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Protein

Protocadherin beta-16

Gene

PCDHB16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-16
Short name:
PCDH-beta-16
Alternative name(s):
Protocadherin-3X
Gene namesi
Name:PCDHB16
Synonyms:KIAA1621, PCDH3X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000272674.3
HGNCiHGNC:14546 PCDHB16
MIMi604967 gene
606345 gene
neXtProtiNX_Q9NRJ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 690ExtracellularSequence analysisAdd BLAST662
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 776CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33032

Polymorphism and mutation databases

BioMutaiPCDHB16
DMDMi308153560

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000394429 – 776Protocadherin beta-16Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NRJ7
PaxDbiQ9NRJ7
PeptideAtlasiQ9NRJ7
PRIDEiQ9NRJ7
ProteomicsDBi82381

PTM databases

GlyConnecti1680
iPTMnetiQ9NRJ7
PhosphoSitePlusiQ9NRJ7

Expressioni

Gene expression databases

BgeeiENSG00000272674 Expressed in 158 organ(s), highest expression level in visceral pleura
CleanExiHS_PCDHB16
ExpressionAtlasiQ9NRJ7 baseline and differential
GenevisibleiQ9NRJ7 HS

Organism-specific databases

HPAiHPA014668

Interactioni

Protein-protein interaction databases

BioGridi121740, 39 interactors
STRINGi9606.ENSP00000354293

Structurei

3D structure databases

ProteinModelPortaliQ9NRJ7
SMRiQ9NRJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9NRJ7
KOiK16494
OrthoDBiEOG091G024L
PhylomeDBiQ9NRJ7
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIGWMHNRR QRQVLVFFVL LSLSGAGAEL GSYSVVEETE RGSFVANLGK
60 70 80 90 100
DLGLGLTEMS TRKARIISQG NKQHLQLKAQ TGDLLINEKL DREELCGPTE
110 120 130 140 150
PCILHFQVLM ENPLEIFQAE LRVIDINDHS PMFTEKEMIL KIPENSPLGT
160 170 180 190 200
EFPLNHALDL DVGSNNVQNY KISPSSHFRV LIHEFRDGRK YPELVLDKEL
210 220 230 240 250
DREEEPQLRL TLTALDGGSP PRSGTAQVRI EVVDINDNAP EFEQPIYKVQ
260 270 280 290 300
IPENSPLGSL VATVSARDLD GGANGKISYT LFQPSEDISK TLEVNPMTGE
310 320 330 340 350
VRLRKQVDFE MVTSYEVRIK ATDGGGLSGK CTLLLQVVDV NDNPPQVTMS
360 370 380 390 400
ALTSPIPENS PEIVVAVFSV SDPDSGNNGK TISSIQEDLP FLLKPSVKNF
410 420 430 440 450
YTLVTERALD REARAEYNIT LTVTDMGTPR LKTEHNITVQ ISDVNDNAPT
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALREFEFR VSATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPF LPLPEAAPGQ TQANSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGRCSMPEG PFPGRLVDVS GTGTLSQSYQ
760 770
YEVCLTGGSE TSEFKFLKPI IPNFSP
Length:776
Mass (Da):84,983
Last modified:October 5, 2010 - v3
Checksum:i03F420D3098D6032
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LP81A0A096LP81_HUMAN
Protocadherin beta-16
PCDHB16
222Annotation score:

Sequence cautioni

The sequence BAB13447 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357P → A in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti482T → I in BAB13447 (PubMed:10997877).Curated1
Sequence conflicti526E → A in AAF81914 (PubMed:11322959).Curated1
Sequence conflicti526E → A in AAG10030 (PubMed:11322959).Curated1
Sequence conflicti526E → A in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti543S → R in AAF81914 (PubMed:11322959).Curated1
Sequence conflicti543S → R in AAG10030 (PubMed:11322959).Curated1
Sequence conflicti543S → R in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti560F → L in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti638Q → H in BAB13447 (PubMed:10997877).Curated1
Sequence conflicti652R → C in BAB13447 (PubMed:10997877).Curated1
Sequence conflicti710A → V in BAB13447 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05558791D → E. Corresponds to variant dbSNP:rs17096969Ensembl.1
Natural variantiVAR_061068347V → L. Corresponds to variant dbSNP:rs28664170Ensembl.1
Natural variantiVAR_061069508A → T. Corresponds to variant dbSNP:rs17844648Ensembl.1
Natural variantiVAR_026478525R → Q2 PublicationsCorresponds to variant dbSNP:rs17844651Ensembl.1
Natural variantiVAR_026479532S → G2 PublicationsCorresponds to variant dbSNP:rs2697532Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217757 mRNA Translation: AAF81914.1
AF282973 Genomic DNA Translation: AAG10030.1
AY013878 mRNA Translation: AAK21988.1
AB046841 mRNA Translation: BAB13447.1 Different initiation.
AK056460 mRNA Translation: BAG51717.1
AC074130 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61975.1
BC036062 mRNA Translation: AAH36062.1
CCDSiCCDS4251.1
RefSeqiNP_066008.2, NM_020957.3
UniGeneiHs.147674
Hs.582172

Genome annotation databases

EnsembliENST00000609684; ENSP00000477314; ENSG00000272674
GeneIDi57717
KEGGihsa:57717
UCSCiuc032vnl.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217757 mRNA Translation: AAF81914.1
AF282973 Genomic DNA Translation: AAG10030.1
AY013878 mRNA Translation: AAK21988.1
AB046841 mRNA Translation: BAB13447.1 Different initiation.
AK056460 mRNA Translation: BAG51717.1
AC074130 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61975.1
BC036062 mRNA Translation: AAH36062.1
CCDSiCCDS4251.1
RefSeqiNP_066008.2, NM_020957.3
UniGeneiHs.147674
Hs.582172

3D structure databases

ProteinModelPortaliQ9NRJ7
SMRiQ9NRJ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121740, 39 interactors
STRINGi9606.ENSP00000354293

PTM databases

GlyConnecti1680
iPTMnetiQ9NRJ7
PhosphoSitePlusiQ9NRJ7

Polymorphism and mutation databases

BioMutaiPCDHB16
DMDMi308153560

Proteomic databases

EPDiQ9NRJ7
PaxDbiQ9NRJ7
PeptideAtlasiQ9NRJ7
PRIDEiQ9NRJ7
ProteomicsDBi82381

Protocols and materials databases

DNASUi57717
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000609684; ENSP00000477314; ENSG00000272674
GeneIDi57717
KEGGihsa:57717
UCSCiuc032vnl.2 human

Organism-specific databases

CTDi57717
EuPathDBiHostDB:ENSG00000272674.3
GeneCardsiPCDHB16
HGNCiHGNC:14546 PCDHB16
HPAiHPA014668
MIMi604967 gene
606345 gene
neXtProtiNX_Q9NRJ7
PharmGKBiPA33032
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9NRJ7
KOiK16494
OrthoDBiEOG091G024L
PhylomeDBiQ9NRJ7
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHB16
GenomeRNAii57717
PROiPR:Q9NRJ7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000272674 Expressed in 158 organ(s), highest expression level in visceral pleura
CleanExiHS_PCDHB16
ExpressionAtlasiQ9NRJ7 baseline and differential
GenevisibleiQ9NRJ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBG_HUMAN
AccessioniPrimary (citable) accession number: Q9NRJ7
Secondary accession number(s): B3KPK5
, Q8IYD5, Q96SE9, Q9HCF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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