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Entry version 112 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein YAE1 homolog

Gene

YAE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:26182403).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein YAE1 homologCurated
Alternative name(s):
Yae1 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YAE1Imported
Synonyms:C7orf36, YAE1D1Imported
ORF Names:GK003
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24857 YAE1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000241127

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961882

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRH1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
YAE1D1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895911 – 226Protein YAE1 homologAdd BLAST226

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRH1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NRH1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NRH1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRH1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRH1

PeptideAtlas

More...
PeptideAtlasi
Q9NRH1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRH1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3927
82361 [Q9NRH1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241127 Expressed in 194 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRH1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRH1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019226
HPA031249

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with LTO1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LTO1Q8WV074EBI-712905,EBI-12249832

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121317, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NRH1, 23 interactors

Molecular INTeraction database

More...
MINTi
Q9NRH1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000223273

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 85deca-GX3 motif; required for interaction with LTO1By similarityAdd BLAST41

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4774 Eukaryota
ENOG4111WXF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000069881

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRH1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IQDMDLC

Database of Orthologous Groups

More...
OrthoDBi
1192442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRH1

TreeFam database of animal gene trees

More...
TreeFami
TF333198

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019191 Essential_protein_Yae1_N
IPR038881 Yae1-like

The PANTHER Classification System

More...
PANTHERi
PTHR18829 PTHR18829, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09811 Yae1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWVQAASLI QGPGDKGDVF DEEADESLLA QREWQSNMQR RVKEGYRDGI
60 70 80 90 100
DAGKAVTLQQ GFNQGYKKGA EVILNYGRLR GTLSALLSWC HLHNNNSTLI
110 120 130 140 150
NKINNLLDAV GQCEEYVLKH LKSITPPSHV VDLLDSIEDM DLCHVVPAEK
160 170 180 190 200
KIDEAKDERL CENNAEFNKN CSKSHSGIDC SYVECCRTQE HAHSENPSPT
210 220
WILEQTASLV KQLGLSVDVL QHLKQL
Length:226
Mass (Da):25,299
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i403133C215381E79
GO
Isoform 2 (identifier: Q9NRH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-206: SALLSWCHLH...PSPTWILEQT → RNSTDWSLLG...NRIIIRGGHI
     207-226: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):22,700
Checksum:iB6182474E46A6ECA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZ57C9IZ57_HUMAN
Protein YAE1 homolog
YAE1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18D → G in CAG33479 (Ref. 3) Curated1
Sequence conflicti21D → E in AAH22043 (PubMed:15489334).Curated1
Sequence conflicti214G → D in CAG33479 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02430668K → E. Corresponds to variant dbSNP:rs6947660Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05529584 – 206SALLS…ILEQT → RNSTDWSLLGLRAPLRSPEV GTQLLPRPLPVPGHMASGAT PKQPTELEATLLSLVPQSGR ATPRFPARLRAPGPGTPSHR RRFRRKPHRDPAAACPAWPP EAPSNSETHFSTYNRIIIRG GHI in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_055296207 – 226Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF226046 mRNA Translation: AAF86946.1
AK293511 mRNA Translation: BAG56994.1
CR457198 mRNA Translation: CAG33479.1
AC004837 Genomic DNA No translation available.
AC011290 Genomic DNA Translation: AAQ96864.1
CH236951 Genomic DNA Translation: EAL23993.1
CH471073 Genomic DNA Translation: EAW94120.1
BC022043 mRNA Translation: AAH22043.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5459.1 [Q9NRH1-1]
CCDS64630.1 [Q9NRH1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001269375.1, NM_001282446.1 [Q9NRH1-2]
NP_064577.1, NM_020192.4 [Q9NRH1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000223273; ENSP00000223273; ENSG00000241127 [Q9NRH1-1]
ENST00000432096; ENSP00000395777; ENSG00000241127 [Q9NRH1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57002

UCSC genome browser

More...
UCSCi
uc003thc.5 human [Q9NRH1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226046 mRNA Translation: AAF86946.1
AK293511 mRNA Translation: BAG56994.1
CR457198 mRNA Translation: CAG33479.1
AC004837 Genomic DNA No translation available.
AC011290 Genomic DNA Translation: AAQ96864.1
CH236951 Genomic DNA Translation: EAL23993.1
CH471073 Genomic DNA Translation: EAW94120.1
BC022043 mRNA Translation: AAH22043.1
CCDSiCCDS5459.1 [Q9NRH1-1]
CCDS64630.1 [Q9NRH1-2]
RefSeqiNP_001269375.1, NM_001282446.1 [Q9NRH1-2]
NP_064577.1, NM_020192.4 [Q9NRH1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121317, 25 interactors
IntActiQ9NRH1, 23 interactors
MINTiQ9NRH1
STRINGi9606.ENSP00000223273

PTM databases

iPTMnetiQ9NRH1
PhosphoSitePlusiQ9NRH1

Polymorphism and mutation databases

BioMutaiYAE1D1
DMDMi68565323

Proteomic databases

EPDiQ9NRH1
jPOSTiQ9NRH1
MassIVEiQ9NRH1
MaxQBiQ9NRH1
PaxDbiQ9NRH1
PeptideAtlasiQ9NRH1
PRIDEiQ9NRH1
ProteomicsDBi3927
82361 [Q9NRH1-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57002

Genome annotation databases

EnsembliENST00000223273; ENSP00000223273; ENSG00000241127 [Q9NRH1-1]
ENST00000432096; ENSP00000395777; ENSG00000241127 [Q9NRH1-2]
GeneIDi57002
KEGGihsa:57002
UCSCiuc003thc.5 human [Q9NRH1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57002

GeneCards: human genes, protein and diseases

More...
GeneCardsi
YAE1
HGNCiHGNC:24857 YAE1
HPAiHPA019226
HPA031249
neXtProtiNX_Q9NRH1
OpenTargetsiENSG00000241127
PharmGKBiPA134961882

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4774 Eukaryota
ENOG4111WXF LUCA
GeneTreeiENSGT00390000011176
HOGENOMiHOG000069881
InParanoidiQ9NRH1
OMAiIQDMDLC
OrthoDBi1192442at2759
PhylomeDBiQ9NRH1
TreeFamiTF333198

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
YAE1D1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57002
PharosiQ9NRH1

Protein Ontology

More...
PROi
PR:Q9NRH1

Gene expression databases

BgeeiENSG00000241127 Expressed in 194 organ(s), highest expression level in intestine
ExpressionAtlasiQ9NRH1 baseline and differential
GenevisibleiQ9NRH1 HS

Family and domain databases

InterProiView protein in InterPro
IPR019191 Essential_protein_Yae1_N
IPR038881 Yae1-like
PANTHERiPTHR18829 PTHR18829, 1 hit
PfamiView protein in Pfam
PF09811 Yae1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYAE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRH1
Secondary accession number(s): A4D1W4
, B4DE83, Q6IAF7, Q8WVZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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