UniProtKB - Q9NRE2 (TSH2_HUMAN)
Protein
Teashirt homolog 2
Gene
TSHZ2
Organism
Homo sapiens (Human)
Status
Functioni
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 239 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 275 – 299 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 380 – 404 | C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
DNA bindingi | 841 – 911 | Homeobox; atypicalAdd BLAST | 71 | |
Zinc fingeri | 926 – 948 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 994 – 1017 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin binding Source: GO_Central
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NRE2 |
Names & Taxonomyi
Protein namesi | Recommended name: Teashirt homolog 2Alternative name(s): Ovarian cancer-related protein 10-2 Short name: OVC10-2 Zinc finger protein 218 |
Gene namesi | Name:TSHZ2 Synonyms:C20orf17, TSH2, ZNF218 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182463.15 |
HGNCi | HGNC:13010, TSHZ2 |
MIMi | 614118, gene |
neXtProti | NX_Q9NRE2 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 128553 |
OpenTargetsi | ENSG00000182463 |
PharmGKBi | PA37589 |
Miscellaneous databases
Pharosi | Q9NRE2, Tbio |
Polymorphism and mutation databases
BioMutai | TSHZ2 |
DMDMi | 108935911 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047064 | 1 – 1034 | Teashirt homolog 2Add BLAST | 1034 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 188 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 306 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 315 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 417 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 461 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 480 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 497 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 601 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 652 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 800 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 820 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 966 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 980 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sumoylated.1 Publication
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9NRE2 |
MassIVEi | Q9NRE2 |
MaxQBi | Q9NRE2 |
PaxDbi | Q9NRE2 |
PeptideAtlasi | Q9NRE2 |
PRIDEi | Q9NRE2 |
ProteomicsDBi | 82344 [Q9NRE2-1] |
PTM databases
iPTMneti | Q9NRE2 |
PhosphoSitePlusi | Q9NRE2 |
Expressioni
Tissue specificityi
Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.1 Publication
Gene expression databases
Bgeei | ENSG00000182463, Expressed in forebrain and 199 other tissues |
ExpressionAtlasi | Q9NRE2, baseline and differential |
Genevisiblei | Q9NRE2, HS |
Organism-specific databases
HPAi | ENSG00000182463, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via homeobox domain) with APBB1 (via PID domain 1).
By similarityBinary interactionsi
Hide detailsQ9NRE2
Protein-protein interaction databases
BioGRIDi | 126131, 24 interactors |
IntActi | Q9NRE2, 20 interactors |
STRINGi | 9606.ENSP00000360552 |
Miscellaneous databases
RNActi | Q9NRE2, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 13 – 38 | Sequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the teashirt C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 239 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 275 – 299 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 380 – 404 | C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 926 – 948 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 994 – 1017 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Coiled coil, Homeobox, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QV71, Eukaryota |
GeneTreei | ENSGT00950000183051 |
HOGENOMi | CLU_010469_0_0_1 |
InParanoidi | Q9NRE2 |
OMAi | MKYQYLR |
OrthoDBi | 106971at2759 |
PhylomeDBi | Q9NRE2 |
TreeFami | TF328447 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR001356, Homeobox_dom IPR027008, Teashirt_fam IPR027010, Tshz2 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12487, PTHR12487, 1 hit PTHR12487:SF3, PTHR12487:SF3, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NRE2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEDSGSVA QLQGGNDTGT
60 70 80 90 100
DEELETGPEQ KGCFSYQNSP GSHLSNQDAE NESLLSDASD QVSDIKSVCG
110 120 130 140 150
RDASDKKAHT HVRLPNEAHN CMDKMTAVYA NILSDSYWSG LGLGFKLSNS
160 170 180 190 200
ERRNCDTRNG SNKSDFDWHQ DALSKSLQQN LPSRSVSKPS LFSSVQLYRQ
210 220 230 240 250
SSKMCGTVFT GASRFRCRQC SAAYDTLVEL TVHMNETGHY QDDNRKKDKL
260 270 280 290 300
RPTSYSKPRK RAFQDMDKED AQKVLKCMFC GDSFDSLQDL SVHMIKTKHY
310 320 330 340 350
QKVPLKEPVP TISSKMVTPA KKRVFDVNRP CSPDSTTGSF ADSFSSQKNA
360 370 380 390 400
NLQLSSNNRY GYQNGASYTW QFEACKSQIL KCMECGSSHD TLQQLTTHMM
410 420 430 440 450
VTGHFLKVTS SASKKGKQLV LDPLAVEKMQ SLSEAPNSDS LAPKPSSNSA
460 470 480 490 500
SDCTASTTEL KKESKKERPE ETSKDEKVVK SEDYEDPLQK PLDPTIKYQY
510 520 530 540 550
LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL
560 570 580 590 600
SEGTKPPLPM GSQVLQIRPN LTNKLRPIAP KWKVMPLVSM PTHLAPYTQV
610 620 630 640 650
KKESEDKDEA VKECGKESPH EEASSFSHSE GDSFRKSETP PEAKKTELGP
660 670 680 690 700
LKEEEKLMKE GSEKEKPQPL EPTSALSNGC ALANHAPALP CINPLSALQS
710 720 730 740 750
VLNNHLGKAT EPLRSPSCSS PSSSTISMFH KSNLNVMDKP VLSPASTRSA
760 770 780 790 800
SVSRRYLFEN SDQPIDLTKS KSKKAESSQA QSCMSPPQKH ALSDIADMVK
810 820 830 840 850
VLPKATTPKP ASSSRVPPMK LEMDVRRFED VSSEVSTLHK RKGRQSNWNP
860 870 880 890 900
QHLLILQAQF ASSLFQTSEG KYLLSDLGPQ ERMQISKFTG LSMTTISHWL
910 920 930 940 950
ANVKYQLRKT GGTKFLKNMD KGHPIFYCSD CASQFRTPST YISHLESHLG
960 970 980 990 1000
FQMKDMTRLS VDQQSKVEQE ISRVSSAQRS PETIAAEEDT DSKFKCKLCC
1010 1020 1030
RTFVSKHAVK LHLSKTHSKS PEHHSQFVTD VDEE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R3C8 | S4R3C8_HUMAN | Teashirt homolog 2 | TSHZ2 | 194 | Annotation score: | ||
B1H0U8 | B1H0U8_HUMAN | Cell growth-inhibiting protein 7 | TSHZ2 hCG_1784586 | 74 | Annotation score: |
Sequence cautioni
The sequence AAF76850 differs from that shown. The sequence differs from that shown due translation of a 3'-UTR region.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 198 | Y → C in CAE45871 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 223 | A → T in CAE45871 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 563 | Q → R in BAC03610 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 916 | L → P in CAE45871 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 983 | T → A in BAH13747 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026679 | 113 | R → S2 PublicationsCorresponds to variant dbSNP:rs739869Ensembl. | 1 | |
Natural variantiVAR_026680 | 681 | A → T. Corresponds to variant dbSNP:rs6097319Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046071 | 1 – 13 | MPRRK…PKRAA → MMAAALLHYT in isoform 2. 1 PublicationAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091206 mRNA Translation: BAC03610.1 AK302570 mRNA Translation: BAH13747.1 BX640770 mRNA Translation: CAE45871.1 AL121902 Genomic DNA No translation available. BX276189 Genomic DNA No translation available. AL050316 Genomic DNA No translation available. AL109930 Genomic DNA No translation available. AL354772 Genomic DNA No translation available. AL354993 Genomic DNA No translation available. AL391097 Genomic DNA No translation available. AF230201 mRNA Translation: AAF76850.1 Sequence problems. |
CCDSi | CCDS33490.1 [Q9NRE2-1] CCDS54474.1 [Q9NRE2-2] |
RefSeqi | NP_001180350.1, NM_001193421.1 [Q9NRE2-2] NP_775756.3, NM_173485.5 [Q9NRE2-1] XP_016883129.1, XM_017027640.1 [Q9NRE2-1] |
Genome annotation databases
Ensembli | ENST00000329613; ENSP00000333114; ENSG00000182463 [Q9NRE2-2] ENST00000371497; ENSP00000360552; ENSG00000182463 [Q9NRE2-1] ENST00000603338; ENSP00000475114; ENSG00000182463 [Q9NRE2-2] |
GeneIDi | 128553 |
KEGGi | hsa:128553 |
UCSCi | uc002xwo.3, human [Q9NRE2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091206 mRNA Translation: BAC03610.1 AK302570 mRNA Translation: BAH13747.1 BX640770 mRNA Translation: CAE45871.1 AL121902 Genomic DNA No translation available. BX276189 Genomic DNA No translation available. AL050316 Genomic DNA No translation available. AL109930 Genomic DNA No translation available. AL354772 Genomic DNA No translation available. AL354993 Genomic DNA No translation available. AL391097 Genomic DNA No translation available. AF230201 mRNA Translation: AAF76850.1 Sequence problems. |
CCDSi | CCDS33490.1 [Q9NRE2-1] CCDS54474.1 [Q9NRE2-2] |
RefSeqi | NP_001180350.1, NM_001193421.1 [Q9NRE2-2] NP_775756.3, NM_173485.5 [Q9NRE2-1] XP_016883129.1, XM_017027640.1 [Q9NRE2-1] |
3D structure databases
SMRi | Q9NRE2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126131, 24 interactors |
IntActi | Q9NRE2, 20 interactors |
STRINGi | 9606.ENSP00000360552 |
PTM databases
iPTMneti | Q9NRE2 |
PhosphoSitePlusi | Q9NRE2 |
Polymorphism and mutation databases
BioMutai | TSHZ2 |
DMDMi | 108935911 |
Proteomic databases
jPOSTi | Q9NRE2 |
MassIVEi | Q9NRE2 |
MaxQBi | Q9NRE2 |
PaxDbi | Q9NRE2 |
PeptideAtlasi | Q9NRE2 |
PRIDEi | Q9NRE2 |
ProteomicsDBi | 82344 [Q9NRE2-1] |
Protocols and materials databases
Antibodypediai | 52541, 112 antibodies |
DNASUi | 128553 |
Genome annotation databases
Ensembli | ENST00000329613; ENSP00000333114; ENSG00000182463 [Q9NRE2-2] ENST00000371497; ENSP00000360552; ENSG00000182463 [Q9NRE2-1] ENST00000603338; ENSP00000475114; ENSG00000182463 [Q9NRE2-2] |
GeneIDi | 128553 |
KEGGi | hsa:128553 |
UCSCi | uc002xwo.3, human [Q9NRE2-1] |
Organism-specific databases
CTDi | 128553 |
DisGeNETi | 128553 |
EuPathDBi | HostDB:ENSG00000182463.15 |
GeneCardsi | TSHZ2 |
HGNCi | HGNC:13010, TSHZ2 |
HPAi | ENSG00000182463, Low tissue specificity |
MIMi | 614118, gene |
neXtProti | NX_Q9NRE2 |
OpenTargetsi | ENSG00000182463 |
PharmGKBi | PA37589 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV71, Eukaryota |
GeneTreei | ENSGT00950000183051 |
HOGENOMi | CLU_010469_0_0_1 |
InParanoidi | Q9NRE2 |
OMAi | MKYQYLR |
OrthoDBi | 106971at2759 |
PhylomeDBi | Q9NRE2 |
TreeFami | TF328447 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRE2 |
Miscellaneous databases
BioGRID-ORCSi | 128553, 1 hit in 846 CRISPR screens |
ChiTaRSi | TSHZ2, human |
GenomeRNAii | 128553 |
Pharosi | Q9NRE2, Tbio |
PROi | PR:Q9NRE2 |
RNActi | Q9NRE2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182463, Expressed in forebrain and 199 other tissues |
ExpressionAtlasi | Q9NRE2, baseline and differential |
Genevisiblei | Q9NRE2, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR001356, Homeobox_dom IPR027008, Teashirt_fam IPR027010, Tshz2 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12487, PTHR12487, 1 hit PTHR12487:SF3, PTHR12487:SF3, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSH2_HUMAN | |
Accessioni | Q9NRE2Primary (citable) accession number: Q9NRE2 Secondary accession number(s): B7Z7W1 Q8N260 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | June 13, 2006 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations