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Entry version 194 (16 Oct 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Bromodomain adjacent to zinc finger domain protein 1A

Gene

BAZ1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.

Miscellaneous

Stimulated by double-stranded DNA and nucleosomal DNA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1148 – 1198PHD-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 1A
Alternative name(s):
ATP-dependent chromatin-remodeling protein
ATP-utilizing chromatin assembly and remodeling factor 1
Short name:
hACF1
CHRAC subunit ACF1
Williams syndrome transcription factor-related chromatin-remodeling factor 180
Short name:
WCRF180
hWALp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAZ1A
Synonyms:ACF1, WCRF180
ORF Names:HSPC317
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:960 BAZ1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRL2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11177

Open Targets

More...
OpenTargetsi
ENSG00000198604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25270

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRL2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105737

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BAZ1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241266

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111671 – 1556Bromodomain adjacent to zinc finger domain protein 1AAdd BLAST1556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei270PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei731PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki952Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei960PhosphoserineBy similarity1
Modified residuei961PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1320PhosphoserineCombined sources1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei1353PhosphoserineBy similarity1
Modified residuei1363PhosphoserineCombined sources1
Modified residuei1371PhosphoserineCombined sources1
Modified residuei1402PhosphoserineCombined sources1
Modified residuei1413PhosphoserineCombined sources1
Modified residuei1417PhosphoserineCombined sources1
Modified residuei1547PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRL2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NRL2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NRL2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRL2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRL2

PeptideAtlas

More...
PeptideAtlasi
Q9NRL2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRL2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82383 [Q9NRL2-1]
82384 [Q9NRL2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRL2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NRL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis and at low or undetectable levels in other tissues analyzed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198604 Expressed in 222 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRL2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRL2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002730

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC.

Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116347, 69 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-434 ACF complex
CPX-785 CHRAC chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NRL2

Database of interacting proteins

More...
DIPi
DIP-36071N

Protein interaction database and analysis system

More...
IntActi
Q9NRL2, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9NRL2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353458

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11556
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NRL2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 128WACPROSITE-ProRule annotationAdd BLAST107
Domaini422 – 487DDTPROSITE-ProRule annotationAdd BLAST66
Domaini1446 – 1516BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 133Required for interaction with NCOR11 PublicationAdd BLAST133
Regioni1 – 128Required for association with the CHRAC1/POLE3 complexAdd BLAST128
Regioni667 – 933Interaction with SMARCA5Add BLAST267

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili306 – 397Sequence analysisAdd BLAST92
Coiled coili634 – 709Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi487 – 491Poly-Glu5
Compositional biasi1239 – 1257Glu-richAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WAL family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1148 – 1198PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1245 Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158135

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000095179

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRL2

KEGG Orthology (KO)

More...
KOi
K11655

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYVLESM

Database of Orthologous Groups

More...
OrthoDBi
858930at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NRL2

TreeFam database of animal gene trees

More...
TreeFami
TF316326

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05504 Bromo_Acf1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037325 Acf1_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR028942 WHIM1_dom
IPR028941 WHIM2_dom
IPR013136 WSTF_Acf1_Cbp146
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF00628 PHD, 1 hit
PF10537 WAC_Acf1_DNA_bd, 1 hit
PF15612 WHIM1, 1 hit
PF15613 WSD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS51136 WAC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLLHRKPFV RQKPPADLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL
60 70 80 90 100
VWSCAVTGRP GLTYQEALES EKKARQNLQS FPEPLIIPVL YLTSLTHRSR
110 120 130 140 150
LHEICDDIFA YVKDRYFVEE TVEVIRNNGA RLQCRILEVL PPSHQNGFAN
160 170 180 190 200
GHVNSVDGET IIISDSDDSE TQSCSFQNGK KKDAIDPLLF KYKVQPTKKE
210 220 230 240 250
LHESAIVKAT QISRRKHLFS RDKLKLFLKQ HCEPQDGVIK IKASSLSTYK
260 270 280 290 300
IAEQDFSYFF PDDPPTFIFS PANRRRGRPP KRIHISQEDN VANKQTLASY
310 320 330 340 350
RSKATKERDK LLKQEEMKSL AFEKAKLKRE KADALEAKKK EKEDKEKKRE
360 370 380 390 400
ELKKIVEEER LKKKEEKERL KVEREKEREK LREEKRKYVE YLKQWSKPRE
410 420 430 440 450
DMECDDLKEL PEPTPVKTRL PPEIFGDALM VLEFLNAFGE LFDLQDEFPD
460 470 480 490 500
GVTLEVLEEA LVGNDSEGPL CELLFFFLTA IFQAIAEEEE EVAKEQLTDA
510 520 530 540 550
DTKDLTEALD EDADPTKSAL SAVASLAAAW PQLHQGCSLK SLDLDSCTLS
560 570 580 590 600
EILRLHILAS GADVTSANAK YRYQKRGGFD ATDDACMELR LSNPSLVKKL
610 620 630 640 650
SSTSVYDLTP GEKMKILHAL CGKLLTLVST RDFIEDYVDI LRQAKQEFRE
660 670 680 690 700
LKAEQHRKER EEAAARIRKR KEEKLKEQEQ KMKEKQEKLK EDEQRNSTAD
710 720 730 740 750
ISIGEEERED FDTSIESKDT EQKELDQDMV TEDEDDPGSH KRGRRGKRGQ
760 770 780 790 800
NGFKEFTRQE QINCVTREPL TADEEEALKQ EHQRKEKELL EKIQSAIACT
810 820 830 840 850
NIFPLGRDRM YRRYWIFPSI PGLFIEEDYS GLTEDMLLPR PSSFQNNVQS
860 870 880 890 900
QDPQVSTKTG EPLMSESTSN IDQGPRDHSV QLPKPVHKPN RWCFYSSCEQ
910 920 930 940 950
LDQLIEALNS RGHRESALKE TLLQEKSRIC AQLARFSEEK FHFSDKPQPD
960 970 980 990 1000
SKPTYSRGRS SNAYDPSQMC AEKQLELRLR DFLLDIEDRI YQGTLGAIKV
1010 1020 1030 1040 1050
TDRHIWRSAL ESGRYELLSE ENKENGIIKT VNEDVEEMEI DEQTKVIVKD
1060 1070 1080 1090 1100
RLLGIKTETP STVSTNASTP QSVSSVVHYL AMALFQIEQG IERRFLKAPL
1110 1120 1130 1140 1150
DASDSGRSYK TVLDRWRESL LSSASLSQVF LHLSTLDRSV IWSKSILNAR
1160 1170 1180 1190 1200
CKICRKKGDA ENMVLCDGCD RGHHTYCVRP KLKTVPEGDW FCPECRPKQR
1210 1220 1230 1240 1250
SRRLSSRQRP SLESDEDVED SMGGEDDEVD GDEEEGQSEE EEYEVEQDED
1260 1270 1280 1290 1300
DSQEEEEVSL PKRGRPQVRL PVKTRGKLSS SFSSRGQQQE PGRYPSRSQQ
1310 1320 1330 1340 1350
STPKTTVSSK TGRSLRKINS APPTETKSLR IASRSTRHSH GPLQADVFVE
1360 1370 1380 1390 1400
LLSPRRKRRG RKSANNTPEN SPNFPNFRVI ATKSSEQSRS VNIASKLSLQ
1410 1420 1430 1440 1450
ESESKRRCRK RQSPEPSPVT LGRRSSGRQG GVHELSAFEQ LVVELVRHDD
1460 1470 1480 1490 1500
SWPFLKLVSK IQVPDYYDII KKPIALNIIR EKVNKCEYKL ASEFIDDIEL
1510 1520 1530 1540 1550
MFSNCFEYNP RNTSEAKAGT RLQAFFHIQA QKLGLHVTPS NVDQVSTPPA

AKKSRI
Length:1,556
Mass (Da):178,702
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D78B9A8ADBF715B
GO
Isoform 2 (identifier: Q9NRL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-535: Missing.

Show »
Length:1,524
Mass (Da):175,385
Checksum:i2DB787369178282B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWN7A0A087WWN7_HUMAN
Bromodomain adjacent to zinc finger...
BAZ1A
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ74H0YJ74_HUMAN
Bromodomain adjacent to zinc finger...
BAZ1A
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJP5H0YJP5_HUMAN
Bromodomain adjacent to zinc finger...
BAZ1A
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ68H0YJ68_HUMAN
Bromodomain adjacent to zinc finger...
BAZ1A
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28995 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135R → T in BAA89209 (PubMed:10662543).Curated1
Sequence conflicti236D → E in BAA89209 (PubMed:10662543).Curated1
Sequence conflicti494K → Q in AAF28995 (Ref. 6) Curated1
Sequence conflicti503 – 508KDLTEA → QDFTEP in AAF28995 (Ref. 6) Curated6
Sequence conflicti525S → P in AAF28995 (Ref. 6) Curated1
Sequence conflicti536 – 540GCSLK → AALKF in AAF28995 (Ref. 6) Curated5
Sequence conflicti551E → D in AAF70601 (PubMed:10880450).Curated1
Sequence conflicti730V → F in BAA89209 (PubMed:10662543).Curated1
Sequence conflicti769P → L in BAA89209 (PubMed:10662543).Curated1
Sequence conflicti1201S → C in BAA89209 (PubMed:10662543).Curated1
Sequence conflicti1206S → F in BAA89209 (PubMed:10662543).Curated1
Sequence conflicti1409R → K in AAF70601 (PubMed:10880450).Curated1
Sequence conflicti1409R → K in CAB43261 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028049344D → E. Corresponds to variant dbSNP:rs1133285Ensembl.1
Natural variantiVAR_0484231366N → K2 PublicationsCorresponds to variant dbSNP:rs1044140Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000551504 – 535Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF213467 mRNA Translation: AAF70601.1
AF221130 mRNA Translation: AAF32366.1
AB032252 mRNA Translation: BAA89209.1
AL121603 Genomic DNA No translation available.
AL355885 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65900.1
AF161435 mRNA Translation: AAF28995.1 Frameshift.
AL050089 mRNA Translation: CAB43261.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41943.1 [Q9NRL2-2]
CCDS9651.1 [Q9NRL2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08738

NCBI Reference Sequences

More...
RefSeqi
NP_038476.2, NM_013448.2 [Q9NRL2-1]
NP_872589.1, NM_182648.1 [Q9NRL2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358716; ENSP00000351555; ENSG00000198604 [Q9NRL2-2]
ENST00000360310; ENSP00000353458; ENSG00000198604 [Q9NRL2-1]
ENST00000382422; ENSP00000371859; ENSG00000198604 [Q9NRL2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11177

UCSC genome browser

More...
UCSCi
uc001wsk.4 human [Q9NRL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213467 mRNA Translation: AAF70601.1
AF221130 mRNA Translation: AAF32366.1
AB032252 mRNA Translation: BAA89209.1
AL121603 Genomic DNA No translation available.
AL355885 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65900.1
AF161435 mRNA Translation: AAF28995.1 Frameshift.
AL050089 mRNA Translation: CAB43261.1
CCDSiCCDS41943.1 [Q9NRL2-2]
CCDS9651.1 [Q9NRL2-1]
PIRiT08738
RefSeqiNP_038476.2, NM_013448.2 [Q9NRL2-1]
NP_872589.1, NM_182648.1 [Q9NRL2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UIYX-ray1.69A/B/C/D1425-1538[»]
SMRiQ9NRL2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116347, 69 interactors
ComplexPortaliCPX-434 ACF complex
CPX-785 CHRAC chromatin remodeling complex
CORUMiQ9NRL2
DIPiDIP-36071N
IntActiQ9NRL2, 37 interactors
MINTiQ9NRL2
STRINGi9606.ENSP00000353458

Chemistry databases

ChEMBLiCHEMBL4105737

PTM databases

iPTMnetiQ9NRL2
PhosphoSitePlusiQ9NRL2
SwissPalmiQ9NRL2

Polymorphism and mutation databases

BioMutaiBAZ1A
DMDMi116241266

Proteomic databases

EPDiQ9NRL2
jPOSTiQ9NRL2
MassIVEiQ9NRL2
MaxQBiQ9NRL2
PaxDbiQ9NRL2
PeptideAtlasiQ9NRL2
PRIDEiQ9NRL2
ProteomicsDBi82383 [Q9NRL2-1]
82384 [Q9NRL2-2]

Genome annotation databases

EnsembliENST00000358716; ENSP00000351555; ENSG00000198604 [Q9NRL2-2]
ENST00000360310; ENSP00000353458; ENSG00000198604 [Q9NRL2-1]
ENST00000382422; ENSP00000371859; ENSG00000198604 [Q9NRL2-1]
GeneIDi11177
KEGGihsa:11177
UCSCiuc001wsk.4 human [Q9NRL2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11177
DisGeNETi11177

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BAZ1A
HGNCiHGNC:960 BAZ1A
HPAiHPA002730
MIMi605680 gene
neXtProtiNX_Q9NRL2
OpenTargetsiENSG00000198604
PharmGKBiPA25270

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1245 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000158135
HOGENOMiHOG000095179
InParanoidiQ9NRL2
KOiK11655
OMAiYYVLESM
OrthoDBi858930at2759
PhylomeDBiQ9NRL2
TreeFamiTF316326

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BAZ1A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11177
PharosiQ9NRL2

Protein Ontology

More...
PROi
PR:Q9NRL2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198604 Expressed in 222 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9NRL2 baseline and differential
GenevisibleiQ9NRL2 HS

Family and domain databases

CDDicd05504 Bromo_Acf1_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR037325 Acf1_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR028942 WHIM1_dom
IPR028941 WHIM2_dom
IPR013136 WSTF_Acf1_Cbp146
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF00628 PHD, 1 hit
PF10537 WAC_Acf1_DNA_bd, 1 hit
PF15612 WHIM1, 1 hit
PF15613 WSD, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS51136 WAC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAZ1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRL2
Secondary accession number(s): Q9NZ15
, Q9P065, Q9UIG1, Q9Y3V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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