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UniProtKB - Q9NRR1 (CYTL1_HUMAN)
Protein
Cytokine-like protein 1
Gene
CYTL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- signaling receptor binding Source: ProtInc
GO - Biological processi
- cartilage homeostasis Source: Ensembl
- chondrocyte differentiation Source: Ensembl
- chondroitin sulfate proteoglycan biosynthetic process Source: Ensembl
- inner ear development Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- signal transduction Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q9NRR1 |
SignaLinki | Q9NRR1 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytokine-like protein 1Alternative name(s): Protein C17 |
Gene namesi | Name:CYTL1 Synonyms:C4orf4 ORF Names:UNQ1942/PRO4425 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24435, CYTL1 |
MIMi | 607930, gene |
neXtProti | NX_Q9NRR1 |
VEuPathDBi | HostDB:ENSG00000170891 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: ProtInc
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 54360 |
OpenTargetsi | ENSG00000170891 |
PharmGKBi | PA134978681 |
Miscellaneous databases
Pharosi | Q9NRR1, Tbio |
Genetic variation databases
BioMutai | CYTL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000020838 | 23 – 136 | Cytokine-like protein 1Add BLAST | 114 |
Proteomic databases
EPDi | Q9NRR1 |
MassIVEi | Q9NRR1 |
PaxDbi | Q9NRR1 |
PeptideAtlasi | Q9NRR1 |
PRIDEi | Q9NRR1 |
ProteomicsDBi | 82406 |
PTM databases
iPTMneti | Q9NRR1 |
PhosphoSitePlusi | Q9NRR1 |
Expressioni
Tissue specificityi
Specifically expressed in CD34+ hematopoietic cells.1 Publication
Gene expression databases
Bgeei | ENSG00000170891, Expressed in tibia and 139 other tissues |
ExpressionAtlasi | Q9NRR1, baseline and differential |
Genevisiblei | Q9NRR1, HS |
Organism-specific databases
HPAi | ENSG00000170891, Tissue enhanced (placenta) |
Interactioni
GO - Molecular functioni
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303550 |
Miscellaneous databases
RNActi | Q9NRR1, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9NRR1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2F0, Eukaryota |
GeneTreei | ENSGT00390000016221 |
HOGENOMi | CLU_138622_1_0_1 |
InParanoidi | Q9NRR1 |
OMAi | CYSRMLT |
OrthoDBi | 1466674at2759 |
PhylomeDBi | Q9NRR1 |
TreeFami | TF333406 |
Family and domain databases
InterProi | View protein in InterPro IPR029253, CYTL1 |
PANTHERi | PTHR15974, PTHR15974, 1 hit |
Pfami | View protein in Pfam PF15153, CYTL1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NRR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP
60 70 80 90 100
SEPCVRYLPR LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY
110 120 130
TIMNSFCRRD LVFLLDDCNA LEYPIPVTTV LPDRQR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y8Q4 | H0Y8Q4_HUMAN | Cytokine-like protein 1 | CYTL1 | 92 | Annotation score: | ||
H0Y9X7 | H0Y9X7_HUMAN | Cytokine-like protein 1 | CYTL1 | 76 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050940 | 51 | S → L. Corresponds to variant dbSNP:rs35755546Ensembl. | 1 | |
Natural variantiVAR_050941 | 136 | R → C. Corresponds to variant dbSNP:rs11722554Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF193766 mRNA Translation: AAF73372.1 AY359101 mRNA Translation: AAQ89459.1 BC031391 mRNA Translation: AAH31391.1 |
CCDSi | CCDS3379.1 |
RefSeqi | NP_061129.1, NM_018659.2 |
Genome annotation databases
Ensembli | ENST00000307746.9; ENSP00000303550.4; ENSG00000170891.11 |
GeneIDi | 54360 |
KEGGi | hsa:54360 |
MANE-Selecti | ENST00000307746.9; ENSP00000303550.4; NM_018659.3; NP_061129.1 |
UCSCi | uc003gig.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF193766 mRNA Translation: AAF73372.1 AY359101 mRNA Translation: AAQ89459.1 BC031391 mRNA Translation: AAH31391.1 |
CCDSi | CCDS3379.1 |
RefSeqi | NP_061129.1, NM_018659.2 |
3D structure databases
AlphaFoldDBi | Q9NRR1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303550 |
PTM databases
iPTMneti | Q9NRR1 |
PhosphoSitePlusi | Q9NRR1 |
Genetic variation databases
BioMutai | CYTL1 |
Proteomic databases
EPDi | Q9NRR1 |
MassIVEi | Q9NRR1 |
PaxDbi | Q9NRR1 |
PeptideAtlasi | Q9NRR1 |
PRIDEi | Q9NRR1 |
ProteomicsDBi | 82406 |
Protocols and materials databases
Antibodypediai | 22593, 103 antibodies from 21 providers |
DNASUi | 54360 |
Genome annotation databases
Ensembli | ENST00000307746.9; ENSP00000303550.4; ENSG00000170891.11 |
GeneIDi | 54360 |
KEGGi | hsa:54360 |
MANE-Selecti | ENST00000307746.9; ENSP00000303550.4; NM_018659.3; NP_061129.1 |
UCSCi | uc003gig.5, human |
Organism-specific databases
CTDi | 54360 |
DisGeNETi | 54360 |
GeneCardsi | CYTL1 |
HGNCi | HGNC:24435, CYTL1 |
HPAi | ENSG00000170891, Tissue enhanced (placenta) |
MIMi | 607930, gene |
neXtProti | NX_Q9NRR1 |
OpenTargetsi | ENSG00000170891 |
PharmGKBi | PA134978681 |
VEuPathDBi | HostDB:ENSG00000170891 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2F0, Eukaryota |
GeneTreei | ENSGT00390000016221 |
HOGENOMi | CLU_138622_1_0_1 |
InParanoidi | Q9NRR1 |
OMAi | CYSRMLT |
OrthoDBi | 1466674at2759 |
PhylomeDBi | Q9NRR1 |
TreeFami | TF333406 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRR1 |
SignaLinki | Q9NRR1 |
Miscellaneous databases
BioGRID-ORCSi | 54360, 12 hits in 1063 CRISPR screens |
ChiTaRSi | CYTL1, human |
GenomeRNAii | 54360 |
Pharosi | Q9NRR1, Tbio |
PROi | PR:Q9NRR1 |
RNActi | Q9NRR1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170891, Expressed in tibia and 139 other tissues |
ExpressionAtlasi | Q9NRR1, baseline and differential |
Genevisiblei | Q9NRR1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029253, CYTL1 |
PANTHERi | PTHR15974, PTHR15974, 1 hit |
Pfami | View protein in Pfam PF15153, CYTL1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CYTL1_HUMAN | |
Accessioni | Q9NRR1Primary (citable) accession number: Q9NRR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot