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UniProtKB - Q9NRK6 (ABCBA_HUMAN)

Entry version 185 (29 Sep 2021)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
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Protein

ATP-binding cassette sub-family B member 10, mitochondrial

Gene

ABCB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225).

May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225).

Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049).

In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685).

4 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.9 µM for Zn (II) mesoporphyrin (ZnMP)1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi527 – 534ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		7.4.2.5, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRK6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1369007, Mitochondrial ABC transporters

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.201.17, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 10, mitochondrialCurated
Alternative name(s):
ABC-mitochondrial erythroid proteinBy similarity
Short name:
ABC-me proteinBy similarity
ATP-binding cassette transporter 10
Short name:
ABC transporter 10 protein
Mitochondrial ATP-binding cassette 21 Publication
Short name:
M-ABC21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCB10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:41, ABCB10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605454, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRK6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135776

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini106 – 170Mitochondrial intermembraneSequence analysisAdd BLAST65
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei171 – 191HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini192 – 215Mitochondrial matrixSequence analysisAdd BLAST24
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 312Mitochondrial intermembraneSequence analysisAdd BLAST76
Transmembranei313 – 333HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini334 – 407Mitochondrial matrixSequence analysisAdd BLAST74
Transmembranei408 – 428HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini429 – 430Mitochondrial intermembraneSequence analysis2
Transmembranei431 – 451HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini452 – 738Mitochondrial matrixSequence analysisAdd BLAST287

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi215C → S: Does not affect ATPase activity; when associated with L-224 and G-582. Activated by Zn (II) mesoporphyrin; when associated with L-224 and G-582. 1 Publication1
Mutagenesisi224C → L: Does not affect ATPase activity; when associated withS-215 and G-582. Activated by Zn (II) mesoporphyrin; when associated with S-215 and G-582. 1 Publication1
Mutagenesisi533K → E: Increases hemoglobin biosynthetic process. 1 Publication1
Mutagenesisi582C → G: Does not affect ATPase activity; when associated with S-215 and L-224. Activated by Zn (II) mesoporphyrin; when associated with S-215 and L-224. 1 Publication1
Mutagenesisi635S → R: Does not rescue hemoglobin and heme biosynthetic process. 1 Publication1
Mutagenesisi638Q → H: Does not rescue hemoglobin and heme biosynthetic process. 1 Publication1
Mutagenesisi658D → A: Does not rescue hemoglobin and heme biosynthetic process. 1 Publication1
Mutagenesisi659E → A: Does not rescue hemoglobin and heme biosynthetic process. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		23456

Open Targets

More...OpenTargetsi		ENSG00000135776

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24385

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRK6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABCB10

Domain mapping of disease mutations (DMDM)

More...DMDMi		143811359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 105MitochondrionBy similarityAdd BLAST105
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000000255106 – 738ATP-binding cassette sub-family B member 10, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei265N6-acetyllysineCombined sources1
Modified residuei582S-glutathionyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Glutathionylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NRK6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NRK6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRK6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRK6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRK6

PeptideAtlas

More...PeptideAtlasi		Q9NRK6

PRoteomics IDEntifications database

More...PRIDEi		Q9NRK6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82382

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NRK6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRK6

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NRK6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRK6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NRK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135776, Expressed in liver and 214 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRK6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135776, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homooligomer (PubMed:23716676, PubMed:30765471).

Interacts with PAAT (PubMed:25063848).

Interacts with SLC25A37; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation (By similarity).

Interacts with FECH; this interaction may allow the formation of an oligomeric complex with SLC25A37 (By similarity).

Forms a complex with ABCB7 and FECH, where a dimeric FECH bridges ABCB7 and ABCB10 homodimers; this complex may be required for cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471).

Interacts with FECH (PubMed:30765471).

By similarity3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117020, 47 interactors

Protein interaction database and analysis system

More...IntActi		Q9NRK6, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355637

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRK6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1738
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRK6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini171 – 457ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST287
Domaini492 – 731ABC transporterPROSITE-ProRule annotationAdd BLAST240

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. [View classification]Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0058, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_84_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRK6

Identification of Orthologs from Complete Genome Data

More...OMAi		LWGAYRV

Database of Orthologous Groups

More...OrthoDBi		684058at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRK6

TreeFam database of animal gene trees

More...TreeFami		TF105198

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1560.10, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030260, ABCB10-like
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter

The PANTHER Classification System

More...PANTHERi		PTHR24221, PTHR24221, 1 hit
PTHR24221:SF553, PTHR24221:SF553, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00664, ABC_membrane, 1 hit
PF00005, ABC_tran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF90123, SSF90123, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50929, ABC_TM1F, 1 hit
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGPPAWPLR LLEPPSPAEP GRLLPVACVW AAASRVPGSL SPFTGLRPAR 
        60         70         80         90        100
LWGAGPALLW GVGAARRWRS GCRGGGPGAS RGVLGLARLL GLWARGPGSC 
       110        120        130        140        150
RCGAFAGPGA PRLPRARFPG GPAAAAWAGD EAWRRGPAAP PGDKGRLRPA 
       160        170        180        190        200
AAGLPEARKL LGLAYPERRR LAAAVGFLTM SSVISMSAPF FLGKIIDVIY 
       210        220        230        240        250
TNPTVDYSDN LTRLCLGLSA VFLCGAAANA IRVYLMQTSG QRIVNRLRTS 
       260        270        280        290        300
LFSSILRQEV AFFDKTRTGE LINRLSSDTA LLGRSVTENL SDGLRAGAQA 
       310        320        330        340        350
SVGISMMFFV SPNLATFVLS VVPPVSIIAV IYGRYLRKLT KVTQDSLAQA 
       360        370        380        390        400
TQLAEERIGN VRTVRAFGKE MTEIEKYASK VDHVMQLARK EAFARAGFFG 
       410        420        430        440        450
ATGLSGNLIV LSVLYKGGLL MGSAHMTVGE LSSFLMYAFW VGISIGGLSS 
       460        470        480        490        500
FYSELMKGLG AGGRLWELLE REPKLPFNEG VILNEKSFQG ALEFKNVHFA 
       510        520        530        540        550
YPARPEVPIF QDFSLSIPSG SVTALVGPSG SGKSTVLSLL LRLYDPASGT 
       560        570        580        590        600
ISLDGHDIRQ LNPVWLRSKI GTVSQEPILF SCSIAENIAY GADDPSSVTA 
       610        620        630        640        650
EEIQRVAEVA NAVAFIRNFP QGFNTVVGEK GVLLSGGQKQ RIAIARALLK 
       660        670        680        690        700
NPKILLLDEA TSALDAENEY LVQEALDRLM DGRTVLVIAH RLSTIKNANM 
       710        720        730 
VAVLDQGKIT EYGKHEELLS KPNGIYRKLM NKQSFISA
Length:738
Mass (Da):79,148
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC68B4FAC0F8B7E43
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti393F → V in AAF78198 (PubMed:10922475).Curated1
Sequence conflicti511Q → K in AAA84438 (PubMed:7766993).Curated1
Sequence conflicti558 – 563IRQLNP → NPSAKPS in AAA84438 (PubMed:7766993).Curated6
Sequence conflicti606 – 611VAEVAN → GLKGQ in BAB20265 (Ref. 2) Curated6
Sequence conflicti615 – 622FIRNFPQG → SPEFPPR in AAA84438 (PubMed:7766993).Curated8
Sequence conflicti691R → S in AAA84438 (PubMed:7766993).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013702150A → S1 PublicationCorresponds to variant dbSNP:rs4148756Ensembl.1
Natural variantiVAR_048133242R → G. Corresponds to variant dbSNP:rs17584642Ensembl.1
Natural variantiVAR_035735471R → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_031435545D → N1 PublicationCorresponds to variant dbSNP:rs35698797Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF216833 mRNA Translation: AAF78198.1
AB013380 mRNA Translation: BAB20265.1
AL121990 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69901.1
BC064930 mRNA Translation: AAH64930.1
U18237 mRNA Translation: AAA84438.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1580.1

NCBI Reference Sequences

More...RefSeqi		NP_036221.2, NM_012089.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344517; ENSP00000355637; ENSG00000135776

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23456

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23456

UCSC genome browser

More...UCSCi		uc001htp.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216833 mRNA Translation: AAF78198.1
AB013380 mRNA Translation: BAB20265.1
AL121990 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69901.1
BC064930 mRNA Translation: AAH64930.1
U18237 mRNA Translation: AAA84438.1
CCDSiCCDS1580.1
RefSeqiNP_036221.2, NM_012089.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZDQX-ray2.85A152-738[»]
4AYTX-ray2.85A152-738[»]
4AYWX-ray3.30A1-738[»]
4AYXX-ray2.90A152-738[»]
SMRiQ9NRK6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117020, 47 interactors
IntActiQ9NRK6, 19 interactors
STRINGi9606.ENSP00000355637

Protein family/group databases

TCDBi3.A.1.201.17, the atp-binding cassette (abc) superfamily

PTM databases

GlyGeniQ9NRK6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9NRK6
MetOSiteiQ9NRK6
PhosphoSitePlusiQ9NRK6
SwissPalmiQ9NRK6

Genetic variation databases

BioMutaiABCB10
DMDMi143811359

Proteomic databases

EPDiQ9NRK6
jPOSTiQ9NRK6
MassIVEiQ9NRK6
MaxQBiQ9NRK6
PaxDbiQ9NRK6
PeptideAtlasiQ9NRK6
PRIDEiQ9NRK6
ProteomicsDBi82382

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34677, 225 antibodies

The DNASU plasmid repository

More...DNASUi		23456

Genome annotation databases

EnsembliENST00000344517; ENSP00000355637; ENSG00000135776
GeneIDi23456
KEGGihsa:23456
UCSCiuc001htp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23456
DisGeNETi23456

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABCB10
HGNCiHGNC:41, ABCB10
HPAiENSG00000135776, Low tissue specificity
MIMi605454, gene
neXtProtiNX_Q9NRK6
OpenTargetsiENSG00000135776
PharmGKBiPA24385
VEuPathDBiHostDB:ENSG00000135776

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0058, Eukaryota
GeneTreeiENSGT00940000157680
HOGENOMiCLU_000604_84_3_1
InParanoidiQ9NRK6
OMAiLWGAYRV
OrthoDBi684058at2759
PhylomeDBiQ9NRK6
TreeFamiTF105198

Enzyme and pathway databases

BRENDAi7.4.2.5, 2681
PathwayCommonsiQ9NRK6
ReactomeiR-HSA-1369007, Mitochondrial ABC transporters

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23456, 61 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABCB10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23456
PharosiQ9NRK6, Tbio

Protein Ontology

More...PROi		PR:Q9NRK6
RNActiQ9NRK6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135776, Expressed in liver and 214 other tissues
GenevisibleiQ9NRK6, HS

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030260, ABCB10-like
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter
PANTHERiPTHR24221, PTHR24221, 1 hit
PTHR24221:SF553, PTHR24221:SF553, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 1 hit
PF00005, ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF90123, SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 1 hit
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCBA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRK6
Secondary accession number(s): Q13040, Q6P1Q8, Q9H3V0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: April 3, 2007
Last modified: September 29, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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