UniProtKB - Q9NRL3 (STRN4_HUMAN)
Protein
Striatin-4
Gene
STRN4
Organism
Homo sapiens (Human)
Status
Functioni
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
Miscellaneous
The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).
GO - Molecular functioni
- armadillo repeat domain binding Source: UniProtKB
- calmodulin binding Source: GO_Central
- protein-containing complex binding Source: UniProtKB
- protein phosphatase 2A binding Source: UniProtKB
Keywordsi
Molecular function | Calmodulin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NRL3 |
SignaLinki | Q9NRL3 |
SIGNORi | Q9NRL3 |
Names & Taxonomyi
Protein namesi | Recommended name: Striatin-4Alternative name(s): Zinedin |
Gene namesi | Name:STRN4 Synonyms:ZIN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15721, STRN4 |
MIMi | 614767, gene |
neXtProti | NX_Q9NRL3 |
VEuPathDBi | HostDB:ENSG00000090372.14 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
- dendritic spine By similarity
Note: CTTNBP2-binding may regulate dendritic spine distribution.By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
- dendrite Source: GO_Central
- dendritic spine Source: UniProtKB-SubCell
- FAR/SIN/STRIPAK complex Source: UniProtKB
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 29888 |
OpenTargetsi | ENSG00000090372 |
PharmGKBi | PA134863218 |
Miscellaneous databases
Pharosi | Q9NRL3, Tbio |
Genetic variation databases
BioMutai | STRN4 |
DMDMi | 152031693 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051239 | 1 – 753 | Striatin-4Add BLAST | 753 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 276 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NRL3 |
jPOSTi | Q9NRL3 |
MassIVEi | Q9NRL3 |
MaxQBi | Q9NRL3 |
PaxDbi | Q9NRL3 |
PeptideAtlasi | Q9NRL3 |
PRIDEi | Q9NRL3 |
ProteomicsDBi | 29195 4874 82385 [Q9NRL3-1] |
PTM databases
iPTMneti | Q9NRL3 |
PhosphoSitePlusi | Q9NRL3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090372, Expressed in testis and 200 other tissues |
ExpressionAtlasi | Q9NRL3, baseline and differential |
Genevisiblei | Q9NRL3, HS |
Organism-specific databases
HPAi | ENSG00000090372, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).
Interacts with CTTNBP2NL.
By similarity1 PublicationBinary interactionsi
Hide detailsQ9NRL3
With | #Exp. | IntAct |
---|---|---|
DR1 [Q01658] | 3 | EBI-717245,EBI-750300 |
GTF3C3 [Q9Y5Q9] | 3 | EBI-717245,EBI-1054873 |
JUN [P05412] | 3 | EBI-717245,EBI-852823 |
GO - Molecular functioni
- armadillo repeat domain binding Source: UniProtKB
- calmodulin binding Source: GO_Central
- protein phosphatase 2A binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 118941, 105 interactors |
IntActi | Q9NRL3, 86 interactors |
STRINGi | 9606.ENSP00000375777 |
Miscellaneous databases
RNActi | Q9NRL3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 436 – 475 | WD 1Add BLAST | 40 | |
Repeati | 489 – 528 | WD 2Add BLAST | 40 | |
Repeati | 542 – 581 | WD 3Add BLAST | 40 | |
Repeati | 587 – 628 | WD 4Add BLAST | 42 | |
Repeati | 635 – 674 | WD 5Add BLAST | 40 | |
Repeati | 677 – 716 | WD 6Add BLAST | 40 | |
Repeati | 723 – 752 | WD 7Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 71 – 79 | Caveolin-bindingSequence analysis | 9 | |
Regioni | 165 – 182 | Calmodulin-bindingSequence analysisAdd BLAST | 18 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 69 – 136 | Sequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 6 – 14 | Poly-Ala | 9 |
Sequence similaritiesi
Belongs to the WD repeat striatin family.Curated
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0642, Eukaryota |
GeneTreei | ENSGT00950000183095 |
HOGENOMi | CLU_009108_2_0_1 |
InParanoidi | Q9NRL3 |
OMAi | LQGMMSD |
OrthoDBi | 334070at2759 |
PhylomeDBi | Q9NRL3 |
TreeFami | TF313387 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR013258, Striatin_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08232, Striatin, 1 hit PF00400, WD40, 4 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NRL3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG
60 70 80 90 100
GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL
110 120 130 140 150
QGERKGQENL KTDLVRRIKM LEYALKQERA KYHKLKFGTD LNQGEKKADV
160 170 180 190 200
SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ YLEEVGYTDT ILDMRSKRVR
210 220 230 240 250
SLLGRSLELN GAVEPSEGAP RAPPGPAGLS GGESLLVKQI EEQIKRNAAG
260 270 280 290 300
KDGKERLGGS VLGQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVKLPSKALV
310 320 330 340 350
PEMEDEDEED DSEDAINEFD FLGSGEDGEG APDPRRCTVD GSPHELESRR
360 370 380 390 400
VKLQGILADL RDVDGLPPKV TGPPPGTPQP RPHEDVFIMD TIGGGEVSLG
410 420 430 440 450
DLADLTVTND NDLSCDLSDS KDAFKKTWNP KFTLRSHYDG IRSLAFHHSQ
460 470 480 490 500
SALLTASEDG TLKLWNLQKA VTAKKNAALD VEPIHAFRAH RGPVLAVAMG
510 520 530 540 550
SNSEYCYSGG ADACIHSWKI PDLSMDPYDG YDPSVLSHVL EGHGDAVWGL
560 570 580 590 600
AFSPTSQRLA SCSADGTVRI WDPSSSSPAC LCTFPTASEH GVPTSVAFTS
610 620 630 640 650
TEPAHIVASF RSGDTVLYDM EVGSALLTLE SRGSSGPTQI NQVVSHPNQP
660 670 680 690 700
LTITAHDDRG IRFLDNRTGK PVHSMVAHLD AVTCLAVDPN GAFLMSGSHD
710 720 730 740 750
CSLRLWSLDN KTCVQEITAH RKKHEEAIHA VACHPSKALI ASAGADALAK
VFV
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GYK2 | F5GYK2_HUMAN | Striatin-4 | STRN4 | 634 | Annotation score: | ||
M0QZM0 | M0QZM0_HUMAN | Striatin-4 | STRN4 | 317 | Annotation score: | ||
M0R0W8 | M0R0W8_HUMAN | Striatin-4 | STRN4 | 180 | Annotation score: | ||
R4GN16 | R4GN16_HUMAN | Striatin-4 | STRN4 | 316 | Annotation score: | ||
M0R317 | M0R317_HUMAN | Striatin-4 | STRN4 | 198 | Annotation score: | ||
M0R0P4 | M0R0P4_HUMAN | Striatin-4 | STRN4 | 139 | Annotation score: | ||
M0QYS2 | M0QYS2_HUMAN | Striatin-4 | STRN4 | 114 | Annotation score: | ||
M0QXN2 | M0QXN2_HUMAN | Striatin-4 | STRN4 | 73 | Annotation score: | ||
M0R2A7 | M0R2A7_HUMAN | Striatin-4 | STRN4 | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 356 | I → V in AAF29527 (PubMed:10748158).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053419 | 568 | V → I. Corresponds to variant dbSNP:rs10409124Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056170 | 1 – 119 | Missing in isoform 2. 1 PublicationAdd BLAST | 119 | |
Alternative sequenceiVSP_056171 | 347 – 376 | ESRRV…GPPPG → GPELHSPTEWQGALSVGKAS PMPDWVGTAG in isoform 2. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_056172 | 377 – 753 | Missing in isoform 2. 1 PublicationAdd BLAST | 377 | |
Alternative sequenceiVSP_056738 | 384 | E → EGSFGFSS in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212940 mRNA Translation: AAF29527.1 AK298804 mRNA Translation: BAG60939.1 AC008622 Genomic DNA No translation available. AC008635 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57442.1 CH471126 Genomic DNA Translation: EAW57443.1 BC004910 mRNA Translation: AAH04910.2 BC034604 mRNA Translation: AAH34604.1 |
CCDSi | CCDS12690.1 [Q9NRL3-1] CCDS42581.1 [Q9NRL3-3] |
RefSeqi | NP_001034966.1, NM_001039877.1 [Q9NRL3-3] NP_037535.2, NM_013403.2 [Q9NRL3-1] |
Genome annotation databases
Ensembli | ENST00000263280; ENSP00000263280; ENSG00000090372 [Q9NRL3-1] ENST00000391910; ENSP00000375777; ENSG00000090372 [Q9NRL3-3] ENST00000435164; ENSP00000473607; ENSG00000090372 [Q9NRL3-2] |
GeneIDi | 29888 |
KEGGi | hsa:29888 |
UCSCi | uc002pfl.4, human [Q9NRL3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212940 mRNA Translation: AAF29527.1 AK298804 mRNA Translation: BAG60939.1 AC008622 Genomic DNA No translation available. AC008635 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57442.1 CH471126 Genomic DNA Translation: EAW57443.1 BC004910 mRNA Translation: AAH04910.2 BC034604 mRNA Translation: AAH34604.1 |
CCDSi | CCDS12690.1 [Q9NRL3-1] CCDS42581.1 [Q9NRL3-3] |
RefSeqi | NP_001034966.1, NM_001039877.1 [Q9NRL3-3] NP_037535.2, NM_013403.2 [Q9NRL3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118941, 105 interactors |
IntActi | Q9NRL3, 86 interactors |
STRINGi | 9606.ENSP00000375777 |
PTM databases
iPTMneti | Q9NRL3 |
PhosphoSitePlusi | Q9NRL3 |
Genetic variation databases
BioMutai | STRN4 |
DMDMi | 152031693 |
Proteomic databases
EPDi | Q9NRL3 |
jPOSTi | Q9NRL3 |
MassIVEi | Q9NRL3 |
MaxQBi | Q9NRL3 |
PaxDbi | Q9NRL3 |
PeptideAtlasi | Q9NRL3 |
PRIDEi | Q9NRL3 |
ProteomicsDBi | 29195 4874 82385 [Q9NRL3-1] |
Protocols and materials databases
ABCDi | Q9NRL3, 1 sequenced antibody |
Antibodypediai | 49367, 174 antibodies |
Genome annotation databases
Ensembli | ENST00000263280; ENSP00000263280; ENSG00000090372 [Q9NRL3-1] ENST00000391910; ENSP00000375777; ENSG00000090372 [Q9NRL3-3] ENST00000435164; ENSP00000473607; ENSG00000090372 [Q9NRL3-2] |
GeneIDi | 29888 |
KEGGi | hsa:29888 |
UCSCi | uc002pfl.4, human [Q9NRL3-1] |
Organism-specific databases
CTDi | 29888 |
DisGeNETi | 29888 |
GeneCardsi | STRN4 |
HGNCi | HGNC:15721, STRN4 |
HPAi | ENSG00000090372, Low tissue specificity |
MIMi | 614767, gene |
neXtProti | NX_Q9NRL3 |
OpenTargetsi | ENSG00000090372 |
PharmGKBi | PA134863218 |
VEuPathDBi | HostDB:ENSG00000090372.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0642, Eukaryota |
GeneTreei | ENSGT00950000183095 |
HOGENOMi | CLU_009108_2_0_1 |
InParanoidi | Q9NRL3 |
OMAi | LQGMMSD |
OrthoDBi | 334070at2759 |
PhylomeDBi | Q9NRL3 |
TreeFami | TF313387 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRL3 |
SignaLinki | Q9NRL3 |
SIGNORi | Q9NRL3 |
Miscellaneous databases
BioGRID-ORCSi | 29888, 16 hits in 995 CRISPR screens |
ChiTaRSi | STRN4, human |
GeneWikii | STRN4 |
GenomeRNAii | 29888 |
Pharosi | Q9NRL3, Tbio |
PROi | PR:Q9NRL3 |
RNActi | Q9NRL3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090372, Expressed in testis and 200 other tissues |
ExpressionAtlasi | Q9NRL3, baseline and differential |
Genevisiblei | Q9NRL3, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR013258, Striatin_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08232, Striatin, 1 hit PF00400, WD40, 4 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STRN4_HUMAN | |
Accessioni | Q9NRL3Primary (citable) accession number: Q9NRL3 Secondary accession number(s): A0A024R0V2 Q8NE53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | July 10, 2007 | |
Last modified: | April 7, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families