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Protein

Zinc finger protein 277

Gene

ZNF277

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri224 – 248C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri355 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 277
Alternative name(s):
Nuclear receptor-interacting factor 4
Gene namesi
Name:ZNF277
Synonyms:NRIF4, ZNF277P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000198839.9
HGNCiHGNC:13070 ZNF277
MIMi605465 gene
neXtProtiNX_Q9NRM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11179
OpenTargetsiENSG00000198839
PharmGKBiPA37646

Polymorphism and mutation databases

BioMutaiZNF277
DMDMi251757417

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000475032 – 450Zinc finger protein 277Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NRM2
MaxQBiQ9NRM2
PaxDbiQ9NRM2
PeptideAtlasiQ9NRM2
PRIDEiQ9NRM2
ProteomicsDBi82389

PTM databases

iPTMnetiQ9NRM2
PhosphoSitePlusiQ9NRM2

Expressioni

Gene expression databases

BgeeiENSG00000198839 Expressed in 211 organ(s), highest expression level in kidney
ExpressionAtlasiQ9NRM2 baseline and differential
GenevisibleiQ9NRM2 HS

Organism-specific databases

HPAiHPA027307

Interactioni

Protein-protein interaction databases

BioGridi116349, 16 interactors
IntActiQ9NRM2, 13 interactors
STRINGi9606.ENSP00000354501

Structurei

3D structure databases

ProteinModelPortaliQ9NRM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZNF277 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri224 – 248C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri355 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2482 Eukaryota
ENOG410XQ2B LUCA
GeneTreeiENSGT00390000010852
HOGENOMiHOG000247001
HOVERGENiHBG054015
InParanoidiQ9NRM2
OMAiHMEETKH
OrthoDBiEOG091G0A09
PhylomeDBiQ9NRM2
TreeFamiTF318036

Family and domain databases

InterProiView protein in InterPro
IPR040048 ZNF277
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR13267 PTHR13267, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9NRM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT
60 70 80 90 100
TLEGSPSVPC IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI
110 120 130 140 150
LYWRKRFTEQ PITDFCSVIR INSTAPFEEQ ENYFLLCDVL PEDRILREEL
160 170 180 190 200
QKQRLREILE QQQQERNDTN FHGVCMFCNE EFLGNRSVIL NHMAREHAFN
210 220 230 240 250
IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK DHMRKKQHRK
260 270 280 290 300
INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA
310 320 330 340 350
SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI
360 370 380 390 400
RRQVHQCRCY GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT
410 420 430 440 450
YENDTLLCTL SDSESDLTAQ EQNENVPIIS EDTSKLYALK QSSILNQLLL
Length:450
Mass (Da):52,788
Last modified:July 7, 2009 - v2
Checksum:i07A35E08BB6E9521
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9M4G5E9M4_HUMAN
Zinc finger protein 277, isoform CR...
ZNF277 hCG_14753
290Annotation score:
C9JH62C9JH62_HUMAN
Zinc finger protein 277
ZNF277
199Annotation score:
F8WBE4F8WBE4_HUMAN
Zinc finger protein 277
ZNF277
107Annotation score:
H7C460H7C460_HUMAN
Zinc finger protein 277
ZNF277
118Annotation score:
C9J3B6C9J3B6_HUMAN
Zinc finger protein 277
ZNF277
98Annotation score:
E7EW13E7EW13_HUMAN
Zinc finger protein 277
ZNF277
50Annotation score:

Sequence cautioni

The sequence AAF85941 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS07413 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059908174V → I. Corresponds to variant dbSNP:rs34571830Ensembl.1
Natural variantiVAR_035574332I → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057415364V → M. Corresponds to variant dbSNP:rs11539696Ensembl.1
Natural variantiVAR_035575445L → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209198 mRNA Translation: AAF85941.1 Different initiation.
AF308819 mRNA Translation: AAL55819.1
AC004112 Genomic DNA Translation: AAS07407.1
AC004111 Genomic DNA Translation: AAS07413.1 Different initiation.
CH471070 Genomic DNA Translation: EAW83461.1
CCDSiCCDS5755.2
RefSeqiNP_068834.2, NM_021994.2
UniGeneiHs.655904

Genome annotation databases

EnsembliENST00000361822; ENSP00000354501; ENSG00000198839
GeneIDi11179
KEGGihsa:11179
UCSCiuc003vge.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209198 mRNA Translation: AAF85941.1 Different initiation.
AF308819 mRNA Translation: AAL55819.1
AC004112 Genomic DNA Translation: AAS07407.1
AC004111 Genomic DNA Translation: AAS07413.1 Different initiation.
CH471070 Genomic DNA Translation: EAW83461.1
CCDSiCCDS5755.2
RefSeqiNP_068834.2, NM_021994.2
UniGeneiHs.655904

3D structure databases

ProteinModelPortaliQ9NRM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116349, 16 interactors
IntActiQ9NRM2, 13 interactors
STRINGi9606.ENSP00000354501

PTM databases

iPTMnetiQ9NRM2
PhosphoSitePlusiQ9NRM2

Polymorphism and mutation databases

BioMutaiZNF277
DMDMi251757417

Proteomic databases

EPDiQ9NRM2
MaxQBiQ9NRM2
PaxDbiQ9NRM2
PeptideAtlasiQ9NRM2
PRIDEiQ9NRM2
ProteomicsDBi82389

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361822; ENSP00000354501; ENSG00000198839
GeneIDi11179
KEGGihsa:11179
UCSCiuc003vge.3 human

Organism-specific databases

CTDi11179
DisGeNETi11179
EuPathDBiHostDB:ENSG00000198839.9
GeneCardsiZNF277
HGNCiHGNC:13070 ZNF277
HPAiHPA027307
MIMi605465 gene
neXtProtiNX_Q9NRM2
OpenTargetsiENSG00000198839
PharmGKBiPA37646
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2482 Eukaryota
ENOG410XQ2B LUCA
GeneTreeiENSGT00390000010852
HOGENOMiHOG000247001
HOVERGENiHBG054015
InParanoidiQ9NRM2
OMAiHMEETKH
OrthoDBiEOG091G0A09
PhylomeDBiQ9NRM2
TreeFamiTF318036

Miscellaneous databases

ChiTaRSiZNF277 human
GeneWikiiZNF277P
GenomeRNAii11179
PROiPR:Q9NRM2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198839 Expressed in 211 organ(s), highest expression level in kidney
ExpressionAtlasiQ9NRM2 baseline and differential
GenevisibleiQ9NRM2 HS

Family and domain databases

InterProiView protein in InterPro
IPR040048 ZNF277
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR13267 PTHR13267, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN277_HUMAN
AccessioniPrimary (citable) accession number: Q9NRM2
Secondary accession number(s): Q75MZ2, Q75MZ3, Q8WY14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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