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Protein

COX assembly mitochondrial protein 2 homolog

Gene

CMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cytochrome c oxidase biogenesis.By similarity

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
COX assembly mitochondrial protein 2 homolog
Gene namesi
Name:CMC2
Synonyms:C16orf61
ORF Names:DC13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103121.8
HGNCiHGNC:24447 CMC2
neXtProtiNX_Q9NRP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi56942
OpenTargetsiENSG00000103121
PharmGKBiPA143485398

Polymorphism and mutation databases

BioMutaiCMC2
DMDMi37999796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929431 – 79COX assembly mitochondrial protein 2 homologAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14 ↔ 47PROSITE-ProRule annotation
Disulfide bondi24 ↔ 37PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9NRP2
MaxQBiQ9NRP2
PaxDbiQ9NRP2
PeptideAtlasiQ9NRP2
PRIDEiQ9NRP2
ProteomicsDBi82399
TopDownProteomicsiQ9NRP2

PTM databases

iPTMnetiQ9NRP2
PhosphoSitePlusiQ9NRP2

Expressioni

Gene expression databases

BgeeiENSG00000103121
CleanExiHS_C16orf61
ExpressionAtlasiQ9NRP2 baseline and differential
GenevisibleiQ9NRP2 HS

Organism-specific databases

HPAiCAB026396
HPA006871

Interactioni

Protein-protein interaction databases

BioGridi121266, 3 interactors
IntActiQ9NRP2, 5 interactors
STRINGi9606.ENSP00000219400

Structurei

3D structure databases

ProteinModelPortaliQ9NRP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 55CHCHPROSITE-ProRule annotationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 24Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi37 – 47Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the CMC family.Curated

Phylogenomic databases

eggNOGiKOG4148 Eukaryota
ENOG41123JB LUCA
GeneTreeiENSGT00390000016908
HOGENOMiHOG000212591
HOVERGENiHBG045487
InParanoidiQ9NRP2
KOiK18172
OMAiCHKEHNV
PhylomeDBiQ9NRP2
TreeFamiTF314049

Family and domain databases

InterProiView protein in InterPro
IPR013892 Cyt_c_biogenesis_Cmc1-like
PANTHERiPTHR22977 PTHR22977, 1 hit
PfamiView protein in Pfam
PF08583 Cmc1, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NRP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPDLSPHLH TEECNVLINL LKECHKNHNI LKFFGYCNDV DRELRKCLKN
60 70
EYVENRTKSR EHGIAMRKKL FNPPEESEK
Length:79
Mass (Da):9,460
Last modified:October 1, 2000 - v1
Checksum:i783381BD6DAFB7AA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03381611T → S. Corresponds to variant dbSNP:rs2303217Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201935 mRNA Translation: AAF86871.1
AC009079 Genomic DNA No translation available.
AC092718 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95557.1
CH471114 Genomic DNA Translation: EAW95559.1
CH471114 Genomic DNA Translation: EAW95560.1
BC032631 mRNA Translation: AAH32631.1
CCDSiCCDS10930.1
RefSeqiNP_064573.1, NM_020188.3
XP_016878956.1, XM_017023467.1
XP_016878957.1, XM_017023468.1
XP_016878958.1, XM_017023469.1
XP_016878959.1, XM_017023470.1
UniGeneiHs.55028

Genome annotation databases

EnsembliENST00000219400; ENSP00000219400; ENSG00000103121
ENST00000564249; ENSP00000456841; ENSG00000103121
ENST00000565650; ENSP00000455457; ENSG00000103121
ENST00000565914; ENSP00000455723; ENSG00000103121
GeneIDi56942
KEGGihsa:56942
UCSCiuc002ffu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOXM2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP2
Secondary accession number(s): D3DUK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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