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Protein

Olfactomedin-like protein 3

Gene

OLFML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-like protein 3
Alternative name(s):
HNOEL-iso
hOLF44
Gene namesi
Name:OLFML3
ORF Names:PSEC0035, PSEC0173, PSEC0244, UNQ663/PRO1294
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116774.11
HGNCiHGNC:24956 OLFML3
MIMi610088 gene
neXtProtiNX_Q9NRN5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56944
OpenTargetsiENSG00000116774
PharmGKBiPA134913777

Polymorphism and mutation databases

DMDMi37999795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002009222 – 406Olfactomedin-like protein 3Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi135 ↔ 328PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NRN5
PaxDbiQ9NRN5
PeptideAtlasiQ9NRN5
PRIDEiQ9NRN5
ProteomicsDBi82393
82394 [Q9NRN5-2]
82395 [Q9NRN5-3]

PTM databases

GlyConnecti1587
iPTMnetiQ9NRN5
PhosphoSitePlusiQ9NRN5

Expressioni

Tissue specificityi

Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer.1 Publication

Gene expression databases

BgeeiENSG00000116774 Expressed in 96 organ(s), highest expression level in ectocervix
CleanExiHS_OLFML3
ExpressionAtlasiQ9NRN5 baseline and differential
GenevisibleiQ9NRN5 HS

Organism-specific databases

HPAiHPA027991

Interactioni

Protein-protein interaction databases

BioGridi121268, 7 interactors
IntActiQ9NRN5, 5 interactors
MINTiQ9NRN5

Structurei

3D structure databases

ProteinModelPortaliQ9NRN5
SMRiQ9NRN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 401Olfactomedin-likePROSITE-ProRule annotationAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili25 – 101Sequence analysisAdd BLAST77

Sequence similaritiesi

Belongs to the OLFML3 family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
ENOG410ZJ72 LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000115263
HOVERGENiHBG108213
InParanoidiQ9NRN5
OMAiGPTEKIY
OrthoDBiEOG091G07TT
PhylomeDBiQ9NRN5
TreeFamiTF352000

Family and domain databases

InterProiView protein in InterPro
IPR003112 Olfac-like_dom
IPR031230 OLFML3
PANTHERiPTHR23192:SF8 PTHR23192:SF8, 1 hit
PfamiView protein in Pfam
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPSTPLLIL FLLSWSGPLQ GQQHHLVEYM ERRLAALEER LAQCQDQSSR
60 70 80 90 100
HAAELRDFKN KMLPLLEVAE KEREALRTEA DTISGRVDRL EREVDYLETQ
110 120 130 140 150
NPALPCVEFD EKVTGGPGTK GKGRRNEKYD MVTDCGYTIS QVRSMKILKR
160 170 180 190 200
FGGPAGLWTK DPLGQTEKIY VLDGTQNDTA FVFPRLRDFT LAMAARKASR
210 220 230 240 250
VRVPFPWVGT GQLVYGGFLY FARRPPGRPG GGGEMENTLQ LIKFHLANRT
260 270 280 290 300
VVDSSVFPAE GLIPPYGLTA DTYIDLAADE EGLWAVYATR EDDRHLCLAK
310 320 330 340 350
LDPQTLDTEQ QWDTPCPREN AEAAFVICGT LYVVYNTRPA SRARIQCSFD
360 370 380 390 400
ASGTLTPERA ALPYFPRRYG AHASLRYNPR ERQLYAWDDG YQIVYKLEMR

KKEEEV
Length:406
Mass (Da):46,010
Last modified:October 1, 2000 - v1
Checksum:i0B5DB1A803BB99D6
GO
Isoform 2 (identifier: Q9NRN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     21-38: GQQHHLVEYMERRLAALE → MAQWHCSQRTQAGGHGVG

Show »
Length:386
Mass (Da):43,588
Checksum:iACCD914542650DBD
GO
Isoform 3 (identifier: Q9NRN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-287: DCGYTISQVR...ADEEGLWAVY → GKQSESRPLT...EDLRVRWDTE
     288-406: Missing.

Show »
Length:287
Mass (Da):32,451
Checksum:iE5FA3E724F51D55B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DNG0B4DNG0_HUMAN
cDNA FLJ58142, highly similar to Ol...
OLFML3
345Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118G → E in BAD96191 (Ref. 5) Curated1
Sequence conflicti131M → K in BAD96941 (Ref. 5) Curated1
Sequence conflicti182V → F in BAD96191 (Ref. 5) Curated1
Sequence conflicti277A → V in AAQ89313 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141281 – 20Missing in isoform 2. CuratedAdd BLAST20
Alternative sequenceiVSP_01412921 – 38GQQHH…LAALE → MAQWHCSQRTQAGGHGVG in isoform 2. CuratedAdd BLAST18
Alternative sequenceiVSP_014130134 – 287DCGYT…LWAVY → GKQSESRPLTLLRTDILPSL LLTLFFTLSQSIVALSSGIC FRETSVMPGLLRRGSGDPGR CGTRSFSILPKIGGNRWANA HYSPDHPPWGSSCWRHLILA SISFSCAFLIRLWLHNLSSE INEDSEAIWWPSWSMDQGST GANREDLRVRWDTE in isoform 3. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_014131288 – 406Missing in isoform 3. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY464015 mRNA Translation: AAR88262.1
AF201945 mRNA Translation: AAF86881.1
AY358954 mRNA Translation: AAQ89313.1
AK075544 mRNA Translation: BAC11687.1
AK223221 mRNA Translation: BAD96941.1
AK222471 mRNA Translation: BAD96191.1
AK075353 mRNA Translation: BAC11564.1
AK075479 mRNA Translation: BAC11644.1
AL731797 Genomic DNA No translation available.
BC009920 mRNA Translation: AAH09920.1
CCDSiCCDS65618.1 [Q9NRN5-2]
CCDS870.1 [Q9NRN5-1]
RefSeqiNP_001273281.1, NM_001286352.2 [Q9NRN5-2]
NP_064575.1, NM_020190.4 [Q9NRN5-1]
XP_016857337.1, XM_017001848.1 [Q9NRN5-2]
UniGeneiHs.9315

Genome annotation databases

EnsembliENST00000320334; ENSP00000322273; ENSG00000116774 [Q9NRN5-1]
ENST00000369551; ENSP00000358564; ENSG00000116774 [Q9NRN5-2]
GeneIDi56944
KEGGihsa:56944
UCSCiuc001eer.3 human [Q9NRN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY464015 mRNA Translation: AAR88262.1
AF201945 mRNA Translation: AAF86881.1
AY358954 mRNA Translation: AAQ89313.1
AK075544 mRNA Translation: BAC11687.1
AK223221 mRNA Translation: BAD96941.1
AK222471 mRNA Translation: BAD96191.1
AK075353 mRNA Translation: BAC11564.1
AK075479 mRNA Translation: BAC11644.1
AL731797 Genomic DNA No translation available.
BC009920 mRNA Translation: AAH09920.1
CCDSiCCDS65618.1 [Q9NRN5-2]
CCDS870.1 [Q9NRN5-1]
RefSeqiNP_001273281.1, NM_001286352.2 [Q9NRN5-2]
NP_064575.1, NM_020190.4 [Q9NRN5-1]
XP_016857337.1, XM_017001848.1 [Q9NRN5-2]
UniGeneiHs.9315

3D structure databases

ProteinModelPortaliQ9NRN5
SMRiQ9NRN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121268, 7 interactors
IntActiQ9NRN5, 5 interactors
MINTiQ9NRN5

PTM databases

GlyConnecti1587
iPTMnetiQ9NRN5
PhosphoSitePlusiQ9NRN5

Polymorphism and mutation databases

DMDMi37999795

Proteomic databases

EPDiQ9NRN5
PaxDbiQ9NRN5
PeptideAtlasiQ9NRN5
PRIDEiQ9NRN5
ProteomicsDBi82393
82394 [Q9NRN5-2]
82395 [Q9NRN5-3]

Protocols and materials databases

DNASUi56944
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320334; ENSP00000322273; ENSG00000116774 [Q9NRN5-1]
ENST00000369551; ENSP00000358564; ENSG00000116774 [Q9NRN5-2]
GeneIDi56944
KEGGihsa:56944
UCSCiuc001eer.3 human [Q9NRN5-1]

Organism-specific databases

CTDi56944
DisGeNETi56944
EuPathDBiHostDB:ENSG00000116774.11
GeneCardsiOLFML3
H-InvDBiHIX0160021
HGNCiHGNC:24956 OLFML3
HPAiHPA027991
MIMi610088 gene
neXtProtiNX_Q9NRN5
OpenTargetsiENSG00000116774
PharmGKBiPA134913777
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
ENOG410ZJ72 LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000115263
HOVERGENiHBG108213
InParanoidiQ9NRN5
OMAiGPTEKIY
OrthoDBiEOG091G07TT
PhylomeDBiQ9NRN5
TreeFamiTF352000

Miscellaneous databases

GeneWikiiOLFML3
GenomeRNAii56944
PROiPR:Q9NRN5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116774 Expressed in 96 organ(s), highest expression level in ectocervix
CleanExiHS_OLFML3
ExpressionAtlasiQ9NRN5 baseline and differential
GenevisibleiQ9NRN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR003112 Olfac-like_dom
IPR031230 OLFML3
PANTHERiPTHR23192:SF8 PTHR23192:SF8, 1 hit
PfamiView protein in Pfam
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOLFL3_HUMAN
AccessioniPrimary (citable) accession number: Q9NRN5
Secondary accession number(s): Q53FR1
, Q53HV9, Q5SQL6, Q69AX9, Q8NBJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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