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Protein

Cytokine-like protein 1

Gene

CYTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • signaling receptor binding Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine-like protein 1
Alternative name(s):
Protein C17
Gene namesi
Name:CYTL1
Synonyms:C4orf4
ORF Names:UNQ1942/PRO4425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000170891.10
HGNCiHGNC:24435 CYTL1
MIMi607930 gene
neXtProtiNX_Q9NRR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54360
OpenTargetsiENSG00000170891
PharmGKBiPA134978681

Polymorphism and mutation databases

BioMutaiCYTL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002083823 – 136Cytokine-like protein 1Add BLAST114

Proteomic databases

EPDiQ9NRR1
PaxDbiQ9NRR1
PeptideAtlasiQ9NRR1
PRIDEiQ9NRR1
ProteomicsDBi82406

PTM databases

iPTMnetiQ9NRR1
PhosphoSitePlusiQ9NRR1

Expressioni

Tissue specificityi

Specifically expressed in CD34+ hematopoietic cells.1 Publication

Gene expression databases

BgeeiENSG00000170891 Expressed in 118 organ(s), highest expression level in tibia
CleanExiHS_CYTL1
ExpressionAtlasiQ9NRR1 baseline and differential
GenevisibleiQ9NRR1 HS

Organism-specific databases

HPAiHPA067201

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303550

Structurei

3D structure databases

ProteinModelPortaliQ9NRR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXZC Eukaryota
ENOG4112045 LUCA
GeneTreeiENSGT00390000016221
HOGENOMiHOG000217919
HOVERGENiHBG079724
InParanoidiQ9NRR1
OMAiPSEPCVR
OrthoDBiEOG091G0UNA
PhylomeDBiQ9NRR1
TreeFamiTF333406

Family and domain databases

InterProiView protein in InterPro
IPR029253 CYTL1
PANTHERiPTHR15974 PTHR15974, 1 hit
PfamiView protein in Pfam
PF15153 CYTL1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9NRR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP
60 70 80 90 100
SEPCVRYLPR LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY
110 120 130
TIMNSFCRRD LVFLLDDCNA LEYPIPVTTV LPDRQR
Length:136
Mass (Da):15,577
Last modified:October 1, 2000 - v1
Checksum:i1CAEE1BFC31A3AE3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9X7H0Y9X7_HUMAN
Cytokine-like protein 1
CYTL1
76Annotation score:
H0Y8Q4H0Y8Q4_HUMAN
Cytokine-like protein 1
CYTL1
92Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05094051S → L. Corresponds to variant dbSNP:rs35755546Ensembl.1
Natural variantiVAR_050941136R → C. Corresponds to variant dbSNP:rs11722554Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193766 mRNA Translation: AAF73372.1
AY359101 mRNA Translation: AAQ89459.1
BC031391 mRNA Translation: AAH31391.1
CCDSiCCDS3379.1
RefSeqiNP_061129.1, NM_018659.2
UniGeneiHs.13872

Genome annotation databases

EnsembliENST00000307746; ENSP00000303550; ENSG00000170891
GeneIDi54360
KEGGihsa:54360
UCSCiuc003gig.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCYTL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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