UniProtKB - Q9NRJ4 (TULP4_HUMAN)
Protein
Tubby-related protein 4
Gene
TULP4
Organism
Homo sapiens (Human)
Status
Functioni
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- post-translational protein modification Source: Reactome
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NRJ4 |
Reactomei | R-HSA-8951664, Neddylation |
SignaLinki | Q9NRJ4 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Tubby-related protein 4Alternative name(s): Tubby superfamily protein Tubby-like protein 4 |
Gene namesi | Name:TULP4 Synonyms:KIAA1397, TUBL4, TUSP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15530, TULP4 |
neXtProti | NX_Q9NRJ4 |
VEuPathDBi | HostDB:ENSG00000130338.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56995 |
OpenTargetsi | ENSG00000130338 |
PharmGKBi | PA134880863 |
Miscellaneous databases
Pharosi | Q9NRJ4, Tdark |
Genetic variation databases
BioMutai | TULP4 |
DMDMi | 212276475 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186472 | 1 – 1543 | Tubby-related protein 4Add BLAST | 1543 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 577 | PhosphoserineCombined sources | 1 | |
Modified residuei | 945 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 950 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1343 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1374 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9NRJ4 |
jPOSTi | Q9NRJ4 |
MassIVEi | Q9NRJ4 |
MaxQBi | Q9NRJ4 |
PaxDbi | Q9NRJ4 |
PeptideAtlasi | Q9NRJ4 |
PRIDEi | Q9NRJ4 |
ProteomicsDBi | 82378 [Q9NRJ4-1] 82379 [Q9NRJ4-2] |
PTM databases
iPTMneti | Q9NRJ4 |
PhosphoSitePlusi | Q9NRJ4 |
Expressioni
Tissue specificityi
Expressed mainly in the brain, skeletal muscle, testis and kidney.
Gene expression databases
Bgeei | ENSG00000130338, Expressed in corpus callosum and 235 other tissues |
ExpressionAtlasi | Q9NRJ4, baseline and differential |
Genevisiblei | Q9NRJ4, HS |
Organism-specific databases
HPAi | ENSG00000130338, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121310, 11 interactors |
IntActi | Q9NRJ4, 6 interactors |
STRINGi | 9606.ENSP00000356064 |
Miscellaneous databases
RNActi | Q9NRJ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 72 | WD 1Add BLAST | 67 | |
Repeati | 73 – 115 | WD 2Add BLAST | 43 | |
Repeati | 116 – 158 | WD 3Add BLAST | 43 | |
Repeati | 159 – 237 | WD 4Add BLAST | 79 | |
Repeati | 238 – 276 | WD 5Add BLAST | 39 | |
Repeati | 277 – 334 | WD 6Add BLAST | 58 | |
Repeati | 335 – 372 | WD 7Add BLAST | 38 | |
Domaini | 364 – 414 | SOCS boxPROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1466 – 1543 | TUBAdd BLAST | 78 |
Domaini
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity
Sequence similaritiesi
Belongs to the TUB family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2503, Eukaryota |
GeneTreei | ENSGT00940000155913 |
HOGENOMi | CLU_002083_1_0_1 |
InParanoidi | Q9NRJ4 |
OMAi | CRNNMNP |
PhylomeDBi | Q9NRJ4 |
TreeFami | TF314076 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001496, SOCS_box IPR025659, Tubby-like_C IPR000007, Tubby_C IPR008983, Tumour_necrosis_fac-like_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF01167, Tub, 1 hit |
SMARTi | View protein in SMART SM00969, SOCS_box, 1 hit SM00320, WD40, 2 hits |
SUPFAMi | SSF49842, SSF49842, 1 hit SSF50978, SSF50978, 1 hit SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS50225, SOCS, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NRJ4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYAAVEHGPV LCSDSNILCL SWKGRVPKSE KEKPVCRRRY YEEGWLATGN
60 70 80 90 100
GRGVVGVTFT SSHCRRDRST PQRINFNLRG HNSEVVLVRW NEPYQKLATC
110 120 130 140 150
DADGGIFVWI QYEGRWSVEL VNDRGAQVSD FTWSHDGTQA LISYRDGFVL
160 170 180 190 200
VGSVSGQRHW SSEINLESQI TCGIWTPDDQ QVLFGTADGQ VIVMDCHGRM
210 220 230 240 250
LAHVLLHESD GVLGMSWNYP IFLVEDSSES DTDSDDYAPP QDGPAAYPIP
260 270 280 290 300
VQNIKPLLTV SFTSGDISLM NNYDDLSPTV IRSGLKEVVA QWCTQGDLLA
310 320 330 340 350
VAGMERQTQL GELPNGPLLK SAMVKFYNVR GEHIFTLDTL VQRPIISICW
360 370 380 390 400
GHRDSRLLMA SGPALYVVRV EHRVSSLQLL CQQAIASTLR EDKDVSKLTL
410 420 430 440 450
PPRLCSYLST AFIPTIKPPI PDPNNMRDFV SYPSAGNERL HCTMKRTEDD
460 470 480 490 500
PEVGGPCYTL YLEYLGGLVP ILKGRRISKL RPEFVIMDPR TDSKPDEIYG
510 520 530 540 550
NSLISTVIDS CNCSDSSDIE LSDDWAAKKS PKISRASKSP KLPRISIEAR
560 570 580 590 600
KSPKLPRAAQ ELSRSPRLPL RKPSVGSPSL TRREFPFEDI TQHNYLAQVT
610 620 630 640 650
SNIWGTKFKI VGLAAFLPTN LGAVIYKTSL LHLQPRQMTI YLPEVRKISM
660 670 680 690 700
DYINLPVFNP NVFSEDEDDL PVTGASGVPE NSPPCTVNIP IAPIHSSAQA
710 720 730 740 750
MSPTQSIGLV QSLLANQNVQ LDVLTNQTTA VGTAEHAGDS ATQYPVSNRY
760 770 780 790 800
SNPGQVIFGS VEMGRIIQNP PPLSLPPPPQ GPMQLSTVGH GDRDHEHLQK
810 820 830 840 850
SAKALRPTPQ LAAEGDAVVF SAPQEVQVTK INPPPPYPGT IPAAPTTAAP
860 870 880 890 900
PPPLPPPQPP VDVCLKKGDF SLYPTSVHYQ TPLGYERITT FDSSGNVEEV
910 920 930 940 950
CRPRTRMLCS QNTYTLPGPG SSATLRLTAT EKKVPQPCSS ATLNRLTVPR
960 970 980 990 1000
YSIPTGDPPP YPEIASQLAQ GRGAAQRSDN SLIHATLRRN NREATLKMAQ
1010 1020 1030 1040 1050
LADSPRAPLQ PLAKSKGGPG GVVTQLPARP PPALYTCSQC SGTGPSSQPG
1060 1070 1080 1090 1100
ASLAHTASAS PLASQSSYSL LSPPDSARDR TDYVNSAFTE DEALSQHCQL
1110 1120 1130 1140 1150
EKPLRHPPLP EAAVTLKRPP PYQWDPMLGE DVWVPQERTA QTSGPNPLKL
1160 1170 1180 1190 1200
SSLMLSQGQH LDVSRLPFIS PKSPASPTAT FQTGYGMGVP YPGSYNNPPL
1210 1220 1230 1240 1250
PGVQAPCSPK DALSPTQFAQ QEPAVVLQPL YPPSLSYCTL PPMYPGSSTC
1260 1270 1280 1290 1300
SSLQLPPVAL HPWSSYSACP PMQNPQGTLP PKPHLVVEKP LVSPPPADLQ
1310 1320 1330 1340 1350
SHLGTEVMVE TADNFQEVLS LTESPVPQRT EKFGKKNRKR LDSRAEEGSV
1360 1370 1380 1390 1400
QAITEGKVKK EARTLSDFNS LISSPHLGRE KKKVKSQKDQ LKSKKLNKTN
1410 1420 1430 1440 1450
EFQDSSESEP ELFISGDELM NQSQGSRKGW KSKRSPRAAG ELEEAKCRRA
1460 1470 1480 1490 1500
SEKEDGRLGS QGFVYVMANK QPLWNEATQV YQLDFGGRVT QESAKNFQIE
1510 1520 1530 1540
LEGRQVMQFG RIDGSAYILD FQYPFSAVQA FAVALANVTQ RLK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WYH3 | A0A087WYH3_HUMAN | Tubby-related protein 4 | TULP4 | 216 | Annotation score: |
Sequence cautioni
The sequence AAF87975 differs from that shown. Reason: Frameshift.Curated
The sequence BAA92635 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 745 | P → Q in AAF87975 (PubMed:11595174).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059841 | 199 | R → S. Corresponds to variant dbSNP:rs705956Ensembl. | 1 | |
Natural variantiVAR_052417 | 214 | G → S. Corresponds to variant dbSNP:rs35262826Ensembl. | 1 | |
Natural variantiVAR_052418 | 522 | S → N. Corresponds to variant dbSNP:rs12206717Ensembl. | 1 | |
Natural variantiVAR_052419 | 979 | D → N. Corresponds to variant dbSNP:rs34622886Ensembl. | 1 | |
Natural variantiVAR_052420 | 1084 | V → I. Corresponds to variant dbSNP:rs34559793EnsemblClinVar. | 1 | |
Natural variantiVAR_052421 | 1281 | P → T. Corresponds to variant dbSNP:rs3749852Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006676 | 672 – 678 | VTGASGV → GDAVWTD in isoform 2. 3 Publications | 7 | |
Alternative sequenceiVSP_006677 | 679 – 1543 | Missing in isoform 2. 3 PublicationsAdd BLAST | 865 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF219946 mRNA Translation: AAF87975.1 Frameshift. AF288480 mRNA Translation: AAG01020.1 AB037818 mRNA Translation: BAA92635.1 Different initiation. AL360169 Genomic DNA No translation available. AL353800 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47661.1 CH471051 Genomic DNA Translation: EAW47662.1 BC152476 mRNA Translation: AAI52477.1 |
CCDSi | CCDS34561.1 [Q9NRJ4-1] CCDS34562.1 [Q9NRJ4-2] |
RefSeqi | NP_001007467.1, NM_001007466.2 [Q9NRJ4-2] NP_064630.2, NM_020245.4 [Q9NRJ4-1] XP_016866558.1, XM_017011069.1 XP_016866559.1, XM_017011070.1 [Q9NRJ4-1] XP_016866560.1, XM_017011071.1 |
Genome annotation databases
Ensembli | ENST00000367094; ENSP00000356061; ENSG00000130338 [Q9NRJ4-2] ENST00000367097; ENSP00000356064; ENSG00000130338 [Q9NRJ4-1] |
GeneIDi | 56995 |
KEGGi | hsa:56995 |
UCSCi | uc003qrf.4, human [Q9NRJ4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF219946 mRNA Translation: AAF87975.1 Frameshift. AF288480 mRNA Translation: AAG01020.1 AB037818 mRNA Translation: BAA92635.1 Different initiation. AL360169 Genomic DNA No translation available. AL353800 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47661.1 CH471051 Genomic DNA Translation: EAW47662.1 BC152476 mRNA Translation: AAI52477.1 |
CCDSi | CCDS34561.1 [Q9NRJ4-1] CCDS34562.1 [Q9NRJ4-2] |
RefSeqi | NP_001007467.1, NM_001007466.2 [Q9NRJ4-2] NP_064630.2, NM_020245.4 [Q9NRJ4-1] XP_016866558.1, XM_017011069.1 XP_016866559.1, XM_017011070.1 [Q9NRJ4-1] XP_016866560.1, XM_017011071.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121310, 11 interactors |
IntActi | Q9NRJ4, 6 interactors |
STRINGi | 9606.ENSP00000356064 |
PTM databases
iPTMneti | Q9NRJ4 |
PhosphoSitePlusi | Q9NRJ4 |
Genetic variation databases
BioMutai | TULP4 |
DMDMi | 212276475 |
Proteomic databases
EPDi | Q9NRJ4 |
jPOSTi | Q9NRJ4 |
MassIVEi | Q9NRJ4 |
MaxQBi | Q9NRJ4 |
PaxDbi | Q9NRJ4 |
PeptideAtlasi | Q9NRJ4 |
PRIDEi | Q9NRJ4 |
ProteomicsDBi | 82378 [Q9NRJ4-1] 82379 [Q9NRJ4-2] |
Protocols and materials databases
Antibodypediai | 1688, 54 antibodies |
DNASUi | 56995 |
Genome annotation databases
Ensembli | ENST00000367094; ENSP00000356061; ENSG00000130338 [Q9NRJ4-2] ENST00000367097; ENSP00000356064; ENSG00000130338 [Q9NRJ4-1] |
GeneIDi | 56995 |
KEGGi | hsa:56995 |
UCSCi | uc003qrf.4, human [Q9NRJ4-1] |
Organism-specific databases
CTDi | 56995 |
DisGeNETi | 56995 |
GeneCardsi | TULP4 |
HGNCi | HGNC:15530, TULP4 |
HPAi | ENSG00000130338, Low tissue specificity |
neXtProti | NX_Q9NRJ4 |
OpenTargetsi | ENSG00000130338 |
PharmGKBi | PA134880863 |
VEuPathDBi | HostDB:ENSG00000130338.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2503, Eukaryota |
GeneTreei | ENSGT00940000155913 |
HOGENOMi | CLU_002083_1_0_1 |
InParanoidi | Q9NRJ4 |
OMAi | CRNNMNP |
PhylomeDBi | Q9NRJ4 |
TreeFami | TF314076 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9NRJ4 |
Reactomei | R-HSA-8951664, Neddylation |
SignaLinki | Q9NRJ4 |
Miscellaneous databases
BioGRID-ORCSi | 56995, 9 hits in 892 CRISPR screens |
ChiTaRSi | TULP4, human |
GenomeRNAii | 56995 |
Pharosi | Q9NRJ4, Tdark |
PROi | PR:Q9NRJ4 |
RNActi | Q9NRJ4, protein |
Gene expression databases
Bgeei | ENSG00000130338, Expressed in corpus callosum and 235 other tissues |
ExpressionAtlasi | Q9NRJ4, baseline and differential |
Genevisiblei | Q9NRJ4, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001496, SOCS_box IPR025659, Tubby-like_C IPR000007, Tubby_C IPR008983, Tumour_necrosis_fac-like_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF01167, Tub, 1 hit |
SMARTi | View protein in SMART SM00969, SOCS_box, 1 hit SM00320, WD40, 2 hits |
SUPFAMi | SSF49842, SSF49842, 1 hit SSF50978, SSF50978, 1 hit SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS50225, SOCS, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TULP4_HUMAN | |
Accessioni | Q9NRJ4Primary (citable) accession number: Q9NRJ4 Secondary accession number(s): Q5T3M2 Q9P2F0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 10, 2021 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families