UniProtKB - Q9NRK6 (ABCBA_HUMAN)
Protein
ATP-binding cassette sub-family B member 10, mitochondrial
Gene
ABCB10
Organism
Homo sapiens (Human)
Status
Functioni
May mediate critical mitochondrial transport functions related to heme biosynthesis.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 527 – 534 | ATP | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
GO - Biological processi
- mitochondrial transport Source: UniProtKB
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.43, 2681 |
PathwayCommonsi | Q9NRK6 |
Reactomei | R-HSA-1369007, Mitochondrial ABC transporters |
Protein family/group databases
TCDBi | 3.A.1.201.17, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family B member 10, mitochondrialAlternative name(s): ATP-binding cassette transporter 10 Short name: ABC transporter 10 protein Mitochondrial ATP-binding cassette 2 Short name: M-ABC2 |
Gene namesi | Name:ABCB10Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:41, ABCB10 |
MIMi | 605454, gene |
neXtProti | NX_Q9NRK6 |
VEuPathDBi | HostDB:ENSG00000135776.4 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Mitochondrion
- integral component of mitochondrial membrane Source: UniProtKB
- mitochondrial inner membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 106 – 170 | Mitochondrial intermembraneSequence analysisAdd BLAST | 65 | |
Transmembranei | 171 – 191 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 192 – 215 | Mitochondrial matrixSequence analysisAdd BLAST | 24 | |
Transmembranei | 216 – 236 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 237 – 312 | Mitochondrial intermembraneSequence analysisAdd BLAST | 76 | |
Transmembranei | 313 – 333 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 334 – 407 | Mitochondrial matrixSequence analysisAdd BLAST | 74 | |
Transmembranei | 408 – 428 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 429 – 430 | Mitochondrial intermembraneSequence analysis | 2 | |
Transmembranei | 431 – 451 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 452 – 738 | Mitochondrial matrixSequence analysisAdd BLAST | 287 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23456 |
OpenTargetsi | ENSG00000135776 |
PharmGKBi | PA24385 |
Miscellaneous databases
Pharosi | Q9NRK6, Tbio |
Genetic variation databases
BioMutai | ABCB10 |
DMDMi | 143811359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 105 | MitochondrionBy similarityAdd BLAST | 105 | |
ChainiPRO_0000000255 | 106 – 738 | ATP-binding cassette sub-family B member 10, mitochondrialAdd BLAST | 633 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 265 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9NRK6 |
jPOSTi | Q9NRK6 |
MassIVEi | Q9NRK6 |
MaxQBi | Q9NRK6 |
PaxDbi | Q9NRK6 |
PeptideAtlasi | Q9NRK6 |
PRIDEi | Q9NRK6 |
ProteomicsDBi | 82382 |
PTM databases
iPTMneti | Q9NRK6 |
MetOSitei | Q9NRK6 |
PhosphoSitePlusi | Q9NRK6 |
SwissPalmi | Q9NRK6 |
Expressioni
Tissue specificityi
Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.
Gene expression databases
Bgeei | ENSG00000135776, Expressed in liver and 214 other tissues |
Genevisiblei | Q9NRK6, HS |
Organism-specific databases
HPAi | ENSG00000135776, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 117020, 43 interactors |
IntActi | Q9NRK6, 19 interactors |
STRINGi | 9606.ENSP00000355637 |
Miscellaneous databases
RNActi | Q9NRK6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NRK6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 171 – 457 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 287 | |
Domaini | 492 – 731 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 240 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. [View classification]Curated
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0058, Eukaryota |
GeneTreei | ENSGT00940000157680 |
HOGENOMi | CLU_000604_84_3_1 |
InParanoidi | Q9NRK6 |
OMAi | MLYTPIK |
OrthoDBi | 684058at2759 |
PhylomeDBi | Q9NRK6 |
TreeFami | TF105198 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR030260, ABCB10-like IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF553, PTHR24221:SF553, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9NRK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGPPAWPLR LLEPPSPAEP GRLLPVACVW AAASRVPGSL SPFTGLRPAR
60 70 80 90 100
LWGAGPALLW GVGAARRWRS GCRGGGPGAS RGVLGLARLL GLWARGPGSC
110 120 130 140 150
RCGAFAGPGA PRLPRARFPG GPAAAAWAGD EAWRRGPAAP PGDKGRLRPA
160 170 180 190 200
AAGLPEARKL LGLAYPERRR LAAAVGFLTM SSVISMSAPF FLGKIIDVIY
210 220 230 240 250
TNPTVDYSDN LTRLCLGLSA VFLCGAAANA IRVYLMQTSG QRIVNRLRTS
260 270 280 290 300
LFSSILRQEV AFFDKTRTGE LINRLSSDTA LLGRSVTENL SDGLRAGAQA
310 320 330 340 350
SVGISMMFFV SPNLATFVLS VVPPVSIIAV IYGRYLRKLT KVTQDSLAQA
360 370 380 390 400
TQLAEERIGN VRTVRAFGKE MTEIEKYASK VDHVMQLARK EAFARAGFFG
410 420 430 440 450
ATGLSGNLIV LSVLYKGGLL MGSAHMTVGE LSSFLMYAFW VGISIGGLSS
460 470 480 490 500
FYSELMKGLG AGGRLWELLE REPKLPFNEG VILNEKSFQG ALEFKNVHFA
510 520 530 540 550
YPARPEVPIF QDFSLSIPSG SVTALVGPSG SGKSTVLSLL LRLYDPASGT
560 570 580 590 600
ISLDGHDIRQ LNPVWLRSKI GTVSQEPILF SCSIAENIAY GADDPSSVTA
610 620 630 640 650
EEIQRVAEVA NAVAFIRNFP QGFNTVVGEK GVLLSGGQKQ RIAIARALLK
660 670 680 690 700
NPKILLLDEA TSALDAENEY LVQEALDRLM DGRTVLVIAH RLSTIKNANM
710 720 730
VAVLDQGKIT EYGKHEELLS KPNGIYRKLM NKQSFISA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 393 | F → V in AAF78198 (PubMed:10922475).Curated | 1 | |
Sequence conflicti | 511 | Q → K in AAA84438 (PubMed:7766993).Curated | 1 | |
Sequence conflicti | 558 – 563 | IRQLNP → NPSAKPS in AAA84438 (PubMed:7766993).Curated | 6 | |
Sequence conflicti | 606 – 611 | VAEVAN → GLKGQ in BAB20265 (Ref. 2) Curated | 6 | |
Sequence conflicti | 615 – 622 | FIRNFPQG → SPEFPPR in AAA84438 (PubMed:7766993).Curated | 8 | |
Sequence conflicti | 691 | R → S in AAA84438 (PubMed:7766993).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013702 | 150 | A → S1 PublicationCorresponds to variant dbSNP:rs4148756Ensembl. | 1 | |
Natural variantiVAR_048133 | 242 | R → G. Corresponds to variant dbSNP:rs17584642Ensembl. | 1 | |
Natural variantiVAR_035735 | 471 | R → T in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_031435 | 545 | D → N1 PublicationCorresponds to variant dbSNP:rs35698797Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216833 mRNA Translation: AAF78198.1 AB013380 mRNA Translation: BAB20265.1 AL121990 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69901.1 BC064930 mRNA Translation: AAH64930.1 U18237 mRNA Translation: AAA84438.1 |
CCDSi | CCDS1580.1 |
RefSeqi | NP_036221.2, NM_012089.2 |
Genome annotation databases
Ensembli | ENST00000344517; ENSP00000355637; ENSG00000135776 |
GeneIDi | 23456 |
KEGGi | hsa:23456 |
UCSCi | uc001htp.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
ABCMdb Database for mutations in ABC proteins |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216833 mRNA Translation: AAF78198.1 AB013380 mRNA Translation: BAB20265.1 AL121990 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69901.1 BC064930 mRNA Translation: AAH64930.1 U18237 mRNA Translation: AAA84438.1 |
CCDSi | CCDS1580.1 |
RefSeqi | NP_036221.2, NM_012089.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ZDQ | X-ray | 2.85 | A | 152-738 | [»] | |
4AYT | X-ray | 2.85 | A | 152-738 | [»] | |
4AYW | X-ray | 3.30 | A | 1-738 | [»] | |
4AYX | X-ray | 2.90 | A | 152-738 | [»] | |
SMRi | Q9NRK6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117020, 43 interactors |
IntActi | Q9NRK6, 19 interactors |
STRINGi | 9606.ENSP00000355637 |
Protein family/group databases
TCDBi | 3.A.1.201.17, the atp-binding cassette (abc) superfamily |
PTM databases
iPTMneti | Q9NRK6 |
MetOSitei | Q9NRK6 |
PhosphoSitePlusi | Q9NRK6 |
SwissPalmi | Q9NRK6 |
Genetic variation databases
BioMutai | ABCB10 |
DMDMi | 143811359 |
Proteomic databases
EPDi | Q9NRK6 |
jPOSTi | Q9NRK6 |
MassIVEi | Q9NRK6 |
MaxQBi | Q9NRK6 |
PaxDbi | Q9NRK6 |
PeptideAtlasi | Q9NRK6 |
PRIDEi | Q9NRK6 |
ProteomicsDBi | 82382 |
Protocols and materials databases
Antibodypediai | 34677, 216 antibodies |
Genome annotation databases
Ensembli | ENST00000344517; ENSP00000355637; ENSG00000135776 |
GeneIDi | 23456 |
KEGGi | hsa:23456 |
UCSCi | uc001htp.4, human |
Organism-specific databases
CTDi | 23456 |
DisGeNETi | 23456 |
GeneCardsi | ABCB10 |
HGNCi | HGNC:41, ABCB10 |
HPAi | ENSG00000135776, Low tissue specificity |
MIMi | 605454, gene |
neXtProti | NX_Q9NRK6 |
OpenTargetsi | ENSG00000135776 |
PharmGKBi | PA24385 |
VEuPathDBi | HostDB:ENSG00000135776.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0058, Eukaryota |
GeneTreei | ENSGT00940000157680 |
HOGENOMi | CLU_000604_84_3_1 |
InParanoidi | Q9NRK6 |
OMAi | MLYTPIK |
OrthoDBi | 684058at2759 |
PhylomeDBi | Q9NRK6 |
TreeFami | TF105198 |
Enzyme and pathway databases
BRENDAi | 3.6.3.43, 2681 |
PathwayCommonsi | Q9NRK6 |
Reactomei | R-HSA-1369007, Mitochondrial ABC transporters |
Miscellaneous databases
BioGRID-ORCSi | 23456, 60 hits in 875 CRISPR screens |
ChiTaRSi | ABCB10, human |
GenomeRNAii | 23456 |
Pharosi | Q9NRK6, Tbio |
PROi | PR:Q9NRK6 |
RNActi | Q9NRK6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135776, Expressed in liver and 214 other tissues |
Genevisiblei | Q9NRK6, HS |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR030260, ABCB10-like IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF553, PTHR24221:SF553, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCBA_HUMAN | |
Accessioni | Q9NRK6Primary (citable) accession number: Q9NRK6 Secondary accession number(s): Q13040, Q6P1Q8, Q9H3V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 2, 2002 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families