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UniProtKB - Q9NRD8 (DUOX2_HUMAN)

Protein

Dual oxidase 2

Gene

DUOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.1 Publication

Catalytic activityi

NAD(P)H + O2 = NAD(P)+ + H2O2.1 Publication

Activity regulationi

Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent.By similarity1 Publication

Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi832 – 8431PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi868 – 8792PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • heme binding Source: InterPro
  • NAD(P)H oxidase activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide, Thyroid hormones biosynthesis
LigandCalcium, FAD, Flavoprotein, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.6.3.1 2681
ReactomeiR-HSA-209968 Thyroxine biosynthesis
SABIO-RKiQ9NRD8
UniPathwayi
UPA00194

Protein family/group databases

PeroxiBasei3338 HsDuOx02
TCDBi5.B.1.1.7 the phagocyte (gp91(phox)) nadph oxidase family

Names & Taxonomyi

Protein namesi
Recommended name:
Dual oxidase 2 (EC:1.11.1.-, EC:1.6.3.1)
Alternative name(s):
Large NOX 2
Long NOX 2
NADH/NADPH thyroid oxidase p138-tox
NADPH oxidase/peroxidase DUOX2
NADPH thyroid oxidase 2
Thyroid oxidase 2
p138 thyroid oxidase
Gene namesi
Name:DUOX2
Synonyms:LNOX2, THOX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140279.12
HGNCiHGNC:13273 DUOX2
MIMi606759 gene
neXtProtiNX_Q9NRD8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 601ExtracellularSequence analysisAdd BLAST576
Transmembranei602 – 622HelicalSequence analysisAdd BLAST21
Topological domaini623 – 1041CytoplasmicSequence analysisAdd BLAST419
Transmembranei1042 – 1062HelicalSequence analysisAdd BLAST21
Topological domaini1063 – 1076ExtracellularSequence analysisAdd BLAST14
Transmembranei1077 – 1097HelicalSequence analysisAdd BLAST21
Topological domaini1098 – 1128CytoplasmicSequence analysisAdd BLAST31
Transmembranei1129 – 1151HelicalSequence analysisAdd BLAST23
Topological domaini1152 – 1185ExtracellularSequence analysisAdd BLAST34
Transmembranei1186 – 1206HelicalSequence analysisAdd BLAST21
Topological domaini1207 – 1223CytoplasmicSequence analysisAdd BLAST17
Transmembranei1224 – 1244HelicalSequence analysisAdd BLAST21
Transmembranei1245 – 1265HelicalSequence analysisAdd BLAST21
Topological domaini1266 – 1548CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Thyroid dyshormonogenesis 6 (TDH6)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
See also OMIM:607200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02532336Q → H in TDH6. 1 Publication1
Natural variantiVAR_025325376R → W in TDH6. 1 PublicationCorresponds to variant dbSNP:rs119472029EnsemblClinVar.1
Natural variantiVAR_0646191518G → S in TDH6; the enzyme is non-functional; expressed at the cell surface of cells albeit at low level. 1 PublicationCorresponds to variant dbSNP:rs368512412Ensembl.1
Defects in DUOX2 may play a role in the pathogenesis of very early onset inflammatory bowel disease (VEOIBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology diagnosed before 6 years of age. VEOIBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but the phenotype of children with onset of Crohn disease occurring younger than the age of 10 is predominantly colonic, with a lower risk of ileal disease. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.1 Publication

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNETi50506
MalaCardsiDUOX2
MIMi607200 phenotype
OpenTargetsiENSG00000140279
Orphaneti95716 Familial thyroid dyshormonogenesis
226316 Genetic transient congenital hypothyroidism
PharmGKBiPA27517

Chemistry databases

GuidetoPHARMACOLOGYi2999

Polymorphism and mutation databases

BioMutaiDUOX2
DMDMi296434485

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000022334926 – 1548Dual oxidase 2Add BLAST1523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 11621 Publication
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi568Interchain (with C-167 in DUOXA2)1 Publication
Disulfide bondi582Interchain (with C-233 in DUOXA2)1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NRD8
PaxDbiQ9NRD8
PeptideAtlasiQ9NRD8
PRIDEiQ9NRD8
ProteomicsDBi82340

PTM databases

iPTMnetiQ9NRD8
PhosphoSitePlusiQ9NRD8

Expressioni

Tissue specificityi

Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis.5 Publications

Developmental stagei

Widely expressed in fetal tissues.1 Publication

Inductioni

By forskolin, thyrotropin and the Th1-specific cytokine IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000140279 Expressed in 119 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_DUOX2
ExpressionAtlasiQ9NRD8 baseline and differential
GenevisibleiQ9NRD8 HS

Interactioni

Subunit structurei

Heterodimer with DUOXA2; disulfide-linked. Interacts with TXNDC11, TPO and CYBA.2 Publications

Protein-protein interaction databases

IntActiQ9NRD8, 1 interactor
STRINGi9606.ENSP00000373691

Structurei

3D structure databases

ProteinModelPortaliQ9NRD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini819 – 854EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini855 – 890EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini899 – 934EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini1084 – 1266Ferric oxidoreductaseAdd BLAST183
Domaini1267 – 1373FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 596Peroxidase-like; mediates peroxidase activityBy similarityAdd BLAST567
Regioni960 – 1245Interaction with TXNDC11By similarityAdd BLAST286

Sequence similaritiesi

In the N-terminal section; belongs to the peroxidase family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000231774
HOVERGENiHBG080428
InParanoidiQ9NRD8
KOiK13411
OrthoDBiEOG091G00PO
PhylomeDBiQ9NRD8
TreeFamiTF105424

Family and domain databases

CDDicd09820 dual_peroxidase_like, 1 hit
cd00051 EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR034818 DUOX2
IPR034821 DUOX_peroxidase
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013112 FAD-bd_8
IPR017927 FAD-bd_FR_type
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide-bd
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67 PTHR11972:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00036 EF-hand_1, 1 hit
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48113 SSF48113, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS51384 FAD_FR, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRARPEALM LLGALLTGSL GPSGNQDALS LPWEVQRYDG WFNNLRHHER 
        60         70         80         90        100
GAVGCRLQRR VPANYADGVY QALEEPQLPN PRRLSNAATR GIAGLPSLHN 
       110        120        130        140        150
RTVLGVFFGY HVLSDVVSVE TPGCPAEFLN IRIPPGDPVF DPDQRGDVVL 
       160        170        180        190        200
PFQRSRWDPE TGRSPSNPRD LANQVTGWLD GSAIYGSSHS WSDALRSFSG 
       210        220        230        240        250
GQLASGPDPA FPRDSQNPLL MWAAPDPATG QNGPRGLYAF GAERGNREPF 
       260        270        280        290        300
LQALGLLWFR YHNLWAQRLA RQHPDWEDEE LFQHARKRVI ATYQNIAVYE 
       310        320        330        340        350
WLPSFLQKTL PEYTGYRPFL DPSISPEFVV ASEQFFSTMV PPGVYMRNAS 
       360        370        380        390        400
CHFRKVLNKG FQSSQALRVC NNYWIRENPN LNSTQEVNEL LLGMASQISE 
       410        420        430        440        450
LEDNIVVEDL RDYWPGPGKF SRTDYVASSI QRGRDMGLPS YSQALLAFGL 
       460        470        480        490        500
DIPRNWSDLN PNVDPQVLEA TAALYNQDLS QLELLLGGLL ESHGDPGPLF 
       510        520        530        540        550
SAIVLDQFVR LRDGDRYWFE NTRNGLFSKK EIEDIRNTTL RDVLVAVINI 
       560        570        580        590        600
DPSALQPNVF VWHKGAPCPQ PKQLTTDGLP QCAPLTVLDF FEGSSPGFAI 
       610        620        630        640        650
TIIALCCLPL VSLLLSGVVA YFRGREHKKL QKKLKESVKK EAAKDGVPAM 
       660        670        680        690        700
EWPGPKERSS PIIIQLLSDR CLQVLNRHLT VLRVVQLQPL QQVNLILSNN 
       710        720        730        740        750
RGCRTLLLKI PKEYDLVLLF SSEEERGAFV QQLWDFCVRW ALGLHVAEMS 
       760        770        780        790        800
EKELFRKAVT KQQRERILEI FFRHLFAQVL DINQADAGTL PLDSSQKVRE 
       810        820        830        840        850
ALTCELSRAE FAESLGLKPQ DMFVESMFSL ADKDGNGYLS FREFLDILVV 
       860        870        880        890        900
FMKGSPEDKS RLMFTMYDLD ENGFLSKDEF FTMMRSFIEI SNNCLSKAQL 
       910        920        930        940        950
AEVVESMFRE SGFQDKEELT WEDFHFMLRD HDSELRFTQL CVKGGGGGGN 
       960        970        980        990       1000
GIRDIFKQNI SCRVSFITRT PGERSHPQGL GPPAPEAPEL GGPGLKKRFG 
      1010       1020       1030       1040       1050
KKAAVPTPRL YTEALQEKMQ RGFLAQKLQQ YKRFVENYRR HIVCVAIFSA 
      1060       1070       1080       1090       1100
ICVGVFADRA YYYGFASPPS DIAQTTLVGI ILSRGTAASV SFMFSYILLT 
      1110       1120       1130       1140       1150
MCRNLITFLR ETFLNRYVPF DAAVDFHRWI AMAAVVLAIL HSAGHAVNVY 
      1160       1170       1180       1190       1200
IFSVSPLSLL ACIFPNVFVN DGSKLPQKFY WWFFQTVPGM TGVLLLLVLA 
      1210       1220       1230       1240       1250
IMYVFASHHF RRRSFRGFWL THHLYILLYA LLIIHGSYAL IQLPTFHIYF 
      1260       1270       1280       1290       1300
LVPAIIYGGD KLVSLSRKKV EISVVKAELL PSGVTYLQFQ RPQGFEYKSG 
      1310       1320       1330       1340       1350
QWVRIACLAL GTTEYHPFTL TSAPHEDTLS LHIRAVGPWT TRLREIYSSP 
      1360       1370       1380       1390       1400
KGNGCAGYPK LYLDGPFGEG HQEWHKFEVS VLVGGGIGVT PFASILKDLV 
      1410       1420       1430       1440       1450
FKSSLGSQML CKKIYFIWVT RTQRQFEWLA DIIQEVEEND HQDLVSVHIY 
      1460       1470       1480       1490       1500
VTQLAEKFDL RTTMLYICER HFQKVLNRSL FTGLRSITHF GRPPFEPFFN 
      1510       1520       1530       1540 
SLQEVHPQVR KIGVFSCGPP GMTKNVEKAC QLVNRQDRAH FMHHYENF
Length:1,548
Mass (Da):175,364
Last modified:May 18, 2010 - v2
Checksum:i7BAA2350EC0A2A7E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RAN8X6RAN8_HUMAN
Dual oxidase 2
DUOX2
1,548Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25N → S in AAF73922 (PubMed:10806195).Curated1
Sequence conflicti25N → S in AAF78954 (PubMed:11514595).Curated1
Sequence conflicti984A → V in AAF78954 (PubMed:11514595).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02532336Q → H in TDH6. 1 Publication1
Natural variantiVAR_025324138P → L1 PublicationCorresponds to variant dbSNP:rs2001616EnsemblClinVar.1
Natural variantiVAR_025325376R → W in TDH6. 1 PublicationCorresponds to variant dbSNP:rs119472029EnsemblClinVar.1
Natural variantiVAR_061177678H → R. Corresponds to variant dbSNP:rs57659670EnsemblClinVar.1
Natural variantiVAR_0470751067S → L3 PublicationsCorresponds to variant dbSNP:rs269868EnsemblClinVar.1
Natural variantiVAR_0755491211R → C Found in a patient with very early onset inflammatory bowel disease; unknown pathological significance; no effect on subcellular location; significantly reduced ROS generation, which may decrease resistance to infection by enteric pathogens, such as Escherichia coli. 1 PublicationCorresponds to variant dbSNP:rs374410986Ensembl.1
Natural variantiVAR_0755501492R → C Found in a patient with very early onset inflammatory bowel disease; unknown pathological significance; no effect on subcellular location; significantly reduced ROS generation, which may decrease resistance to infection by enteric pathogens, such as Escherichia coli. 1 PublicationCorresponds to variant dbSNP:rs374410986Ensembl.1
Natural variantiVAR_0646191518G → S in TDH6; the enzyme is non-functional; expressed at the cell surface of cells albeit at low level. 1 PublicationCorresponds to variant dbSNP:rs368512412Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230496 mRNA Translation: AAF73922.1
AF267981 mRNA Translation: AAF78954.1
AC091117 Genomic DNA No translation available.
AF181972 mRNA Translation: AAF20055.1
GU174495 Genomic DNA Translation: ADB22378.1
CCDSiCCDS10117.1
CCDS86454.1
RefSeqiNP_054799.4, NM_014080.4
UniGeneiHs.71377

Genome annotation databases

EnsembliENST00000603300; ENSP00000475084; ENSG00000140279
GeneIDi50506
KEGGihsa:50506
UCSCiuc010bea.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Undiagnosed Disease Network

DUOX2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230496 mRNA Translation: AAF73922.1
AF267981 mRNA Translation: AAF78954.1
AC091117 Genomic DNA No translation available.
AF181972 mRNA Translation: AAF20055.1
GU174495 Genomic DNA Translation: ADB22378.1
CCDSiCCDS10117.1
CCDS86454.1
RefSeqiNP_054799.4, NM_014080.4
UniGeneiHs.71377

3D structure databases

ProteinModelPortaliQ9NRD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NRD8, 1 interactor
STRINGi9606.ENSP00000373691

Chemistry databases

GuidetoPHARMACOLOGYi2999

Protein family/group databases

PeroxiBasei3338 HsDuOx02
TCDBi5.B.1.1.7 the phagocyte (gp91(phox)) nadph oxidase family

PTM databases

iPTMnetiQ9NRD8
PhosphoSitePlusiQ9NRD8

Polymorphism and mutation databases

BioMutaiDUOX2
DMDMi296434485

Proteomic databases

EPDiQ9NRD8
PaxDbiQ9NRD8
PeptideAtlasiQ9NRD8
PRIDEiQ9NRD8
ProteomicsDBi82340

Protocols and materials databases

DNASUi50506
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000603300; ENSP00000475084; ENSG00000140279
GeneIDi50506
KEGGihsa:50506
UCSCiuc010bea.4 human

Organism-specific databases

CTDi50506
DisGeNETi50506
EuPathDBiHostDB:ENSG00000140279.12
GeneCardsiDUOX2
H-InvDBiHIX0038086
HGNCiHGNC:13273 DUOX2
MalaCardsiDUOX2
MIMi606759 gene
607200 phenotype
neXtProtiNX_Q9NRD8
OpenTargetsiENSG00000140279
Orphaneti95716 Familial thyroid dyshormonogenesis
226316 Genetic transient congenital hypothyroidism
PharmGKBiPA27517
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000231774
HOVERGENiHBG080428
InParanoidiQ9NRD8
KOiK13411
OrthoDBiEOG091G00PO
PhylomeDBiQ9NRD8
TreeFamiTF105424

Enzyme and pathway databases

UniPathwayi
UPA00194

BRENDAi1.6.3.1 2681
ReactomeiR-HSA-209968 Thyroxine biosynthesis
SABIO-RKiQ9NRD8

Miscellaneous databases

ChiTaRSiDUOX2 human
GeneWikiiDual_oxidase_2
GenomeRNAii50506
PROiPR:Q9NRD8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140279 Expressed in 119 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_DUOX2
ExpressionAtlasiQ9NRD8 baseline and differential
GenevisibleiQ9NRD8 HS

Family and domain databases

CDDicd09820 dual_peroxidase_like, 1 hit
cd00051 EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR034818 DUOX2
IPR034821 DUOX_peroxidase
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013112 FAD-bd_8
IPR017927 FAD-bd_FR_type
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide-bd
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67 PTHR11972:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00036 EF-hand_1, 1 hit
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48113 SSF48113, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS51384 FAD_FR, 1 hit
PS50292 PEROXIDASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUOX2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRD8
Secondary accession number(s): A8MQ13
, D2XI64, Q9NR02, Q9UHF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 18, 2010
Last modified: October 10, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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