UniProtKB - Q9NRD8 (DUOX2_HUMAN)
Dual oxidase 2
DUOX2
Functioni
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
1 PublicationCatalytic activityi
Activity regulationi
: thyroid hormone biosynthesis Pathwayi
This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 832 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 834 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 836 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 838 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 843 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 868 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 870 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 872 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 879 | Calcium 2PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- heme binding Source: InterPro
- NAD(P)H oxidase H2O2-forming activity Source: UniProtKB
- NADH oxidase H202-forming activity Source: RHEA
- NADPH oxidase H202-forming activity Source: RHEA
- peroxidase activity Source: UniProtKB-KW
- superoxide-generating NAD(P)H oxidase activity Source: GO_Central
GO - Biological processi
- cuticle development Source: UniProtKB
- cytokine-mediated signaling pathway Source: UniProtKB
- defense response Source: GO_Central
- hormone biosynthetic process Source: UniProtKB-KW
- hydrogen peroxide biosynthetic process Source: UniProtKB
- hydrogen peroxide catabolic process Source: UniProtKB-KW
- positive regulation of cell motility Source: UniProtKB
- positive regulation of wound healing Source: UniProtKB
- response to cAMP Source: UniProtKB
- response to oxidative stress Source: InterPro
- response to virus Source: UniProtKB
- superoxide anion generation Source: UniProtKB
- thyroid hormone generation Source: Reactome
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Hydrogen peroxide, Thyroid hormones biosynthesis |
Ligand | Calcium, FAD, Flavoprotein, Metal-binding, NADP |
Enzyme and pathway databases
BRENDAi | 1.6.3.1, 2681 |
PathwayCommonsi | Q9NRD8 |
Reactomei | R-HSA-209968, Thyroxine biosynthesis |
SABIO-RKi | Q9NRD8 |
SignaLinki | Q9NRD8 |
SIGNORi | Q9NRD8 |
UniPathwayi | UPA00194 |
Protein family/group databases
PeroxiBasei | 3338, HsDuOx02 |
TCDBi | 5.B.1.1.7, the phagocyte (gp91(phox)) nadph oxidase family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DUOX2 Synonyms:LNOX2, THOX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13273, DUOX2 |
MIMi | 606759, gene |
neXtProti | NX_Q9NRD8 |
VEuPathDBi | HostDB:ENSG00000140279 |
Subcellular locationi
Plasma membrane
- Apical cell membrane 2 Publications; Multi-pass membrane protein 1 Publication
Other locations
- Cell junction 1 Publication
Note: Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens, such as Escherichia coli.1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- NADPH oxidase complex Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- apical part of cell Source: UniProtKB
- cell junction Source: UniProtKB-SubCell
- cell leading edge Source: UniProtKB
- cell surface Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 601 | ExtracellularSequence analysisAdd BLAST | 576 | |
Transmembranei | 602 – 622 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 623 – 1041 | CytoplasmicSequence analysisAdd BLAST | 419 | |
Transmembranei | 1042 – 1062 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1063 – 1076 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 1077 – 1097 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1098 – 1128 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 1129 – 1151 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 1152 – 1185 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 1186 – 1206 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1207 – 1223 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 1224 – 1244 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1245 – 1265 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1266 – 1548 | CytoplasmicSequence analysisAdd BLAST | 283 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Thyroid dyshormonogenesis 6 (TDH6)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025323 | 36 | Q → H in TDH6. 1 Publication | 1 | |
Natural variantiVAR_025325 | 376 | R → W in TDH6. 1 PublicationCorresponds to variant dbSNP:rs119472029EnsemblClinVar. | 1 | |
Natural variantiVAR_064619 | 1518 | G → S in TDH6; the enzyme is non-functional; expressed at the cell surface of cells albeit at low level. 1 PublicationCorresponds to variant dbSNP:rs368512412Ensembl. | 1 |
Keywords - Diseasei
Congenital hypothyroidism, Disease variantOrganism-specific databases
DisGeNETi | 50506 |
MalaCardsi | DUOX2 |
MIMi | 607200, phenotype |
OpenTargetsi | ENSG00000140279 |
Orphaneti | 95716, Familial thyroid dyshormonogenesis 226316, Genetic transient congenital hypothyroidism |
PharmGKBi | PA27517 |
Miscellaneous databases
Pharosi | Q9NRD8, Tchem |
Chemistry databases
GuidetoPHARMACOLOGYi | 2999 |
Genetic variation databases
BioMutai | DUOX2 |
DMDMi | 296434485 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000223349 | 26 – 1548 | Dual oxidase 2Add BLAST | 1523 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 124 ↔ 1162 | 1 Publication | ||
Glycosylationi | 348 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 382 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 455 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 537 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 568 | Interchain (with C-167 in DUOXA2)1 Publication | ||
Disulfide bondi | 582 | Interchain (with C-233 in DUOXA2)1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q9NRD8 |
jPOSTi | Q9NRD8 |
MassIVEi | Q9NRD8 |
PaxDbi | Q9NRD8 |
PeptideAtlasi | Q9NRD8 |
PRIDEi | Q9NRD8 |
ProteomicsDBi | 82340 |
PTM databases
GlyGeni | Q9NRD8, 5 sites |
iPTMneti | Q9NRD8 |
PhosphoSitePlusi | Q9NRD8 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000140279, Expressed in nasal cavity epithelium and 133 other tissues |
ExpressionAtlasi | Q9NRD8, baseline and differential |
Genevisiblei | Q9NRD8, HS |
Organism-specific databases
HPAi | ENSG00000140279, Tissue enhanced (gallbladder, thyroid gland, urinary bladder) |
Interactioni
Subunit structurei
Heterodimer with DUOXA2; disulfide-linked.
Interacts with TXNDC11, TPO and CYBA.
2 PublicationsBinary interactionsi
Q9NRD8
With | #Exp. | IntAct |
---|---|---|
DUOXA2 [Q1HG44] | 5 | EBI-12740885,EBI-25589731 |
Protein-protein interaction databases
BioGRIDi | 119077, 3 interactors |
IntActi | Q9NRD8, 2 interactors |
STRINGi | 9606.ENSP00000475084 |
Miscellaneous databases
RNActi | Q9NRD8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 819 – 854 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 855 – 890 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 899 – 934 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1084 – 1266 | Ferric oxidoreductaseAdd BLAST | 183 | |
Domaini | 1267 – 1373 | FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST | 107 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 596 | Peroxidase-like; mediates peroxidase activityBy similarityAdd BLAST | 567 | |
Regioni | 960 – 1245 | Interaction with TXNDC11By similarityAdd BLAST | 286 | |
Regioni | 971 – 991 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0039, Eukaryota |
GeneTreei | ENSGT00940000160291 |
InParanoidi | Q9NRD8 |
PhylomeDBi | Q9NRD8 |
TreeFami | TF105424 |
Family and domain databases
CDDi | cd09820, dual_peroxidase_like, 1 hit cd00051, EFh, 2 hits |
Gene3Di | 1.10.640.10, 1 hit 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR034818, DUOX2 IPR034821, DUOX_peroxidase IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR013112, FAD-bd_8 IPR017927, FAD-bd_FR_type IPR013130, Fe3_Rdtase_TM_dom IPR013121, Fe_red_NAD-bd_6 IPR039261, FNR_nucleotide-bd IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal IPR017938, Riboflavin_synthase-like_b-brl |
PANTHERi | PTHR11972:SF67, PTHR11972:SF67, 1 hit |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit PF00036, EF-hand_1, 1 hit PF08022, FAD_binding_8, 1 hit PF01794, Ferric_reduct, 1 hit PF08030, NAD_binding_6, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF48113, SSF48113, 1 hit SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS51384, FAD_FR, 1 hit PS50292, PEROXIDASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLRARPEALM LLGALLTGSL GPSGNQDALS LPWEVQRYDG WFNNLRHHER
60 70 80 90 100
GAVGCRLQRR VPANYADGVY QALEEPQLPN PRRLSNAATR GIAGLPSLHN
110 120 130 140 150
RTVLGVFFGY HVLSDVVSVE TPGCPAEFLN IRIPPGDPVF DPDQRGDVVL
160 170 180 190 200
PFQRSRWDPE TGRSPSNPRD LANQVTGWLD GSAIYGSSHS WSDALRSFSG
210 220 230 240 250
GQLASGPDPA FPRDSQNPLL MWAAPDPATG QNGPRGLYAF GAERGNREPF
260 270 280 290 300
LQALGLLWFR YHNLWAQRLA RQHPDWEDEE LFQHARKRVI ATYQNIAVYE
310 320 330 340 350
WLPSFLQKTL PEYTGYRPFL DPSISPEFVV ASEQFFSTMV PPGVYMRNAS
360 370 380 390 400
CHFRKVLNKG FQSSQALRVC NNYWIRENPN LNSTQEVNEL LLGMASQISE
410 420 430 440 450
LEDNIVVEDL RDYWPGPGKF SRTDYVASSI QRGRDMGLPS YSQALLAFGL
460 470 480 490 500
DIPRNWSDLN PNVDPQVLEA TAALYNQDLS QLELLLGGLL ESHGDPGPLF
510 520 530 540 550
SAIVLDQFVR LRDGDRYWFE NTRNGLFSKK EIEDIRNTTL RDVLVAVINI
560 570 580 590 600
DPSALQPNVF VWHKGAPCPQ PKQLTTDGLP QCAPLTVLDF FEGSSPGFAI
610 620 630 640 650
TIIALCCLPL VSLLLSGVVA YFRGREHKKL QKKLKESVKK EAAKDGVPAM
660 670 680 690 700
EWPGPKERSS PIIIQLLSDR CLQVLNRHLT VLRVVQLQPL QQVNLILSNN
710 720 730 740 750
RGCRTLLLKI PKEYDLVLLF SSEEERGAFV QQLWDFCVRW ALGLHVAEMS
760 770 780 790 800
EKELFRKAVT KQQRERILEI FFRHLFAQVL DINQADAGTL PLDSSQKVRE
810 820 830 840 850
ALTCELSRAE FAESLGLKPQ DMFVESMFSL ADKDGNGYLS FREFLDILVV
860 870 880 890 900
FMKGSPEDKS RLMFTMYDLD ENGFLSKDEF FTMMRSFIEI SNNCLSKAQL
910 920 930 940 950
AEVVESMFRE SGFQDKEELT WEDFHFMLRD HDSELRFTQL CVKGGGGGGN
960 970 980 990 1000
GIRDIFKQNI SCRVSFITRT PGERSHPQGL GPPAPEAPEL GGPGLKKRFG
1010 1020 1030 1040 1050
KKAAVPTPRL YTEALQEKMQ RGFLAQKLQQ YKRFVENYRR HIVCVAIFSA
1060 1070 1080 1090 1100
ICVGVFADRA YYYGFASPPS DIAQTTLVGI ILSRGTAASV SFMFSYILLT
1110 1120 1130 1140 1150
MCRNLITFLR ETFLNRYVPF DAAVDFHRWI AMAAVVLAIL HSAGHAVNVY
1160 1170 1180 1190 1200
IFSVSPLSLL ACIFPNVFVN DGSKLPQKFY WWFFQTVPGM TGVLLLLVLA
1210 1220 1230 1240 1250
IMYVFASHHF RRRSFRGFWL THHLYILLYA LLIIHGSYAL IQLPTFHIYF
1260 1270 1280 1290 1300
LVPAIIYGGD KLVSLSRKKV EISVVKAELL PSGVTYLQFQ RPQGFEYKSG
1310 1320 1330 1340 1350
QWVRIACLAL GTTEYHPFTL TSAPHEDTLS LHIRAVGPWT TRLREIYSSP
1360 1370 1380 1390 1400
KGNGCAGYPK LYLDGPFGEG HQEWHKFEVS VLVGGGIGVT PFASILKDLV
1410 1420 1430 1440 1450
FKSSLGSQML CKKIYFIWVT RTQRQFEWLA DIIQEVEEND HQDLVSVHIY
1460 1470 1480 1490 1500
VTQLAEKFDL RTTMLYICER HFQKVLNRSL FTGLRSITHF GRPPFEPFFN
1510 1520 1530 1540
SLQEVHPQVR KIGVFSCGPP GMTKNVEKAC QLVNRQDRAH FMHHYENF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RAN8 | X6RAN8_HUMAN | NAD(P)H oxidase (H(2)O(2)-forming) | DUOX2 | 1,548 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | N → S in AAF73922 (PubMed:10806195).Curated | 1 | |
Sequence conflicti | 25 | N → S in AAF78954 (PubMed:11514595).Curated | 1 | |
Sequence conflicti | 984 | A → V in AAF78954 (PubMed:11514595).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025323 | 36 | Q → H in TDH6. 1 Publication | 1 | |
Natural variantiVAR_025324 | 138 | P → L1 PublicationCorresponds to variant dbSNP:rs2001616EnsemblClinVar. | 1 | |
Natural variantiVAR_025325 | 376 | R → W in TDH6. 1 PublicationCorresponds to variant dbSNP:rs119472029EnsemblClinVar. | 1 | |
Natural variantiVAR_061177 | 678 | H → R. Corresponds to variant dbSNP:rs57659670EnsemblClinVar. | 1 | |
Natural variantiVAR_047075 | 1067 | S → L3 PublicationsCorresponds to variant dbSNP:rs269868EnsemblClinVar. | 1 | |
Natural variantiVAR_075549 | 1211 | R → C Found in a patient with very early onset inflammatory bowel disease; unknown pathological significance; no effect on subcellular location; significantly reduced ROS generation, which may decrease resistance to infection by enteric pathogens, such as Escherichia coli. 1 PublicationCorresponds to variant dbSNP:rs374410986Ensembl. | 1 | |
Natural variantiVAR_075550 | 1492 | R → C Found in a patient with very early onset inflammatory bowel disease; unknown pathological significance; no effect on subcellular location; significantly reduced ROS generation, which may decrease resistance to infection by enteric pathogens, such as Escherichia coli. 1 PublicationCorresponds to variant dbSNP:rs747720952EnsemblClinVar. | 1 | |
Natural variantiVAR_064619 | 1518 | G → S in TDH6; the enzyme is non-functional; expressed at the cell surface of cells albeit at low level. 1 PublicationCorresponds to variant dbSNP:rs368512412Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230496 mRNA Translation: AAF73922.1 AF267981 mRNA Translation: AAF78954.1 AC091117 Genomic DNA No translation available. AF181972 mRNA Translation: AAF20055.1 GU174495 Genomic DNA Translation: ADB22378.1 |
CCDSi | CCDS10117.1 CCDS86454.1 |
RefSeqi | NP_054799.4, NM_014080.4 |
Genome annotation databases
Ensembli | ENST00000603300; ENSP00000475084; ENSG00000140279 |
GeneIDi | 50506 |
KEGGi | hsa:50506 |
UCSCi | uc010bea.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Undiagnosed Disease Network DUOX2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230496 mRNA Translation: AAF73922.1 AF267981 mRNA Translation: AAF78954.1 AC091117 Genomic DNA No translation available. AF181972 mRNA Translation: AAF20055.1 GU174495 Genomic DNA Translation: ADB22378.1 |
CCDSi | CCDS10117.1 CCDS86454.1 |
RefSeqi | NP_054799.4, NM_014080.4 |
3D structure databases
SMRi | Q9NRD8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119077, 3 interactors |
IntActi | Q9NRD8, 2 interactors |
STRINGi | 9606.ENSP00000475084 |
Chemistry databases
GuidetoPHARMACOLOGYi | 2999 |
Protein family/group databases
PeroxiBasei | 3338, HsDuOx02 |
TCDBi | 5.B.1.1.7, the phagocyte (gp91(phox)) nadph oxidase family |
PTM databases
GlyGeni | Q9NRD8, 5 sites |
iPTMneti | Q9NRD8 |
PhosphoSitePlusi | Q9NRD8 |
Genetic variation databases
BioMutai | DUOX2 |
DMDMi | 296434485 |
Proteomic databases
EPDi | Q9NRD8 |
jPOSTi | Q9NRD8 |
MassIVEi | Q9NRD8 |
PaxDbi | Q9NRD8 |
PeptideAtlasi | Q9NRD8 |
PRIDEi | Q9NRD8 |
ProteomicsDBi | 82340 |
Protocols and materials databases
Antibodypediai | 24313, 175 antibodies from 21 providers |
DNASUi | 50506 |
Genome annotation databases
Ensembli | ENST00000603300; ENSP00000475084; ENSG00000140279 |
GeneIDi | 50506 |
KEGGi | hsa:50506 |
UCSCi | uc010bea.4, human |
Organism-specific databases
CTDi | 50506 |
DisGeNETi | 50506 |
GeneCardsi | DUOX2 |
HGNCi | HGNC:13273, DUOX2 |
HPAi | ENSG00000140279, Tissue enhanced (gallbladder, thyroid gland, urinary bladder) |
MalaCardsi | DUOX2 |
MIMi | 606759, gene 607200, phenotype |
neXtProti | NX_Q9NRD8 |
OpenTargetsi | ENSG00000140279 |
Orphaneti | 95716, Familial thyroid dyshormonogenesis 226316, Genetic transient congenital hypothyroidism |
PharmGKBi | PA27517 |
VEuPathDBi | HostDB:ENSG00000140279 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0039, Eukaryota |
GeneTreei | ENSGT00940000160291 |
InParanoidi | Q9NRD8 |
PhylomeDBi | Q9NRD8 |
TreeFami | TF105424 |
Enzyme and pathway databases
UniPathwayi | UPA00194 |
BRENDAi | 1.6.3.1, 2681 |
PathwayCommonsi | Q9NRD8 |
Reactomei | R-HSA-209968, Thyroxine biosynthesis |
SABIO-RKi | Q9NRD8 |
SignaLinki | Q9NRD8 |
SIGNORi | Q9NRD8 |
Miscellaneous databases
BioGRID-ORCSi | 50506, 7 hits in 1037 CRISPR screens |
ChiTaRSi | DUOX2, human |
GeneWikii | Dual_oxidase_2 |
GenomeRNAii | 50506 |
Pharosi | Q9NRD8, Tchem |
PROi | PR:Q9NRD8 |
RNActi | Q9NRD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140279, Expressed in nasal cavity epithelium and 133 other tissues |
ExpressionAtlasi | Q9NRD8, baseline and differential |
Genevisiblei | Q9NRD8, HS |
Family and domain databases
CDDi | cd09820, dual_peroxidase_like, 1 hit cd00051, EFh, 2 hits |
Gene3Di | 1.10.640.10, 1 hit 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR034818, DUOX2 IPR034821, DUOX_peroxidase IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR013112, FAD-bd_8 IPR017927, FAD-bd_FR_type IPR013130, Fe3_Rdtase_TM_dom IPR013121, Fe_red_NAD-bd_6 IPR039261, FNR_nucleotide-bd IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal IPR017938, Riboflavin_synthase-like_b-brl |
PANTHERi | PTHR11972:SF67, PTHR11972:SF67, 1 hit |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit PF00036, EF-hand_1, 1 hit PF08022, FAD_binding_8, 1 hit PF01794, Ferric_reduct, 1 hit PF08030, NAD_binding_6, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF48113, SSF48113, 1 hit SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS51384, FAD_FR, 1 hit PS50292, PEROXIDASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DUOX2_HUMAN | |
Accessioni | Q9NRD8Primary (citable) accession number: Q9NRD8 Secondary accession number(s): A8MQ13 Q9UHF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families