594 Genomic DNA Translation: ADP91271.1
HQ205595 Genomic DNA Translation: ADP91273.1
HQ205596 Genomic DNA Translation: ADP91275.1
HQ205597 Genomic DNA Translation: ADP91277.1
HQ205598 Genomic DNA Translation: ADP91279.1
HQ205599 Genomic DNA Translation: ADP91281.1
HQ205600 Genomic DNA Translation: ADP91283.1
HQ205601 Genomic DNA Translation: ADP91285.1
HQ205602 Genomic DNA Translation: ADP91287.1
HQ205603 Genomic DNA Translation: ADP91289.1
HQ205604 Genomic DNA Translation: ADP91291.1
HQ205605 Genomic DNA Translation: ADP91293.1
HQ205606 Genomic DNA Translation: ADP91295.1
HQ205607 Genomic DNA Translation: ADP91297.1
HQ205608 Genomic DNA Translation: ADP91299.1
HQ205609 Genomic DNA Translation: ADP91301.1
HQ205610 Genomic DNA Translation: ADP91303.1
HQ205611 Genomic DNA Translation: ADP91305.1
HQ205612 Genomic DNA Translation: ADP91307.1
HQ205613 Genomic DNA Translation: ADP91309.1
HQ205614 Genomic DNA Translation: ADP91311.1
HQ205615 Genomic DNA Translation: ADP91313.1
HQ205616 Genomic DNA Translation: ADP91315.1
HQ205617 Genomic DNA Translation: ADP91317.1
HQ205618 Genomic DNA Translation: ADP91319.1
HQ205619 Genomic DNA Translation: ADP91321.1
HQ205620 Genomic DNA Translation: ADP91323.1
HQ205621 Genomic DNA Translation: ADP91325.1
HQ205622 Genomic DNA Translation: ADP91327.1
HQ205623 Genomic DNA Translation: ADP91329.1
HQ205624 Genomic DNA Translation: ADP91331.1
HQ205625 Genomic DNA Translation: ADP91333.1
BT006631 mRNA Translation: AAP35277.1
AP000436 Genomic DNA No translation available.
AP003068 Genomic DNA No translation available.
BC009897 mRNA Translation: AAH09897.1
BC012767 mRNA Translation: AAH12767.1
BC014520 mRNA Translation: AAH14520.1
CCDSiCCDS8089.1 [Q9NRS6-1]
CCDS8090.1 [Q9NRS6-2]
RefSeqiNP_037438.2, NM_013306.4 [Q9NRS6-1]
NP_680086.2, NM_147777.3 [Q9NRS6-2]
UniGeneiHs.80132

Genome annotation databases

EnsembliENST00000352068; ENSP00000316410; ENSG00000110025 [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025 [Q9NRS6-1]
GeneIDi29907
KEGGihsa:29907
UCSCiuc001ock.4 human [Q9NRS6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175267 mRNA Translation: AAF89955.1
AF175268 mRNA Translation: AAF89956.1
HQ205586 Genomic DNA Translation: ADP91255.1
HQ205587 Genomic DNA Translation: ADP91257.1
HQ205588 Genomic DNA Translation: ADP91259.1
HQ205589 Genomic DNA Translation: ADP91261.1
HQ205590 Genomic DNA Translation: ADP91263.1
HQ205591 Genomic DNA Translation: ADP91265.1
HQ205592 Genomic DNA Translation: ADP91267.1
HQ205593 Genomic DNA Translation: ADP91269.1
HQ205594 Genomic DNA Translation: ADP91271.1
HQ205595 Genomic DNA Translation: ADP91273.1
HQ205596 Genomic DNA Translation: ADP91275.1
HQ205597 Genomic DNA Translation: ADP91277.1
HQ205598 Genomic DNA Translation: ADP91279.1
HQ205599 Genomic DNA Translation: ADP91281.1
HQ205600 Genomic DNA Translation: ADP91283.1
HQ205601 Genomic DNA Translation: ADP91285.1
HQ205602 Genomic DNA Translation: ADP91287.1
HQ205603 Genomic DNA Translation: ADP91289.1
HQ205604 Genomic DNA Translation: ADP91291.1
HQ205605 Genomic DNA Translation: ADP91293.1
HQ205606 Genomic DNA Translation: ADP91295.1
HQ205607 Genomic DNA Translation: ADP91297.1
HQ205608 Genomic DNA Translation: ADP91299.1
HQ205609 Genomic DNA Translation: ADP91301.1
HQ205610 Genomic DNA Translation: ADP91303.1
HQ205611 Genomic DNA Translation: ADP91305.1
HQ205612 Genomic DNA Translation: ADP91307.1
HQ205613 Genomic DNA Translation: ADP91309.1
HQ205614 Genomic DNA Translation: ADP91311.1
HQ205615 Genomic DNA Translation: ADP91313.1
HQ205616 Genomic DNA Translation: ADP91315.1
HQ205617 Genomic DNA Translation: ADP91317.1
HQ205618 Genomic DNA Translation: ADP91319.1
HQ205619 Genomic DNA Translation: ADP91321.1
HQ205620 Genomic DNA Translation: ADP91323.1
HQ205621 Genomic DNA Translation: ADP91325.1
HQ205622 Genomic DNA Translation: ADP91327.1
HQ205623 Genomic DNA Translation: ADP91329.1
HQ205624 Genomic DNA Translation: ADP91331.1
HQ205625 Genomic DNA Translation: ADP91333.1
BT006631 mRNA Translation: AAP35277.1
AP000436 Genomic DNA No translation available.
AP003068 Genomic DNA No translation available.
BC009897 mRNA Translation: AAH09897.1
BC012767 mRNA Translation: AAH12767.1
BC014520 mRNA Translation: AAH14520.1
CCDSiCCDS8089.1 [Q9NRS6-1]
CCDS8090.1 [Q9NRS6-2]
RefSeqiNP_037438.2, NM_013306.4 [Q9NRS6-1]
NP_680086.2, NM_147777.3 [Q9NRS6-2]
UniGeneiHs.80132

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ECMX-ray2.35A1-126[»]
ProteinModelPortaliQ9NRS6
SMRiQ9NRS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118955, 10 interactors
IntActiQ9NRS6, 6 interactors
MINTiQ9NRS6
STRINGi9606.ENSP00000366452

PTM databases

iPTMnetiQ9NRS6
PhosphoSitePlusiQ9NRS6

Polymorphism and mutation databases

BioMutaiSNX15
DMDMi13124562

Proteomic databases

EPDiQ9NRS6
MaxQBiQ9NRS6
PaxDbiQ9NRS6
PeptideAtlasiQ9NRS6
PRIDEiQ9NRS6
ProteomicsDBi82421
82422 [Q9NRS6-2]

Protocols and materials databases

DNASUi29907
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352068; ENSP00000316410; ENSG00000110025 [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025 [Q9NRS6-1]
GeneIDi29907
KEGGihsa:29907
UCSCiuc001ock.4 human [Q9NRS6-1]

Organism-specific databases

CTDi29907
EuPathDBiHostDB:ENSG00000110025.12
GeneCardsiSNX15
HGNCiHGNC:14978 SNX15
HPAiHPA038955
MIMi605964 gene
neXtProtiNX_Q9NRS6
OpenTargetsiENSG00000110025
PharmGKBiPA37953
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0603 Eukaryota
KOG2101 Eukaryota
ENOG4111HIS LUCA
GeneTreeiENSGT00890000139413
HOGENOMiHOG000154362
HOVERGENiHBG066336
InParanoidiQ9NRS6
KOiK17927
OMAiVSRDLHI
OrthoDBiEOG091G0CNL
PhylomeDBiQ9NRS6
TreeFamiTF323964

Miscellaneous databases

GeneWikiiSNX15
GenomeRNAii29907
PROiPR:Q9NRS6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110025 Expressed in 93 organ(s), highest expression level in cerebellum
CleanExiHS_SNX15
ExpressionAtlasiQ9NRS6 baseline and differential
GenevisibleiQ9NRS6 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR035048 SNX15
PANTHERiPTHR15508:SF7 PTHR15508:SF7, 1 hit
PfamiView protein in Pfam
PF04212 MIT, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX15_HUMAN
AccessioniPrimary (citable) accession number: Q9NRS6
Secondary accession number(s): E5KQS6, Q9NRS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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