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Entry version 158 (13 Feb 2019)
Sequence version 2 (27 May 2002)
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Protein

Interleukin-17 receptor B

Gene

IL17RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine receptor activity Source: UniProtKB
  • interleukin-17 receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-448424 Interleukin-17 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NRM6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-17 receptor B
Short name:
IL-17 receptor B
Short name:
IL-17RB
Alternative name(s):
Cytokine receptor-like 4
IL-17 receptor homolog 1
Short name:
IL-17Rh1
Short name:
IL17Rh1
Interleukin-17B receptor
Short name:
IL-17B receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL17RB
Synonyms:CRL4, EVI27, IL17BR
ORF Names:UNQ2501/PRO19612
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000056736.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18015 IL17RB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605458 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRM6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 292ExtracellularSequence analysisAdd BLAST275
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 502CytoplasmicSequence analysisAdd BLAST189

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55540

Open Targets

More...
OpenTargetsi
ENSG00000056736

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29796

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL17RB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21263748

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 172 PublicationsAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001103218 – 502Interleukin-17 receptor BAdd BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRM6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRM6

PeptideAtlas

More...
PeptideAtlasi
Q9NRM6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRM6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82390
82391 [Q9NRM6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRM6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000056736 Expressed in 169 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRM6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRM6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005482

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DAZAP2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120708, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NRM6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288167

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NRM6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NRM6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini331 – 477SEFIRPROSITE-ProRule annotationAdd BLAST147

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK7X Eukaryota
ENOG410YA4Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161145

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112985

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052063

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRM6

KEGG Orthology (KO)

More...
KOi
K05165

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTVCYFT

Database of Orthologous Groups

More...
OrthoDBi
577180at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRM6

TreeFam database of animal gene trees

More...
TreeFami
TF329644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039465 IL-17_rcpt-like
IPR032356 IL17R_fnIII_D1
IPR038683 IL17RA/B_FnIII-like_1_sf
IPR013568 SEFIR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15583 PTHR15583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16556 IL17R_fnIII_D1, 1 hit
PF08357 SEFIR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51534 SEFIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV
60 70 80 90 100
EPVTTSVATG DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV
110 120 130 140 150
RCNYTEAFQT QTRPSGGKWT FSYIGFPVEL NTVYFIGAHN IPNANMNEDG
160 170 180 190 200
PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW DPNITACKKN EETVEVNFTT
210 220 230 240 250
TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT GDSEGATVQL
260 270 280 290 300
TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV
310 320 330 340 350
ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY
360 370 380 390 400
FTEFLQNHCR SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV
410 420 430 440 450
NSVCDGTCGK SEGSPSENSQ DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE
460 470 480 490 500
IDTKDDYNAL SVCPKYHLMK DATAFCAELL HVKQQVSAGK RSQACHDGCC

SL
Length:502
Mass (Da):55,885
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDB87586FAAE49CC
GO
Isoform 2 (identifier: Q9NRM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-288: LTPYFPTCGS...PLDNNKSKPG → VKFSELLWGG...SNALLPADTS
     289-502: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:288
Mass (Da):31,773
Checksum:iFCBFB384C674F9AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZN0C9IZN0_HUMAN
Interleukin-17 receptor B
IL17RB
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6L → I in AAF86051 (PubMed:10815801).Curated1
Sequence conflicti6L → I in AAF86052 (PubMed:10815801).Curated1
Sequence conflicti422 – 426LFPLA → SSPCL AA sequence (PubMed:10749887).Curated5
Sequence conflicti427 – 502Missing AA sequence (PubMed:10749887).CuratedAdd BLAST76
Sequence conflicti468L → F in AAF86051 (PubMed:10815801).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059304177G → R. Corresponds to variant dbSNP:rs2232337Ensembl.1
Natural variantiVAR_049178209A → V. Corresponds to variant dbSNP:rs2232340Ensembl.1
Natural variantiVAR_049179232R → Q. Corresponds to variant dbSNP:rs2232343Ensembl.1
Natural variantiVAR_019209278F → L1 PublicationCorresponds to variant dbSNP:rs2232346Ensembl.1
Natural variantiVAR_019210451I → T1 PublicationCorresponds to variant dbSNP:rs2232350Ensembl.1
Natural variantiVAR_019211458N → S1 PublicationCorresponds to variant dbSNP:rs2232351Ensembl.1
Natural variantiVAR_019212499C → R1 PublicationCorresponds to variant dbSNP:rs28385751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001740250 – 288LTPYF…KSKPG → VKFSELLWGGKGHRRLFHHS LLLRMSSLLSNALLPADTS in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_001741289 – 502Missing in isoform 2. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF208110 mRNA Translation: AAF86051.1
AF208111 mRNA Translation: AAF86052.1
AF212365 mRNA Translation: AAF78776.1
AF250309 mRNA Translation: AAK37428.1
AY359122 mRNA Translation: AAQ89956.1
AY518533 Genomic DNA Translation: AAR89910.1
BC000980 mRNA Translation: AAH00980.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2874.1 [Q9NRM6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_061195.2, NM_018725.3 [Q9NRM6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654970

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288167; ENSP00000288167; ENSG00000056736 [Q9NRM6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55540

UCSC genome browser

More...
UCSCi
uc003dha.4 human [Q9NRM6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208110 mRNA Translation: AAF86051.1
AF208111 mRNA Translation: AAF86052.1
AF212365 mRNA Translation: AAF78776.1
AF250309 mRNA Translation: AAK37428.1
AY359122 mRNA Translation: AAQ89956.1
AY518533 Genomic DNA Translation: AAR89910.1
BC000980 mRNA Translation: AAH00980.1
CCDSiCCDS2874.1 [Q9NRM6-1]
RefSeqiNP_061195.2, NM_018725.3 [Q9NRM6-1]
UniGeneiHs.654970

3D structure databases

ProteinModelPortaliQ9NRM6
SMRiQ9NRM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120708, 30 interactors
IntActiQ9NRM6, 2 interactors
STRINGi9606.ENSP00000288167

PTM databases

iPTMnetiQ9NRM6
PhosphoSitePlusiQ9NRM6

Polymorphism and mutation databases

BioMutaiIL17RB
DMDMi21263748

Proteomic databases

MaxQBiQ9NRM6
PaxDbiQ9NRM6
PeptideAtlasiQ9NRM6
PRIDEiQ9NRM6
ProteomicsDBi82390
82391 [Q9NRM6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55540
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288167; ENSP00000288167; ENSG00000056736 [Q9NRM6-1]
GeneIDi55540
KEGGihsa:55540
UCSCiuc003dha.4 human [Q9NRM6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55540
DisGeNETi55540
EuPathDBiHostDB:ENSG00000056736.9

GeneCards: human genes, protein and diseases

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GeneCardsi
IL17RB

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0119152
HGNCiHGNC:18015 IL17RB
HPAiHPA005482
MIMi605458 gene
neXtProtiNX_Q9NRM6
OpenTargetsiENSG00000056736
PharmGKBiPA29796

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IK7X Eukaryota
ENOG410YA4Q LUCA
GeneTreeiENSGT00940000161145
HOGENOMiHOG000112985
HOVERGENiHBG052063
InParanoidiQ9NRM6
KOiK05165
OMAiHTVCYFT
OrthoDBi577180at2759
PhylomeDBiQ9NRM6
TreeFamiTF329644

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling
SIGNORiQ9NRM6

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IL17RB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55540

Protein Ontology

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PROi
PR:Q9NRM6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000056736 Expressed in 169 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9NRM6 baseline and differential
GenevisibleiQ9NRM6 HS

Family and domain databases

Gene3Di2.60.40.2160, 1 hit
InterProiView protein in InterPro
IPR039465 IL-17_rcpt-like
IPR032356 IL17R_fnIII_D1
IPR038683 IL17RA/B_FnIII-like_1_sf
IPR013568 SEFIR_dom
PANTHERiPTHR15583 PTHR15583, 1 hit
PfamiView protein in Pfam
PF16556 IL17R_fnIII_D1, 1 hit
PF08357 SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534 SEFIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI17RB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRM6
Secondary accession number(s): Q9BPZ0, Q9NRL4, Q9NRM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: February 13, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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