UniProtKB - Q9NRP7 (STK36_HUMAN)

BLAST

>sp|Q9NRP7|STK36_HUMAN Serine/threonine-protein kinase 36 OS=Homo sapiens OX=9606 GN=STK36 PE=1 SV=2
MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH
PNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHR
ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHT
ADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPR
QRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSR
ILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILAS
ELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEW
QHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLS
SLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFA
CTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGN
SRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISS
ALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYS
CCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGM
EKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRL
TPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEG
ELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLC
PSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQV
CCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSD
LLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHS
MALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQL
LGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSL
QQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM

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History
Entry version 163 (07 Nov 2018)
Sequence version 2 (21 Mar 2006)
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Protein

Serine/threonine-protein kinase 36

Gene

STK36

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.By similarity1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactorⁱ

Mg²⁺Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	33	ATP		1
Active siteⁱ	125	Proton acceptorPROSITE-ProRule annotationBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 18	ATPPROSITE-ProRule annotationBy similarity		9

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Traceable author statementⁱ
- 10806483
metal ion binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 10806483
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10806483

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: Ensembl
cilium assembly Source: UniProtKB
epithelial cilium movement Source: Ensembl
positive regulation of hh target transcription factor activity Source: UniProtKB
positive regulation of smoothened signaling pathway Source: UniProtKB
post-embryonic development Source: UniProtKB
protein phosphorylation
Source: UniProtKB
Traceable author statementⁱ
- 10806483
regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10806483

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cilium biogenesis/degradation
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9NRP7
SIGNORⁱ	Q9NRP7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase 36 (EC:2.7.11.1) Alternative name(s): Fused homolog
Gene namesⁱ	Name:STK36Imported Synonyms:KIAA1278Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163482.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17209 STK36
MIMⁱ	607652 gene
neXtProtⁱ	NX_Q9NRP7

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	33	K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000163482
Orphanetⁱ	244 Primary ciliary dyskinesia
PharmGKBⁱ	PA38212

Chemistry databases

ChEMBLⁱ	CHEMBL4312

ChEMBLⁱ

CHEMBL4312

Polymorphism and mutation databases

BioMutaⁱ	STK36
DMDMⁱ	90101761

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000229020	1 – 1315	Serine/threonine-protein kinase 36Add BLAST		1315

Proteomic databases

EPDⁱ	Q9NRP7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NRP7
PaxDbⁱ	Q9NRP7
PeptideAtlas More...PeptideAtlasⁱ	Q9NRP7
PRIDEⁱ	Q9NRP7
ProteomicsDBⁱ	82401 82402 [Q9NRP7-2]

PTM databases

iPTMnetⁱ	Q9NRP7
PhosphoSitePlusⁱ	Q9NRP7

Expressionⁱ

Tissue specificityⁱ

Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163482 Expressed in 163 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_STK36
ExpressionAtlasⁱ	Q9NRP7 baseline and differential
Genevisibleⁱ	Q9NRP7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027409 HPA027453 HPA030058

HPAⁱ

HPA027409
HPA027453
HPA030058

Interactionⁱ

Subunit structureⁱ

Interacts with GLI1, GLI2 and GLI3 (PubMed:10806483). Interacts with SPAG16 and KIF27.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GLI1	P08151	2	EBI-863797,EBI-308084
GLI3	P10071	2	EBI-863797,EBI-308055
SUFU	Q9UMX1	3	EBI-863797,EBI-740595

GO - Molecular functionⁱ

transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10806483

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118032, 14 interactors
IntActⁱ	Q9NRP7, 8 interactors
STRINGⁱ	9606.ENSP00000295709

Chemistry databases

BindingDBⁱ

Q9NRP7

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NRP7
SMRⁱ	Q9NRP7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 254	Protein kinasePROSITE-ProRule annotationAdd BLAST		251

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0597 Eukaryota ENOG410XRQ6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144066
HOGENOMⁱ	HOG000015284
HOVERGENⁱ	HBG094005
InParanoidⁱ	Q9NRP7
KEGG Orthology (KO) More...KOⁱ	K06228
OMAⁱ	ACKRMAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04G9
PhylomeDBⁱ	Q9NRP7
TreeFamⁱ	TF105340

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 13 Publications (identifier: Q9NRP7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR 
        60         70         80         90        100
EIEIMRGLRH PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED 
       110        120        130        140        150
QVQAIAAQLV SALYYLHSHR ILHRDMKPQN ILLAKGGGIK LCDFGFARAM 
       160        170        180        190        200
STNTMVLTSI KGTPLYMSPE LVEERPYDHT ADLWSVGCIL YELAVGTPPF 
       210        220        230        240        250
YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR QRLSWPDLLY 
       260        270        280        290        300
HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 
       310        320        330        340        350
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE 
       360        370        380        390        400
SSLLAGILAS ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG 
       410        420        430        440        450
QRSTDVVDLE NEEPDSDNEW QHLLETTEPV PIQLKAPLTL LCNPDFCQRI 
       460        470        480        490        500
QSQLHEAGGQ ILKGILEGAS HILPAFRVLS SLLSSCSDSV ALYSFCREAG 
       510        520        530        540        550
LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA CTFNLERSQT 
       560        570        580        590        600
SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 
       610        620        630        640        650
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ 
       660        670        680        690        700
SEDIPGAISS ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS 
       710        720        730        740        750
LISGLQHPIL CLHLLKVLYS CCLVSEGLCR LLGQEPLALE SLFMLIQGKV 
       760        770        780        790        800
KVVDWEESTE VTLYFLSLLV FRLQNLPCGM EKLGSDVATL FTHSHVVSLV 
       810        820        830        840        850
SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL TPPGSCGFYD 
       860        870        880        890        900
GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG 
       910        920        930        940        950
ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI 
       960        970        980        990       1000
LMSILKHLLC PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL 
      1010       1020       1030       1040       1050
LIGVLADLRD SEVAAHLLQV CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ 
      1060       1070       1080       1090       1100
FVNTVSASPR TIVSFLSVAL LSDQPLLTSD LLSLLAHTAR VLSPSHLSFI 
      1110       1120       1130       1140       1150
QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS MALRGALQSQ 
      1160       1170       1180       1190       1200
SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 
      1210       1220       1230       1240       1250
LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK 
      1260       1270       1280       1290       1300
EAALIALRSL QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK 
      1310 
HCRKLIHLLR PAHSM

Length:1,315

Mass (Da):143,995

Last modified:March 21, 2006 - v2

Checksum:ⁱ793F4638F1871C01

Isoform 21 Publication (identifier: Q9NRP7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
838-858: Missing.

« Hide

        10         20         30         40         50
MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR 
        60         70         80         90        100
EIEIMRGLRH PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED 
       110        120        130        140        150
QVQAIAAQLV SALYYLHSHR ILHRDMKPQN ILLAKGGGIK LCDFGFARAM 
       160        170        180        190        200
STNTMVLTSI KGTPLYMSPE LVEERPYDHT ADLWSVGCIL YELAVGTPPF 
       210        220        230        240        250
YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR QRLSWPDLLY 
       260        270        280        290        300
HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 
       310        320        330        340        350
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE 
       360        370        380        390        400
SSLLAGILAS ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG 
       410        420        430        440        450
QRSTDVVDLE NEEPDSDNEW QHLLETTEPV PIQLKAPLTL LCNPDFCQRI 
       460        470        480        490        500
QSQLHEAGGQ ILKGILEGAS HILPAFRVLS SLLSSCSDSV ALYSFCREAG 
       510        520        530        540        550
LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA CTFNLERSQT 
       560        570        580        590        600
SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 
       610        620        630        640        650
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ 
       660        670        680        690        700
SEDIPGAISS ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS 
       710        720        730        740        750
LISGLQHPIL CLHLLKVLYS CCLVSEGLCR LLGQEPLALE SLFMLIQGKV 
       760        770        780        790        800
KVVDWEESTE VTLYFLSLLV FRLQNLPCGM EKLGSDVATL FTHSHVVSLV 
       810        820        830        840        850
SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAELLT EQGKASLIRD 
       860        870        880        890        900
MSSSEMWTVL WHRFSMVLRL PEEASAQEGE LSLSSPPSPE PDWTLISPQG 
       910        920        930        940        950
MAALLSLAMA TFTQEPQLCL SCLSQHGSIL MSILKHLLCP SFLNQLRQAP 
       960        970        980        990       1000
HGSEFLPVVV LSVCQLLCFP FALDMDADLL IGVLADLRDS EVAAHLLQVC 
      1010       1020       1030       1040       1050
CYHLPLMQVE LPISLLTRLA LMDPTSLNQF VNTVSASPRT IVSFLSVALL 
      1060       1070       1080       1090       1100
SDQPLLTSDL LSLLAHTARV LSPSHLSFIQ ELLAGSDESY RPLRSLLGHP 
      1110       1120       1130       1140       1150
ENSVRAHTYR LLGHLLQHSM ALRGALQSQS GLLSLLLLGL GDKDPVVRCS 
      1160       1170       1180       1190       1200
ASFAVGNAAY QAGPLGPALA AAVPSMTQLL GDPQAGIRRN VASALGNLGP 
      1210       1220       1230       1240       1250
EGLGEELLQC EVPQRLLEMA CGDPQPNVKE AALIALRSLQ QEPGIHQVLV 
      1260       1270       1280       1290 
SLGASEKLSL LSLGNQSLPH SSPRPASAKH CRKLIHLLRP AHSM

Note: No experimental confirmation available.Curated

Show »

Length:1,294

Mass (Da):141,737

Checksum:ⁱ42376671A0F272AF

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JDA4	C9JDA4_HUMAN	Serine/threonine-protein kinase 36 Serine/threonine-protein kinase 36	STK36	278	Annotation score:
C9J1B8	C9J1B8_HUMAN	Serine/threonine-protein kinase 36 Serine/threonine-protein kinase 36	STK36	75	Annotation score:
H7C2A4	H7C2A4_HUMAN	Serine/threonine-protein kinase 36 Serine/threonine-protein kinase 36	STK36	148	Annotation score:
H7C359	H7C359_HUMAN	Serine/threonine-protein kinase 36 Serine/threonine-protein kinase 36	STK36	66	Annotation score:
H7C2I3	H7C2I3_HUMAN	Serine/threonine-protein kinase 36 Serine/threonine-protein kinase 36	STK36	106	Annotation score:

Sequence cautionⁱ

The sequence BAA86592 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB14184 differs from that shown. Reason: Frameshift at position 987.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	229	N → D in AAH26158 (PubMed:15489334).Curated	1
Sequence conflictⁱ	971 – 986	Missing (PubMed:14702039).CuratedAdd BLAST	16
Sequence conflictⁱ	1003	G → V in AAF97028 (PubMed:10806483).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041177	90	I → M1 PublicationCorresponds to variant dbSNP:rs55706732Ensembl.	1
Natural variantⁱVAR_041178	240	R → W1 PublicationCorresponds to variant dbSNP:rs35038757Ensembl.	1
Natural variantⁱVAR_041179	295	K → R1 PublicationCorresponds to variant dbSNP:rs1863703Ensembl.	1
Natural variantⁱVAR_041180	329	D → N1 PublicationCorresponds to variant dbSNP:rs34027859Ensembl.	1
Natural variantⁱVAR_041181	462	L → V1 PublicationCorresponds to variant dbSNP:rs45586733Ensembl.	1
Natural variantⁱVAR_025727	463	K → N1 PublicationCorresponds to variant dbSNP:rs17856747Ensembl.	1
Natural variantⁱVAR_041182	476	F → S1 PublicationCorresponds to variant dbSNP:rs34128793Ensembl.	1
Natural variantⁱVAR_041183	477	R → W1 PublicationCorresponds to variant dbSNP:rs16859180Ensembl.	1
Natural variantⁱVAR_041184	583	R → Q1 PublicationCorresponds to variant dbSNP:rs1344642EnsemblClinVar.	1
Natural variantⁱVAR_057112	638	Q → P. Corresponds to variant dbSNP:rs6709303Ensembl.	1
Natural variantⁱVAR_041185	660	S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1244829273Ensembl.	1
Natural variantⁱVAR_041186	672	L → P1 PublicationCorresponds to variant dbSNP:rs35448374Ensembl.	1
Natural variantⁱVAR_025728	767	S → T1 PublicationCorresponds to variant dbSNP:rs17856748Ensembl.	1
Natural variantⁱVAR_041187	767	S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041188	816	T → A1 PublicationCorresponds to variant dbSNP:rs34271431Ensembl.	1
Natural variantⁱVAR_041189	839	R → Q1 PublicationCorresponds to variant dbSNP:rs13023540Ensembl.	1
Natural variantⁱVAR_041190	840	L → V1 PublicationCorresponds to variant dbSNP:rs36099639Ensembl.	1
Natural variantⁱVAR_025729	1003	G → D2 PublicationsCorresponds to variant dbSNP:rs1863704EnsemblClinVar.	1
Natural variantⁱVAR_061747	1004	V → I. Corresponds to variant dbSNP:rs55633575Ensembl.	1
Natural variantⁱVAR_041191	1111	Y → C1 PublicationCorresponds to variant dbSNP:rs56278660Ensembl.	1
Natural variantⁱVAR_041192	1112	R → Q1 PublicationCorresponds to variant dbSNP:rs12993599Ensembl.	1
Natural variantⁱVAR_041193	1138	Q → K in an ovarian serous carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041194	1185	P → S in an ovarian endometrioid sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041195	1313	H → P1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_051983	838 – 858	Missing in isoform 2. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF200815 mRNA Translation: AAF97028.1 AB033104 mRNA Translation: BAA86592.1 Different initiation. AC009974 Genomic DNA No translation available. BC026158 mRNA Translation: AAH26158.1 AL133630 mRNA Translation: CAB63754.1 AK022692 mRNA Translation: BAB14184.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2421.1 [Q9NRP7-1] CCDS58750.1 [Q9NRP7-2]
PIRⁱ	T43465
NCBI Reference Sequences More...RefSeqⁱ	NP_001230242.1, NM_001243313.1 [Q9NRP7-2] NP_056505.2, NM_015690.4 [Q9NRP7-1] XP_005246521.1, XM_005246464.1 [Q9NRP7-1] XP_016859293.1, XM_017003804.1 [Q9NRP7-2]
UniGeneⁱ	Hs.471404 Hs.712986

Genome annotation databases

Ensemblⁱ	ENST00000295709; ENSP00000295709; ENSG00000163482 [Q9NRP7-1] ENST00000392105; ENSP00000375954; ENSG00000163482 [Q9NRP7-2] ENST00000440309; ENSP00000394095; ENSG00000163482 [Q9NRP7-1]
GeneIDⁱ	27148
KEGGⁱ	hsa:27148
UCSC genome browser More...UCSCⁱ	uc002viu.4 human [Q9NRP7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NRP7	Testicular tissue protein Li 188		HUMAN		1315	UniRef100_Q9NRP7
Serine/threonine-protein kinase 36 (Fragment)		HUMAN		278
UPI0005D03576		HUMAN		1261
UPI0005D01468		HUMAN		784

Protein	Similar proteins		Species	Score	Length	Source
Q9NRP7	Serine/threonine-protein kinase 36		PONAB		1315	UniRef90_Q9NRP7
Testicular tissue protein Li 188		HUMAN		1315
Serine/threonine kinase 36		CHLSB		1317
STK36 isoform 6		PANTR		1316
Serine/threonine kinase 36		AOTNA		1315
+67
Q9NRP7-2	STK36 isoform 5		PANTR		1295	UniRef90_Q9NRP7-2
STK36 isoform 2		PONAB		1294
Serine/threonine kinase 36		GORGO		1294
Uncharacterized protein		NOMLE		1291
Uncharacterized protein		PAPAN		1287
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9NRP7	Serine/threonine-protein kinase 36		PONAB		1315	UniRef50_Q9NRP7
Serine/threonine-protein kinase 36		MOUSE		1316
Testicular tissue protein Li 188		HUMAN		1315
Serine/threonine kinase 36		CHLSB		1317
STK36 isoform 6		PANTR		1316
+385

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF200815 mRNA Translation: AAF97028.1 AB033104 mRNA Translation: BAA86592.1 Different initiation. AC009974 Genomic DNA No translation available. BC026158 mRNA Translation: AAH26158.1 AL133630 mRNA Translation: CAB63754.1 AK022692 mRNA Translation: BAB14184.1 Frameshift.
CCDSⁱ	CCDS2421.1 [Q9NRP7-1] CCDS58750.1 [Q9NRP7-2]
PIRⁱ	T43465
RefSeqⁱ	NP_001230242.1, NM_001243313.1 [Q9NRP7-2] NP_056505.2, NM_015690.4 [Q9NRP7-1] XP_005246521.1, XM_005246464.1 [Q9NRP7-1] XP_016859293.1, XM_017003804.1 [Q9NRP7-2]
UniGeneⁱ	Hs.471404 Hs.712986

3D structure databases

ProteinModelPortalⁱ	Q9NRP7
SMRⁱ	Q9NRP7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118032, 14 interactors
IntActⁱ	Q9NRP7, 8 interactors
STRINGⁱ	9606.ENSP00000295709

Chemistry databases

BindingDBⁱ	Q9NRP7
ChEMBLⁱ	CHEMBL4312

PTM databases

iPTMnetⁱ	Q9NRP7
PhosphoSitePlusⁱ	Q9NRP7

Polymorphism and mutation databases

BioMutaⁱ	STK36
DMDMⁱ	90101761

Proteomic databases

EPDⁱ	Q9NRP7
MaxQBⁱ	Q9NRP7
PaxDbⁱ	Q9NRP7
PeptideAtlasⁱ	Q9NRP7
PRIDEⁱ	Q9NRP7
ProteomicsDBⁱ	82401 82402 [Q9NRP7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27148
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295709; ENSP00000295709; ENSG00000163482 [Q9NRP7-1] ENST00000392105; ENSP00000375954; ENSG00000163482 [Q9NRP7-2] ENST00000440309; ENSP00000394095; ENSG00000163482 [Q9NRP7-1]
GeneIDⁱ	27148
KEGGⁱ	hsa:27148
UCSCⁱ	uc002viu.4 human [Q9NRP7-1]

Organism-specific databases

CTDⁱ	27148
EuPathDBⁱ	HostDB:ENSG00000163482.11
GeneCardsⁱ	STK36
H-InvDBⁱ	HIX0002836
HGNCⁱ	HGNC:17209 STK36
HPAⁱ	HPA027409 HPA027453 HPA030058
MIMⁱ	607652 gene
neXtProtⁱ	NX_Q9NRP7
OpenTargetsⁱ	ENSG00000163482
Orphanetⁱ	244 Primary ciliary dyskinesia
PharmGKBⁱ	PA38212
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0597 Eukaryota ENOG410XRQ6 LUCA
GeneTreeⁱ	ENSGT00910000144066
HOGENOMⁱ	HOG000015284
HOVERGENⁱ	HBG094005
InParanoidⁱ	Q9NRP7
KOⁱ	K06228
OMAⁱ	ACKRMAE
OrthoDBⁱ	EOG091G04G9
PhylomeDBⁱ	Q9NRP7
TreeFamⁱ	TF105340

Enzyme and pathway databases

SignaLinkⁱ	Q9NRP7
SIGNORⁱ	Q9NRP7

Miscellaneous databases

ChiTaRSⁱ	STK36 human
GeneWikiⁱ	STK36
GenomeRNAiⁱ	27148
Protein Ontology More...PROⁱ	PR:Q9NRP7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163482 Expressed in 163 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_STK36
ExpressionAtlasⁱ	Q9NRP7 baseline and differential
Genevisibleⁱ	Q9NRP7 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STK36_HUMAN
Accessionⁱ	Q9NRP7Primary (citable) accession number: Q9NRP7 Secondary accession number(s): B7WPM3 , Q8TC32, Q9H9N9, Q9UF35, Q9ULE2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	March 21, 2006
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q9NRP7 (STK36_HUMAN)

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Serine/threonine-protein kinase 36

STK36

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GO - Molecular functionⁱ

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Keywords - Cellular componentⁱ

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PTM / Processingⁱ

Expressionⁱ

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Keywords - Coding sequence diversityⁱ

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