UniProtKB - Q9NRI5 (DISC1_HUMAN)
Disrupted in schizophrenia 1 protein
DISC1
Functioni
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846).
Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity).
Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846).
Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity).
Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity).
Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360).
Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity).
Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030).
By similarity3 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
- kinesin binding Source: Ensembl
- molecular adaptor activity Source: Ensembl
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- canonical Wnt signaling pathway Source: Ensembl
- cell proliferation in forebrain Source: Ensembl
- cilium assembly Source: GO_Central
- microtubule cytoskeleton organization Source: UniProtKB
- mitochondrial calcium ion homeostasis Source: Ensembl
- negative regulation of protein binding Source: ARUK-UCL
- neuron migration Source: UniProtKB
- non-motile cilium assembly Source: SYSCILIA_CCNET
- positive regulation of axon extension Source: Ensembl
- positive regulation of cell-matrix adhesion Source: Ensembl
- positive regulation of neuroblast proliferation Source: UniProtKB
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of ubiquitin-dependent protein catabolic process Source: Ensembl
- positive regulation of Wnt signaling pathway Source: UniProtKB
- protein localization to centrosome Source: Ensembl
- pyramidal neuron migration to cerebral cortex Source: Ensembl
- regulation of dendritic spine development Source: Ensembl
- regulation of synapse maturation Source: Ensembl
- regulation of synaptic transmission, glutamatergic Source: Ensembl
- response to electrical stimulus Source: Ensembl
- TOR signaling Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NRI5 |
SignaLinki | Q9NRI5 |
SIGNORi | Q9NRI5 |
Protein family/group databases
MoonDBi | Q9NRI5, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Disrupted in schizophrenia 1 proteinCurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2888, DISC1 |
MIMi | 605210, gene |
neXtProti | NX_Q9NRI5 |
VEuPathDBi | HostDB:ENSG00000162946 |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Cytoskeleton
- cytoskeleton 2 Publications
- centrosome 2 Publications
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Other locations
- postsynaptic density By similarity
Note: Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198, PubMed:15797709). Colocalizes with PCNT at the centrosome (PubMed:18955030).By similarity3 Publications
Cytoskeleton
- centrosome Source: UniProtKB
- ciliary basal body Source: Ensembl
- dynein complex Source: Ensembl
- intermediate filament cytoskeleton Source: HPA
- kinesin complex Source: Ensembl
- microtubule Source: GO_Central
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleus Source: Ensembl
Other locations
- cell body Source: Ensembl
- central region of growth cone Source: Ensembl
- ciliary base Source: SYSCILIA_CCNET
- perinuclear region of cytoplasm Source: Ensembl
- postsynaptic density Source: UniProtKB-SubCell
- synaptic vesicle Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, Microtubule, Mitochondrion, SynapsePathology & Biotechi
Involvement in diseasei
Schizophrenia 9 (SCZD9)4 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 372 | K → R: Reduced ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 815 | L → P: Impairs interaction with NDEL1; when associated with P-822. 1 Publication | 1 | |
Mutagenesisi | 822 | L → P: Impairs interaction with NDEL1; when associated with P-815. 1 Publication | 1 |
Keywords - Diseasei
SchizophreniaOrganism-specific databases
DisGeNETi | 27185 |
MalaCardsi | DISC1 |
MIMi | 604906, phenotype |
OpenTargetsi | ENSG00000162946 |
Orphaneti | 171703, Microcephaly-polymicrogyria-corpus callosum agenesis syndrome |
PharmGKBi | PA27342 |
Miscellaneous databases
Pharosi | Q9NRI5, Tbio |
Genetic variation databases
BioMutai | DISC1 |
DMDMi | 160332362 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079916 | 1 – 854 | Disrupted in schizophrenia 1 proteinAdd BLAST | 854 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 372 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9NRI5 |
jPOSTi | Q9NRI5 |
MassIVEi | Q9NRI5 |
MaxQBi | Q9NRI5 |
PaxDbi | Q9NRI5 |
PeptideAtlasi | Q9NRI5 |
PRIDEi | Q9NRI5 |
ProteomicsDBi | 82365 [Q9NRI5-1] 82366 [Q9NRI5-2] 82367 [Q9NRI5-3] 82368 [Q9NRI5-4] 82369 [Q9NRI5-5] 82370 [Q9NRI5-6] 82371 [Q9NRI5-7] 82372 [Q9NRI5-8] |
PTM databases
iPTMneti | Q9NRI5 |
PhosphoSitePlusi | Q9NRI5 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000162946, Expressed in sural nerve and 163 other tissues |
ExpressionAtlasi | Q9NRI5, baseline and differential |
Genevisiblei | Q9NRI5, HS |
Organism-specific databases
HPAi | ENSG00000162946, Tissue enhanced (retina) |
Interactioni
Subunit structurei
Interacts with NDEL1 (PubMed:12506198).
Interacts with CCDC88A (via C-terminus); the interaction is direct.
Interacts with GSK3B (By similarity).
Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1 (PubMed:12812986). Interaction with microtubules may be mediated in part by TRAF3IP1.
Interacts (via C-terminal) with PCNT (PubMed:18955030).
Interacts with CHCHD6 (PubMed:22228767).
Interacts with CCDC141 (By similarity).
Interacts with FBXW7, the substrate-recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex; the interaction targets DISC1 for proteasomal degradation (PubMed:28727686).
Interacts with ZNF365 (PubMed:17389905).
Interacts with ATF4; inhibiting ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (By similarity).
Interacts with PDE4B (isoform PDE4B5) (PubMed:17519386).
By similarity9 PublicationsBinary interactionsi
Q9NRI5
Isoform 1 [Q9NRI5-1]
Isoform 2 [Q9NRI5-2]
Isoform 3 [Q9NRI5-3]
With | #Exp. | IntAct |
---|---|---|
Ccdc141 [A2AST1] from Mus musculus. | 6 | EBI-21925300,EBI-20565696 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- kinesin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 118061, 418 interactors |
CORUMi | Q9NRI5 |
DIPi | DIP-33828N |
ELMi | Q9NRI5 |
IntActi | Q9NRI5, 949 interactors |
MINTi | Q9NRI5 |
STRINGi | 9606.ENSP00000355593 |
Miscellaneous databases
RNActi | Q9NRI5, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9NRI5 |
SASBDBi | Q9NRI5 |
SMRi | Q9NRI5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 292 | Interaction with MAP1A1 PublicationAdd BLAST | 292 | |
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 179 – 205 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 221 – 257 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 278 – 323 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 293 – 696 | Interaction with TRAF3IP11 PublicationAdd BLAST | 404 | |
Regioni | 440 – 597 | Required for localization to punctate cytoplasmic fociAdd BLAST | 158 | |
Regioni | 446 – 854 | Necessary and sufficient for interaction with PCNT and localization at the centrosome1 PublicationAdd BLAST | 409 | |
Regioni | 598 – 854 | Interaction with ATF4 and ATF51 PublicationAdd BLAST | 257 | |
Regioni | 716 – 739 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 727 – 854 | Interaction with PAFAH1B11 PublicationAdd BLAST | 128 | |
Regioni | 802 – 835 | Interaction with NDEL1Add BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 366 – 394 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 452 – 505 | Sequence analysisAdd BLAST | 54 | |
Coiled coili | 602 – 666 | Sequence analysisAdd BLAST | 65 | |
Coiled coili | 802 – 830 | Sequence analysisAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 197 – 203 | Interaction with FBXW71 Publication | 7 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S3S3, Eukaryota |
GeneTreei | ENSGT00390000006176 |
HOGENOMi | CLU_1514037_0_0_1 |
InParanoidi | Q9NRI5 |
OMAi | CMEDNHP |
PhylomeDBi | Q9NRI5 |
TreeFami | TF332357 |
Family and domain databases
InterProi | View protein in InterPro IPR026081, DISC1 |
PANTHERi | PTHR14332, PTHR14332, 1 hit |
s (11+)i Sequence
Sequence statusi: Complete.
This entry describes 11 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 11 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST
60 70 80 90 100
GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS
110 120 130 140 150
KSAAAPTVTS VRGTSAHFGI QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM
160 170 180 190 200
DSSETLDASW EAACSDGARR VRAAGSLPSA ELSSNSCSPG CGPEVPPTPP
210 220 230 240 250
GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ SPQEMGAKAA
260 270 280 290 300
SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
310 320 330 340 350
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV
360 370 380 390 400
ISLRLKLQKL QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA
410 420 430 440 450
LSSFLGHLAA QVQAALRRGA TQQASGDDTH TPLRMEPRLL EPTAQDSLHV
460 470 480 490 500
SITRRDWLLQ EKQQLQKEIE ALQARMFVLE AKDQQLRREI EEQEQQLQWQ
510 520 530 540 550
GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP ETIRSLQERI
560 570 580 590 600
KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH
610 620 630 640 650
FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR
660 670 680 690 700
REVEHQETAY ETSVKENTMK YMETLKNKLC SCKCPLLGKV WEADLEACRL
710 720 730 740 750
LIQSLQLQEA RGSLSVEDER QMDDLEGAAP PIPPRLHSED KRKTPLKVLE
760 770 780 790 800
EWKTHLIPSL HCAGGEQKEE SYILSAELGE KCEDIGKKLL YLEDQLHTAI
810 820 830 840 850
HSHDEDLIQS LRRELQMVKE TLQAMILQLQ PAKEAGEREA AASCMTAGVH
EAQA
The sequence of this isoform differs from the canonical sequence as follows:
350-356: VISLRLK → LRRYNKD
357-854: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
23-372: Missing.
545-551: SLQERIK → RKPFLDG
552-854: Missing.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC4P0B1 | C4P0B1_HUMAN | Disrupted in schizophrenia 1 isofor... | DISC1 | 622 | Annotation score: | ||
A0A087WYX6 | A0A087WYX6_HUMAN | Disrupted in schizophrenia 1 protei... | DISC1 | 732 | Annotation score: | ||
C4P093 | C4P093_HUMAN | Disrupted in schizophrenia 1 isofor... | DISC1 | 547 | Annotation score: | ||
C4P0A0 | C4P0A0_HUMAN | Disrupted in schizophrenia 1 isofor... | DISC1 | 442 | Annotation score: | ||
C4P0B0 | C4P0B0_HUMAN | Disrupted in schizophrenia 1 isofor... | DISC1 | 609 | Annotation score: | ||
C4P092 | C4P092_HUMAN | Disrupted in schizophrenia 1 isofor... | DISC1 | 382 | Annotation score: | ||
H0Y7U2 | H0Y7U2_HUMAN | Disrupted in schizophrenia 1 protei... | DISC1 | 44 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030422 | 5 | G → V1 PublicationCorresponds to variant dbSNP:rs3738400Ensembl. | 1 | |
Natural variantiVAR_061642 | 116 | A → V. Corresponds to variant dbSNP:rs56020408Ensembl. | 1 | |
Natural variantiVAR_022437 | 264 | R → Q3 PublicationsCorresponds to variant dbSNP:rs3738401EnsemblClinVar. | 1 | |
Natural variantiVAR_061643 | 328 | T → N. Corresponds to variant dbSNP:rs55795950Ensembl. | 1 | |
Natural variantiVAR_050954 | 330 | L → F. Corresponds to variant dbSNP:rs34622148EnsemblClinVar. | 1 | |
Natural variantiVAR_061644 | 531 | G → R. Corresponds to variant dbSNP:rs56229136EnsemblClinVar. | 1 | |
Natural variantiVAR_026704 | 607 | L → F Associated with susceptibility to schizoaffective disorder. 1 PublicationCorresponds to variant dbSNP:rs6675281EnsemblClinVar. | 1 | |
Natural variantiVAR_022438 | 704 | S → C2 PublicationsCorresponds to variant dbSNP:rs821616Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047525 | 23 – 372 | Missing in isoform 11. 1 PublicationAdd BLAST | 350 | |
Alternative sequenceiVSP_019314 | 350 – 369 | VISLR…VENDD → LEPIALDPPWKPRHPEPNSY in isoform 4. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_047526 | 350 – 356 | VISLRLK → LRRYNKD in isoform 10. 1 Publication | 7 | |
Alternative sequenceiVSP_047527 | 357 – 854 | Missing in isoform 10. 1 PublicationAdd BLAST | 498 | |
Alternative sequenceiVSP_019315 | 370 – 854 | Missing in isoform 4. 1 PublicationAdd BLAST | 485 | |
Alternative sequenceiVSP_043583 | 545 – 559 | SLQER…LSLKE → RNKCEGKYYEVHGNT in isoform 7. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_047528 | 545 – 551 | SLQERIK → RKPFLDG in isoform 11. 1 Publication | 7 | |
Alternative sequenceiVSP_047529 | 552 – 854 | Missing in isoform 11. 1 PublicationAdd BLAST | 303 | |
Alternative sequenceiVSP_043584 | 560 – 579 | Missing in isoform 7. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_043585 | 564 – 579 | VCMSE…RKKVN → ETISGRLKTSPRRLDH in isoform 6. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_043586 | 580 – 854 | Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST | 275 | |
Alternative sequenceiVSP_043214 | 661 – 854 | ETSVK…HEAQA → DGVSLCRPVWSAVVRSCSLQ PLPPEFKQFSCLSLRSSWDY RCPPPCLANFVFLVEMGFYH VDQTGLKLLTSSDPPSSASQ SAGITDMSHCAWPLQ in isoform 5. 1 PublicationAdd BLAST | 194 | |
Alternative sequenceiVSP_043587 | 661 – 695 | ETSVK…WEADL → AASVHCLGKCGKLTWKLVDC LSRAYSSRKPGEACL in isoform 8. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_019316 | 661 – 678 | ETSVK…TLKNK → GYKYCDAESWTQRSQQLA in isoform 3. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_047530 | 661 – 662 | ET → GR in isoform 9. 1 Publication | 2 | |
Alternative sequenceiVSP_047531 | 663 – 854 | Missing in isoform 9. 1 PublicationAdd BLAST | 192 | |
Alternative sequenceiVSP_019317 | 679 – 854 | Missing in isoform 3. 1 PublicationAdd BLAST | 176 | |
Alternative sequenceiVSP_043588 | 696 – 854 | Missing in isoform 8. 1 PublicationAdd BLAST | 159 | |
Alternative sequenceiVSP_003849 | 748 – 769 | Missing in isoform 2. 1 PublicationAdd BLAST | 22 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5V4B | X-ray | 2.60 | C | 193-207 | [»] | |
AlphaFoldDBi | Q9NRI5 | |||||
SASBDBi | Q9NRI5 | |||||
SMRi | Q9NRI5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118061, 418 interactors |
CORUMi | Q9NRI5 |
DIPi | DIP-33828N |
ELMi | Q9NRI5 |
IntActi | Q9NRI5, 949 interactors |
MINTi | Q9NRI5 |
STRINGi | 9606.ENSP00000355593 |
Protein family/group databases
MoonDBi | Q9NRI5, Predicted |
PTM databases
iPTMneti | Q9NRI5 |
PhosphoSitePlusi | Q9NRI5 |
Genetic variation databases
BioMutai | DISC1 |
DMDMi | 160332362 |
Proteomic databases
EPDi | Q9NRI5 |
jPOSTi | Q9NRI5 |
MassIVEi | Q9NRI5 |
MaxQBi | Q9NRI5 |
PaxDbi | Q9NRI5 |
PeptideAtlasi | Q9NRI5 |
PRIDEi | Q9NRI5 |
ProteomicsDBi | 82365 [Q9NRI5-1] 82366 [Q9NRI5-2] 82367 [Q9NRI5-3] 82368 [Q9NRI5-4] 82369 [Q9NRI5-5] 82370 [Q9NRI5-6] 82371 [Q9NRI5-7] 82372 [Q9NRI5-8] |
Protocols and materials databases
Antibodypediai | 34687, 643 antibodies from 39 providers |
DNASUi | 27185 |
Genome annotation databases
Organism-specific databases
CTDi | 27185 |
DisGeNETi | 27185 |
GeneCardsi | DISC1 |
HGNCi | HGNC:2888, DISC1 |
HPAi | ENSG00000162946, Tissue enhanced (retina) |
MalaCardsi | DISC1 |
MIMi | 604906, phenotype 605210, gene |
neXtProti | NX_Q9NRI5 |
OpenTargetsi | ENSG00000162946 |
Orphaneti | 171703, Microcephaly-polymicrogyria-corpus callosum agenesis syndrome |
PharmGKBi | PA27342 |
VEuPathDBi | HostDB:ENSG00000162946 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3S3, Eukaryota |
GeneTreei | ENSGT00390000006176 |
HOGENOMi | CLU_1514037_0_0_1 |
InParanoidi | Q9NRI5 |
OMAi | CMEDNHP |
PhylomeDBi | Q9NRI5 |
TreeFami | TF332357 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRI5 |
SignaLinki | Q9NRI5 |
SIGNORi | Q9NRI5 |
Miscellaneous databases
BioGRID-ORCSi | 27185, 7 hits in 1066 CRISPR screens |
GeneWikii | DISC1 |
GenomeRNAii | 27185 |
Pharosi | Q9NRI5, Tbio |
PROi | PR:Q9NRI5 |
RNActi | Q9NRI5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162946, Expressed in sural nerve and 163 other tissues |
ExpressionAtlasi | Q9NRI5, baseline and differential |
Genevisiblei | Q9NRI5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026081, DISC1 |
PANTHERi | PTHR14332, PTHR14332, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DISC1_HUMAN | |
Accessioni | Q9NRI5Primary (citable) accession number: Q9NRI5 Secondary accession number(s): A6NLH2 Q9NRI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | November 13, 2007 | |
Last modified: | May 25, 2022 | |
This is version 180 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references