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Protein

Serine/threonine-protein kinase 36

Gene

STK36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATP1
Active sitei125Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCilium biogenesis/degradation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9NRP7
SIGNORiQ9NRP7

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 36 (EC:2.7.11.1)
Alternative name(s):
Fused homolog
Gene namesi
Name:STK36Imported
Synonyms:KIAA1278Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163482.11
HGNCiHGNC:17209 STK36
MIMi607652 gene
neXtProtiNX_Q9NRP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000163482
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA38212

Chemistry databases

ChEMBLiCHEMBL4312

Polymorphism and mutation databases

BioMutaiSTK36
DMDMi90101761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002290201 – 1315Serine/threonine-protein kinase 36Add BLAST1315

Proteomic databases

EPDiQ9NRP7
MaxQBiQ9NRP7
PaxDbiQ9NRP7
PeptideAtlasiQ9NRP7
PRIDEiQ9NRP7
ProteomicsDBi82401
82402 [Q9NRP7-2]

PTM databases

iPTMnetiQ9NRP7
PhosphoSitePlusiQ9NRP7

Expressioni

Tissue specificityi

Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.1 Publication

Gene expression databases

BgeeiENSG00000163482 Expressed in 163 organ(s), highest expression level in right uterine tube
CleanExiHS_STK36
ExpressionAtlasiQ9NRP7 baseline and differential
GenevisibleiQ9NRP7 HS

Organism-specific databases

HPAiHPA027409
HPA027453
HPA030058

Interactioni

Subunit structurei

Interacts with GLI1, GLI2 and GLI3 (PubMed:10806483). Interacts with SPAG16 and KIF27.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118032, 14 interactors
IntActiQ9NRP7, 8 interactors
STRINGi9606.ENSP00000295709

Chemistry databases

BindingDBiQ9NRP7

Structurei

3D structure databases

ProteinModelPortaliQ9NRP7
SMRiQ9NRP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 254Protein kinasePROSITE-ProRule annotationAdd BLAST251

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0597 Eukaryota
ENOG410XRQ6 LUCA
GeneTreeiENSGT00910000144066
HOGENOMiHOG000015284
HOVERGENiHBG094005
InParanoidiQ9NRP7
KOiK06228
OMAiACKRMAE
OrthoDBiEOG091G04G9
PhylomeDBiQ9NRP7
TreeFamiTF105340

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 13 Publications (identifier: Q9NRP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR
60 70 80 90 100
EIEIMRGLRH PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED
110 120 130 140 150
QVQAIAAQLV SALYYLHSHR ILHRDMKPQN ILLAKGGGIK LCDFGFARAM
160 170 180 190 200
STNTMVLTSI KGTPLYMSPE LVEERPYDHT ADLWSVGCIL YELAVGTPPF
210 220 230 240 250
YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR QRLSWPDLLY
260 270 280 290 300
HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR
310 320 330 340 350
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE
360 370 380 390 400
SSLLAGILAS ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG
410 420 430 440 450
QRSTDVVDLE NEEPDSDNEW QHLLETTEPV PIQLKAPLTL LCNPDFCQRI
460 470 480 490 500
QSQLHEAGGQ ILKGILEGAS HILPAFRVLS SLLSSCSDSV ALYSFCREAG
510 520 530 540 550
LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA CTFNLERSQT
560 570 580 590 600
SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN
610 620 630 640 650
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ
660 670 680 690 700
SEDIPGAISS ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS
710 720 730 740 750
LISGLQHPIL CLHLLKVLYS CCLVSEGLCR LLGQEPLALE SLFMLIQGKV
760 770 780 790 800
KVVDWEESTE VTLYFLSLLV FRLQNLPCGM EKLGSDVATL FTHSHVVSLV
810 820 830 840 850
SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL TPPGSCGFYD
860 870 880 890 900
GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG
910 920 930 940 950
ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI
960 970 980 990 1000
LMSILKHLLC PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL
1010 1020 1030 1040 1050
LIGVLADLRD SEVAAHLLQV CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ
1060 1070 1080 1090 1100
FVNTVSASPR TIVSFLSVAL LSDQPLLTSD LLSLLAHTAR VLSPSHLSFI
1110 1120 1130 1140 1150
QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS MALRGALQSQ
1160 1170 1180 1190 1200
SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL
1210 1220 1230 1240 1250
LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK
1260 1270 1280 1290 1300
EAALIALRSL QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK
1310
HCRKLIHLLR PAHSM
Length:1,315
Mass (Da):143,995
Last modified:March 21, 2006 - v2
Checksum:i793F4638F1871C01
GO
Isoform 21 Publication (identifier: Q9NRP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,294
Mass (Da):141,737
Checksum:i42376671A0F272AF
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDA4C9JDA4_HUMAN
Serine/threonine-protein kinase 36
STK36
278Annotation score:
C9J1B8C9J1B8_HUMAN
Serine/threonine-protein kinase 36
STK36
75Annotation score:
H7C2A4H7C2A4_HUMAN
Serine/threonine-protein kinase 36
STK36
148Annotation score:
H7C359H7C359_HUMAN
Serine/threonine-protein kinase 36
STK36
66Annotation score:
H7C2I3H7C2I3_HUMAN
Serine/threonine-protein kinase 36
STK36
106Annotation score:

Sequence cautioni

The sequence BAA86592 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14184 differs from that shown. Reason: Frameshift at position 987.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229N → D in AAH26158 (PubMed:15489334).Curated1
Sequence conflicti971 – 986Missing (PubMed:14702039).CuratedAdd BLAST16
Sequence conflicti1003G → V in AAF97028 (PubMed:10806483).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04117790I → M1 PublicationCorresponds to variant dbSNP:rs55706732Ensembl.1
Natural variantiVAR_041178240R → W1 PublicationCorresponds to variant dbSNP:rs35038757Ensembl.1
Natural variantiVAR_041179295K → R1 PublicationCorresponds to variant dbSNP:rs1863703Ensembl.1
Natural variantiVAR_041180329D → N1 PublicationCorresponds to variant dbSNP:rs34027859Ensembl.1
Natural variantiVAR_041181462L → V1 PublicationCorresponds to variant dbSNP:rs45586733Ensembl.1
Natural variantiVAR_025727463K → N1 PublicationCorresponds to variant dbSNP:rs17856747Ensembl.1
Natural variantiVAR_041182476F → S1 PublicationCorresponds to variant dbSNP:rs34128793Ensembl.1
Natural variantiVAR_041183477R → W1 PublicationCorresponds to variant dbSNP:rs16859180Ensembl.1
Natural variantiVAR_041184583R → Q1 PublicationCorresponds to variant dbSNP:rs1344642EnsemblClinVar.1
Natural variantiVAR_057112638Q → P. Corresponds to variant dbSNP:rs6709303Ensembl.1
Natural variantiVAR_041185660S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1244829273Ensembl.1
Natural variantiVAR_041186672L → P1 PublicationCorresponds to variant dbSNP:rs35448374Ensembl.1
Natural variantiVAR_025728767S → T1 PublicationCorresponds to variant dbSNP:rs17856748Ensembl.1
Natural variantiVAR_041187767S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041188816T → A1 PublicationCorresponds to variant dbSNP:rs34271431Ensembl.1
Natural variantiVAR_041189839R → Q1 PublicationCorresponds to variant dbSNP:rs13023540Ensembl.1
Natural variantiVAR_041190840L → V1 PublicationCorresponds to variant dbSNP:rs36099639Ensembl.1
Natural variantiVAR_0257291003G → D2 PublicationsCorresponds to variant dbSNP:rs1863704EnsemblClinVar.1
Natural variantiVAR_0617471004V → I. Corresponds to variant dbSNP:rs55633575Ensembl.1
Natural variantiVAR_0411911111Y → C1 PublicationCorresponds to variant dbSNP:rs56278660Ensembl.1
Natural variantiVAR_0411921112R → Q1 PublicationCorresponds to variant dbSNP:rs12993599Ensembl.1
Natural variantiVAR_0411931138Q → K in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411941185P → S in an ovarian endometrioid sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411951313H → P1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051983838 – 858Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200815 mRNA Translation: AAF97028.1
AB033104 mRNA Translation: BAA86592.1 Different initiation.
AC009974 Genomic DNA No translation available.
BC026158 mRNA Translation: AAH26158.1
AL133630 mRNA Translation: CAB63754.1
AK022692 mRNA Translation: BAB14184.1 Frameshift.
CCDSiCCDS2421.1 [Q9NRP7-1]
CCDS58750.1 [Q9NRP7-2]
PIRiT43465
RefSeqiNP_001230242.1, NM_001243313.1 [Q9NRP7-2]
NP_056505.2, NM_015690.4 [Q9NRP7-1]
XP_005246521.1, XM_005246464.1 [Q9NRP7-1]
XP_016859293.1, XM_017003804.1 [Q9NRP7-2]
UniGeneiHs.471404
Hs.712986

Genome annotation databases

EnsembliENST00000295709; ENSP00000295709; ENSG00000163482 [Q9NRP7-1]
ENST00000392105; ENSP00000375954; ENSG00000163482 [Q9NRP7-2]
ENST00000440309; ENSP00000394095; ENSG00000163482 [Q9NRP7-1]
GeneIDi27148
KEGGihsa:27148
UCSCiuc002viu.4 human [Q9NRP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200815 mRNA Translation: AAF97028.1
AB033104 mRNA Translation: BAA86592.1 Different initiation.
AC009974 Genomic DNA No translation available.
BC026158 mRNA Translation: AAH26158.1
AL133630 mRNA Translation: CAB63754.1
AK022692 mRNA Translation: BAB14184.1 Frameshift.
CCDSiCCDS2421.1 [Q9NRP7-1]
CCDS58750.1 [Q9NRP7-2]
PIRiT43465
RefSeqiNP_001230242.1, NM_001243313.1 [Q9NRP7-2]
NP_056505.2, NM_015690.4 [Q9NRP7-1]
XP_005246521.1, XM_005246464.1 [Q9NRP7-1]
XP_016859293.1, XM_017003804.1 [Q9NRP7-2]
UniGeneiHs.471404
Hs.712986

3D structure databases

ProteinModelPortaliQ9NRP7
SMRiQ9NRP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118032, 14 interactors
IntActiQ9NRP7, 8 interactors
STRINGi9606.ENSP00000295709

Chemistry databases

BindingDBiQ9NRP7
ChEMBLiCHEMBL4312

PTM databases

iPTMnetiQ9NRP7
PhosphoSitePlusiQ9NRP7

Polymorphism and mutation databases

BioMutaiSTK36
DMDMi90101761

Proteomic databases

EPDiQ9NRP7
MaxQBiQ9NRP7
PaxDbiQ9NRP7
PeptideAtlasiQ9NRP7
PRIDEiQ9NRP7
ProteomicsDBi82401
82402 [Q9NRP7-2]

Protocols and materials databases

DNASUi27148
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295709; ENSP00000295709; ENSG00000163482 [Q9NRP7-1]
ENST00000392105; ENSP00000375954; ENSG00000163482 [Q9NRP7-2]
ENST00000440309; ENSP00000394095; ENSG00000163482 [Q9NRP7-1]
GeneIDi27148
KEGGihsa:27148
UCSCiuc002viu.4 human [Q9NRP7-1]

Organism-specific databases

CTDi27148
EuPathDBiHostDB:ENSG00000163482.11
GeneCardsiSTK36
H-InvDBiHIX0002836
HGNCiHGNC:17209 STK36
HPAiHPA027409
HPA027453
HPA030058
MIMi607652 gene
neXtProtiNX_Q9NRP7
OpenTargetsiENSG00000163482
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA38212
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0597 Eukaryota
ENOG410XRQ6 LUCA
GeneTreeiENSGT00910000144066
HOGENOMiHOG000015284
HOVERGENiHBG094005
InParanoidiQ9NRP7
KOiK06228
OMAiACKRMAE
OrthoDBiEOG091G04G9
PhylomeDBiQ9NRP7
TreeFamiTF105340

Enzyme and pathway databases

SignaLinkiQ9NRP7
SIGNORiQ9NRP7

Miscellaneous databases

ChiTaRSiSTK36 human
GeneWikiiSTK36
GenomeRNAii27148
PROiPR:Q9NRP7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163482 Expressed in 163 organ(s), highest expression level in right uterine tube
CleanExiHS_STK36
ExpressionAtlasiQ9NRP7 baseline and differential
GenevisibleiQ9NRP7 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK36_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP7
Secondary accession number(s): B7WPM3
, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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