UniProtKB - Q9NRN5 (OLFL3_HUMAN)
Olfactomedin-like protein 3
OLFML3
Functioni
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).
May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
By similarity1 PublicationKeywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q9NRN5 |
SignaLinki | Q9NRN5 |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactomedin-like protein 3Alternative name(s): HNOEL-iso hOLF44 |
Gene namesi | Name:OLFML3 ORF Names:PSEC0035, PSEC0173, PSEC0244, UNQ663/PRO1294 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24956, OLFML3 |
MIMi | 610088, gene |
neXtProti | NX_Q9NRN5 |
VEuPathDBi | HostDB:ENSG00000116774 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular vesicle Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 56944 |
OpenTargetsi | ENSG00000116774 |
PharmGKBi | PA134913777 |
Miscellaneous databases
Pharosi | Q9NRN5, Tbio |
Genetic variation databases
BioMutai | OLFML3 |
DMDMi | 37999795 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000020092 | 22 – 406 | Olfactomedin-like protein 3Add BLAST | 385 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 135 ↔ 328 | PROSITE-ProRule annotation | ||
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 248 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9NRN5 |
MassIVEi | Q9NRN5 |
PaxDbi | Q9NRN5 |
PeptideAtlasi | Q9NRN5 |
PRIDEi | Q9NRN5 |
ProteomicsDBi | 82393 [Q9NRN5-1] 82394 [Q9NRN5-2] 82395 [Q9NRN5-3] |
PTM databases
GlyConnecti | 1587, 52 N-Linked glycans (2 sites) |
GlyGeni | Q9NRN5, 2 sites, 55 N-linked glycans (2 sites) |
iPTMneti | Q9NRN5 |
PhosphoSitePlusi | Q9NRN5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000116774, Expressed in ectocervix and 119 other tissues |
ExpressionAtlasi | Q9NRN5, baseline and differential |
Genevisiblei | Q9NRN5, HS |
Organism-specific databases
HPAi | ENSG00000116774, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121268, 11 interactors |
IntActi | Q9NRN5, 7 interactors |
MINTi | Q9NRN5 |
STRINGi | 9606.ENSP00000322273 |
Miscellaneous databases
RNActi | Q9NRN5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 134 – 401 | Olfactomedin-likePROSITE-ProRule annotationAdd BLAST | 268 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 25 – 101 | Sequence analysisAdd BLAST | 77 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG3545, Eukaryota |
GeneTreei | ENSGT00940000158083 |
InParanoidi | Q9NRN5 |
OMAi | EQLLYAW |
PhylomeDBi | Q9NRN5 |
TreeFami | TF352000 |
Family and domain databases
InterProi | View protein in InterPro IPR003112, Olfac-like_dom IPR031230, OLFML3 |
PANTHERi | PTHR23192:SF8, PTHR23192:SF8, 1 hit |
Pfami | View protein in Pfam PF02191, OLF, 1 hit |
SMARTi | View protein in SMART SM00284, OLF, 1 hit |
PROSITEi | View protein in PROSITE PS51132, OLF, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPSTPLLIL FLLSWSGPLQ GQQHHLVEYM ERRLAALEER LAQCQDQSSR
60 70 80 90 100
HAAELRDFKN KMLPLLEVAE KEREALRTEA DTISGRVDRL EREVDYLETQ
110 120 130 140 150
NPALPCVEFD EKVTGGPGTK GKGRRNEKYD MVTDCGYTIS QVRSMKILKR
160 170 180 190 200
FGGPAGLWTK DPLGQTEKIY VLDGTQNDTA FVFPRLRDFT LAMAARKASR
210 220 230 240 250
VRVPFPWVGT GQLVYGGFLY FARRPPGRPG GGGEMENTLQ LIKFHLANRT
260 270 280 290 300
VVDSSVFPAE GLIPPYGLTA DTYIDLAADE EGLWAVYATR EDDRHLCLAK
310 320 330 340 350
LDPQTLDTEQ QWDTPCPREN AEAAFVICGT LYVVYNTRPA SRARIQCSFD
360 370 380 390 400
ASGTLTPERA ALPYFPRRYG AHASLRYNPR ERQLYAWDDG YQIVYKLEMR
KKEEEV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB4DNG0 | B4DNG0_HUMAN | Olfactomedin-like protein 3 | OLFML3 | 345 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | G → E in BAD96191 (Ref. 5) Curated | 1 | |
Sequence conflicti | 131 | M → K in BAD96941 (Ref. 5) Curated | 1 | |
Sequence conflicti | 182 | V → F in BAD96191 (Ref. 5) Curated | 1 | |
Sequence conflicti | 277 | A → V in AAQ89313 (PubMed:12975309).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014128 | 1 – 20 | Missing in isoform 2. CuratedAdd BLAST | 20 | |
Alternative sequenceiVSP_014129 | 21 – 38 | GQQHH…LAALE → MAQWHCSQRTQAGGHGVG in isoform 2. CuratedAdd BLAST | 18 | |
Alternative sequenceiVSP_014130 | 134 – 287 | DCGYT…LWAVY → GKQSESRPLTLLRTDILPSL LLTLFFTLSQSIVALSSGIC FRETSVMPGLLRRGSGDPGR CGTRSFSILPKIGGNRWANA HYSPDHPPWGSSCWRHLILA SISFSCAFLIRLWLHNLSSE INEDSEAIWWPSWSMDQGST GANREDLRVRWDTE in isoform 3. 1 PublicationAdd BLAST | 154 | |
Alternative sequenceiVSP_014131 | 288 – 406 | Missing in isoform 3. 1 PublicationAdd BLAST | 119 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY464015 mRNA Translation: AAR88262.1 AF201945 mRNA Translation: AAF86881.1 AY358954 mRNA Translation: AAQ89313.1 AK075544 mRNA Translation: BAC11687.1 AK223221 mRNA Translation: BAD96941.1 AK222471 mRNA Translation: BAD96191.1 AK075353 mRNA Translation: BAC11564.1 AK075479 mRNA Translation: BAC11644.1 AL731797 Genomic DNA No translation available. BC009920 mRNA Translation: AAH09920.1 |
CCDSi | CCDS65618.1 [Q9NRN5-2] CCDS870.1 [Q9NRN5-1] |
RefSeqi | NP_001273281.1, NM_001286352.2 [Q9NRN5-2] NP_064575.1, NM_020190.4 [Q9NRN5-1] XP_016857337.1, XM_017001848.1 [Q9NRN5-2] |
Genome annotation databases
Ensembli | ENST00000320334; ENSP00000322273; ENSG00000116774 ENST00000369551; ENSP00000358564; ENSG00000116774 [Q9NRN5-2] |
GeneIDi | 56944 |
KEGGi | hsa:56944 |
MANE-Selecti | ENST00000320334.5; ENSP00000322273.4; NM_020190.5; NP_064575.1 |
UCSCi | uc001eer.3, human [Q9NRN5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY464015 mRNA Translation: AAR88262.1 AF201945 mRNA Translation: AAF86881.1 AY358954 mRNA Translation: AAQ89313.1 AK075544 mRNA Translation: BAC11687.1 AK223221 mRNA Translation: BAD96941.1 AK222471 mRNA Translation: BAD96191.1 AK075353 mRNA Translation: BAC11564.1 AK075479 mRNA Translation: BAC11644.1 AL731797 Genomic DNA No translation available. BC009920 mRNA Translation: AAH09920.1 |
CCDSi | CCDS65618.1 [Q9NRN5-2] CCDS870.1 [Q9NRN5-1] |
RefSeqi | NP_001273281.1, NM_001286352.2 [Q9NRN5-2] NP_064575.1, NM_020190.4 [Q9NRN5-1] XP_016857337.1, XM_017001848.1 [Q9NRN5-2] |
3D structure databases
SMRi | Q9NRN5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121268, 11 interactors |
IntActi | Q9NRN5, 7 interactors |
MINTi | Q9NRN5 |
STRINGi | 9606.ENSP00000322273 |
PTM databases
GlyConnecti | 1587, 52 N-Linked glycans (2 sites) |
GlyGeni | Q9NRN5, 2 sites, 55 N-linked glycans (2 sites) |
iPTMneti | Q9NRN5 |
PhosphoSitePlusi | Q9NRN5 |
Genetic variation databases
BioMutai | OLFML3 |
DMDMi | 37999795 |
Proteomic databases
jPOSTi | Q9NRN5 |
MassIVEi | Q9NRN5 |
PaxDbi | Q9NRN5 |
PeptideAtlasi | Q9NRN5 |
PRIDEi | Q9NRN5 |
ProteomicsDBi | 82393 [Q9NRN5-1] 82394 [Q9NRN5-2] 82395 [Q9NRN5-3] |
Protocols and materials databases
ABCDi | Q9NRN5, 3 sequenced antibodies |
Antibodypediai | 53757, 79 antibodies from 20 providers |
DNASUi | 56944 |
Genome annotation databases
Ensembli | ENST00000320334; ENSP00000322273; ENSG00000116774 ENST00000369551; ENSP00000358564; ENSG00000116774 [Q9NRN5-2] |
GeneIDi | 56944 |
KEGGi | hsa:56944 |
MANE-Selecti | ENST00000320334.5; ENSP00000322273.4; NM_020190.5; NP_064575.1 |
UCSCi | uc001eer.3, human [Q9NRN5-1] |
Organism-specific databases
CTDi | 56944 |
DisGeNETi | 56944 |
GeneCardsi | OLFML3 |
HGNCi | HGNC:24956, OLFML3 |
HPAi | ENSG00000116774, Low tissue specificity |
MIMi | 610088, gene |
neXtProti | NX_Q9NRN5 |
OpenTargetsi | ENSG00000116774 |
PharmGKBi | PA134913777 |
VEuPathDBi | HostDB:ENSG00000116774 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3545, Eukaryota |
GeneTreei | ENSGT00940000158083 |
InParanoidi | Q9NRN5 |
OMAi | EQLLYAW |
PhylomeDBi | Q9NRN5 |
TreeFami | TF352000 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRN5 |
SignaLinki | Q9NRN5 |
Miscellaneous databases
BioGRID-ORCSi | 56944, 230 hits in 1031 CRISPR screens |
ChiTaRSi | OLFML3, human |
GeneWikii | OLFML3 |
GenomeRNAii | 56944 |
Pharosi | Q9NRN5, Tbio |
PROi | PR:Q9NRN5 |
RNActi | Q9NRN5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116774, Expressed in ectocervix and 119 other tissues |
ExpressionAtlasi | Q9NRN5, baseline and differential |
Genevisiblei | Q9NRN5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003112, Olfac-like_dom IPR031230, OLFML3 |
PANTHERi | PTHR23192:SF8, PTHR23192:SF8, 1 hit |
Pfami | View protein in Pfam PF02191, OLF, 1 hit |
SMARTi | View protein in SMART SM00284, OLF, 1 hit |
PROSITEi | View protein in PROSITE PS51132, OLF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OLFL3_HUMAN | |
Accessioni | Q9NRN5Primary (citable) accession number: Q9NRN5 Secondary accession number(s): Q53FR1 Q8NBJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families