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Protein

C-C motif chemokine 28

Gene

CCL28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell chemotaxis Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • cytolysis in other organism Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: InterPro
  • killing of cells of other organism Source: UniProtKB
  • negative regulation of leukocyte tethering or rolling Source: UniProtKB
  • positive regulation of cell-matrix adhesion Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • response to nutrient Source: Ensembl

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Mucosae-associated epithelial chemokine
Short name:
MEC
Protein CCK1
Small-inducible cytokine A28
Gene namesi
Name:CCL28
Synonyms:SCYA28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000151882.11
HGNCiHGNC:17700 CCL28
MIMi605240 gene
neXtProtiNX_Q9NRJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56477
OpenTargetsiENSG00000151882
PharmGKBiPA38463

Polymorphism and mutation databases

BioMutaiCCL28
DMDMi12230650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000524220 – 127C-C motif chemokine 28Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NRJ3
PeptideAtlasiQ9NRJ3
PRIDEiQ9NRJ3
ProteomicsDBi82377

PTM databases

iPTMnetiQ9NRJ3
PhosphoSitePlusiQ9NRJ3

Expressioni

Tissue specificityi

Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Gene expression databases

BgeeiENSG00000151882
CleanExiHS_CCL28
ExpressionAtlasiQ9NRJ3 baseline and differential
GenevisibleiQ9NRJ3 HS

Organism-specific databases

HPAiHPA077434

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi121147, 3 interactors
DIPiDIP-57392N
IntActiQ9NRJ3, 8 interactors
MINTiQ9NRJ3
STRINGi9606.ENSP00000354416

Structurei

3D structure databases

ProteinModelPortaliQ9NRJ3
SMRiQ9NRJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBTP Eukaryota
ENOG411138S LUCA
GeneTreeiENSGT00530000063923
HOGENOMiHOG000036970
HOVERGENiHBG101413
InParanoidiQ9NRJ3
KOiK05513
OMAiGNICHKK
OrthoDBiEOG091G0U3F
PhylomeDBiQ9NRJ3
TreeFamiTF337014

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR
60 70 80 90 100
IQRADGDCDL AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH
110 120
RKKHHGKRNS NRAHQGKHET YGHKTPY
Length:127
Mass (Da):14,280
Last modified:October 1, 2000 - v1
Checksum:i3E8551A63A2C8D62
GO
Isoform 2 (identifier: Q9NRJ3-2) [UniParc]FASTAAdd to basket
Also known as: CCL28chi

The sequence of this isoform differs from the canonical sequence as follows:
     64-127: ILHVKRRRIC...HETYGHKTPY → MLECSDMISA...ARTTILLSSG

Show »
Length:117
Mass (Da):12,375
Checksum:i2E0390498F47B135
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04773564 – 127ILHVK…HKTPY → MLECSDMISAHYNLHLPGSN DSPTSAFQVAGITAFMSSAE ESVSARTTILLSSG in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220210 mRNA Translation: AAF87205.1
AF266504 mRNA Translation: AAG16691.1
AF110384 mRNA Translation: AAG43193.1
HM067700 mRNA Translation: ADH95184.1
AC025457 Genomic DNA No translation available.
BC062668 mRNA Translation: AAH62668.1
BC069532 mRNA Translation: AAH69532.1
CCDSiCCDS3944.1 [Q9NRJ3-1]
RefSeqiNP_001288802.1, NM_001301873.1 [Q9NRJ3-1]
NP_001288803.1, NM_001301874.1 [Q9NRJ3-1]
NP_683513.1, NM_148672.3 [Q9NRJ3-1]
UniGeneiHs.656904

Genome annotation databases

EnsembliENST00000361115; ENSP00000354416; ENSG00000151882 [Q9NRJ3-1]
ENST00000489442; ENSP00000426424; ENSG00000151882 [Q9NRJ3-1]
GeneIDi56477
KEGGihsa:56477
UCSCiuc003jnu.4 human [Q9NRJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCL28_HUMAN
AccessioniPrimary (citable) accession number: Q9NRJ3
Secondary accession number(s): D7RIE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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