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UniProtKB - Q9NRP7 (STK36_HUMAN)

Entry version 182 (02 Jun 2021)
Sequence version 2 (21 Mar 2006)
Previous versions | rss
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Protein

Serine/threonine-protein kinase 36

Gene

STK36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483).

Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483).

GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483).

Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity).

Essential for construction of the central pair apparatus of motile cilia.

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCilium biogenesis/degradation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRP7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NRP7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NRP7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase 36 (EC:2.7.11.1)
Alternative name(s):
Fused homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STK36Imported
Synonyms:KIAA1278Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17209, STK36

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607652, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRP7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163482.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		27148

MalaCards human disease database

More...MalaCardsi		STK36

Open Targets

More...OpenTargetsi		ENSG00000163482

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		244, Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38212

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRP7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4312

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		Q9NRP7

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STK36

Domain mapping of disease mutations (DMDM)

More...DMDMi		90101761

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002290201 – 1315Serine/threonine-protein kinase 36Add BLAST1315

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NRP7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRP7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRP7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRP7

PeptideAtlas

More...PeptideAtlasi		Q9NRP7

PRoteomics IDEntifications database

More...PRIDEi		Q9NRP7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82401 [Q9NRP7-1]
82402 [Q9NRP7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163482, Expressed in right uterine tube and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRP7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRP7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163482, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GLI1, GLI2 and GLI3 (PubMed:10806483).

Interacts with SPAG16 and KIF27.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118032, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q9NRP7, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295709

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NRP7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRP7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRP7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 254Protein kinasePROSITE-ProRule annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni312 – 347DisorderedSequence analysisAdd BLAST36
Regioni365 – 387DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0597, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158375

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002453_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRP7

Identification of Orthologs from Complete Genome Data

More...OMAi		ARAMSIH

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRP7

TreeFam database of animal gene trees

More...TreeFami		TF105340

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 13 Publications (identifier: Q9NRP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR 
        60         70         80         90        100
EIEIMRGLRH PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED 
       110        120        130        140        150
QVQAIAAQLV SALYYLHSHR ILHRDMKPQN ILLAKGGGIK LCDFGFARAM 
       160        170        180        190        200
STNTMVLTSI KGTPLYMSPE LVEERPYDHT ADLWSVGCIL YELAVGTPPF 
       210        220        230        240        250
YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR QRLSWPDLLY 
       260        270        280        290        300
HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 
       310        320        330        340        350
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE 
       360        370        380        390        400
SSLLAGILAS ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG 
       410        420        430        440        450
QRSTDVVDLE NEEPDSDNEW QHLLETTEPV PIQLKAPLTL LCNPDFCQRI 
       460        470        480        490        500
QSQLHEAGGQ ILKGILEGAS HILPAFRVLS SLLSSCSDSV ALYSFCREAG 
       510        520        530        540        550
LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA CTFNLERSQT 
       560        570        580        590        600
SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 
       610        620        630        640        650
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ 
       660        670        680        690        700
SEDIPGAISS ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS 
       710        720        730        740        750
LISGLQHPIL CLHLLKVLYS CCLVSEGLCR LLGQEPLALE SLFMLIQGKV 
       760        770        780        790        800
KVVDWEESTE VTLYFLSLLV FRLQNLPCGM EKLGSDVATL FTHSHVVSLV 
       810        820        830        840        850
SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL TPPGSCGFYD 
       860        870        880        890        900
GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG 
       910        920        930        940        950
ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI 
       960        970        980        990       1000
LMSILKHLLC PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL 
      1010       1020       1030       1040       1050
LIGVLADLRD SEVAAHLLQV CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ 
      1060       1070       1080       1090       1100
FVNTVSASPR TIVSFLSVAL LSDQPLLTSD LLSLLAHTAR VLSPSHLSFI 
      1110       1120       1130       1140       1150
QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS MALRGALQSQ 
      1160       1170       1180       1190       1200
SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 
      1210       1220       1230       1240       1250
LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK 
      1260       1270       1280       1290       1300
EAALIALRSL QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK 
      1310 
HCRKLIHLLR PAHSM
Length:1,315
Mass (Da):143,995
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i793F4638F1871C01
GO
Isoform 21 Publication (identifier: Q9NRP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-858: Missing.

Show »
Length:1,294
Mass (Da):141,737
Checksum:i42376671A0F272AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDA4C9JDA4_HUMAN
Serine/threonine-protein kinase 36
STK36
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2I3H7C2I3_HUMAN
Serine/threonine-protein kinase 36
STK36
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1B8C9J1B8_HUMAN
Serine/threonine-protein kinase 36
STK36
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2A4H7C2A4_HUMAN
Serine/threonine-protein kinase 36
STK36
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C359H7C359_HUMAN
Serine/threonine-protein kinase 36
STK36
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86592 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14184 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229N → D in AAH26158 (PubMed:15489334).Curated1
Sequence conflicti971 – 986Missing (PubMed:14702039).CuratedAdd BLAST16
Sequence conflicti1003G → V in AAF97028 (PubMed:10806483).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04117790I → M1 PublicationCorresponds to variant dbSNP:rs55706732Ensembl.1
Natural variantiVAR_041178240R → W1 PublicationCorresponds to variant dbSNP:rs35038757Ensembl.1
Natural variantiVAR_041179295K → R1 PublicationCorresponds to variant dbSNP:rs1863703Ensembl.1
Natural variantiVAR_041180329D → N1 PublicationCorresponds to variant dbSNP:rs34027859EnsemblClinVar.1
Natural variantiVAR_041181462L → V1 PublicationCorresponds to variant dbSNP:rs45586733Ensembl.1
Natural variantiVAR_025727463K → N1 PublicationCorresponds to variant dbSNP:rs17856747Ensembl.1
Natural variantiVAR_041182476F → S1 PublicationCorresponds to variant dbSNP:rs34128793Ensembl.1
Natural variantiVAR_041183477R → W1 PublicationCorresponds to variant dbSNP:rs16859180Ensembl.1
Natural variantiVAR_041184583R → Q1 PublicationCorresponds to variant dbSNP:rs1344642EnsemblClinVar.1
Natural variantiVAR_057112638Q → P. Corresponds to variant dbSNP:rs6709303Ensembl.1
Natural variantiVAR_041185660S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1244829273Ensembl.1
Natural variantiVAR_041186672L → P1 PublicationCorresponds to variant dbSNP:rs35448374Ensembl.1
Natural variantiVAR_025728767S → T1 PublicationCorresponds to variant dbSNP:rs17856748Ensembl.1
Natural variantiVAR_041187767S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041188816T → A1 PublicationCorresponds to variant dbSNP:rs34271431Ensembl.1
Natural variantiVAR_041189839R → Q1 PublicationCorresponds to variant dbSNP:rs13023540EnsemblClinVar.1
Natural variantiVAR_041190840L → V1 PublicationCorresponds to variant dbSNP:rs36099639EnsemblClinVar.1
Natural variantiVAR_0257291003G → D2 PublicationsCorresponds to variant dbSNP:rs1863704EnsemblClinVar.1
Natural variantiVAR_0617471004V → I. Corresponds to variant dbSNP:rs55633575Ensembl.1
Natural variantiVAR_0411911111Y → C1 PublicationCorresponds to variant dbSNP:rs56278660Ensembl.1
Natural variantiVAR_0411921112R → Q1 PublicationCorresponds to variant dbSNP:rs12993599Ensembl.1
Natural variantiVAR_0411931138Q → K in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411941185P → S in an ovarian endometrioid sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411951313H → P1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051983838 – 858Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF200815 mRNA Translation: AAF97028.1
AB033104 mRNA Translation: BAA86592.1 Different initiation.
AC009974 Genomic DNA No translation available.
BC026158 mRNA Translation: AAH26158.1
AL133630 mRNA Translation: CAB63754.1
AK022692 mRNA Translation: BAB14184.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2421.1 [Q9NRP7-1]
CCDS58750.1 [Q9NRP7-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T43465

NCBI Reference Sequences

More...RefSeqi		NP_001230242.1, NM_001243313.1 [Q9NRP7-2]
NP_056505.2, NM_015690.4 [Q9NRP7-1]
XP_005246521.1, XM_005246464.1
XP_016859293.1, XM_017003804.1 [Q9NRP7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295709; ENSP00000295709; ENSG00000163482 [Q9NRP7-1]
ENST00000392105; ENSP00000375954; ENSG00000163482 [Q9NRP7-2]
ENST00000440309; ENSP00000394095; ENSG00000163482 [Q9NRP7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27148

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27148

UCSC genome browser

More...UCSCi		uc002viu.4, human [Q9NRP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200815 mRNA Translation: AAF97028.1
AB033104 mRNA Translation: BAA86592.1 Different initiation.
AC009974 Genomic DNA No translation available.
BC026158 mRNA Translation: AAH26158.1
AL133630 mRNA Translation: CAB63754.1
AK022692 mRNA Translation: BAB14184.1 Frameshift.
CCDSiCCDS2421.1 [Q9NRP7-1]
CCDS58750.1 [Q9NRP7-2]
PIRiT43465
RefSeqiNP_001230242.1, NM_001243313.1 [Q9NRP7-2]
NP_056505.2, NM_015690.4 [Q9NRP7-1]
XP_005246521.1, XM_005246464.1
XP_016859293.1, XM_017003804.1 [Q9NRP7-2]

3D structure databases

SMRiQ9NRP7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118032, 16 interactors
IntActiQ9NRP7, 14 interactors
STRINGi9606.ENSP00000295709

Chemistry databases

BindingDBiQ9NRP7
ChEMBLiCHEMBL4312
DrugBankiDB12010, Fostamatinib
DrugCentraliQ9NRP7

PTM databases

iPTMnetiQ9NRP7
PhosphoSitePlusiQ9NRP7

Genetic variation databases

BioMutaiSTK36
DMDMi90101761

Proteomic databases

jPOSTiQ9NRP7
MassIVEiQ9NRP7
MaxQBiQ9NRP7
PaxDbiQ9NRP7
PeptideAtlasiQ9NRP7
PRIDEiQ9NRP7
ProteomicsDBi82401 [Q9NRP7-1]
82402 [Q9NRP7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34284, 177 antibodies

The DNASU plasmid repository

More...DNASUi		27148

Genome annotation databases

EnsembliENST00000295709; ENSP00000295709; ENSG00000163482 [Q9NRP7-1]
ENST00000392105; ENSP00000375954; ENSG00000163482 [Q9NRP7-2]
ENST00000440309; ENSP00000394095; ENSG00000163482 [Q9NRP7-1]
GeneIDi27148
KEGGihsa:27148
UCSCiuc002viu.4, human [Q9NRP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27148
DisGeNETi27148

GeneCards: human genes, protein and diseases

More...GeneCardsi		STK36
HGNCiHGNC:17209, STK36
HPAiENSG00000163482, Tissue enhanced (testis)
MalaCardsiSTK36
MIMi607652, gene
neXtProtiNX_Q9NRP7
OpenTargetsiENSG00000163482
Orphaneti244, Primary ciliary dyskinesia
PharmGKBiPA38212
VEuPathDBiHostDB:ENSG00000163482.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0597, Eukaryota
GeneTreeiENSGT00940000158375
HOGENOMiCLU_002453_2_0_1
InParanoidiQ9NRP7
OMAiARAMSIH
PhylomeDBiQ9NRP7
TreeFamiTF105340

Enzyme and pathway databases

PathwayCommonsiQ9NRP7
SignaLinkiQ9NRP7
SIGNORiQ9NRP7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27148, 2 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STK36, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STK36

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27148
PharosiQ9NRP7, Tbio

Protein Ontology

More...PROi		PR:Q9NRP7
RNActiQ9NRP7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163482, Expressed in right uterine tube and 179 other tissues
ExpressionAtlasiQ9NRP7, baseline and differential
GenevisibleiQ9NRP7, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTK36_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRP7
Secondary accession number(s): B7WPM3
, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 2, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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