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Entry version 155 (16 Oct 2019)
Sequence version 3 (13 Jun 2006)
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Protein

Teashirt homolog 2

Gene

TSHZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri215 – 239C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi841 – 911Homeobox; atypicalAdd BLAST71
Zinc fingeri926 – 948C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri994 – 1017C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teashirt homolog 2
Alternative name(s):
Ovarian cancer-related protein 10-2
Short name:
OVC10-2
Zinc finger protein 218
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSHZ2
Synonyms:C20orf17, TSH2, ZNF218
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13010 TSHZ2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614118 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRE2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
128553

Open Targets

More...
OpenTargetsi
ENSG00000182463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37589

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRE2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSHZ2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108935911

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470641 – 1034Teashirt homolog 2Add BLAST1034

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki800Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki820Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki966Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei980PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NRE2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NRE2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRE2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRE2

PeptideAtlas

More...
PeptideAtlasi
Q9NRE2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRE2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82344 [Q9NRE2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRE2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182463 Expressed in 184 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRE2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRE2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038123

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126131, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NRE2, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360552

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NRE2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 38Sequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 239C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri926 – 948C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri994 – 1017C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ7P Eukaryota
ENOG4110HP7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231480

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRE2

KEGG Orthology (KO)

More...
KOi
K09236

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKYQYLR

Database of Orthologous Groups

More...
OrthoDBi
106971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRE2

TreeFam database of animal gene trees

More...
TreeFami
TF328447

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR027010 Tshz2
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR12487 PTHR12487, 1 hit
PTHR12487:SF3 PTHR12487:SF3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEDSGSVA QLQGGNDTGT
60 70 80 90 100
DEELETGPEQ KGCFSYQNSP GSHLSNQDAE NESLLSDASD QVSDIKSVCG
110 120 130 140 150
RDASDKKAHT HVRLPNEAHN CMDKMTAVYA NILSDSYWSG LGLGFKLSNS
160 170 180 190 200
ERRNCDTRNG SNKSDFDWHQ DALSKSLQQN LPSRSVSKPS LFSSVQLYRQ
210 220 230 240 250
SSKMCGTVFT GASRFRCRQC SAAYDTLVEL TVHMNETGHY QDDNRKKDKL
260 270 280 290 300
RPTSYSKPRK RAFQDMDKED AQKVLKCMFC GDSFDSLQDL SVHMIKTKHY
310 320 330 340 350
QKVPLKEPVP TISSKMVTPA KKRVFDVNRP CSPDSTTGSF ADSFSSQKNA
360 370 380 390 400
NLQLSSNNRY GYQNGASYTW QFEACKSQIL KCMECGSSHD TLQQLTTHMM
410 420 430 440 450
VTGHFLKVTS SASKKGKQLV LDPLAVEKMQ SLSEAPNSDS LAPKPSSNSA
460 470 480 490 500
SDCTASTTEL KKESKKERPE ETSKDEKVVK SEDYEDPLQK PLDPTIKYQY
510 520 530 540 550
LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL
560 570 580 590 600
SEGTKPPLPM GSQVLQIRPN LTNKLRPIAP KWKVMPLVSM PTHLAPYTQV
610 620 630 640 650
KKESEDKDEA VKECGKESPH EEASSFSHSE GDSFRKSETP PEAKKTELGP
660 670 680 690 700
LKEEEKLMKE GSEKEKPQPL EPTSALSNGC ALANHAPALP CINPLSALQS
710 720 730 740 750
VLNNHLGKAT EPLRSPSCSS PSSSTISMFH KSNLNVMDKP VLSPASTRSA
760 770 780 790 800
SVSRRYLFEN SDQPIDLTKS KSKKAESSQA QSCMSPPQKH ALSDIADMVK
810 820 830 840 850
VLPKATTPKP ASSSRVPPMK LEMDVRRFED VSSEVSTLHK RKGRQSNWNP
860 870 880 890 900
QHLLILQAQF ASSLFQTSEG KYLLSDLGPQ ERMQISKFTG LSMTTISHWL
910 920 930 940 950
ANVKYQLRKT GGTKFLKNMD KGHPIFYCSD CASQFRTPST YISHLESHLG
960 970 980 990 1000
FQMKDMTRLS VDQQSKVEQE ISRVSSAQRS PETIAAEEDT DSKFKCKLCC
1010 1020 1030
RTFVSKHAVK LHLSKTHSKS PEHHSQFVTD VDEE
Length:1,034
Mass (Da):115,005
Last modified:June 13, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FC14F93D4CD48F6
GO
Isoform 2 (identifier: Q9NRE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MPRRKQQAPKRAA → MMAAALLHYT

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):114,589
Checksum:i4195F81B388007E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3C8S4R3C8_HUMAN
Teashirt homolog 2
TSHZ2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1H0U8B1H0U8_HUMAN
Cell growth-inhibiting protein 7
TSHZ2 hCG_1784586
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF76850 differs from that shown. The sequence differs from that shown due translation of a 3'-UTR region.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198Y → C in CAE45871 (PubMed:17974005).Curated1
Sequence conflicti223A → T in CAE45871 (PubMed:17974005).Curated1
Sequence conflicti563Q → R in BAC03610 (PubMed:14702039).Curated1
Sequence conflicti916L → P in CAE45871 (PubMed:17974005).Curated1
Sequence conflicti983T → A in BAH13747 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026679113R → S2 PublicationsCorresponds to variant dbSNP:rs739869Ensembl.1
Natural variantiVAR_026680681A → T. Corresponds to variant dbSNP:rs6097319Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460711 – 13MPRRK…PKRAA → MMAAALLHYT in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK091206 mRNA Translation: BAC03610.1
AK302570 mRNA Translation: BAH13747.1
BX640770 mRNA Translation: CAE45871.1
AL121902 Genomic DNA No translation available.
BX276189 Genomic DNA No translation available.
AL050316 Genomic DNA No translation available.
AL109930 Genomic DNA No translation available.
AL354772 Genomic DNA No translation available.
AL354993 Genomic DNA No translation available.
AL391097 Genomic DNA No translation available.
AF230201 mRNA Translation: AAF76850.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS33490.1 [Q9NRE2-1]
CCDS54474.1 [Q9NRE2-2]

NCBI Reference Sequences

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RefSeqi
NP_001180350.1, NM_001193421.1 [Q9NRE2-2]
NP_775756.3, NM_173485.5 [Q9NRE2-1]
XP_016883129.1, XM_017027640.1 [Q9NRE2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000329613; ENSP00000333114; ENSG00000182463 [Q9NRE2-2]
ENST00000371497; ENSP00000360552; ENSG00000182463 [Q9NRE2-1]
ENST00000603338; ENSP00000475114; ENSG00000182463 [Q9NRE2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
128553

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:128553

UCSC genome browser

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UCSCi
uc002xwo.3 human [Q9NRE2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091206 mRNA Translation: BAC03610.1
AK302570 mRNA Translation: BAH13747.1
BX640770 mRNA Translation: CAE45871.1
AL121902 Genomic DNA No translation available.
BX276189 Genomic DNA No translation available.
AL050316 Genomic DNA No translation available.
AL109930 Genomic DNA No translation available.
AL354772 Genomic DNA No translation available.
AL354993 Genomic DNA No translation available.
AL391097 Genomic DNA No translation available.
AF230201 mRNA Translation: AAF76850.1 Sequence problems.
CCDSiCCDS33490.1 [Q9NRE2-1]
CCDS54474.1 [Q9NRE2-2]
RefSeqiNP_001180350.1, NM_001193421.1 [Q9NRE2-2]
NP_775756.3, NM_173485.5 [Q9NRE2-1]
XP_016883129.1, XM_017027640.1 [Q9NRE2-1]

3D structure databases

SMRiQ9NRE2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126131, 5 interactors
IntActiQ9NRE2, 18 interactors
STRINGi9606.ENSP00000360552

PTM databases

iPTMnetiQ9NRE2
PhosphoSitePlusiQ9NRE2

Polymorphism and mutation databases

BioMutaiTSHZ2
DMDMi108935911

Proteomic databases

jPOSTiQ9NRE2
MassIVEiQ9NRE2
MaxQBiQ9NRE2
PaxDbiQ9NRE2
PeptideAtlasiQ9NRE2
PRIDEiQ9NRE2
ProteomicsDBi82344 [Q9NRE2-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
128553

Genome annotation databases

EnsembliENST00000329613; ENSP00000333114; ENSG00000182463 [Q9NRE2-2]
ENST00000371497; ENSP00000360552; ENSG00000182463 [Q9NRE2-1]
ENST00000603338; ENSP00000475114; ENSG00000182463 [Q9NRE2-2]
GeneIDi128553
KEGGihsa:128553
UCSCiuc002xwo.3 human [Q9NRE2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
128553
DisGeNETi128553

GeneCards: human genes, protein and diseases

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GeneCardsi
TSHZ2
HGNCiHGNC:13010 TSHZ2
HPAiHPA038123
MIMi614118 gene
neXtProtiNX_Q9NRE2
OpenTargetsiENSG00000182463
PharmGKBiPA37589

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ7P Eukaryota
ENOG4110HP7 LUCA
GeneTreeiENSGT00950000183051
HOGENOMiHOG000231480
InParanoidiQ9NRE2
KOiK09236
OMAiMKYQYLR
OrthoDBi106971at2759
PhylomeDBiQ9NRE2
TreeFamiTF328447

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TSHZ2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
128553
PharosiQ9NRE2

Protein Ontology

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PROi
PR:Q9NRE2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182463 Expressed in 184 organ(s), highest expression level in forebrain
ExpressionAtlasiQ9NRE2 baseline and differential
GenevisibleiQ9NRE2 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR027010 Tshz2
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF3 PTHR12487:SF3, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRE2
Secondary accession number(s): B7Z7W1
, J3KNQ0, Q4VXM4, Q6N003, Q8N260
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 13, 2006
Last modified: October 16, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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