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Entry version 166 (16 Oct 2019)
Sequence version 2 (04 Nov 2008)
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Protein

Tubby-related protein 4

Gene

TULP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NRJ4

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubby-related protein 4
Alternative name(s):
Tubby superfamily protein
Tubby-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TULP4
Synonyms:KIAA1397, TUBL4, TUSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15530 TULP4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRJ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56995

Open Targets

More...
OpenTargetsi
ENSG00000130338

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134880863

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRJ4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TULP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276475

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001864721 – 1543Tubby-related protein 4Add BLAST1543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei577PhosphoserineCombined sources1
Modified residuei945Asymmetric dimethylarginineBy similarity1
Modified residuei950Asymmetric dimethylarginineBy similarity1
Modified residuei1343PhosphoserineCombined sources1
Modified residuei1374PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRJ4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NRJ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NRJ4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRJ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRJ4

PeptideAtlas

More...
PeptideAtlasi
Q9NRJ4

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRJ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82378 [Q9NRJ4-1]
82379 [Q9NRJ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRJ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in the brain, skeletal muscle, testis and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130338 Expressed in 226 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NRJ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRJ4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005445

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121310, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NRJ4, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356064

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati6 – 72WD 1Add BLAST67
Repeati73 – 115WD 2Add BLAST43
Repeati116 – 158WD 3Add BLAST43
Repeati159 – 237WD 4Add BLAST79
Repeati238 – 276WD 5Add BLAST39
Repeati277 – 334WD 6Add BLAST58
Repeati335 – 372WD 7Add BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini364 – 414SOCS boxPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1466 – 1543TUBAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2503 Eukaryota
ENOG410YEKG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060128

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRJ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRNNMNP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRJ4

TreeFam database of animal gene trees

More...
TreeFami
TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001496 SOCS_box
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR008983 Tumour_necrosis_fac-like_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01167 Tub, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00969 SOCS_box, 1 hit
SM00320 WD40, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 1 hit
SSF50978 SSF50978, 1 hit
SSF54518 SSF54518, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50225 SOCS, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYAAVEHGPV LCSDSNILCL SWKGRVPKSE KEKPVCRRRY YEEGWLATGN
60 70 80 90 100
GRGVVGVTFT SSHCRRDRST PQRINFNLRG HNSEVVLVRW NEPYQKLATC
110 120 130 140 150
DADGGIFVWI QYEGRWSVEL VNDRGAQVSD FTWSHDGTQA LISYRDGFVL
160 170 180 190 200
VGSVSGQRHW SSEINLESQI TCGIWTPDDQ QVLFGTADGQ VIVMDCHGRM
210 220 230 240 250
LAHVLLHESD GVLGMSWNYP IFLVEDSSES DTDSDDYAPP QDGPAAYPIP
260 270 280 290 300
VQNIKPLLTV SFTSGDISLM NNYDDLSPTV IRSGLKEVVA QWCTQGDLLA
310 320 330 340 350
VAGMERQTQL GELPNGPLLK SAMVKFYNVR GEHIFTLDTL VQRPIISICW
360 370 380 390 400
GHRDSRLLMA SGPALYVVRV EHRVSSLQLL CQQAIASTLR EDKDVSKLTL
410 420 430 440 450
PPRLCSYLST AFIPTIKPPI PDPNNMRDFV SYPSAGNERL HCTMKRTEDD
460 470 480 490 500
PEVGGPCYTL YLEYLGGLVP ILKGRRISKL RPEFVIMDPR TDSKPDEIYG
510 520 530 540 550
NSLISTVIDS CNCSDSSDIE LSDDWAAKKS PKISRASKSP KLPRISIEAR
560 570 580 590 600
KSPKLPRAAQ ELSRSPRLPL RKPSVGSPSL TRREFPFEDI TQHNYLAQVT
610 620 630 640 650
SNIWGTKFKI VGLAAFLPTN LGAVIYKTSL LHLQPRQMTI YLPEVRKISM
660 670 680 690 700
DYINLPVFNP NVFSEDEDDL PVTGASGVPE NSPPCTVNIP IAPIHSSAQA
710 720 730 740 750
MSPTQSIGLV QSLLANQNVQ LDVLTNQTTA VGTAEHAGDS ATQYPVSNRY
760 770 780 790 800
SNPGQVIFGS VEMGRIIQNP PPLSLPPPPQ GPMQLSTVGH GDRDHEHLQK
810 820 830 840 850
SAKALRPTPQ LAAEGDAVVF SAPQEVQVTK INPPPPYPGT IPAAPTTAAP
860 870 880 890 900
PPPLPPPQPP VDVCLKKGDF SLYPTSVHYQ TPLGYERITT FDSSGNVEEV
910 920 930 940 950
CRPRTRMLCS QNTYTLPGPG SSATLRLTAT EKKVPQPCSS ATLNRLTVPR
960 970 980 990 1000
YSIPTGDPPP YPEIASQLAQ GRGAAQRSDN SLIHATLRRN NREATLKMAQ
1010 1020 1030 1040 1050
LADSPRAPLQ PLAKSKGGPG GVVTQLPARP PPALYTCSQC SGTGPSSQPG
1060 1070 1080 1090 1100
ASLAHTASAS PLASQSSYSL LSPPDSARDR TDYVNSAFTE DEALSQHCQL
1110 1120 1130 1140 1150
EKPLRHPPLP EAAVTLKRPP PYQWDPMLGE DVWVPQERTA QTSGPNPLKL
1160 1170 1180 1190 1200
SSLMLSQGQH LDVSRLPFIS PKSPASPTAT FQTGYGMGVP YPGSYNNPPL
1210 1220 1230 1240 1250
PGVQAPCSPK DALSPTQFAQ QEPAVVLQPL YPPSLSYCTL PPMYPGSSTC
1260 1270 1280 1290 1300
SSLQLPPVAL HPWSSYSACP PMQNPQGTLP PKPHLVVEKP LVSPPPADLQ
1310 1320 1330 1340 1350
SHLGTEVMVE TADNFQEVLS LTESPVPQRT EKFGKKNRKR LDSRAEEGSV
1360 1370 1380 1390 1400
QAITEGKVKK EARTLSDFNS LISSPHLGRE KKKVKSQKDQ LKSKKLNKTN
1410 1420 1430 1440 1450
EFQDSSESEP ELFISGDELM NQSQGSRKGW KSKRSPRAAG ELEEAKCRRA
1460 1470 1480 1490 1500
SEKEDGRLGS QGFVYVMANK QPLWNEATQV YQLDFGGRVT QESAKNFQIE
1510 1520 1530 1540
LEGRQVMQFG RIDGSAYILD FQYPFSAVQA FAVALANVTQ RLK
Length:1,543
Mass (Da):169,000
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i803AB78FF8DF2E98
GO
Isoform 2 (identifier: Q9NRJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-678: VTGASGV → GDAVWTD
     679-1543: Missing.

Show »
Length:678
Mass (Da):75,852
Checksum:i6C2EA8130490EE32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYH3A0A087WYH3_HUMAN
Tubby-related protein 4
TULP4
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF87975 differs from that shown. Reason: Frameshift.Curated
The sequence BAA92635 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti745P → Q in AAF87975 (PubMed:11595174).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059841199R → S. Corresponds to variant dbSNP:rs705956Ensembl.1
Natural variantiVAR_052417214G → S. Corresponds to variant dbSNP:rs35262826Ensembl.1
Natural variantiVAR_052418522S → N. Corresponds to variant dbSNP:rs12206717Ensembl.1
Natural variantiVAR_052419979D → N. Corresponds to variant dbSNP:rs34622886Ensembl.1
Natural variantiVAR_0524201084V → I. Corresponds to variant dbSNP:rs34559793Ensembl.1
Natural variantiVAR_0524211281P → T. Corresponds to variant dbSNP:rs3749852Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006676672 – 678VTGASGV → GDAVWTD in isoform 2. 3 Publications7
Alternative sequenceiVSP_006677679 – 1543Missing in isoform 2. 3 PublicationsAdd BLAST865

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF219946 mRNA Translation: AAF87975.1 Frameshift.
AF288480 mRNA Translation: AAG01020.1
AB037818 mRNA Translation: BAA92635.1 Different initiation.
AL360169 Genomic DNA No translation available.
AL353800 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47661.1
CH471051 Genomic DNA Translation: EAW47662.1
BC152476 mRNA Translation: AAI52477.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34561.1 [Q9NRJ4-1]
CCDS34562.1 [Q9NRJ4-2]

NCBI Reference Sequences

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RefSeqi
NP_001007467.1, NM_001007466.2 [Q9NRJ4-2]
NP_064630.2, NM_020245.4 [Q9NRJ4-1]
XP_016866558.1, XM_017011069.1
XP_016866559.1, XM_017011070.1 [Q9NRJ4-1]
XP_016866560.1, XM_017011071.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367094; ENSP00000356061; ENSG00000130338 [Q9NRJ4-2]
ENST00000367097; ENSP00000356064; ENSG00000130338 [Q9NRJ4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56995

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56995

UCSC genome browser

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UCSCi
uc003qrf.4 human [Q9NRJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219946 mRNA Translation: AAF87975.1 Frameshift.
AF288480 mRNA Translation: AAG01020.1
AB037818 mRNA Translation: BAA92635.1 Different initiation.
AL360169 Genomic DNA No translation available.
AL353800 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47661.1
CH471051 Genomic DNA Translation: EAW47662.1
BC152476 mRNA Translation: AAI52477.1
CCDSiCCDS34561.1 [Q9NRJ4-1]
CCDS34562.1 [Q9NRJ4-2]
RefSeqiNP_001007467.1, NM_001007466.2 [Q9NRJ4-2]
NP_064630.2, NM_020245.4 [Q9NRJ4-1]
XP_016866558.1, XM_017011069.1
XP_016866559.1, XM_017011070.1 [Q9NRJ4-1]
XP_016866560.1, XM_017011071.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121310, 9 interactors
IntActiQ9NRJ4, 6 interactors
STRINGi9606.ENSP00000356064

PTM databases

iPTMnetiQ9NRJ4
PhosphoSitePlusiQ9NRJ4

Polymorphism and mutation databases

BioMutaiTULP4
DMDMi212276475

Proteomic databases

EPDiQ9NRJ4
jPOSTiQ9NRJ4
MassIVEiQ9NRJ4
MaxQBiQ9NRJ4
PaxDbiQ9NRJ4
PeptideAtlasiQ9NRJ4
PRIDEiQ9NRJ4
ProteomicsDBi82378 [Q9NRJ4-1]
82379 [Q9NRJ4-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56995

Genome annotation databases

EnsembliENST00000367094; ENSP00000356061; ENSG00000130338 [Q9NRJ4-2]
ENST00000367097; ENSP00000356064; ENSG00000130338 [Q9NRJ4-1]
GeneIDi56995
KEGGihsa:56995
UCSCiuc003qrf.4 human [Q9NRJ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56995
DisGeNETi56995

GeneCards: human genes, protein and diseases

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GeneCardsi
TULP4
HGNCiHGNC:15530 TULP4
HPAiHPA005445
neXtProtiNX_Q9NRJ4
OpenTargetsiENSG00000130338
PharmGKBiPA134880863

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2503 Eukaryota
ENOG410YEKG LUCA
GeneTreeiENSGT00940000155913
HOGENOMiHOG000060128
InParanoidiQ9NRJ4
OMAiCRNNMNP
PhylomeDBiQ9NRJ4
TreeFamiTF314076

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ9NRJ4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TULP4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56995
PharosiQ9NRJ4

Protein Ontology

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PROi
PR:Q9NRJ4

Gene expression databases

BgeeiENSG00000130338 Expressed in 226 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9NRJ4 baseline and differential
GenevisibleiQ9NRJ4 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001496 SOCS_box
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR008983 Tumour_necrosis_fac-like_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167 Tub, 1 hit
SMARTiView protein in SMART
SM00969 SOCS_box, 1 hit
SM00320 WD40, 2 hits
SUPFAMiSSF49842 SSF49842, 1 hit
SSF50978 SSF50978, 1 hit
SSF54518 SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS50225 SOCS, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTULP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRJ4
Secondary accession number(s): Q5T3M2
, Q5T3M3, Q9HD22, Q9P2F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 4, 2008
Last modified: October 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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