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UniProtKB - Q9NRG4 (SMYD2_HUMAN)

Entry version 169 (23 Feb 2022)
Sequence version 2 (13 Sep 2005)
Previous versions | rss
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Protein

N-lysine methyltransferase SMYD2

Gene

SMYD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi52Zinc 1PROSITE-ProRule annotation1
Metal bindingi55Zinc 1PROSITE-ProRule annotation1
Metal bindingi65Zinc 2PROSITE-ProRule annotation1
Metal bindingi68Zinc 2PROSITE-ProRule annotation1
Metal bindingi74Zinc 1PROSITE-ProRule annotation1
Metal bindingi78Zinc 1PROSITE-ProRule annotation1
Metal bindingi86Zinc 2PROSITE-ProRule annotation1
Metal bindingi90Zinc 2PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei137S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei240Peptide substrate; via carbonyl oxygen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri52 – 90MYND-typePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRG4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-6804760, Regulation of TP53 Activity through Methylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NRG4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NRG4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-lysine methyltransferase SMYD2 (EC:2.1.1.-3 Publications)
Alternative name(s):
HSKM-B
Histone methyltransferase SMYD2 (EC:2.1.1.3543 Publications)
Lysine N-methyltransferase 3C
SET and MYND domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMYD2
Synonyms:KMT3C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20982, SMYD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610663, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRG4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143499

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi187E → K: Abolishes methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi189E → K: Strongly reduces methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi190E → K: Strongly reduces methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi207H → A: Abolishes methyltransferase activity. 1 Publication1
Mutagenesisi240Y → F: Abolishes methyltransferase activity. 2 Publications1
Mutagenesisi245Y → F: Strongly reduces methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi252D → R: Slightly reduces methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi253R → Q: No effect on methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi306R → E: No effect on methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi374Y → A: Abolishes methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi429E → K: Reduces methyltransferase activity on p53/TP53. 1 Publication1
Mutagenesisi431E → K: Strongly reduces methyltransferase activity on p53/TP53. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		56950

Open Targets

More...OpenTargetsi		ENSG00000143499

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134930268

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRG4, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2169716

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2714

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SMYD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		90185234

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002183091 – 433N-lysine methyltransferase SMYD2Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei283PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NRG4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NRG4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRG4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRG4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRG4

PeptideAtlas

More...PeptideAtlasi		Q9NRG4

PRoteomics IDEntifications database

More...PRIDEi		Q9NRG4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82355 [Q9NRG4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRG4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is repressed by CEBPA.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143499, Expressed in left ventricle myocardium and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRG4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRG4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143499, Group enriched (heart muscle, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNA polymerase II and HELZ.

Interacts with SIN3A and HDAC1 (By similarity).

Interacts (via MYND-type zinc finger) with EPB41L3.

Interacts (via SET domain) with p53/TP53.

Interacts with RB1 and HSP90AA1.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121274, 59 interactors

Database of interacting proteins

More...DIPi		DIP-50202N

Protein interaction database and analysis system

More...IntActi		Q9NRG4, 40 interactors

Molecular INTeraction database

More...MINTi		Q9NRG4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355924

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NRG4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRG4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRG4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 241SETPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 19S-adenosyl-L-methionine binding3
Regioni183 – 185Peptide substrate binding3
Regioni206 – 207S-adenosyl-L-methionine binding2
Regioni258 – 260S-adenosyl-L-methionine binding3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri52 – 90MYND-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2084, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018406_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRG4

Identification of Orthologs from Complete Genome Data

More...OMAi		EHCFTRR

Database of Orthologous Groups

More...OrthoDBi		981799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRG4

TreeFam database of animal gene trees

More...TreeFami		TF106487

Family and domain databases

Conserved Domains Database

More...CDDi		cd19202, SET_SMYD2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00329

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001214, SET_dom
IPR044419, SMYD2_SET
IPR011990, TPR-like_helical_dom_sf
IPR002893, Znf_MYND

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00856, SET, 1 hit
PF01753, zf-MYND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50280, SET, 1 hit
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAEGLGGLE RFCSPGKGRG LRALQPFQVG DLLFSCPAYA YVLTVNERGN 
        60         70         80         90        100
HCEYCFTRKE GLSKCGRCKQ AFYCNVECQK EDWPMHKLEC SPMVVFGENW 
       110        120        130        140        150
NPSETVRLTA RILAKQKIHP ERTPSEKLLA VKEFESHLDK LDNEKKDLIQ 
       160        170        180        190        200
SDIAALHHFY SKHLGFPDND SLVVLFAQVN CNGFTIEDEE LSHLGSAIFP 
       210        220        230        240        250
DVALMNHSCC PNVIVTYKGT LAEVRAVQEI KPGEEVFTSY IDLLYPTEDR 
       260        270        280        290        300
NDRLRDSYFF TCECQECTTK DKDKAKVEIR KLSDPPKAEA IRDMVRYARN 
       310        320        330        340        350
VIEEFRRAKH YKSPSELLEI CELSQEKMSS VFEDSNVYML HMMYQAMGVC 
       360        370        380        390        400
LYMQDWEGAL QYGQKIIKPY SKHYPLYSLN VASMWLKLGR LYMGLEHKAA 
       410        420        430 
GEKALKKAIA IMEVAHGKDH PYISEIKQEI ESH
Length:433
Mass (Da):49,688
Last modified:September 13, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EEA5B8417870F5D
GO
Isoform 2 (identifier: Q9NRG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-433: Missing.

Show »
Length:272
Mass (Da):30,964
Checksum:iF6A2B20624CED9C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0R0U3B0R0U3_HUMAN
N-lysine methyltransferase SMYD2
SMYD2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023442165G → E3 PublicationsCorresponds to variant dbSNP:rs1134647Ensembl.1
Natural variantiVAR_052991430I → M. Corresponds to variant dbSNP:rs11120301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056005273 – 433Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF226053 mRNA Translation: AAF86953.1
AK313868 mRNA Translation: BAG36596.1
AL929236 Genomic DNA No translation available.
BC017080 mRNA Translation: AAH17080.2
BC098276 mRNA Translation: AAH98276.1
BC098133 mRNA Translation: AAH98133.1
BC098305 mRNA Translation: AAH98305.1
BC098335 mRNA Translation: AAH98335.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31022.1 [Q9NRG4-1]

NCBI Reference Sequences

More...RefSeqi		NP_064582.2, NM_020197.2 [Q9NRG4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366957; ENSP00000355924; ENSG00000143499

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56950

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000366957.10; ENSP00000355924.5; NM_020197.3; NP_064582.2

UCSC genome browser

More...UCSCi		uc057pjy.1, human [Q9NRG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226053 mRNA Translation: AAF86953.1
AK313868 mRNA Translation: BAG36596.1
AL929236 Genomic DNA No translation available.
BC017080 mRNA Translation: AAH17080.2
BC098276 mRNA Translation: AAH98276.1
BC098133 mRNA Translation: AAH98133.1
BC098305 mRNA Translation: AAH98305.1
BC098335 mRNA Translation: AAH98335.1
CCDSiCCDS31022.1 [Q9NRG4-1]
RefSeqiNP_064582.2, NM_020197.2 [Q9NRG4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RIBX-ray2.79A/B1-433[»]
3S7BX-ray2.42A1-433[»]
3S7DX-ray2.30A1-433[»]
3S7FX-ray2.85A1-433[»]
3S7JX-ray3.04A1-433[»]
3TG4X-ray2.00A1-433[»]
3TG5X-ray2.30A1-433[»]
4O6FX-ray2.82A1-433[»]
4WUYX-ray1.63A1-433[»]
4YNDX-ray2.79A1-433[»]
5ARFX-ray1.92A2-433[»]
5ARGX-ray1.99A2-433[»]
5KJKX-ray1.93A5-433[»]
5KJLX-ray2.70A5-433[»]
5KJMX-ray2.19A5-433[»]
5KJNX-ray2.72A5-433[»]
5V3HX-ray2.69A1-433[»]
5WCGX-ray2.02A1-433[»]
6CBXX-ray1.94A/B1-433[»]
6CBYX-ray2.55A/B1-433[»]
6MONX-ray2.71A/B5-433[»]
6N3GX-ray2.43A1-433[»]
SMRiQ9NRG4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121274, 59 interactors
DIPiDIP-50202N
IntActiQ9NRG4, 40 interactors
MINTiQ9NRG4
STRINGi9606.ENSP00000355924

Chemistry databases

BindingDBiQ9NRG4
ChEMBLiCHEMBL2169716
GuidetoPHARMACOLOGYi2714

PTM databases

iPTMnetiQ9NRG4
PhosphoSitePlusiQ9NRG4

Genetic variation databases

BioMutaiSMYD2
DMDMi90185234

Proteomic databases

EPDiQ9NRG4
jPOSTiQ9NRG4
MassIVEiQ9NRG4
MaxQBiQ9NRG4
PaxDbiQ9NRG4
PeptideAtlasiQ9NRG4
PRIDEiQ9NRG4
ProteomicsDBi82355 [Q9NRG4-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9NRG4, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34617, 342 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		56950

Genome annotation databases

EnsembliENST00000366957; ENSP00000355924; ENSG00000143499
GeneIDi56950
KEGGihsa:56950
MANE-SelectiENST00000366957.10; ENSP00000355924.5; NM_020197.3; NP_064582.2
UCSCiuc057pjy.1, human [Q9NRG4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56950
DisGeNETi56950

GeneCards: human genes, protein and diseases

More...GeneCardsi		SMYD2
HGNCiHGNC:20982, SMYD2
HPAiENSG00000143499, Group enriched (heart muscle, skeletal muscle)
MIMi610663, gene
neXtProtiNX_Q9NRG4
OpenTargetsiENSG00000143499
PharmGKBiPA134930268
VEuPathDBiHostDB:ENSG00000143499

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2084, Eukaryota
GeneTreeiENSGT00940000157082
HOGENOMiCLU_018406_0_0_1
InParanoidiQ9NRG4
OMAiEHCFTRR
OrthoDBi981799at2759
PhylomeDBiQ9NRG4
TreeFamiTF106487

Enzyme and pathway databases

PathwayCommonsiQ9NRG4
ReactomeiR-HSA-3214841, PKMTs methylate histone lysines
R-HSA-6804760, Regulation of TP53 Activity through Methylation
SignaLinkiQ9NRG4
SIGNORiQ9NRG4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56950, 6 hits in 1051 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SMYD2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56950
PharosiQ9NRG4, Tchem

Protein Ontology

More...PROi		PR:Q9NRG4
RNActiQ9NRG4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143499, Expressed in left ventricle myocardium and 241 other tissues
ExpressionAtlasiQ9NRG4, baseline and differential
GenevisibleiQ9NRG4, HS

Family and domain databases

CDDicd19202, SET_SMYD2, 1 hit
Gene3Di1.25.40.10, 1 hit
IDEALiIID00329
InterProiView protein in InterPro
IPR001214, SET_dom
IPR044419, SMYD2_SET
IPR011990, TPR-like_helical_dom_sf
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF00856, SET, 1 hit
PF01753, zf-MYND, 1 hit
SMARTiView protein in SMART
SM00317, SET, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMYD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRG4
Secondary accession number(s): B2R9P9
, I6L9H7, Q4V765, Q5VSH9, Q96AI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: September 13, 2005
Last modified: February 23, 2022
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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