UniProtKB - Q9NRR1 (CYTL1_HUMAN)

BLAST

>sp|Q9NRR1|CYTL1_HUMAN Cytokine-like protein 1 OS=Homo sapiens OX=9606 GN=CYTL1 PE=1 SV=1
MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSEPCVRYLPR
LYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTIMNSFCRRDLVFLLDDCNA
LEYPIPVTTVLPDRQR

Align
Format
Add to basket Added to basket
History
Entry version 110 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Cytokine-like protein 1

Gene

CYTL1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 10857752

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cartilage homeostasis Source: Ensembl
chondrocyte differentiation Source: Ensembl
chondroitin sulfate proteoglycan biosynthetic process Source: Ensembl
inner ear development Source: Ensembl
positive regulation of DNA-binding transcription factor activity Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10857752

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytokine-like protein 1 Alternative name(s): Protein C17
Gene namesⁱ	Name:CYTL1 Synonyms:C4orf4 ORF Names:UNQ1942/PRO4425
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170891.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24435 CYTL1
MIMⁱ	607930 gene
neXtProtⁱ	NX_Q9NRR1

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54360
Open Targets More...OpenTargetsⁱ	ENSG00000170891
PharmGKBⁱ	PA134978681

Polymorphism and mutation databases

BioMutaⁱ	CYTL1

BioMutaⁱ

CYTL1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST		22
ChainⁱPRO_0000020838	23 – 136	Cytokine-like protein 1Add BLAST		114

Proteomic databases

EPDⁱ	Q9NRR1
PaxDbⁱ	Q9NRR1
PeptideAtlas More...PeptideAtlasⁱ	Q9NRR1
PRIDEⁱ	Q9NRR1
ProteomicsDBⁱ	82406

PTM databases

iPTMnetⁱ	Q9NRR1
PhosphoSitePlusⁱ	Q9NRR1

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in CD34+ hematopoietic cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170891 Expressed in 118 organ(s), highest expression level in tibia
CleanExⁱ	HS_CYTL1
ExpressionAtlasⁱ	Q9NRR1 baseline and differential
Genevisibleⁱ	Q9NRR1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067201

HPAⁱ

HPA067201

Interactionⁱ

GO - Molecular functionⁱ

signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 10857752

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303550

STRINGⁱ

9606.ENSP00000303550

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NRR1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IXZC Eukaryota ENOG4112045 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016221
HOGENOMⁱ	HOG000217919
HOVERGENⁱ	HBG079724
InParanoidⁱ	Q9NRR1
OMAⁱ	CYSRMLT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UNA
PhylomeDBⁱ	Q9NRR1
TreeFamⁱ	TF333406

Family and domain databases

InterProⁱ	View protein in InterPro IPR029253 CYTL1
PANTHERⁱ	PTHR15974 PTHR15974, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15153 CYTL1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9NRR1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP 
        60         70         80         90        100
SEPCVRYLPR LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY 
       110        120        130 
TIMNSFCRRD LVFLLDDCNA LEYPIPVTTV LPDRQR

Length:136

Mass (Da):15,577

Last modified:October 1, 2000 - v1

Checksum:ⁱ1CAEE1BFC31A3AE3

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y9X7	H0Y9X7_HUMAN	Cytokine-like protein 1 Cytokine-like protein 1	CYTL1	76	Annotation score:
H0Y8Q4	H0Y8Q4_HUMAN	Cytokine-like protein 1 Cytokine-like protein 1	CYTL1	92	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050940	51	S → L. Corresponds to variant dbSNP:rs35755546Ensembl.		1
Natural variantⁱVAR_050941	136	R → C. Corresponds to variant dbSNP:rs11722554Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF193766 mRNA Translation: AAF73372.1 AY359101 mRNA Translation: AAQ89459.1 BC031391 mRNA Translation: AAH31391.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3379.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061129.1, NM_018659.2
UniGeneⁱ	Hs.13872

Genome annotation databases

Ensemblⁱ	ENST00000307746; ENSP00000303550; ENSG00000170891
GeneIDⁱ	54360
KEGGⁱ	hsa:54360
UCSC genome browser More...UCSCⁱ	uc003gig.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NRR1	CYTL1 isoform 1		PANTR		136	UniRef90_Q9NRR1
Cytokine-like protein 1		MACMU		136
Cytokine like 1		MACFA		136
Uncharacterized protein		MACNE		136
CYTL1 isoform 1		PONAB		136
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9NRR1	Uncharacterized protein		CHLSB		136	UniRef50_Q9NRR1
CYTL1 isoform 1		PANTR		136
CYTL1 isoform 1		PONAB		136
Uncharacterized protein		COLAP		136
Uncharacterized protein		PAPAN		136
+101

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF193766 mRNA Translation: AAF73372.1 AY359101 mRNA Translation: AAQ89459.1 BC031391 mRNA Translation: AAH31391.1
CCDSⁱ	CCDS3379.1
RefSeqⁱ	NP_061129.1, NM_018659.2
UniGeneⁱ	Hs.13872

3D structure databases

ProteinModelPortalⁱ	Q9NRR1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303550

STRINGⁱ

9606.ENSP00000303550

PTM databases

iPTMnetⁱ	Q9NRR1
PhosphoSitePlusⁱ	Q9NRR1

Polymorphism and mutation databases

BioMutaⁱ	CYTL1

BioMutaⁱ

CYTL1

Proteomic databases

EPDⁱ	Q9NRR1
PaxDbⁱ	Q9NRR1
PeptideAtlasⁱ	Q9NRR1
PRIDEⁱ	Q9NRR1
ProteomicsDBⁱ	82406

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54360
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000307746; ENSP00000303550; ENSG00000170891
GeneIDⁱ	54360
KEGGⁱ	hsa:54360
UCSCⁱ	uc003gig.5 human

Organism-specific databases

CTDⁱ	54360
DisGeNETⁱ	54360
EuPathDBⁱ	HostDB:ENSG00000170891.10
GeneCardsⁱ	CYTL1
HGNCⁱ	HGNC:24435 CYTL1
HPAⁱ	HPA067201
MIMⁱ	607930 gene
neXtProtⁱ	NX_Q9NRR1
OpenTargetsⁱ	ENSG00000170891
PharmGKBⁱ	PA134978681
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXZC Eukaryota ENOG4112045 LUCA
GeneTreeⁱ	ENSGT00390000016221
HOGENOMⁱ	HOG000217919
HOVERGENⁱ	HBG079724
InParanoidⁱ	Q9NRR1
OMAⁱ	CYSRMLT
OrthoDBⁱ	EOG091G0UNA
PhylomeDBⁱ	Q9NRR1
TreeFamⁱ	TF333406

Miscellaneous databases

ChiTaRSⁱ	CYTL1 human
GenomeRNAiⁱ	54360
Protein Ontology More...PROⁱ	PR:Q9NRR1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170891 Expressed in 118 organ(s), highest expression level in tibia
CleanExⁱ	HS_CYTL1
ExpressionAtlasⁱ	Q9NRR1 baseline and differential
Genevisibleⁱ	Q9NRR1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029253 CYTL1
PANTHERⁱ	PTHR15974 PTHR15974, 1 hit
Pfamⁱ	View protein in Pfam PF15153 CYTL1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CYTL1_HUMAN
Accessionⁱ	Q9NRR1Primary (citable) accession number: Q9NRR1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NRR1 (CYTL1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cytokine-like protein 1

CYTL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ