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Entry version 148 (16 Oct 2019)
Sequence version 2 (08 Nov 2005)
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Protein

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Gene

AASDHPPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Binds 1 Mg2+ ion.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.44 mM for magnesium1 Publication
  2. KM=0.025 mM for coenzyme A1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei47Coenzyme A1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi129Magnesium1
    Metal bindingi181Magnesium1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS14278-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.8.7 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-199220 Vitamin B5 (pantothenate) metabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9NRN7

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001260

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC:2.7.8.7)
    Alternative name(s):
    4'-phosphopantetheinyl transferase
    Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
    Short name:
    AASD-PPT
    LYS5 ortholog
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    ORF Names:CGI-80, HAH-P, HSPC223, x0005
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:14235 AASDHPPT

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    607756 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NRN7

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47R → A: Reduces affinity for magnesium 7-fold, and enzyme activity 2-fold. 1 Publication1
    Mutagenesisi86R → A: Reduces affinity for magnesium and coenzyme A, and reduces enzyme activity 7-fold. 1 Publication1
    Mutagenesisi111H → A: Reduces affinity for magnesium 75-fold, and enzyme activity 150-fold. 1 Publication1
    Mutagenesisi112Q → E: Reduces affinity for magnesium 200-fold and abolishes enzyme activity; when associated with Q-181. 1 Publication1
    Mutagenesisi129D → A: Reduces affinity for magnesium 10-fold, and enzyme activity 30000-fold. 1 Publication1
    Mutagenesisi181E → A: Reduces affinity for magnesium 40-fold, and enzyme activity 32000-fold. 1 Publication1
    Mutagenesisi181E → Q: Reduces affinity for magnesium 20-fold, and enzyme activity 6500-fold. 1 Publication1
    Mutagenesisi185K → A: Reduces enzyme activity 2000-fold, with only minor change in the affinity for magnesium and coenzyme A. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    60496

    Open Targets

    More...
    OpenTargetsi
    ENSG00000149313

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24368

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9NRN7

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3137295

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    AASDHPPT

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    81170356

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001757361 – 309L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAdd BLAST309

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NRN7

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9NRN7

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9NRN7

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NRN7

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NRN7

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NRN7

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NRN7

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    3900
    82396 [Q9NRN7-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NRN7

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NRN7

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9NRN7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000149313 Expressed in 240 organ(s), highest expression level in neocortex

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NRN7 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NRN7 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA026687

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    Interacts with FASN.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    121927, 40 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NRN7, 22 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9NRN7

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000278618

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1309
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NRN7

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9NRN7

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni86 – 91Coenzyme A binding6
    Regioni108 – 111Coenzyme A binding4
    Regioni181 – 185Coenzyme A binding5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0945 Eukaryota
    COG2091 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000004663

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000265195

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NRN7

    KEGG Orthology (KO)

    More...
    KOi
    K06133

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IPWSEIR

    Database of Orthologous Groups

    More...
    OrthoDBi
    960416at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NRN7

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313753

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.470.20, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR008278 4-PPantetheinyl_Trfase_dom
    IPR037143 4-PPantetheinyl_Trfase_dom_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01648 ACPS, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56214 SSF56214, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NRN7-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MVFPAKRFCL VPSMEGVRWA FSCGTWLPSR AEWLLAVRSI QPEEKERIGQ
    60 70 80 90 100
    FVFARDAKAA MAGRLMIRKL VAEKLNIPWN HIRLQRTAKG KPVLAKDSSN
    110 120 130 140 150
    PYPNFNFNIS HQGDYAVLAA EPELQVGIDI MKTSFPGRGS IPEFFHIMKR
    160 170 180 190 200
    KFTNKEWETI RSFKDEWTQL DMFYRNWALK ESFIKAIGVG LGFELQRLEF
    210 220 230 240 250
    DLSPLNLDIG QVYKETRLFL DGEEEKEWAF EESKIDEHHF VAVALRKPDG
    260 270 280 290 300
    SRHQDVPSQD DSKPTQRQFT ILNFNDLMSS AVPMTPEDPS FWDCFCFTEE

    IPIRNGTKS
    Length:309
    Mass (Da):35,776
    Last modified:November 8, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6263E302600FDDED
    GO
    Isoform 2 (identifier: Q9NRN7-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         138-138: R → T
         139-309: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:138
    Mass (Da):15,574
    Checksum:iEBB854D6A68B6AAC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PLW6E9PLW6_HUMAN
    L-aminoadipate-semialdehyde dehydro...
    AASDHPPT
    190Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PNF3E9PNF3_HUMAN
    L-aminoadipate-semialdehyde dehydro...
    AASDHPPT
    160Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAD34075 differs from that shown. Reason: Frameshift.Curated
    The sequence AAF86879 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136 – 141PGRGSI → FQVVVQF in AAG49439 (PubMed:10931946).Curated6
    Sequence conflicti307 – 309TKS → YKVMMIP in AAG49439 (PubMed:10931946).Curated3

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055783138R → T in isoform 2. 1 Publication1
    Alternative sequenceiVSP_055784139 – 309Missing in isoform 2. 1 PublicationAdd BLAST171

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF302110 mRNA Translation: AAG30872.1
    AF151838 mRNA Translation: AAD34075.1 Frameshift.
    AF151057 mRNA Translation: AAF36143.1
    AF136978 mRNA Translation: AAG49439.1
    AF201943 mRNA Translation: AAF86879.1 Different initiation.
    AK312529 mRNA Translation: BAG35428.1
    AK293362 mRNA Translation: BAG56878.1
    AP001001 Genomic DNA No translation available.
    CH471065 Genomic DNA Translation: EAW67078.1
    BC015470 mRNA Translation: AAH15470.1
    BC016728 mRNA Translation: AAH16728.1
    AL050073 mRNA Translation: CAB43257.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS31664.1 [Q9NRN7-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T08733

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_056238.2, NM_015423.2 [Q9NRN7-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000278618; ENSP00000278618; ENSG00000149313 [Q9NRN7-1]
    ENST00000525660; ENSP00000437144; ENSG00000149313 [Q9NRN7-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    60496

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:60496

    UCSC genome browser

    More...
    UCSCi
    uc001pjc.2 human [Q9NRN7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF302110 mRNA Translation: AAG30872.1
    AF151838 mRNA Translation: AAD34075.1 Frameshift.
    AF151057 mRNA Translation: AAF36143.1
    AF136978 mRNA Translation: AAG49439.1
    AF201943 mRNA Translation: AAF86879.1 Different initiation.
    AK312529 mRNA Translation: BAG35428.1
    AK293362 mRNA Translation: BAG56878.1
    AP001001 Genomic DNA No translation available.
    CH471065 Genomic DNA Translation: EAW67078.1
    BC015470 mRNA Translation: AAH15470.1
    BC016728 mRNA Translation: AAH16728.1
    AL050073 mRNA Translation: CAB43257.1
    CCDSiCCDS31664.1 [Q9NRN7-1]
    PIRiT08733
    RefSeqiNP_056238.2, NM_015423.2 [Q9NRN7-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2BYDX-ray2.00A14-309[»]
    2C43X-ray1.93A14-309[»]
    2CG5X-ray2.70A14-309[»]
    SMRiQ9NRN7
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi121927, 40 interactors
    IntActiQ9NRN7, 22 interactors
    MINTiQ9NRN7
    STRINGi9606.ENSP00000278618

    Chemistry databases

    ChEMBLiCHEMBL3137295
    SwissLipidsiSLP:000001260

    PTM databases

    iPTMnetiQ9NRN7
    PhosphoSitePlusiQ9NRN7
    SwissPalmiQ9NRN7

    Polymorphism and mutation databases

    BioMutaiAASDHPPT
    DMDMi81170356

    Proteomic databases

    EPDiQ9NRN7
    jPOSTiQ9NRN7
    MassIVEiQ9NRN7
    MaxQBiQ9NRN7
    PaxDbiQ9NRN7
    PeptideAtlasiQ9NRN7
    PRIDEiQ9NRN7
    ProteomicsDBi3900
    82396 [Q9NRN7-1]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    60496

    Genome annotation databases

    EnsembliENST00000278618; ENSP00000278618; ENSG00000149313 [Q9NRN7-1]
    ENST00000525660; ENSP00000437144; ENSG00000149313 [Q9NRN7-2]
    GeneIDi60496
    KEGGihsa:60496
    UCSCiuc001pjc.2 human [Q9NRN7-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    60496
    DisGeNETi60496

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    AASDHPPT
    HGNCiHGNC:14235 AASDHPPT
    HPAiHPA026687
    MIMi607756 gene
    neXtProtiNX_Q9NRN7
    OpenTargetsiENSG00000149313
    PharmGKBiPA24368

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0945 Eukaryota
    COG2091 LUCA
    GeneTreeiENSGT00390000004663
    HOGENOMiHOG000265195
    InParanoidiQ9NRN7
    KOiK06133
    OMAiIPWSEIR
    OrthoDBi960416at2759
    PhylomeDBiQ9NRN7
    TreeFamiTF313753

    Enzyme and pathway databases

    BioCyciMetaCyc:HS14278-MONOMER
    BRENDAi2.7.8.7 2681
    ReactomeiR-HSA-199220 Vitamin B5 (pantothenate) metabolism
    SABIO-RKiQ9NRN7

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    AASDHPPT human
    EvolutionaryTraceiQ9NRN7

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    AASDHPPT

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    60496
    PharosiQ9NRN7

    Protein Ontology

    More...
    PROi
    PR:Q9NRN7

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000149313 Expressed in 240 organ(s), highest expression level in neocortex
    ExpressionAtlasiQ9NRN7 baseline and differential
    GenevisibleiQ9NRN7 HS

    Family and domain databases

    Gene3Di3.90.470.20, 2 hits
    InterProiView protein in InterPro
    IPR008278 4-PPantetheinyl_Trfase_dom
    IPR037143 4-PPantetheinyl_Trfase_dom_sf
    PfamiView protein in Pfam
    PF01648 ACPS, 1 hit
    SUPFAMiSSF56214 SSF56214, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADPPT_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRN7
    Secondary accession number(s): B2R6D1
    , B4DDW7, Q9C068, Q9P0Q3, Q9UG80, Q9Y389
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 16, 2019
    This is version 148 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
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