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UniProtKB - Q9NRE2 (TSH2_HUMAN)

Entry version 166 (29 Sep 2021)
Sequence version 3 (13 Jun 2006)
Previous versions | rss
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Protein

Teashirt homolog 2

Gene

TSHZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).

Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri215 – 239C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi841 – 911Homeobox; atypicalAdd BLAST71
Zinc fingeri926 – 948C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri994 – 1017C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRE2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teashirt homolog 2
Alternative name(s):
Ovarian cancer-related protein 10-2
Short name:
OVC10-2
Zinc finger protein 218
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSHZ2
Synonyms:C20orf17, TSH2, ZNF218
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13010, TSHZ2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614118, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRE2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182463

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		128553

Open Targets

More...OpenTargetsi		ENSG00000182463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37589

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRE2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSHZ2

Domain mapping of disease mutations (DMDM)

More...DMDMi		108935911

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470641 – 1034Teashirt homolog 2Add BLAST1034

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki800Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki820Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki966Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei980PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NRE2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRE2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRE2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRE2

PeptideAtlas

More...PeptideAtlasi		Q9NRE2

PRoteomics IDEntifications database

More...PRIDEi		Q9NRE2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82344 [Q9NRE2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRE2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182463, Expressed in forebrain and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRE2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRE2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182463, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126131, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q9NRE2, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360552

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRE2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRE2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90DisorderedSequence analysisAdd BLAST90
Regioni239 – 265DisorderedSequence analysisAdd BLAST27
Regioni432 – 496DisorderedSequence analysisAdd BLAST65
Regioni598 – 676DisorderedSequence analysisAdd BLAST79
Regioni763 – 789DisorderedSequence analysisAdd BLAST27
Regioni1014 – 1034DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 38Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 37Acidic residuesSequence analysisAdd BLAST15
Compositional biasi61 – 90Polar residuesSequence analysisAdd BLAST30
Compositional biasi432 – 457Polar residuesSequence analysisAdd BLAST26
Compositional biasi458 – 490Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi599 – 667Basic and acidic residuesSequence analysisAdd BLAST69
Compositional biasi774 – 788Polar residuesSequence analysisAdd BLAST15
Compositional biasi1015 – 1034Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the teashirt C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 239C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri926 – 948C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri994 – 1017C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV71, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010469_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRE2

Identification of Orthologs from Complete Genome Data

More...OMAi		SGHYQDD

Database of Orthologous Groups

More...OrthoDBi		106971at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRE2

TreeFam database of animal gene trees

More...TreeFami		TF328447

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001356, Homeobox_dom
IPR027008, Teashirt_fam
IPR027010, Tshz2
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR12487, PTHR12487, 1 hit
PTHR12487:SF3, PTHR12487:SF3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEDSGSVA QLQGGNDTGT 
        60         70         80         90        100
DEELETGPEQ KGCFSYQNSP GSHLSNQDAE NESLLSDASD QVSDIKSVCG 
       110        120        130        140        150
RDASDKKAHT HVRLPNEAHN CMDKMTAVYA NILSDSYWSG LGLGFKLSNS 
       160        170        180        190        200
ERRNCDTRNG SNKSDFDWHQ DALSKSLQQN LPSRSVSKPS LFSSVQLYRQ 
       210        220        230        240        250
SSKMCGTVFT GASRFRCRQC SAAYDTLVEL TVHMNETGHY QDDNRKKDKL 
       260        270        280        290        300
RPTSYSKPRK RAFQDMDKED AQKVLKCMFC GDSFDSLQDL SVHMIKTKHY 
       310        320        330        340        350
QKVPLKEPVP TISSKMVTPA KKRVFDVNRP CSPDSTTGSF ADSFSSQKNA 
       360        370        380        390        400
NLQLSSNNRY GYQNGASYTW QFEACKSQIL KCMECGSSHD TLQQLTTHMM 
       410        420        430        440        450
VTGHFLKVTS SASKKGKQLV LDPLAVEKMQ SLSEAPNSDS LAPKPSSNSA 
       460        470        480        490        500
SDCTASTTEL KKESKKERPE ETSKDEKVVK SEDYEDPLQK PLDPTIKYQY 
       510        520        530        540        550
LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL 
       560        570        580        590        600
SEGTKPPLPM GSQVLQIRPN LTNKLRPIAP KWKVMPLVSM PTHLAPYTQV 
       610        620        630        640        650
KKESEDKDEA VKECGKESPH EEASSFSHSE GDSFRKSETP PEAKKTELGP 
       660        670        680        690        700
LKEEEKLMKE GSEKEKPQPL EPTSALSNGC ALANHAPALP CINPLSALQS 
       710        720        730        740        750
VLNNHLGKAT EPLRSPSCSS PSSSTISMFH KSNLNVMDKP VLSPASTRSA 
       760        770        780        790        800
SVSRRYLFEN SDQPIDLTKS KSKKAESSQA QSCMSPPQKH ALSDIADMVK 
       810        820        830        840        850
VLPKATTPKP ASSSRVPPMK LEMDVRRFED VSSEVSTLHK RKGRQSNWNP 
       860        870        880        890        900
QHLLILQAQF ASSLFQTSEG KYLLSDLGPQ ERMQISKFTG LSMTTISHWL 
       910        920        930        940        950
ANVKYQLRKT GGTKFLKNMD KGHPIFYCSD CASQFRTPST YISHLESHLG 
       960        970        980        990       1000
FQMKDMTRLS VDQQSKVEQE ISRVSSAQRS PETIAAEEDT DSKFKCKLCC 
      1010       1020       1030 
RTFVSKHAVK LHLSKTHSKS PEHHSQFVTD VDEE
Length:1,034
Mass (Da):115,005
Last modified:June 13, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FC14F93D4CD48F6
GO
Isoform 2 (identifier: Q9NRE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MPRRKQQAPKRAA → MMAAALLHYT

Show »
Length:1,031
Mass (Da):114,589
Checksum:i4195F81B388007E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3C8S4R3C8_HUMAN
Teashirt homolog 2
TSHZ2
194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1H0U8B1H0U8_HUMAN
Cell growth-inhibiting protein 7
TSHZ2 hCG_1784586
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF76850 differs from that shown. The sequence differs from that shown due translation of a 3'-UTR region.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198Y → C in CAE45871 (PubMed:17974005).Curated1
Sequence conflicti223A → T in CAE45871 (PubMed:17974005).Curated1
Sequence conflicti563Q → R in BAC03610 (PubMed:14702039).Curated1
Sequence conflicti916L → P in CAE45871 (PubMed:17974005).Curated1
Sequence conflicti983T → A in BAH13747 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026679113R → S2 PublicationsCorresponds to variant dbSNP:rs739869Ensembl.1
Natural variantiVAR_026680681A → T. Corresponds to variant dbSNP:rs6097319Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460711 – 13MPRRK…PKRAA → MMAAALLHYT in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091206 mRNA Translation: BAC03610.1
AK302570 mRNA Translation: BAH13747.1
BX640770 mRNA Translation: CAE45871.1
AL121902 Genomic DNA No translation available.
BX276189 Genomic DNA No translation available.
AL050316 Genomic DNA No translation available.
AL109930 Genomic DNA No translation available.
AL354772 Genomic DNA No translation available.
AL354993 Genomic DNA No translation available.
AL391097 Genomic DNA No translation available.
AF230201 mRNA Translation: AAF76850.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33490.1 [Q9NRE2-1]
CCDS54474.1 [Q9NRE2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001180350.1, NM_001193421.1 [Q9NRE2-2]
NP_775756.3, NM_173485.5 [Q9NRE2-1]
XP_016883129.1, XM_017027640.1 [Q9NRE2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329613; ENSP00000333114; ENSG00000182463 [Q9NRE2-2]
ENST00000371497; ENSP00000360552; ENSG00000182463 [Q9NRE2-1]
ENST00000603338; ENSP00000475114; ENSG00000182463 [Q9NRE2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		128553

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:128553

UCSC genome browser

More...UCSCi		uc002xwo.3, human [Q9NRE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091206 mRNA Translation: BAC03610.1
AK302570 mRNA Translation: BAH13747.1
BX640770 mRNA Translation: CAE45871.1
AL121902 Genomic DNA No translation available.
BX276189 Genomic DNA No translation available.
AL050316 Genomic DNA No translation available.
AL109930 Genomic DNA No translation available.
AL354772 Genomic DNA No translation available.
AL354993 Genomic DNA No translation available.
AL391097 Genomic DNA No translation available.
AF230201 mRNA Translation: AAF76850.1 Sequence problems.
CCDSiCCDS33490.1 [Q9NRE2-1]
CCDS54474.1 [Q9NRE2-2]
RefSeqiNP_001180350.1, NM_001193421.1 [Q9NRE2-2]
NP_775756.3, NM_173485.5 [Q9NRE2-1]
XP_016883129.1, XM_017027640.1 [Q9NRE2-1]

3D structure databases

SMRiQ9NRE2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126131, 25 interactors
IntActiQ9NRE2, 20 interactors
STRINGi9606.ENSP00000360552

PTM databases

iPTMnetiQ9NRE2
PhosphoSitePlusiQ9NRE2

Genetic variation databases

BioMutaiTSHZ2
DMDMi108935911

Proteomic databases

jPOSTiQ9NRE2
MassIVEiQ9NRE2
MaxQBiQ9NRE2
PaxDbiQ9NRE2
PeptideAtlasiQ9NRE2
PRIDEiQ9NRE2
ProteomicsDBi82344 [Q9NRE2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52541, 120 antibodies

The DNASU plasmid repository

More...DNASUi		128553

Genome annotation databases

EnsembliENST00000329613; ENSP00000333114; ENSG00000182463 [Q9NRE2-2]
ENST00000371497; ENSP00000360552; ENSG00000182463 [Q9NRE2-1]
ENST00000603338; ENSP00000475114; ENSG00000182463 [Q9NRE2-2]
GeneIDi128553
KEGGihsa:128553
UCSCiuc002xwo.3, human [Q9NRE2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		128553
DisGeNETi128553

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSHZ2
HGNCiHGNC:13010, TSHZ2
HPAiENSG00000182463, Low tissue specificity
MIMi614118, gene
neXtProtiNX_Q9NRE2
OpenTargetsiENSG00000182463
PharmGKBiPA37589
VEuPathDBiHostDB:ENSG00000182463

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QV71, Eukaryota
GeneTreeiENSGT00950000183051
HOGENOMiCLU_010469_0_0_1
InParanoidiQ9NRE2
OMAiSGHYQDD
OrthoDBi106971at2759
PhylomeDBiQ9NRE2
TreeFamiTF328447

Enzyme and pathway databases

PathwayCommonsiQ9NRE2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		128553, 6 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TSHZ2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		128553
PharosiQ9NRE2, Tbio

Protein Ontology

More...PROi		PR:Q9NRE2
RNActiQ9NRE2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182463, Expressed in forebrain and 200 other tissues
ExpressionAtlasiQ9NRE2, baseline and differential
GenevisibleiQ9NRE2, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356, Homeobox_dom
IPR027008, Teashirt_fam
IPR027010, Tshz2
IPR013087, Znf_C2H2_type
PANTHERiPTHR12487, PTHR12487, 1 hit
PTHR12487:SF3, PTHR12487:SF3, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRE2
Secondary accession number(s): B7Z7W1
, J3KNQ0, Q4VXM4, Q6N003, Q8N260
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 13, 2006
Last modified: September 29, 2021
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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