UniProtKB - Q9NRL3 (STRN4_HUMAN)

BLAST

>sp|Q9NRL3|STRN4_HUMAN Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2
MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS
KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD
VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL
EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS
TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG
IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH
RKKHEEAIHAVACHPSKALIASAGADALAKVFV

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History
Entry version 164 (07 Nov 2018)
Sequence version 2 (10 Jul 2007)
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Protein

Striatin-4

Gene

STRN4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Miscellaneous

The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).

GO - Molecular functionⁱ

armadillo repeat domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18502210
calmodulin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18782753
protein phosphatase 2A binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18782753

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding

Molecular function

Calmodulin-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9NRL3

SignaLinkⁱ

Q9NRL3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Striatin-4 Alternative name(s): Zinedin
Gene namesⁱ	Name:STRN4 Synonyms:ZIN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090372.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15721 STRN4
MIMⁱ	614767 gene
neXtProtⁱ	NX_Q9NRL3

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29888
Open Targets More...OpenTargetsⁱ	ENSG00000090372
PharmGKBⁱ	PA134863218

Polymorphism and mutation databases

BioMutaⁱ	STRN4
DMDMⁱ	152031693

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051239	1 – 753	Striatin-4Add BLAST		753

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	53	PhosphoserineCombined sources	1
Modified residueⁱ	206	PhosphoserineCombined sources	1
Modified residueⁱ	276	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NRL3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NRL3
PaxDbⁱ	Q9NRL3
PeptideAtlas More...PeptideAtlasⁱ	Q9NRL3
PRIDEⁱ	Q9NRL3
ProteomicsDBⁱ	82385

PTM databases

iPTMnetⁱ	Q9NRL3
PhosphoSitePlusⁱ	Q9NRL3

Miscellaneous databases

PMAP-CutDBⁱ	Q9NRL3

PMAP-CutDBⁱ

Q9NRL3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090372 Expressed in 188 organ(s), highest expression level in testis
CleanExⁱ	HS_STRN4
ExpressionAtlasⁱ	Q9NRL3 baseline and differential
Genevisibleⁱ	Q9NRL3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043051 HPA043527 HPA056706

HPAⁱ

HPA043051
HPA043527
HPA056706

Interactionⁱ

Subunit structureⁱ

Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
JUN	P05412	3	EBI-717245,EBI-852823

With

Entry

#Exp.

IntAct

Notes

JUN

P05412

EBI-717245,EBI-852823

GO - Molecular functionⁱ

armadillo repeat domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18502210
calmodulin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein phosphatase 2A binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18782753

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118941, 86 interactors
IntActⁱ	Q9NRL3, 64 interactors
STRINGⁱ	9606.ENSP00000375777

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NRL3
SMRⁱ	Q9NRL3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	436 – 475	WD 1Add BLAST	40
Repeatⁱ	489 – 528	WD 2Add BLAST	40
Repeatⁱ	542 – 581	WD 3Add BLAST	40
Repeatⁱ	587 – 628	WD 4Add BLAST	42
Repeatⁱ	635 – 674	WD 5Add BLAST	40
Repeatⁱ	677 – 716	WD 6Add BLAST	40
Repeatⁱ	723 – 752	WD 7Add BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	71 – 79	Caveolin-bindingSequence analysis		9
Regionⁱ	165 – 182	Calmodulin-bindingSequence analysisAdd BLAST		18

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	69 – 136	Sequence analysisAdd BLAST		68

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	6 – 14	Poly-Ala		9

Sequence similaritiesⁱ

Belongs to the WD repeat striatin family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0642 Eukaryota ENOG410XR31 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055597
HOGENOMⁱ	HOG000236343
HOVERGENⁱ	HBG007117
InParanoidⁱ	Q9NRL3
KEGG Orthology (KO) More...KOⁱ	K17608
OMAⁱ	TWNPRFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0509
PhylomeDBⁱ	Q9NRL3
TreeFamⁱ	TF313387

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR013258 Striatin_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08232 Striatin, 1 hit PF00400 WD40, 4 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NRL3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG 
        60         70         80         90        100
GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL 
       110        120        130        140        150
QGERKGQENL KTDLVRRIKM LEYALKQERA KYHKLKFGTD LNQGEKKADV 
       160        170        180        190        200
SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ YLEEVGYTDT ILDMRSKRVR 
       210        220        230        240        250
SLLGRSLELN GAVEPSEGAP RAPPGPAGLS GGESLLVKQI EEQIKRNAAG 
       260        270        280        290        300
KDGKERLGGS VLGQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVKLPSKALV 
       310        320        330        340        350
PEMEDEDEED DSEDAINEFD FLGSGEDGEG APDPRRCTVD GSPHELESRR 
       360        370        380        390        400
VKLQGILADL RDVDGLPPKV TGPPPGTPQP RPHEDVFIMD TIGGGEVSLG 
       410        420        430        440        450
DLADLTVTND NDLSCDLSDS KDAFKKTWNP KFTLRSHYDG IRSLAFHHSQ 
       460        470        480        490        500
SALLTASEDG TLKLWNLQKA VTAKKNAALD VEPIHAFRAH RGPVLAVAMG 
       510        520        530        540        550
SNSEYCYSGG ADACIHSWKI PDLSMDPYDG YDPSVLSHVL EGHGDAVWGL 
       560        570        580        590        600
AFSPTSQRLA SCSADGTVRI WDPSSSSPAC LCTFPTASEH GVPTSVAFTS 
       610        620        630        640        650
TEPAHIVASF RSGDTVLYDM EVGSALLTLE SRGSSGPTQI NQVVSHPNQP 
       660        670        680        690        700
LTITAHDDRG IRFLDNRTGK PVHSMVAHLD AVTCLAVDPN GAFLMSGSHD 
       710        720        730        740        750
CSLRLWSLDN KTCVQEITAH RKKHEEAIHA VACHPSKALI ASAGADALAK 

VFV

Length:753

Mass (Da):80,596

Last modified:July 10, 2007 - v2

Checksum:ⁱ339AC24E26A9CD54

Isoform 2 (identifier: Q9NRL3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.
     347-376: ESRRVKLQGILADLRDVDGLPPKVTGPPPG → GPELHSPTEWQGALSVGKASPMPDWVGTAG
     377-753: Missing.

« Hide

        10         20         30         40         50
MLEYALKQER AKYHKLKFGT DLNQGEKKAD VSEQVSNGPV ESVTLENSPL 
        60         70         80         90        100
VWKEGRQLLR QYLEEVGYTD TILDMRSKRV RSLLGRSLEL NGAVEPSEGA 
       110        120        130        140        150
PRAPPGPAGL SGGESLLVKQ IEEQIKRNAA GKDGKERLGG SVLGQIPFLQ 
       160        170        180        190        200
NCEDEDSDED DELDSVQHKK QRVKLPSKAL VPEMEDEDEE DDSEDAINEF 
       210        220        230        240        250
DFLGSGEDGE GAPDPRRCTV DGSPHELGPE LHSPTEWQGA LSVGKASPMP 

DWVGTAG

Note: No experimental confirmation available.

Show »

Length:257

Mass (Da):28,106

Checksum:ⁱA3898671C11A1A4C

Isoform 3 (identifier: Q9NRL3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
384-384: E → EGSFGFSS

« Hide

        10         20         30         40         50
MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG 
        60         70         80         90        100
GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL 
       110        120        130        140        150
QGERKGQENL KTDLVRRIKM LEYALKQERA KYHKLKFGTD LNQGEKKADV 
       160        170        180        190        200
SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ YLEEVGYTDT ILDMRSKRVR 
       210        220        230        240        250
SLLGRSLELN GAVEPSEGAP RAPPGPAGLS GGESLLVKQI EEQIKRNAAG 
       260        270        280        290        300
KDGKERLGGS VLGQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVKLPSKALV 
       310        320        330        340        350
PEMEDEDEED DSEDAINEFD FLGSGEDGEG APDPRRCTVD GSPHELESRR 
       360        370        380        390        400
VKLQGILADL RDVDGLPPKV TGPPPGTPQP RPHEGSFGFS SDVFIMDTIG 
       410        420        430        440        450
GGEVSLGDLA DLTVTNDNDL SCDLSDSKDA FKKTWNPKFT LRSHYDGIRS 
       460        470        480        490        500
LAFHHSQSAL LTASEDGTLK LWNLQKAVTA KKNAALDVEP IHAFRAHRGP 
       510        520        530        540        550
VLAVAMGSNS EYCYSGGADA CIHSWKIPDL SMDPYDGYDP SVLSHVLEGH 
       560        570        580        590        600
GDAVWGLAFS PTSQRLASCS ADGTVRIWDP SSSSPACLCT FPTASEHGVP 
       610        620        630        640        650
TSVAFTSTEP AHIVASFRSG DTVLYDMEVG SALLTLESRG SSGPTQINQV 
       660        670        680        690        700
VSHPNQPLTI TAHDDRGIRF LDNRTGKPVH SMVAHLDAVT CLAVDPNGAF 
       710        720        730        740        750
LMSGSHDCSL RLWSLDNKTC VQEITAHRKK HEEAIHAVAC HPSKALIASA 
       760
GADALAKVFV

Show »

Length:760

Mass (Da):81,266

Checksum:ⁱ653E59DBCD215E42

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GYK2	F5GYK2_HUMAN	Striatin-4 Striatin-4	STRN4	634	Annotation score:
M0QZM0	M0QZM0_HUMAN	Striatin-4 Striatin-4	STRN4	317	Annotation score:
M0R317	M0R317_HUMAN	Striatin-4 Striatin-4	STRN4	198	Annotation score:
M0R0W8	M0R0W8_HUMAN	Striatin-4 Striatin-4	STRN4	180	Annotation score:
M0R0P4	M0R0P4_HUMAN	Striatin-4 Striatin-4	STRN4	139	Annotation score:
M0R2A7	M0R2A7_HUMAN	Striatin-4 Striatin-4	STRN4	103	Annotation score:
R4GN16	R4GN16_HUMAN	Striatin-4 Striatin-4	STRN4	316	Annotation score:
M0QYS2	M0QYS2_HUMAN	Striatin-4 Striatin-4	STRN4	114	Annotation score:
M0QXN2	M0QXN2_HUMAN	Striatin-4 Striatin-4	STRN4	73	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	356	I → V in AAF29527 (PubMed:10748158).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053419	568	V → I. Corresponds to variant dbSNP:rs10409124Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056170	1 – 119	Missing in isoform 2. 1 PublicationAdd BLAST	119
Alternative sequenceⁱVSP_056171	347 – 376	ESRRV…GPPPG → GPELHSPTEWQGALSVGKAS PMPDWVGTAG in isoform 2. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_056172	377 – 753	Missing in isoform 2. 1 PublicationAdd BLAST	377
Alternative sequenceⁱVSP_056738	384	E → EGSFGFSS in isoform 3. Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF212940 mRNA Translation: AAF29527.1 AK298804 mRNA Translation: BAG60939.1 AC008622 Genomic DNA No translation available. AC008635 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57442.1 CH471126 Genomic DNA Translation: EAW57443.1 BC004910 mRNA Translation: AAH04910.2 BC034604 mRNA Translation: AAH34604.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12690.1 [Q9NRL3-1] CCDS42581.1 [Q9NRL3-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001034966.1, NM_001039877.1 [Q9NRL3-3] NP_037535.2, NM_013403.2 [Q9NRL3-1]
UniGeneⁱ	Hs.631590

Genome annotation databases

Ensemblⁱ	ENST00000263280; ENSP00000263280; ENSG00000090372 [Q9NRL3-1] ENST00000391910; ENSP00000375777; ENSG00000090372 [Q9NRL3-3] ENST00000435164; ENSP00000473607; ENSG00000090372 [Q9NRL3-2]
GeneIDⁱ	29888
KEGGⁱ	hsa:29888
UCSC genome browser More...UCSCⁱ	uc002pfl.4 human [Q9NRL3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NRL3	Striatin-4		HUMAN		634	UniRef100_Q9NRL3
Q9NRL3-3	Zinedin variant (Fragment)		HUMAN		755	UniRef100_Q9NRL3-3

Protein	Similar proteins		Species	Score	Length	Source
Q9NRL3	Striatin-4		HUMAN		634	UniRef90_Q9NRL3
Striatin-4 isoform 1		CALJA		753
STRN4 isoform 2		PANTR		753
Striatin-4 isoform 1		MACMU		753
Uncharacterized protein		MACNE		634
+33
Q9NRL3-2	STRN4 isoform 13		PONAB		308	UniRef90_Q9NRL3-2
STRN4 isoform 14 (Fragment)		PANTR		258
STRN4 isoform 14 (Fragment)		PONAB		258
Q9NRL3-3	Striatin-4		MOUSE		760	UniRef90_Q9NRL3-3
Zinedin variant (Fragment)		HUMAN		755
striatin-4 isoform X1		LIPVE		766
Uncharacterized protein		Cebus capucinus imitator		760
Uncharacterized protein		FELCA		760
+91

Protein	Similar proteins		Species	Score	Length	Source
Q9NRL3	Striatin-4		MOUSE		760	UniRef50_Q9NRL3
Striatin-4		HUMAN		634
STRN4 isoform 3		PONAB		753
STRN4 isoform 2		PANTR		753
Striatin-4 isoform 1		MACMU		753
+359
Q9NRL3-2	STRN4 isoform 13		PONAB		308	UniRef50_Q9NRL3-2
STRN4 isoform 14 (Fragment)		PANTR		258
Striatin-4		PTEAL		371
Striatin, calmodulin-binding protein 4 (Fragment)		NEOVI		332
Striatin-4 (Fragment)		HUMAN		316
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF212940 mRNA Translation: AAF29527.1 AK298804 mRNA Translation: BAG60939.1 AC008622 Genomic DNA No translation available. AC008635 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57442.1 CH471126 Genomic DNA Translation: EAW57443.1 BC004910 mRNA Translation: AAH04910.2 BC034604 mRNA Translation: AAH34604.1
CCDSⁱ	CCDS12690.1 [Q9NRL3-1] CCDS42581.1 [Q9NRL3-3]
RefSeqⁱ	NP_001034966.1, NM_001039877.1 [Q9NRL3-3] NP_037535.2, NM_013403.2 [Q9NRL3-1]
UniGeneⁱ	Hs.631590

3D structure databases

ProteinModelPortalⁱ	Q9NRL3
SMRⁱ	Q9NRL3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118941, 86 interactors
IntActⁱ	Q9NRL3, 64 interactors
STRINGⁱ	9606.ENSP00000375777

PTM databases

iPTMnetⁱ	Q9NRL3
PhosphoSitePlusⁱ	Q9NRL3

Polymorphism and mutation databases

BioMutaⁱ	STRN4
DMDMⁱ	152031693

Proteomic databases

EPDⁱ	Q9NRL3
MaxQBⁱ	Q9NRL3
PaxDbⁱ	Q9NRL3
PeptideAtlasⁱ	Q9NRL3
PRIDEⁱ	Q9NRL3
ProteomicsDBⁱ	82385

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263280; ENSP00000263280; ENSG00000090372 [Q9NRL3-1] ENST00000391910; ENSP00000375777; ENSG00000090372 [Q9NRL3-3] ENST00000435164; ENSP00000473607; ENSG00000090372 [Q9NRL3-2]
GeneIDⁱ	29888
KEGGⁱ	hsa:29888
UCSCⁱ	uc002pfl.4 human [Q9NRL3-1]

Organism-specific databases

CTDⁱ	29888
DisGeNETⁱ	29888
EuPathDBⁱ	HostDB:ENSG00000090372.14
GeneCardsⁱ	STRN4
H-InvDBⁱ	HIX0096898
HGNCⁱ	HGNC:15721 STRN4
HPAⁱ	HPA043051 HPA043527 HPA056706
MIMⁱ	614767 gene
neXtProtⁱ	NX_Q9NRL3
OpenTargetsⁱ	ENSG00000090372
PharmGKBⁱ	PA134863218
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0642 Eukaryota ENOG410XR31 LUCA
GeneTreeⁱ	ENSGT00520000055597
HOGENOMⁱ	HOG000236343
HOVERGENⁱ	HBG007117
InParanoidⁱ	Q9NRL3
KOⁱ	K17608
OMAⁱ	TWNPRFT
OrthoDBⁱ	EOG091G0509
PhylomeDBⁱ	Q9NRL3
TreeFamⁱ	TF313387

Enzyme and pathway databases

SignaLinkⁱ	Q9NRL3

SignaLinkⁱ

Q9NRL3

Miscellaneous databases

ChiTaRSⁱ	STRN4 human
GeneWikiⁱ	STRN4
GenomeRNAiⁱ	29888
PMAP-CutDBⁱ	Q9NRL3
Protein Ontology More...PROⁱ	PR:Q9NRL3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090372 Expressed in 188 organ(s), highest expression level in testis
CleanExⁱ	HS_STRN4
ExpressionAtlasⁱ	Q9NRL3 baseline and differential
Genevisibleⁱ	Q9NRL3 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR013258 Striatin_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF08232 Striatin, 1 hit PF00400 WD40, 4 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STRN4_HUMAN
Accessionⁱ	Q9NRL3Primary (citable) accession number: Q9NRL3 Secondary accession number(s): A0A024R0V2 , B4DQH7, F8VYA6, Q8NE53
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	July 10, 2007
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q9NRL3 (STRN4_HUMAN)

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Striatin-4

STRN4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ